EKS-TAR-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	523.5	2.8E-157	346	619	274

Status

Unreviewed

Ensembl Protein

ENSTRUP00000019839

UniProt Accession

H2T5A0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAST4

Gene Synonyms/Alias

MAST4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000007967	ENSTRUP00000019839	ENSTRUT00000019920
ENSTRUG00000007967	ENSTRUP00000019838	ENSTRUT00000019919
ENSTRUG00000007967	ENSTRUP00000019843	ENSTRUT00000019924
ENSTRUG00000007967	ENSTRUP00000019841	ENSTRUT00000019922
ENSTRUG00000007967	ENSTRUP00000019842	ENSTRUT00000019923
ENSTRUG00000007967	ENSTRUP00000019840	ENSTRUT00000019921

Organism

Takifugu rubripes

Functional Description

Protein Length

1343

Protein Sequence
(FASTA)

CRTSNRKSLI GSGQSSGLPR PHSPLSSFTG TSPQDSPRNF SPSASAHFSF ARSTRTDGRR 60

WSLASLPSSG YGTNTPSSTI SSSCSSQEKL HQLPFQPTPD ELHFLSKHFC TESISGDECR 120

RATAMRPRSR SLSPGRSPSC FDHEIIMMNH VYKERFPKAT AQMEERIQEV IRSSSPESVL 180

PLADGVLGFA HHQIIELARD CLEKSRLGLI TSSYFCELTD KLERLVLEST QRSESEEVNF 240

IRELVKKILI IIARPARLLE CLEFDPEEFY HLLEAAEGHA KEGQGIKTDI PRYIISQLGL 300

TRDPLEEIAQ LTSSDSGIAE TPETDDSSHS LSTALKSRRK PCELDFEMTK LISNGAYGAV 360

YLVRHKETKQ RFAMKKINKQ NLILRNQIQQ AFVERDILTF AENPFVVSMY CSFETRRHLC 420

MVMEYVEGGD CATLLKNMGP LPVDMARMYF AETVLALEYL HNYGIVHRDL KPDNLLVTSM 480

GHIKLTDFGL SKVGLMNMTT NLYEGHIEKD AREFSDKQVC GTPEYIAPEV ILRQGYGKPV 540

DWWAMGIILY EFLVGCVPFF GDTPEELFGQ VISDEINWPE GEDAPPPDAQ ELITLLLRQN 600

PLERLGTGGA AEVKQHQFFH NLDWNSLLRQ KAEFIPQLES EDDTSYFDTR SEKYHHLETE 660

EEDTNDEDFN VELRQFSSCS HRFSKVCAPL HYRCTTLSHR LMPPLSHIKT VSQSLKSSGE 720

SQRTGLAALK RSLRCTVYSS LDLSRGHLEE KGETEGKKSE SPLTLDSLSW TPDFAELPSL 780

SQSTDTDGVN PGPRPNLLPK LAISAESEGD ETSGLGDPSK TSLSIAELPQ GSFSEHLDQL 840

TPRGEGMESP DATSQASADQ DGQTNPVQNK RPAERTGAVP KVPKSVSTGA LSLMIPGDIF 900

GVSPLASPLS PYSLSSDPSS RDSSPSRDSS LFSASPRQPI IIHSSGKKFG FTLRAIRVYA 960

CDGDVYTVYH MVWNVDDGGP AHKAGLKAGD LITHVNGEAV HGLVHTEVVE LLIKSGNKVA 1020

ISTTPFENTS IKTGPARRNS YRSKMVRCAK KPKKEKTPER RRSLFRRFAM QPSPLLHTSR 1080

SFSSLNHSLS SGESLPGSPT HSLSPHSPTA ALRPTPDFTQ SVPGGNSSQS SSPSSSAPNS 1140

PAGSGHIRPS TLHGLGPKLP GQRLRQGRRK SASSIPLSPL ARTPSPTPQP TSPQRSPSPL 1200

LSGHSVSISK TTQAFPAKIH SPPTIVRHIV RPKSAEPPRS PLLKRVQSEE KLSPSYTGEK 1260

KHLCSRKHSL EVTQEEVQDE EPATVLQSVD ETVCEPPAVT RIRPVEQGCL KRPVGRKMGR 1320

QEQEWSERRD SLQKQDALRE PDS 1343

Nucleotide Sequence
(FASTA)

