EKS-TAR-00389
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00389
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR494.91.1E-148690946257
StatusUnreviewed
Ensembl ProteinENSTRUP00000021302
UniProt AccessionH2T9G2;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4 (1 of 2)
Gene Synonyms/Alias ERBB4 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000008503ENSTRUP00000021303ENSTRUT00000021391
ENSTRUG00000008503ENSTRUP00000021304ENSTRUT00000021392
ENSTRUG00000008503ENSTRUP00000021301ENSTRUT00000021389
ENSTRUG00000008503ENSTRUP00000021302ENSTRUT00000021390
OrganismTakifugu rubripes
Functional Description
Protein Length1296
Protein Sequence
(FASTA)
VCAGTENKLS TLSDLDQQYQ TMRKNYENCE VVMGNLEITS IDRSRNLTFL RSIREVTGYV 60
LVALNQFDYL PLENLRIIRG TKLYEDRYAL AIFLNYRRDG NSGLRQLGLK NLTEILNGGV 120
YVDRNNFLCH ADTIHWQDIV KHPRIHPLVV PTNSSITCQK CHRSCNGRCW GPKVDQCQSL 180
TKTVCAEQCD GRCFGPYISD CCHRECAGGC YGPKDTDCFA CTNFNDSGAC VTQCPQPFFY 240
NSITFQLEHN VRTKYTYGAF CVKKCPHNFV VDHSSCVRAC PSNKMEVEEN GIKICIPCTD 300
ICPKACDGIG TASLQTAQTV DSSNIDKFVN CTKINGNLVF LITGIKGDSY HNIEALDPEK 360
LNVFRTVREI TGFLNIQSWP DNMTDLSVFS NLATIGGRTL YSGISLLVLK QQGISSLQLQ 420
SLREISAGNV HVADNSQLCY YNTINWTRLF RTAHQKALIR NNQSPEQCSK KRMVCDPLCS 480
GAGCWGPGPD QCLSCKYFSR GRTCVDGCNL YEGEIREYAN ESVCVECDGQ CELADDDSLT 540
CHGPGPEHCE KCLHFKDGPN CVEKCPDGLQ GANSFIFKYA EANNECHPCH ANCTQGCIGP 600
RLQDCIGLMD RGQRSMPVFS RTPLIAAGVI GVLFMVVILV LSVAVSVRRK NIKKKRALRR 660
FLETELVEPL TPSGTAPNQA QLRILKETEL KRVKVLGSGA FGTVYKGIWV PEGEKVKIPV 720
AVKILNEATG PKANVEFMDE ALIMASMEHP HLVRLLGVCL SPTIQLVTQL MPHGCLLDYV 780
HEHKDNIGSQ LLLNWCVQIA KGMMYLEERR LVHRDLAARN VLVKSPNHIK ITDFGLARLL 840
DVNEKEYNAD GGKMAIKWMA LECIHYRKFT HQSDVWSYGV TIWELMTFGG KPYDGISTRD 900
IPDLLEKGER LPQPPICTID VYMVMVKCWM IDADSRPKFK ELAAEFTRMA RDPQRYLVIQ 960
GDDCMKLPGP NDSKFFQSLL AEEELEDLMD AEEYLVPHSF NIPPLAYTPR TRMDSNKVGI 1020
GAIHPPCTMD NNKNQFGYQD PSFSMEKMLA TLPRGVSGAS VSGGCLPTQD LASGVQVGNQ 1080
DDPRCNGTLK KQASPSVQKG GGDDSSGQRY SADPTGLLSE RGAKGDQDGY MAAMRDKKIS 1140
DYLNPVEENP FVTRRRNGDA HAVMDGAGCH TLHIAAAAAA PKNQHIHGDD EYINEPLYLN 1200
TFLNPGDKNG LTASNTIMKN KKANFDNPEY WQHSLPPKSS LHNPEYLQDC STRFFYRQNG 1260
RIRPAVAENQ EYLSEAAMKA GNVLPPPPYR QRNTVV 1296
Nucleotide Sequence
(FASTA)
GTGTGTGCTG GTACGGAGAA CAAGCTAAGC ACGCTGTCTG ACCTGGACCA GCAGTACCAA 60
ACCATGAGGA AGAACTATGA AAACTGCGAG GTCGTCATGG GCAACCTTGA GATCACGAGC 120
ATCGACCGCA GCCGGAACCT CACCTTCCTC AGGTCTATCC GGGAAGTGAC TGGCTATGTG 180
TTAGTGGCCT TGAACCAGTT TGACTACCTG CCTTTGGAGA ACCTGAGGAT CATCCGCGGA 240
ACAAAACTGT ATGAAGACCG CTACGCTCTC GCAATCTTTC TCAATTACAG GCGGGATGGG 300
AACTCCGGCC TTCGCCAGCT CGGCCTGAAA AACCTGACAG AGATCTTGAA TGGAGGTGTG 360
TATGTTGACC GCAACAACTT CCTGTGCCAC GCAGACACCA TCCATTGGCA AGACATTGTC 420
