EKS-TAR-00509
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00509
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR544.52.6E-163566922357
StatusUnreviewed
Ensembl ProteinENSTRUP00000018651
UniProt AccessionH2T1W6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB (1 of 2)
Gene Synonyms/Alias PDGFRB (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000007528ENSTRUP00000018655ENSTRUT00000018731
ENSTRUG00000007528ENSTRUP00000018651ENSTRUT00000018727
ENSTRUG00000007528ENSTRUP00000018652ENSTRUT00000018728
ENSTRUG00000007528ENSTRUP00000018653ENSTRUT00000018729
ENSTRUG00000007528ENSTRUP00000018654ENSTRUT00000018730
OrganismTakifugu rubripes
Functional Description
Protein Length1059
Protein Sequence
(FASTA)
LKIVPEEKQL ILAEGSSLSL TCAGSSETTW DLKSDDVPFF QMKAESSDLN YKIVQSNSTA 60
SVLTLWHVDW KNTAVYQCRE QLTGEIKEVA VFVPDPEVWF IESSHGMVTK TSGESTVPCV 120
VTNPNITVTL YDKDTDLPVN GVYVPSEGFK AYLDYRTYVC RGELNGEVKE SQAFNVYSIH 180
VPEDIDAYVN ASQTVLKQGE PLTVNCTVQG VELVLFSWDI PNRDVSRRIV KHKPETVVLS 240
ATTMRSCLVF PHATVAHSGT YVCHAHESTQ DQKAFASVNI TVLERGFVAV KSTRKQNITA 300
ELQENVELRV EIEAYPPPQI RWKKDGAPVR GDKTIIIRQE HEIRYVTILT LVRVRTEQKG 360
LYTALITNED DVKEVTFALE VQVLARIKDL TDHHLPGKKQ LVTCVAEGVP TPTIQWYSCD 420
SMLKCNNQTS LWQQLKADPE LLSIHTSVTE ARQTNQVRSQ VTFFKPQHTT VRCETTNQEG 480
LIDFRDVKLV SSSLFSQVVL LAVVLTLVPI IIMSIIILIA VWKKKPRYEI RWKVIESVSQ 540
DGHEYIYVDP IHLPYDLAWE MPRDNLVLGR TLGSGAFGRV VEATAHGLSH SQSSIKVAVK 600
MLKATARRSE TQALMSELKI MSHLGPHLNI VNLLAACTKH GPLYLVTEYC RYGDLVDYLH 660
RNKHTFLQYY LDKNQDDGSL ISGGSTPLSQ SLFSYVSFGS ESDGGYMDMS KDEPAVYVPM 720
QEQMDTIKYA DIQPSPYESP YQQDLYQEQG GGRVDLVISD SPALTYDDLL GFSYQVAKGM 780
EFLASKNCVH RDLAARNVLI CEGKLVKICD FGLARDIMHD SNYISKGSTF LPLKWMAPES 840
IFHNLYTTLS DVWSYGILLW EIFTLGGTPY PDLPMNELFY SALKRGYRMA KPAHASDEVY 900
EIMKRCWDET FEKRPDFSFL VHCVGDMLTD SYKKKYSQVN ETFLKSDHPA VARTKPRLSS 960
PFPIANPAFG SPSLEAEVQE GVTSFNEYII PIPDPKPEEA FTDVPSESPA LSSLALEEET 1020
DSVHDSTDTL PEEDRLEETS ERDALLGSSG TPEVEDSFL 1059
Nucleotide Sequence
(FASTA)
CTGAAGATCG TACCTGAAGA GAAACAGCTC ATCCTGGCTG AGGGATCATC CCTGTCCCTC 60
ACCTGTGCCG GCTCATCAGA GACCACCTGG GACTTGAAGA GCGACGATGT GCCGTTCTTC 120
CAAATGAAGG CAGAGAGCAG TGACCTGAAC TACAAAATTG TGCAGAGCAA CAGCACAGCC 180
AGCGTTTTGA CATTATGGCA CGTGGACTGG AAGAACACGG CGGTTTATCA GTGCAGAGAG 240
CAGCTCACTG GAGAAATTAA AGAAGTGGCT GTTTTTGTTC CGGACCCTGA GGTGTGGTTC 300
ATTGAAAGCT CCCACGGCAT GGTCACGAAG ACCAGCGGTG AAAGCACGGT CCCCTGCGTG 360
GTCACTAATC CAAACATCAC GGTCACCCTT TATGACAAGG ACACCGATTT GCCCGTCAAC 420
GGGGTTTATG TTCCTAGTGA GGGCTTCAAG GCATATCTGG ACTACAGGAC CTATGTGTGT 480