TGCAGGACCA GCAACAGAAA GAGCCTGATA GGCAGCGGCC AGTCTTCAGG GTTGCCGCGA 60

CCTCACTCGC CTCTCTCGTC CTTTACAGGA ACAAGCCCAC AAGACAGCCC CAGAAATTTC 120

TCTCCTAGTG CCTCTGCTCA TTTTTCTTTT GCACGAAGCA CCAGAACTGA TGGCCGCCGC 180

TGGTCGTTGG CGTCCCTTCC TTCCTCTGGC TATGGAACGA ACACGCCCAG CTCCACCATC 240

TCTTCATCCT GTTCATCACA GGAGAAGCTG CACCAGCTGC CCTTCCAGCC TACACCCGAT 300

GAACTGCACT TCCTCTCCAA GCACTTCTGC ACTGAAAGCA TCTCCGGGGA CGAATGCCGC 360

AGGGCCACAG CCATGCGACC GCGCTCACGC AGTCTCAGCC CTGGACGATC TCCCTCCTGC 420

TTCGACCACG AGATTATTAT GATGAATCAC GTCTACAAGG AGCGGTTTCC GAAGGCCACA 480

GCTCAGATGG AGGAAAGGAT TCAGGAGGTT ATCCGCAGCA GCTCCCCAGA GAGCGTCCTC 540

CCTTTAGCAG ATGGCGTGCT CGGCTTTGCT CATCACCAGA TAATTGAACT GGCCCGTGAC 600

TGCCTGGAGA AGAGCCGCCT CGGACTCATC ACCTCCAGCT ACTTCTGCGA GCTCACTGAC 660

AAGCTGGAGA GACTCGTTCT GGAGTCCACA CAGAGATCAG AGAGTGAGGA AGTAAACTTC 720

ATCAGAGAGC TGGTGAAGAA GATCCTCATC ATTATCGCGC GACCTGCTCG ACTGCTGGAA 780

TGCCTGGAGT TCGACCCAGA GGAGTTCTAC CACCTTTTGG AGGCGGCTGA AGGACACGCC 840

AAAGAGGGCC AGGGCATCAA AACAGACATT CCTCGTTATA TCATCAGCCA GCTGGGACTC 900

ACAAGAGATC CTCTGGAAGA AATCGCTCAG CTGACCAGCA GTGACAGCGG GATAGCAGAA 960

ACCCCAGAAA CGGATGACTC TTCTCACAGC CTCAGCACAG CCCTGAAATC ACGACGTAAA 1020

CCCTGTGAAC TAGACTTTGA GATGACAAAG CTGATCAGCA ATGGTGCTTA TGGAGCCGTG 1080

TACCTGGTCC GACACAAGGA GACAAAGCAG CGGTTCGCCA TGAAAAAGAT CAATAAGCAG 1140

AACCTCATTT TGAGGAATCA GATCCAACAA GCCTTCGTGG AGAGAGACAT CCTCACCTTT 1200

GCTGAGAATC CATTTGTGGT GTCCATGTAC TGCTCCTTCG AGACGCGACG GCACCTGTGC 1260

ATGGTCATGG AATATGTTGA AGGTGGAGAC TGTGCTACCC TTCTAAAAAA CATGGGCCCC 1320

CTCCCTGTGG ATATGGCTAG AATGTACTTT GCAGAGACGG TACTAGCTCT GGAGTATCTC 1380

CACAACTACG GCATCGTGCA CAGGGACCTC AAACCAGACA ATTTGCTGGT GACCTCAATG 1440

GGCCACATTA AGCTGACGGA TTTTGGATTG TCCAAAGTTG GGCTGATGAA CATGACCACT 1500

AACCTGTATG AGGGACATAT AGAGAAAGAT GCCCGGGAGT TTTCTGATAA GCAGGTGTGT 1560

GGTACTCCGG AGTATATCGC ACCAGAGGTG ATCCTAAGGC AAGGCTACGG GAAGCCCGTG 1620

GACTGGTGGG CCATGGGCAT CATCCTTTAC GAGTTCCTTG TGGGCTGTGT ACCTTTTTTC 1680

GGAGACACTC CTGAAGAGCT GTTTGGTCAG GTCATCAGTG ATGAGATCAA CTGGCCTGAG 1740

GGAGAAGACG CTCCGCCGCC TGACGCTCAG GAACTCATCA CCTTACTGCT CAGACAGAAC 1800

