EKS-TAR-00359

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00359

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	448.4	2.5E-134	204	491	288

Status

Unreviewed

Ensembl Protein

ENSTRUP00000017213

UniProt Accession

H2SXS4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000007007	ENSTRUP00000017211	ENSTRUT00000017284
ENSTRUG00000007007	ENSTRUP00000017212	ENSTRUT00000017285
ENSTRUG00000007007	ENSTRUP00000017213	ENSTRUT00000017286

Organism

Takifugu rubripes

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

LCNMNVTVQA PGKEVETKPL KREEHECVCE GSSCASGNRC MGHLCFSSLT DSAGSLVYQK 60

GCFKIYEQST MTCKTPPSRD QIVECCSGHL CNLNSTVELP VKAPLGLKSE ELPSYSVTTL 120

VIVIVAPIIV LIVLSAAAIL VFRRIHHNQM ERLTSRDAEY GTIDGLIASN VGDSTLADLL 180

DHSCTSGSGS GLPFLVQRTV ARQITLNECV GKGRYGEVWR GQWQGENVAV KIFSSRDEKS 240

WFRETEIYNT VLLRHENILG FIASDMTSRN SSTQLWLITH FQEMGSLYDY LQLSTLDASS 300

CLCMALSIAC GLAHLHVEIF GTQGKPAIAH RDLKSKNILV KKNGQCCIAD LGLAVMHFQD 360

TNELDVGNNP KVGTKRYMAP EVLDDSIQMD CFESFKRVDI WALGLVLWEI ARRTVSNGIV 420

EDYKPPFHDV VPSDPSFEDM KKVVCVDQQR PNIPNRWFSD PTLTSMAKLM KECWYQNPSA 480

RLTALRIKKT LTKIDNSLDK IKMDI 505

Nucleotide Sequence
(FASTA)

CTGTGTAACA TGAATGTCAC TGTGCAAGCT CCAGGGAAAG AGGTTGAGAC AAAGCCTCTG 60

AAAAGGGAGG AGCATGAGTG TGTATGTGAG GGCAGCTCAT GCGCGTCGGG AAATCGCTGC 120

ATGGGTCACC TTTGCTTCTC ATCTTTGACG GACAGCGCCG GCTCCCTGGT GTACCAGAAG 180

GGATGCTTTA AGATCTATGA GCAGAGCACA ATGACGTGCA AGACCCCACC CTCCCGAGAC 240

CAGATCGTGG AATGCTGCTC CGGTCACCTG TGTAACTTAA ACAGCACGGT GGAGCTGCCT 300

GTTAAAGCAC CTTTAGGCCT CAAATCTGAA GAACTTCCCA GCTACAGCGT GACCACGCTG 360

GTCATTGTCA TTGTGGCCCC CATCATCGTC CTCATCGTCC TCTCCGCCGC CGCCATCCTG 420

GTGTTCAGAC GCATCCACCA TAACCAGATG GAGAGGTTAA CGTCGCGGGA CGCAGAGTAC 480

GGAACCATCG ACGGCCTCAT CGCGTCCAAC GTCGGTGACA GCACCCTGGC GGATCTGTTG 540

GATCACTCCT GTACTTCTGG AAGTGGTTCA GGGTTGCCTT TCCTTGTTCA GAGAACCGTG 600

GCCAGACAAA TTACCCTTAA TGAGTGTGTG GGTAAGGGCC GTTATGGTGA AGTGTGGAGG 660

GGTCAGTGGC AGGGGGAGAA CGTTGCAGTC AAGATTTTCT CTTCCAGAGA CGAGAAGTCC 720

TGGTTCAGAG AGACGGAGAT CTACAACACG GTGCTGCTGC GACACGAGAA CATCCTGGGC 780

TTCATAGCTT CTGACATGAC CTCCAGGAAC TCCAGCACCC AGCTGTGGTT GATCACTCAC 840

TTCCAAGAGA TGGGCTCCCT GTACGACTAC CTCCAGCTCA GCACTCTGGA TGCTTCCAGC 900

TGCCTCTGCA TGGCTCTCTC CATCGCCTGC GGGCTGGCGC ATCTCCACGT GGAGATCTTT 960

GGCACCCAGG GCAAACCGGC CATCGCCCAC CGAGACCTGA AGAGCAAAAA CATACTGGTT 1020

AAAAAGAACG GGCAGTGCTG CATCGCTGAC CTCGGTCTGG CCGTCATGCA TTTTCAAGAC 1080

ACCAATGAGC TGGACGTGGG GAATAATCCC AAAGTGGGCA CGAAGCGCTA CATGGCCCCC 1140

GAGGTGCTCG ATGACTCCAT CCAGATGGAC TGTTTTGAGT CCTTCAAAAG AGTGGACATC 1200

TGGGCCCTGG GCCTTGTCCT GTGGGAGATC GCCAGGAGGA CGGTTAGCAA TGGTATCGTG 1260

GAAGACTACA AGCCGCCGTT CCACGACGTG GTCCCCAGTG ATCCCAGTTT TGAGGACATG 1320

AAGAAGGTTG TGTGTGTGGA CCAGCAGAGG CCAAACATAC CAAACAGATG GTTTTCGGAC 1380

CCAACTCTGA CCTCCATGGC CAAACTGATG AAGGAGTGCT GGTACCAGAA TCCTTCGGCC 1440

AGGCTAACAG CGTTACGCAT CAAAAAGACT CTCACAAAGA TCGACAACTC TCTGGACAAA 1500

ATCAAAATGG ACATTTGA 1518

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+eiy+tvllrhenil+fia

Q: 204   ITLNECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIA  263

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+++e+gsL+dyL+ +tld++++l +als+a+GlahLH ei+gt+

Q: 264   SDMTSRNSSTQLWLITHFQEMGSLYDYLQLSTLDASSCLCMALSIACGLAHLHVEIFGTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++ ++++eld+ +n +vGtkRYmaPE

Q: 324   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDTNELDVGNNPKVGTKRYMAPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++++++fe+fkr+D+++lgLvlWE+a+R+ + +++ve+yk+pf++vv+sdPs+e+m

Q: 382   VLDDSIQMDCFESFKRVDIWALGLVLWEIARRTVS-NGIVEDYKPPFHDVVPSDPSFEDM  440

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+++++rP+ip++w ++++l++++kl++ecW+++p+aRltalr+kk+l

Q: 441   KKVVCVDQQRPNIPNRWFSDPTLTSMAKLMKECWYQNPSARLTALRIKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

ITLNECVGKG RYGEVWRGQW QGENVAVKIF SSRDEKSWFR ETEIYNTVLL RHENILGFIA 60

SDMTSRNSST QLWLITHFQE MGSLYDYLQL STLDASSCLC MALSIACGLA HLHVEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHFQDTNE LDVGNNPKVG TKRYMAPEVL 180

DDSIQMDCFE SFKRVDIWAL GLVLWEIARR TVSNGIVEDY KPPFHDVVPS DPSFEDMKKV 240

VCVDQQRPNI PNRWFSDPTL TSMAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013