CGGGGAGAGC TGAACGGGGA GGTGAAAGAG TCCCAGGCCT TCAACGTCTA CAGCATTCAC 540
GTCCCAGAGG ACATCGACGC CTACGTGAAT GCCTCCCAGA CCGTCCTGAA GCAAGGCGAA 600
CCGCTGACAG TGAACTGCAC AGTGCAAGGA GTGGAGCTGG TGCTTTTTTC CTGGGATATC 660
CCCAACAGAG ACGTGAGTAG GCGGATTGTT AAGCATAAGC CGGAGACCGT GGTCCTCTCT 720
GCCACAACCA TGCGCTCCTG CCTGGTCTTT CCTCATGCTA CGGTGGCCCA CAGTGGAACC 780
TACGTCTGCC ATGCTCATGA GAGCACCCAG GACCAGAAGG CCTTTGCCAG TGTCAACATC 840
ACTGTTCTGG AGAGAGGCTT TGTGGCTGTG AAATCTACTC GAAAACAAAA CATCACCGCT 900
GAACTGCAGG AAAACGTTGA GCTGAGAGTG GAAATCGAAG CCTACCCTCC CCCTCAGATC 960
CGCTGGAAGA AAGACGGTGC CCCGGTCAGG GGAGACAAAA CCATCATAAT CAGACAAGAG 1020
CATGAAATCA GGTATGTGAC CATTCTGACC CTGGTGAGGG TGAGGACAGA GCAAAAGGGT 1080
CTCTACACGG CCCTCATCAC AAATGAAGAT GATGTGAAGG AGGTGACCTT TGCCCTGGAA 1140
GTACAAGTTC TCGCTCGGAT TAAAGACCTG ACGGACCACC ACCTCCCTGG GAAGAAGCAG 1200
TTGGTGACGT GTGTGGCCGA GGGGGTCCCG ACCCCCACCA TCCAGTGGTA CAGCTGCGAC 1260
AGCATGCTGA AGTGCAACAA CCAGACGAGC TTGTGGCAGC AGCTCAAAGC AGATCCAGAG 1320
CTGCTGAGCA TCCACACCAG CGTCACCGAG GCGCGTCAGA CCAACCAGGT ACGGAGCCAA 1380
GTGACCTTCT TTAAACCCCA GCACACCACC GTCCGCTGCG AGACTACCAA CCAAGAAGGA 1440
CTCATCGACT TCAGGGATGT CAAACTGGTG TCCAGCTCTC TGTTCTCCCA GGTGGTGTTG 1500
TTGGCTGTTG TCCTGACGTT AGTGCCCATC ATCATCATGT CCATCATCAT CCTCATCGCT 1560
GTGTGGAAGA AGAAGCCGCG CTATGAGATC AGATGGAAGG TGATCGAGTC GGTGAGCCAG 1620
GACGGCCACG AGTACATCTA CGTGGACCCC ATCCACCTGC CCTATGACCT GGCCTGGGAA 1680
ATGCCACGAG ACAACCTGGT TCTGGGTCGC ACGCTCGGAT CAGGAGCCTT TGGCAGGGTG 1740
GTCGAGGCCA CCGCGCACGG ACTCTCGCAT TCCCAATCCA GCATTAAAGT GGCAGTGAAA 1800
ATGCTGAAGG CTACGGCCCG GAGGAGCGAG ACCCAGGCTC TGATGTCAGA ACTGAAGATC 1860
ATGAGTCACC TGGGGCCTCA CCTCAACATT GTCAACTTAC TGGCAGCTTG CACCAAACAT 1920
GGACCTCTGT ATCTCGTCAC TGAGTATTGT CGCTATGGTG ACCTGGTGGA CTACCTGCAC 1980
AGGAACAAGC ACACCTTTTT GCAGTACTAC CTGGACAAAA ACCAAGATGA CGGCAGTCTA 2040
ATCTCAGGAG GGAGTACTCC CCTCAGCCAG AGTCTCTTCA GCTATGTGTC TTTTGGAAGC 2100
GAGAGTGATG GAGGATACAT GGACATGAGT AAAGACGAGC CTGCAGTTTA CGTTCCCATG 2160
CAGGAGCAGA TGGACACCAT CAAGTATGCA GACATCCAAC CGTCTCCGTA CGAGTCGCCC 2220
TACCAGCAGG ACCTCTACCA AGAGCAAGGT GGGGGCAGGG TGGACCTGGT CATCAGCGAC 2280
TCTCCTGCTC TGACCTACGA CGACCTTCTG GGCTTCAGCT ACCAGGTGGC CAAAGGGATG 2340
GAGTTCCTCG CCTCCAAGAA CTGCGTCCAT CGAGACCTCG CGGCAAGAAA TGTGTTGATC 2400
TGTGAGGGCA AACTTGTGAA GATCTGTGAC TTTGGCCTGG CCAGAGACAT CATGCACGAC 2460
TCCAACTACA TCTCAAAAGG CAGCACATTT CTGCCTTTGA AATGGATGGC ACCGGAAAGC 2520
ATCTTCCATA ACCTGTACAC AACCCTGAGT GATGTGTGGT CATACGGCAT TCTTCTTTGG 2580
GAGATTTTCA CGCTGGGAGG AACGCCGTAC CCGGATCTAC CCATGAATGA GCTGTTCTAC 2640
AGCGCGCTGA AGCGAGGCTA CCGAATGGCC AAGCCCGCTC ACGCCTCTGA CGAAGTGTAT 2700