CCTCTGGAGA GGTTGGGCAC AGGAGGAGCG GCGGAGGTGA AGCAGCATCA GTTCTTCCAC 1860

AACCTGGACT GGAACAGCCT GCTGAGGCAG AAGGCGGAGT TCATCCCACA ACTGGAATCT 1920

GAAGATGACA CCAGTTACTT TGATACTCGC TCTGAGAAGT ACCATCACCT GGAGACCGAG 1980

GAAGAGGACA CAAACGACGA AGACTTCAAC GTGGAGCTGC GGCAGTTCTC CTCATGCTCT 2040

CACCGATTCT CCAAGGTTTG CGCACCATTG CACTATCGGT GCACAACGCT GTCACACAGG 2100

CTTATGCCCC CTCTCTCTCA CATCAAAACA GTGTCACAGA GTCTGAAAAG TAGCGGGGAG 2160

TCTCAGAGGA CGGGTTTAGC TGCACTGAAA CGTTCCCTCA GATGTACCGT TTACAGCAGC 2220

CTGGATTTGT CCCGTGGGCA CCTGGAGGAG AAGGGAGAGA CGGAGGGGAA GAAGAGCGAG 2280

AGTCCACTGA CTCTCGACTC GCTCAGCTGG ACGCCGGATT TTGCTGAACT GCCATCGTTG 2340

TCCCAGTCAA CAGACACGGA TGGTGTGAAT CCGGGTCCTC GTCCAAACCT GCTACCAAAG 2400

CTCGCCATCT CAGCAGAAAG CGAAGGAGAC GAGACCTCGG GACTCGGTGA CCCCAGCAAG 2460

ACGTCCCTCT CCATCGCTGA ACTCCCCCAG GGAAGTTTCT CGGAACATCT GGATCAGTTG 2520

ACACCCAGAG GTGAAGGAAT GGAGAGCCCT GATGCTACCA GCCAGGCCTC TGCAGACCAA 2580

GATGGCCAGA CGAACCCTGT GCAGAACAAG AGGCCCGCAG AGAGGACGGG AGCTGTGCCA 2640

AAAGTCCCAA AGTCGGTCTC CACCGGTGCC CTGTCTCTGA TGATTCCTGG AGATATATTT 2700

GGAGTGTCAC CTCTAGCCAG CCCACTATCA CCTTACTCCC TCTCCTCGGA CCCCTCTTCA 2760

AGAGACTCTT CCCCCAGCAG AGATTCCTCT CTCTTCTCTG CCAGTCCACG GCAGCCCATC 2820

ATTATCCACA GCTCAGGAAA GAAGTTTGGC TTCACGTTGA GGGCAATCAG GGTGTACGCC 2880

TGTGATGGTG ACGTGTACAC CGTCTACCAT ATGGTCTGGA ATGTAGACGA CGGTGGACCG 2940

GCACATAAGG CAGGACTCAA AGCTGGAGAT CTCATCACTC ATGTGAATGG CGAAGCAGTT 3000

CACGGTCTCG TCCACACTGA AGTGGTGGAG CTCCTGATAA AGAGTGGTAA CAAAGTAGCC 3060

ATTTCAACAA CCCCCTTTGA AAACACTTCA ATAAAAACCG GTCCGGCGAG GAGGAACAGC 3120

TACAGAAGCA AGATGGTCAG ATGTGCCAAA AAGCCCAAGA AGGAGAAAAC ACCAGAGAGA 3180

AGACGCTCTC TTTTCAGGCG TTTCGCAATG CAGCCCTCTC CTCTCCTCCA TACAAGTCGC 3240

AGCTTCTCGT CTCTGAATCA CTCCTTGTCA TCTGGTGAGA GTCTCCCTGG CTCCCCCACC 3300

CATAGTCTGT CCCCTCATTC CCCCACCGCA GCCCTCCGTC CAACACCAGA TTTTACCCAG 3360

TCAGTTCCAG GTGGAAACTC TTCCCAAAGT AGTTCACCCA GCTCCAGCGC CCCCAACTCC 3420

CCTGCAGGGT CCGGCCATAT CCGTCCCAGC ACTCTCCACG GCCTCGGCCC CAAGCTGCCA 3480

GGCCAAAGAC TTCGTCAAGG ACGCCGCAAG TCTGCCAGTA GCATTCCCCT TTCTCCTTTG 3540

