EKS-TAR-00423

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00423

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	325.7	4.8E-97	364	612	249

Status

Unreviewed

Ensembl Protein

ENSTRUP00000020815

UniProt Accession

H2T822;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK4

Gene Synonyms/Alias

PAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000008318	ENSTRUP00000020812	ENSTRUT00000020899
ENSTRUG00000008318	ENSTRUP00000020813	ENSTRUT00000020900
ENSTRUG00000008318	ENSTRUP00000020814	ENSTRUT00000020901
ENSTRUG00000008318	ENSTRUP00000020815	ENSTRUT00000020902

Organism

Takifugu rubripes

Functional Description

Protein Length

631

Protein Sequence
(FASTA)

MFTKKKKSRI QISAPSNFEH RVHTDFDEQE QKFVGLPRQW QSLIEDTAKR PKPFIDANVI 60

TTVEPRKTIV RGSSKVGADG SLTWLLDEFD NMSVTCSNSL RRGSPPTHPH KDYSSTEGGR 120

GMSQCRDRQR PEQGGADPRH TQRGVHPQWD EGGHIRPQQQ PRGQEPGRHQ RDRPGSGPPP 180

PPHRDRGPRD RGQEQFDHRD QPDNRPKSSY VVREGSPQSP RDKRPLSGPN IRTPNLPVTE 240

GVMKTAQQNT RPFNTYPRTD SDGGRSPTGQ EVQRNSLSHK SFLMVDEGSL VPPKGHVLSH 300

HPHTPHPSVP APRPPVPHGP PSSGAPPQGR SPQREPQRVS HEQFRAALQM VVDPGDPRTY 360

LDNYIKIGEG STGIVCIATV KTTGKLVAVK KMDLRKQQRR ELLFNEVVIM RDYHHENVVE 420

MYNSYLVGDE LWVVMEFLEG GALTDIVTHT RMNEEQIATV CLSVLKALSV LHKQGVIHRD 480

IKSDSILLTH DGRVKLSDFG FCAQVSKEVQ KRKSLVGTPY WMAPELISRL PYGPEVDIWS 540

LGIMVIEMVD GEPPYFNEPP LKAMKMIRDN LPPKLKNLHK VSPLLKGFLD RMLVRDPAQR 600

AAASEILKHP FLTKAGPPSC IVPLMRQNRM R 631

Nucleotide Sequence
(FASTA)