GAGATCATGA AGAGGTGCTG GGACGAGACG TTTGAGAAGA GGCCCGACTT TTCCTTTCTG 2760
GTTCACTGTG TGGGGGATAT GCTGACAGAC AGCTATAAAA AGAAATACAG CCAAGTCAAT 2820
GAAACCTTCC TGAAGAGCGA CCACCCCGCA GTGGCACGCA CCAAACCTCG ACTCTCCTCG 2880
CCTTTTCCGA TCGCCAACCC GGCGTTCGGT TCCCCTTCCC TGGAGGCAGA GGTTCAGGAG 2940
GGGGTGACCT CCTTTAACGA GTACATCATT CCCATCCCAG ACCCCAAACC GGAGGAAGCT 3000
TTCACCGACG TGCCCTCAGA AAGCCCTGCT CTCAGCTCTT TGGCTCTAGA GGAGGAGACC 3060
GACTCTGTGC ACGACTCCAC TGACACGCTG CCGGAGGAGG ACAGGCTGGA GGAGACCAGC 3120
GAGAGGGACG CGCTGCTGGG ATCATCTGGG ACACCTGAGG TTGAAGACAG CTTCCTGTAG 3180
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s++++kvavkmlk tar se +almselki+shlG
Q: 566   LVLGRTLGSGAFGRVVEATAHGLSHSQSSIKVAVKMLKATARRSETQALMSELKIMSHLG  625
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnll actk Gp+y++teyc+yGdl++yl+r++++fl+ +l+k++++ + ++  +
Q: 626   PHLNIVNLLAACTKHGPLYLVTEYCRYGDLVDYLHRNKHTFLQYYLDKNQDDGSLISGGS  685
         ************************************************999999999999
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
          + ++sl s++s+ ses++ y+d++kd                ++d+++s ++++++++ 
Q: 686   TPLSQSLFSYVSFGSESDGGYMDMSKDepavyvpmqeqmdtikYADIQPSPYESPYQQDL  745
         9*********************************************************97
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          + +   + + ++  ds +l+++dll fsyqvakGmeflaskncvhrdlaarnvl++eGk
Q: 746   YQEQGGGRVDLVIS-DSPALTYDDLLGFSYQVAKGMEFLASKNCVHRDLAARNVLICEGK  804
         77766666666665.59*******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvwsyGillweif+
Q: 805   LVKICDFGLARDIMHDSNYISKGSTFLPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFT  864
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         lG+tpyp+l++++ fy ++k+Gyrma+pa+a++e+yeim++cw++ +ekrp f+ lv+
Q: 865   LGGTPYPDLPMNELFYSALKRGYRMAKPAHASDEVYEIMKRCWDETFEKRPDFSFLVH  922
         *****************************************************99886
Domain Sequence
(FASTA)
LVLGRTLGSG AFGRVVEATA HGLSHSQSSI KVAVKMLKAT ARRSETQALM SELKIMSHLG 60
PHLNIVNLLA ACTKHGPLYL VTEYCRYGDL VDYLHRNKHT FLQYYLDKNQ DDGSLISGGS 120
TPLSQSLFSY VSFGSESDGG YMDMSKDEPA VYVPMQEQMD TIKYADIQPS PYESPYQQDL 180
YQEQGGGRVD LVISDSPALT YDDLLGFSYQ VAKGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMHDSNYIS KGSTFLPLKW MAPESIFHNL YTTLSDVWSY GILLWEIFTL 300
GGTPYPDLPM NELFYSALKR GYRMAKPAHA SDEVYEIMKR CWDETFEKRP DFSFLVH 357
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TEN-00510
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 3.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013