AAACACCCCC GGATCCATCC ACTGGTGGTG CCCACCAACA GCAGCATCAC ATGTCAAAAG 480
TGTCACCGCT CCTGCAACGG TCGCTGTTGG GGTCCCAAAG TGGACCAGTG TCAAAGCTTA 540
ACCAAGACGG TGTGTGCTGA GCAGTGCGAC GGCCGGTGCT TCGGACCCTA CATTAGCGAC 600
TGCTGTCATC GAGAGTGTGC AGGTGGCTGC TACGGACCAA AGGACACAGA CTGCTTTGCC 660
TGTACCAACT TCAATGACAG TGGGGCGTGT GTGACCCAGT GTCCACAGCC ATTCTTCTAC 720
AACTCCATCA CCTTCCAACT GGAACACAAC GTCAGGACCA AATACACCTA TGGAGCTTTC 780
TGCGTCAAGA AATGTCCACA TAACTTCGTG GTGGATCACA GCTCCTGCGT GAGAGCGTGC 840
CCCAGCAACA AGATGGAGGT GGAGGAGAAC GGCATTAAAA TCTGCATCCC TTGTACTGAC 900
ATCTGCCCTA AAGCGTGTGA TGGGATCGGC ACAGCCAGCC TGCAGACGGC CCAGACGGTG 960
GACTCCAGCA ACATCGACAA GTTTGTCAAC TGCACCAAAA TCAATGGCAA CTTGGTGTTC 1020
CTCATCACAG GGATCAAAGG AGACAGCTAT CACAACATCG AAGCACTGGA CCCCGAAAAA 1080
CTCAACGTAT TCCGGACTGT TCGGGAAATA ACAGGCTTCC TGAACATCCA GTCTTGGCCC 1140
GACAACATGA CGGACCTAAG CGTGTTCTCC AACTTGGCCA CCATTGGAGG GAGGACACTG 1200
TACAGTGGAA TCTCCCTGCT GGTTTTAAAG CAGCAGGGCA TCTCCTCACT GCAGCTCCAA 1260
TCTCTACGGG AGATCAGCGC CGGTAACGTG CACGTTGCGG ACAACAGCCA ACTCTGCTAC 1320
TACAACACCA TCAACTGGAC CAGACTGTTC CGTACCGCCC ACCAGAAGGC GCTGATCCGC 1380
AACAACCAAA GCCCAGAGCA GTGTTCCAAG AAGCGCATGG TGTGTGACCC GCTGTGTTCA 1440
GGCGCAGGGT GCTGGGGTCC GGGCCCCGAC CAGTGCCTCT CCTGCAAATA CTTCAGCCGC 1500
GGACGAACGT GCGTGGACGG GTGCAATCTA TACGAGGGGG AAATCCGAGA GTATGCCAAC 1560
GAGTCGGTTT GTGTGGAATG CGATGGCCAG TGCGAACTTG CAGATGACGA CTCTCTGACC 1620
TGCCACGGTC CGGGACCAGA GCATTGTGAG AAATGCCTTC ATTTCAAGGA TGGTCCCAAC 1680
TGTGTGGAGA AGTGTCCCGA TGGCCTTCAG GGCGCCAACA GCTTCATCTT CAAGTATGCA 1740
GAGGCCAACA ATGAATGTCA TCCCTGCCAC GCCAACTGCA CACAGGGGTG CATTGGACCA 1800
AGACTGCAAG ACTGCATTGG CTTGATGGAC AGGGGTCAAA GGTCAATGCC AGTTTTCTCC 1860
AGAACCCCTC TGATTGCTGC AGGAGTGATT GGTGTCCTCT TCATGGTTGT GATCTTGGTT 1920
CTGAGTGTAG CCGTGTCAGT GCGACGCAAG AACATCAAGA AGAAGAGAGC ACTCCGCCGC 1980
TTCCTGGAGA CAGAGCTCGT GGAGCCTCTC ACGCCCAGCG GAACAGCACC AAACCAAGCA 2040
CAGCTGCGCA TCCTGAAAGA AACAGAACTG AAAAGGGTTA AAGTCCTCGG CTCCGGGGCG 2100
TTTGGGACTG TTTACAAGGG GATTTGGGTC CCAGAAGGGG AGAAGGTGAA GATTCCTGTA 2160
GCCGTTAAAA TATTAAATGA AGCAACGGGA CCCAAGGCTA ACGTGGAGTT CATGGATGAG 2220
GCCCTCATCA TGGCTAGCAT GGAGCACCCC CACTTGGTCC GCCTGCTGGG TGTCTGCTTG 2280
AGTCCCACCA TCCAGCTGGT CACGCAGCTG ATGCCTCACG GGTGCCTGCT CGACTACGTC 2340
CACGAGCACA AGGACAACAT TGGGTCCCAG CTGTTGCTCA ACTGGTGTGT CCAGATTGCC 2400
AAGGGAATGA TGTATTTGGA AGAGCGAAGG CTTGTTCACA GAGACCTAGC TGCCCGAAAC 2460
GTCCTGGTCA AGTCTCCCAA CCACATCAAG ATCACAGACT TCGGGCTGGC TCGCCTGCTG 2520
GATGTGAATG AGAAGGAATA TAACGCTGAT GGAGGAAAGA TGGCCATCAA ATGGATGGCC 2580
CTGGAGTGCA TCCACTACAG GAAGTTTACT CATCAGAGTG ACGTGTGGAG TTACGGGGTC 2640
ACCATTTGGG AGCTAATGAC ATTTGGAGGG AAGCCGTACG ATGGGATTTC CACCAGGGAC 2700
ATCCCTGACC TGCTGGAGAA AGGAGAGCGC CTTCCTCAGC CCCCCATCTG CACCATTGAT 2760
