EKS-TAR-00050
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00050
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak279.47.6E-838371109273
StatusUnreviewed
Ensembl ProteinENSTRUP00000022495
UniProt AccessionH2TCV2;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000008949ENSTRUP00000022495ENSTRUT00000022589
ENSTRUG00000008949ENSTRUP00000022494ENSTRUT00000022588
ENSTRUG00000008949ENSTRUP00000022496ENSTRUT00000022590
OrganismTakifugu rubripes
Functional Description
Protein Length1124
Protein Sequence
(FASTA)
LPVSAQTRTH TRTHTFTPVH KVKDRGGSQR SSSSTGANLQ VHLYFVPATK KSTTIHISSG 60
PISAEAVCMQ AGEKSGILPV YIGLFGLASA DLSFWYPPSH VFNTEENLQV CFRVRFFFGN 120
WFDQGPRTAC RHSLTRDRTS PVLDHSGIAY LFAQLRSDFT TGEAGLSPPL TNQDECLGLA 180
VLDLWRLAKE KRQSVKDLCK SVSYKSCLPK SHRADIEKRN WVERYRIRNT LKHFLKKIGN 240
CPVDDCNLKL MYLTELAGIQ PSLGSETFHV DPSSPHSSSR SAVSLVRVTG ESGIQTSESC 300
DGPVVRSSQW QTFCDFKEIT DISIRRICRD QVPHDSRMVT MTRKDDACLD VEFQSLKEAL 360
SFVSLVDGYF RLTTDSTHYF CHDIAPPSTL EGIENHCHGP ITSEFAVSKL KKSGSEGGTF 420
LLRQSPKAYG EFFLTVCIQT PLGPDYKDCL IIKNEHYSLP GVRKSFSSLK ELTGYYQQNK 480
LLLADVPVKL SRCCPPRSQE LTNLIIMRNS SFVEAQLSPT LEGNKLSHIQ FQMIKYEDLQ 540
WGESLGQGSF TRLFKGYKSD MRNGGKYMSI FLKELDVSHR NLWESFFEAA SLMSQISHKH 600
LILTHGVSVH GVKNIIVQEF MEYGALDLYL KRGRSVSVSW KLDVAKQLAS VLNFLEQNNI 660
IHGNICAKNL LLAREGDPSK SVPPFIKLSD PGISVMMLGK DVVVDRIPWV APEVLLSPDN 720
MTLECDKWSF GATLWELFNN GNNPLLGWDL DMKQKFYESF QQLPPSQWTE LADLINQCMD 780
YQADFRPSCR SIIRQLNSLI TSDYVILFAT EPDTENPAWR ALGPSQQEQA GFEERHLRYI 840
SLLGKGNFGS VELCCYDPLG DNTGELVAVK KLQPSKQSSM DDFKKEVKTL SVLHCEYIVK 900
YKGVCYSMGR LSMSLVMEYL PYGSLIGYLE NNRHKVNTRR MLLFASQICK GMEYLQSLRF 960
VHRDLAARNI LVASESLVKI GDFGLTKIIP CNKEYYRVTQ PGESPIFWYA PESITESRFS 1020
HESDVWSFGV VLHELFSYCD INSNPKRLFM QEIGHNMQTP SISLHLANIL KNNWRLPAPP 1080
DCPPKVYGMM KECWQYNFTE RPCFSLLGNQ IEVIMQDERD NFKG 1124
Nucleotide Sequence
(FASTA)
CTTCCTGTCA GTGCACAGAC ACGCACACAC ACACGCACAC ACACATTCAC TCCAGTCCAC 60
AAGGTAAAGG ACCGCGGAGG CAGCCAGAGG TCCAGTTCCA GTACCGGAGC TAACCTACAA 120
GTGCACCTCT ATTTCGTCCC CGCGACTAAA AAATCGACAA CAATTCACAT TTCATCTGGC 180