ATGTTTACCA AGAAGAAGAA GTCTCGGATC CAGATCTCTG CTCCGTCCAA CTTCGAGCAT 60

CGCGTCCACA CAGACTTCGA TGAGCAGGAG CAGAAATTTG TAGGGCTGCC TCGGCAATGG 120

CAGTCGCTTA TAGAAGACAC AGCCAAAAGG CCGAAACCCT TCATTGATGC AAATGTCATC 180

ACTACTGTGG AGCCACGAAA GACGATTGTA CGCGGCAGCA GCAAGGTGGG GGCCGATGGC 240

TCCCTTACGT GGCTGCTGGA TGAGTTTGAC AACATGTCTG TGACTTGCTC CAACTCCTTG 300

CGACGCGGTA GCCCCCCCAC CCACCCTCAC AAGGACTACA GCTCTACGGA AGGAGGGAGA 360

GGAATGTCAC AGTGTAGAGA CCGGCAGAGA CCAGAACAGG GTGGGGCCGA CCCGCGCCAC 420

ACTCAGCGTG GAGTCCATCC ACAGTGGGAC GAAGGCGGCC ACATACGGCC CCAGCAGCAG 480

CCTCGGGGCC AAGAGCCGGG TAGACACCAG AGGGACAGGC CAGGCTCAGG CCCACCTCCA 540

CCCCCCCACA GAGACAGAGG TCCTCGTGAC CGCGGACAGG AGCAGTTTGA TCACAGAGAT 600

CAACCTGACA ACAGGCCAAA GTCCAGTTAC GTGGTCCGAG AGGGCAGCCC TCAGTCTCCC 660

AGGGATAAGA GGCCCCTGTC TGGACCCAAC ATCCGCACCC CAAATCTCCC TGTCACAGAA 720

GGGGTGATGA AGACAGCCCA ACAGAACACG CGACCCTTTA ACACCTATCC AAGAACCGAC 780

AGCGACGGTG GACGCAGTCC AACAGGACAG GAAGTACAAA GAAACAGTTT AAGTCACAAG 840

AGTTTTTTGA TGGTCGATGA AGGCAGTTTG GTCCCTCCTA AAGGTCATGT CCTAAGCCAT 900

CATCCACACA CACCGCACCC CAGCGTTCCG GCCCCACGGC CCCCTGTGCC ACATGGGCCC 960

CCATCGTCGG GCGCTCCGCC CCAGGGCAGA TCGCCGCAAC GAGAGCCCCA GAGAGTTTCT 1020

CATGAGCAGT TCAGAGCGGC GCTACAAATG GTGGTGGATC CTGGCGATCC ACGGACCTAT 1080

TTGGACAACT ACATTAAAAT AGGAGAGGGG TCCACCGGAA TCGTGTGTAT CGCCACGGTC 1140

AAGACCACGG GGAAATTGGT GGCGGTGAAG AAGATGGACC TGAGGAAGCA GCAGCGTAGA 1200

GAACTGCTCT TCAATGAGGT CGTAATCATG CGGGACTATC ATCATGAGAA TGTGGTGGAG 1260

ATGTACAACA GCTACCTGGT GGGAGATGAG CTCTGGGTGG TCATGGAGTT CCTGGAGGGG 1320

GGGGCTCTGA CTGACATTGT GACACACACA AGGATGAACG AGGAGCAGAT TGCTACAGTG 1380

TGCCTGTCTG TCCTGAAAGC ATTATCTGTC CTCCACAAAC AGGGCGTTAT CCACAGAGAC 1440

ATCAAGAGTG ACTCCATCCT TCTCACTCAC GATGGCCGTG TGAAGCTGTC GGACTTTGGC 1500

TTCTGTGCCC AGGTCTCCAA GGAAGTGCAA AAAAGAAAGT CTCTGGTTGG GACACCGTAC 1560

TGGATGGCTC CTGAGCTCAT CTCAAGGTTG CCTTATGGAC CAGAGGTGGA CATCTGGTCG 1620

CTGGGAATCA TGGTCATCGA GATGGTGGAC GGGGAGCCGC CGTACTTTAA CGAGCCACCG 1680

CTCAAAGCTA TGAAAATGAT TCGAGACAAC TTGCCTCCAA AACTAAAGAA CCTGCACAAG 1740

GTCTCTCCTC TGCTCAAAGG CTTTTTGGAC CGGATGTTGG TGCGGGACCC TGCTCAGAGG 1800

GCCGCGGCCA GCGAAATCCT CAAACACCCC TTCCTGACGA AGGCGGGTCC CCCGTCCTGC 1860

ATCGTCCCTC TTATGAGACA GAACAGGATG AGATGA 1896

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v++a+ k+tg+lva+kk++l+kq++ e+l++e+ ++++++h+n+ve+++

Q: 364   YIKIGEGSTGIVCIATVKTTGKLVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVEMYN  423

         568*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vlkaL+ lH+++viHrd

Q: 424   SYLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLKALSVLHKQGVIHRD  480

         *************************...9*******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt++g+VkLsdfg++aq++k+++krk++vgtpywmAPE+i+  +  Y  ++Di

Q: 481   IKSDSILLTHDGRVKLSDFGFCAQVSKEVQKRKSLVGTPYWMAPELIS--RLPYGPEVDI  538

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++++plka+ +i +n ppklk+ +k+s+ +k f++++l ++p+

Q: 539   WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNLHKVSPLLKGFLDRMLVRDPA  598

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++ase+lkh+Fl

Q: 599   QRAAASEILKHPFL  612

         *************7

Domain Sequence
(FASTA)

YIKIGEGSTG IVCIATVKTT GKLVAVKKMD LRKQQRRELL FNEVVIMRDY HHENVVEMYN 60

SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIATVCLS VLKALSVLHK QGVIHRDIKS 120

DSILLTHDGR VKLSDFGFCA QVSKEVQKRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI 180

MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP KLKNLHKVSP LLKGFLDRML VRDPAQRAAA 240

SEILKHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013