GTGTACATGG TCATGGTCAA ATGCTGGATG ATCGATGCCG ACAGTCGGCC CAAGTTCAAG 2820
GAGCTGGCTG CAGAGTTCAC TCGGATGGCT CGTGATCCCC AGAGGTACCT GGTCATCCAG 2880
GGTGACGATT GCATGAAGCT GCCAGGCCCA AATGACAGTA AGTTCTTCCA GAGCCTCCTG 2940
GCTGAGGAGG AGCTGGAGGA CCTGATGGAT GCAGAGGAGT ACCTGGTGCC GCACTCCTTC 3000
AACATCCCAC CGTTGGCGTA CACCCCACGC ACGCGCATGG ACTCCAACAA GGTAGGCATT 3060
GGTGCAATTC ACCCTCCTTG CACCATGGAT AATAATAAAA ACCAGTTTGG CTATCAAGAC 3120
CCCAGTTTTA GCATGGAAAA AATGCTGGCT ACCTTGCCGA GGGGGGTCTC CGGTGCCTCA 3180
GTGTCCGGAG GCTGTCTGCC CACTCAGGAC TTGGCCTCAG GGGTGCAGGT GGGCAACCAA 3240
GACGACCCCC GTTGCAATGG CACCCTGAAG AAGCAGGCCT CCCCAAGCGT TCAGAAAGGT 3300
GGGGGAGATG ACAGCAGCGG TCAACGTTAC AGTGCTGATC CAACCGGTCT GTTATCAGAA 3360
CGAGGAGCGA AAGGAGACCA GGATGGCTAC ATGGCCGCCA TGAGAGACAA GAAAATCTCA 3420
GATTATCTCA ACCCAGTGGA AGAAAACCCC TTTGTGACGC GCCGTAGGAA TGGCGACGCA 3480
CATGCGGTGA TGGATGGAGC AGGCTGCCAC ACCCTCCACA TAGCTGCAGC TGCAGCTGCA 3540
CCCAAGAATC AGCACATTCA CGGGGACGAT GAGTACATCA ACGAGCCTCT GTACCTGAAT 3600
ACTTTCCTAA ACCCTGGGGA CAAGAACGGA TTAACCGCTA GCAACACCAT CATGAAAAAT 3660
AAGAAGGCCA ATTTTGACAA TCCTGAATAC TGGCAGCACA GTCTACCCCC GAAGTCTTCG 3720
CTCCACAACC CCGAGTACCT GCAGGACTGC AGCACGCGCT TCTTCTACCG ACAGAATGGA 3780
CGCATTCGTC CCGCTGTTGC AGAGAACCAG GAGTACCTGT CAGAGGCAGC GATGAAAGCC 3840
GGCAACGTTT TGCCACCGCC TCCCTACAGA CAGAGGAACA CTGTAGTGTA G 3891
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipva+k+l+e+tg+kan e++deal++as++h
Q: 690   LKRVKVLGSGAFGTVYKGIWVPEGEKVKIPVAVKILNEATGPKANVEFMDEALIMASMEH  749
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 750   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  809
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnh+kitdfGla+ll+ +eke++a+ggk++ikw+ale+i++rk+
Q: 810   RLVHRDLAARNVLVKSPNHIKITDFGLARLLDVNEKEYNADGGKMAIKWMALECIHYRKF  869
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgi++++ipdllekGerl+qppictidvymv+vkcw
Q: 870   THQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCW  929
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mida+srpkfkela+ef
Q: 930   MIDADSRPKFKELAAEF  946
         ***************99
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGEKVKIP VAVKILNEAT GPKANVEFMD EALIMASMEH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHI KITDFGLARL LDVNEKEYNA DGGKMAIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGISTR DIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CII-00175
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-MAM-00300
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00357
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TEN-00387
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00377
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013