CCAATCTCAG CTGAAGCTGT CTGTATGCAA GCAGGGGAAA AAAGTGGGAT TTTGCCTGTC 240
TACATTGGTC TGTTTGGCTT GGCATCAGCT GACCTTTCCT TTTGGTATCC TCCCTCACAC 300
GTGTTTAACA CGGAAGAAAA CCTTCAAGTC TGCTTCAGAG TCAGGTTTTT CTTTGGAAAC 360
TGGTTTGATC AAGGTCCCAG AACAGCCTGC CGCCACAGTC TGACCAGAGA CAGAACGAGC 420
CCAGTGCTGG ACCACAGCGG CATTGCTTAT CTGTTCGCTC AGCTGCGATC TGACTTTACC 480
ACCGGCGAGG CAGGATTGTC TCCGCCTTTG ACCAACCAGG ACGAATGCCT CGGCCTCGCT 540
GTGCTGGACC TGTGGAGGCT GGCCAAAGAG AAACGTCAGA GTGTGAAAGA TCTGTGCAAG 600
AGCGTCAGCT ATAAATCGTG CCTTCCAAAG TCACATCGCG CCGACATAGA GAAACGAAAC 660
TGGGTGGAAC GTTATCGGAT CCGAAACACC CTCAAGCATT TCTTGAAGAA GATTGGGAAC 720
TGCCCGGTAG ATGACTGCAA CCTGAAGCTC ATGTACCTGA CTGAACTGGC CGGCATCCAG 780
CCTTCTCTGG GCAGCGAGAC CTTCCACGTG GATCCCTCTT CCCCCCATTC CAGCTCCCGT 840
TCAGCTGTCT CTCTGGTTCG GGTCACTGGG GAATCCGGGA TTCAAACCAG TGAAAGTTGT 900
GACGGACCTG TGGTGAGATC CAGTCAGTGG CAGACCTTTT GTGATTTCAA AGAAATAACA 960
GACATCAGTA TCAGAAGGAT CTGCCGTGAT CAGGTCCCAC ACGACAGTCG AATGGTGACG 1020
ATGACCCGCA AGGACGACGC GTGTTTGGAT GTGGAGTTCC AGAGCCTGAA GGAAGCGCTC 1080
TCCTTCGTGT CACTGGTTGA TGGCTACTTC AGACTGACGA CAGACTCCAC CCACTACTTC 1140
TGCCACGACA TCGCTCCTCC GAGTACCCTG GAGGGCATCG AAAACCACTG CCACGGTCCA 1200
ATCACGTCAG AGTTCGCAGT CAGTAAGCTG AAAAAGTCAG GATCTGAAGG TGGTACCTTC 1260
CTCCTGCGCC AGAGCCCCAA GGCCTATGGT GAATTCTTCC TCACTGTTTG CATTCAGACT 1320
CCTCTGGGGC CAGATTATAA AGACTGTCTC ATCATTAAGA ATGAGCACTA CAGCCTTCCA 1380
GGTGTTCGCA AATCCTTTTC CAGTCTGAAG GAGCTGACTG GATATTACCA ACAAAACAAG 1440
CTGTTACTGG CTGATGTTCC TGTGAAGCTG TCCCGCTGCT GTCCGCCTCG ATCACAAGAA 1500
CTCACAAATT TGATCATCAT GCGCAACAGC AGCTTCGTGG AGGCTCAGCT GTCCCCCACC 1560
CTGGAAGGAA ACAAACTGAG TCATATCCAG TTTCAAATGA TCAAATATGA AGACCTGCAG 1620
TGGGGAGAAA GCCTGGGACA GGGGTCCTTC ACTCGCCTTT TTAAAGGCTA CAAATCAGAC 1680
ATGCGGAATG GCGGGAAATA CATGTCCATT TTCCTGAAGG AACTGGACGT CTCCCACCGG 1740
AACCTTTGGG AATCATTCTT CGAAGCCGCC AGTCTGATGA GTCAGATTTC ACACAAGCAC 1800
CTCATTCTCA CGCACGGCGT CAGCGTTCAC GGAGTCAAAA ACATCATAGT CCAGGAGTTT 1860
ATGGAGTACG GGGCTCTTGA CCTTTACCTG AAAAGAGGAA GATCTGTGTC AGTGAGCTGG 1920
