EKS-TAR-00611

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00611

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	345.3	4.0E-103	18	276	259

Status

Unreviewed

Ensembl Protein

ENSTRUP00000017521

UniProt Accession

H2SYN1;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000007131	ENSTRUP00000017519	ENSTRUT00000017593
ENSTRUG00000007131	ENSTRUP00000017520	ENSTRUT00000017594
ENSTRUG00000007131	ENSTRUP00000017521	ENSTRUT00000017595

Organism

Takifugu rubripes

Functional Description

Protein Length

769

Protein Sequence
(FASTA)

MSPLRDAQLG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTMSH PRLCQYVDIS 60

RGKHERLIVV AEHYESNLSD FQKQGKAVRC SSPEKVLQVA YEVLEGLEFM NKHGLVHRAL 120

GAHNVLMDCK GNVKLAKFGL YHMTDHGADV DFPIGYPAYL APEVIAQGCF HPSDSSHDEA 180

PLPSGPKTDV WSLGVLLFEL CAGRRLLQNI DISDRLKFIL NLGCMDDIVT VLAEEHGCLD 240

TIKDLPPNVL GLLRKCLLFL PSKRLTPAEL LRDPIFSGIS CLYTSFLKPV SLFSSSLRCA 300

HLELPEDISD LCKDDDEEDY LSERAIDEVY HLWCLAGGDL EKELINKGII QSKPPICTLP 360

NFVLEDGESF GQGRDRSFLL DDTTVTLSLC QLRNRLKDVA GEAYYPLLED EQSSLPQSNS 420

SNELSATVTL PLIIRERDTE YQLNRIVLFD RLLKAYPYKK NLVWKEARVD IPPLVRGLAW 480

AALLGIEGDI QSRYESIDKD TPIPTDRQIE VDIPRCHQYD ELLSSPQGHI KFRRVLKAWV 540

VSHPDLVYWQ GLDSLCAPFL YLNFNNEATP ALAYACMSAF IPKYLYNFFL KDNSHVIQEY 600

LTVFSQMIAF HDPELSNHLN EIGFIPDLYA IPWFLTMFTH VFPLHKIFHL WDTLLLGNSS 660

FPFCIGVAIL QQLRDRLLAN GFNECILLFS DLPEIDIERC VRESISLFCW SPKSATYRQH 720

AQPPKATTDN GFGKTPTYYS SEYQDMPKTD LEMNLTQDWS LLKCCAKSA 769

Nucleotide Sequence
(FASTA)