GCTCGCACGC CTTCACCTAC CCCCCAACCA ACATCGCCGC AGCGCTCACC ATCTCCCCTT 3600

CTCAGTGGGC ATTCTGTGTC TATTTCTAAG ACCACACAAG CCTTCCCAGC CAAGATACAT 3660

TCCCCCCCAA CAATCGTGCG CCATATCGTA CGACCCAAAA GTGCTGAACC GCCCCGCTCG 3720

CCCCTCCTAA AACGTGTCCA GTCTGAGGAG AAGCTGTCTC CCTCTTACAC TGGAGAAAAG 3780

AAGCACCTGT GTTCCAGGAA GCACAGCCTC GAGGTCACCC AAGAGGAGGT CCAGGATGAA 3840

GAACCAGCAA CTGTCTTACA GAGTGTGGAT GAAACCGTCT GTGAGCCCCC AGCAGTCACA 3900

CGTATACGAC CTGTGGAGCA GGGCTGCCTA AAGCGCCCCG TCGGCCGCAA GATGGGCCGA 3960

CAGGAACAGG AATGGTCGGA GAGGAGGGAC TCTCTGCAGA AGCAGGATGC CCTCCGTGAA 4020

CCCGACTCG 4029

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         fe+ klis+GayGavylvrhket++rfa+kki+kq+lil+nq+qq+f+erdil++aenpf

Q: 346   FEMTKLISNGAYGAVYLVRHKETKQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF  405

         8999********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vvs+y+s+etrr+l++vmeyveGGd+++llkn+G+l+v+mar+y+ae+vlaleylh+yGi

Q: 406   VVSMYCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGI  465

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnll+ts+GhikltdfGlskvglm++ttnlyeg+i+kdaref+dkqvcgtPey

Q: 466   VHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMNMTTNLYEGHIEKDAREFSDKQVCGTPEY  525

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevilrqgygkpvdwwa+giilyeflvg+vpffgdtpeelf+qv+sdei+wPe+++a

Q: 526   IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEGEDAP  585

         ************************************************************

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

         +++a+eli+ ll++nP erlgtg+aaevkqh+f+

Q: 586   PPDAQELITLLLRQNPLERLGTGGAAEVKQHQFF  619

         ********************************97

Domain Sequence
(FASTA)

FEMTKLISNG AYGAVYLVRH KETKQRFAMK KINKQNLILR NQIQQAFVER DILTFAENPF 60

VVSMYCSFET RRHLCMVMEY VEGGDCATLL KNMGPLPVDM ARMYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LVTSMGHIKL TDFGLSKVGL MNMTTNLYEG HIEKDAREFS DKQVCGTPEY 180

IAPEVILRQG YGKPVDWWAM GIILYEFLVG CVPFFGDTPE ELFGQVISDE INWPEGEDAP 240

PPDAQELITL LLRQNPLERL GTGGAAEVKQ HQFF 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013