ATGAGCCCCC TCAGAGACGC ACAGCTGGGG GCTTTCACCT TCTTTGCCTC AGCTCTACCT 60

CATGATGTTT GTGGGAGCAA TGGTCTCCCT CTTACCCCCA ACTCCATCAA AATCCTGGGA 120

CGATTCCAAA TCCTCAAGAC TATGAGCCAT CCCAGACTCT GTCAATACGT TGACATCTCC 180

AGAGGCAAAC ATGAACGGCT GATTGTTGTT GCCGAGCACT ATGAAAGCAA TTTAAGTGAT 240

TTTCAAAAGC AGGGAAAAGC AGTCAGATGT TCTAGCCCAG AGAAGGTGCT ACAGGTCGCC 300

TATGAGGTCC TGGAGGGTCT GGAGTTCATG AACAAACACG GTCTGGTTCA CAGGGCGCTT 360

GGCGCACACA ACGTTCTCAT GGACTGCAAG GGAAACGTCA AGCTGGCGAA GTTCGGCCTT 420

TATCACATGA CTGACCACGG AGCTGATGTA GATTTCCCCA TTGGGTACCC AGCATACCTT 480

GCTCCAGAGG TAATTGCTCA GGGCTGTTTT CACCCCAGTG ACTCTTCCCA TGATGAAGCT 540

CCTCTTCCCT CAGGACCCAA GACTGATGTC TGGTCTCTCG GGGTTCTGCT CTTTGAATTA 600

TGCGCAGGCA GACGACTCCT GCAGAATATT GATATAAGTG ACAGGCTGAA ATTCATTCTG 660

AACTTGGGCT GCATGGATGA CATTGTCACC GTCCTTGCCG AGGAACACGG TTGCCTGGAT 720

ACCATTAAGG ATCTGCCCCC GAATGTTCTC GGGTTACTGA GGAAATGCTT GCTTTTTCTT 780

CCATCTAAAA GGCTGACCCC TGCAGAGCTG CTGCGAGACC CCATCTTCAG CGGAATCTCC 840

TGCCTCTACA CGTCCTTCCT CAAACCTGTT AGCCTCTTCT CGTCCTCGCT GCGCTGTGCA 900

CATCTGGAAC TCCCAGAAGA CATCAGCGAC CTCTGCAAAG ATGATGATGA AGAAGATTAC 960

CTGTCTGAGC GCGCCATAGA CGAGGTGTAC CACCTGTGGT GCTTGGCTGG GGGAGACCTG 1020

GAGAAGGAGC TGATCAACAA GGGGATCATC CAGTCTAAAC CTCCCATCTG CACCCTACCC 1080

AATTTTGTCC TGGAAGACGG GGAGTCATTC GGCCAGGGAC GGGATCGTAG TTTCTTACTC 1140

GACGACACAA CAGTGACGCT CTCGCTCTGC CAACTCCGAA ATAGACTGAA GGACGTAGCA 1200

GGGGAAGCCT ATTACCCTCT TCTAGAAGAT GAGCAGTCGA GTCTCCCCCA GTCCAACAGC 1260

AGCAACGAAC TGTCGGCCAC CGTCACGCTG CCGCTCATCA TCCGGGAGAG AGACACAGAG 1320

TACCAACTGA ACCGCATCGT CCTCTTTGAC AGGCTGCTCA AGGCTTATCC TTACAAGAAG 1380

AACTTAGTCT GGAAAGAGGC CAGAGTGGAT ATCCCTCCTC TTGTTCGAGG GCTGGCTTGG 1440

GCCGCGCTGC TCGGCATTGA GGGAGACATT CAGTCCAGAT ATGAGAGCAT CGACAAGGAC 1500

ACTCCCATCC CCACAGACAG ACAGATCGAG GTGGACATCC CACGCTGCCA CCAGTACGAC 1560

GAGCTGTTGT CGTCCCCCCA GGGTCACATC AAGTTCAGGC GCGTGTTGAA AGCCTGGGTG 1620

GTCTCCCATC CTGACCTGGT CTACTGGCAG GGATTGGATT CACTTTGCGC CCCATTCCTG 1680

TACTTGAATT TCAACAACGA AGCAACCCCA GCTCTGGCCT ATGCCTGCAT GTCTGCCTTC 1740

ATCCCCAAAT ACTTGTACAA TTTCTTCCTG AAGGACAACT CTCATGTCAT CCAAGAGTAT 1800

TTGACCGTCT TCTCCCAGAT GATTGCCTTC CATGACCCGG AGCTCAGCAA CCATCTGAAT 1860

GAGATTGGCT TCATCCCAGA TCTTTATGCC ATTCCCTGGT TCCTGACTAT GTTTACACAT 1920

GTGTTTCCAC TACACAAGAT CTTCCACCTG TGGGACACGC TGCTGCTGGG GAACTCCTCT 1980

TTCCCCTTCT GCATCGGCGT GGCCATACTG CAGCAGCTCA GAGATCGCCT CCTGGCTAAC 2040

GGCTTCAATG AGTGCATCCT GCTGTTCTCA GACCTACCTG AAATTGACAT CGAGCGATGC 2100

GTTCGGGAAT CCATCAGCCT GTTCTGCTGG AGTCCGAAGA GCGCTACGTA CCGACAGCAC 2160

GCTCAACCCC CGAAGGCAAC CACCGACAAC GGCTTCGGCA AAACGCCAAC ATATTACAGC 2220

TCTGAATACC AGGACATGCC CAAGACCGAC CTGGAAATGA ATTTGACGCA GGATTGGTCT 2280

TTGCTGAAAT GCTGTGCAAA ATCTGCA 2307

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk++ h+rLcqY+disrgkher+ivvaeh+e +

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTMSHPRLCQYVDISRGKHERLIVVAEHYESN  77

         589*********************************************************

S: 61    LeDllkerkpvses...lvlriayevlsgldylnkhnivhralepksilldrkgqkvkLa  117

         L D+ k++k v +s   +vl++ayevl+gl+++nkh++vhral  +++l+d kg+ vkLa

Q: 78    LSDFQKQGKAVRCSspeKVLQVAYEVLEGLEFMNKHGLVHRALGAHNVLMDCKGN-VKLA  136

         ***********998454699***********************************.****

S: 118   kyGLyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLgli  168

         k+GLyh+t++G+dvdfpigy++ylaPe+i+q+         ++ +l++++k DvWsLg++

Q: 137   KFGLYHMTDHGADVDFPIGYPAYLAPEVIAQGcfhpsdsshDEAPLPSGPKTDVWSLGVL  196

         ***************************************9999*****************

S: 169   llelilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkC  228

         l+el+ g++L +++d+s+rlk++l+l++ d+ + +laee++cld ik+l+ ++  ll+kC

Q: 197   LFELCAGRRLLQNIDISDRLKFILNLGCMDDIVTVLAEEHGCLDTIKDLPPNVLGLLRKC  256

         ************************************************************

S: 229   LtllpskRpspdellkekvf  248

         L +lpskR +p ell++++f

Q: 257   LLFLPSKRLTPAELLRDPIF  276

         *****************997

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT MSHPRLCQYV DISRGKHERL IVVAEHYESN 60

LSDFQKQGKA VRCSSPEKVL QVAYEVLEGL EFMNKHGLVH RALGAHNVLM DCKGNVKLAK 120

FGLYHMTDHG ADVDFPIGYP AYLAPEVIAQ GCFHPSDSSH DEAPLPSGPK TDVWSLGVLL 180

FELCAGRRLL QNIDISDRLK FILNLGCMDD IVTVLAEEHG CLDTIKDLPP NVLGLLRKCL 240

LFLPSKRLTP AELLRDPIF 259

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013