AAACTGGACG TAGCCAAGCA GCTTGCGTCA GTGCTGAATT TTCTGGAGCA AAATAATATC 1980
ATTCATGGAA ACATCTGTGC CAAAAACCTG CTGCTGGCCA GAGAAGGTGA CCCATCAAAG 2040
AGCGTCCCTC CCTTCATCAA GCTGAGCGAC CCTGGAATCA GCGTGATGAT GCTGGGGAAA 2100
GATGTGGTCG TTGACAGGAT TCCTTGGGTG GCGCCTGAGG TGCTGTTGTC CCCTGATAAT 2160
ATGACTCTGG AGTGTGATAA GTGGAGCTTT GGCGCCACGC TGTGGGAGCT CTTCAACAAC 2220
GGGAACAATC CTCTGCTCGG CTGGGATCTG GACATGAAGC AGAAGTTTTA TGAGAGCTTC 2280
CAGCAGCTGC CTCCGTCCCA GTGGACTGAG CTGGCTGATC TGATCAATCA GTGCATGGAC 2340
TACCAGGCGG ACTTCAGACC CTCCTGCCGC AGCATCATTC GTCAGCTCAA CAGCCTGATT 2400
ACTTCAGATT ACGTGATACT CTTCGCCACC GAGCCCGACA CGGAGAACCC TGCCTGGAGA 2460
GCCCTCGGAC CTTCTCAGCA GGAGCAGGCA GGGTTTGAGG AGAGACACTT GCGCTACATC 2520
TCCCTTCTAG GAAAAGGAAA CTTTGGTAGC GTCGAACTTT GCTGTTACGA TCCGCTGGGT 2580
GACAACACGG GTGAGCTGGT CGCAGTGAAG AAGCTACAAC CCAGCAAGCA GTCGTCCATG 2640
GACGACTTCA AGAAGGAGGT CAAAACCTTG AGCGTTTTAC ACTGCGAATA CATTGTGAAA 2700
TACAAAGGCG TCTGCTACAG TATGGGTCGA CTCAGTATGA GTTTGGTGAT GGAGTACCTG 2760
CCTTATGGCA GCCTCATTGG CTACTTGGAA AATAACCGAC ATAAGGTCAA CACAAGGCGG 2820
ATGCTGCTTT TTGCTTCCCA GATCTGTAAG GGGATGGAGT ACCTGCAGTC CCTGCGCTTT 2880
GTGCACAGGG ACCTCGCAGC CAGAAACATC CTGGTGGCCA GCGAGTCACT GGTGAAAATT 2940
GGAGATTTTG GGCTTACCAA GATCATTCCG TGCAACAAGG AATACTACCG GGTCACACAG 3000
CCCGGAGAGA GTCCCATCTT CTGGTATGCT CCAGAGTCCA TCACCGAATC CAGATTCTCC 3060
CACGAATCTG ACGTCTGGAG TTTCGGAGTG GTTCTACACG AGCTCTTTTC CTACTGTGAC 3120
ATAAATTCCA ACCCCAAACG ACTTTTTATG CAGGAGATTG GACATAACAT GCAGACTCCG 3180
TCTATTTCAT TACACCTGGC AAATATTCTA AAGAATAACT GGAGGCTTCC TGCCCCTCCA 3240
GACTGCCCTC CCAAGGTGTA CGGCATGATG AAGGAGTGCT GGCAGTACAA CTTCACGGAG 3300
CGGCCATGTT TCTCCCTCCT GGGAAACCAA ATTGAAGTTA TCATGCAGGA CGAGCGAGAC 3360
AACTTCAAAG GCTGA 3375
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         l++i+ Lgkg+f++v+++++d+ gd+t+e va+k L++s +  + dfk+e+++ls l+ e
Q: 837   LRYISLLGKGNFGSVELCCYDPLGDNTGELVAVKKLQPSKQSSMDDFKKEVKTLSVLHCE  896
         578999******************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
          ivk+kgvc++ g+    lVmey+++GsL  yL+++++++++ + l +a+q++k+meYL+
Q: 897   YIVKYKGVCYSMGRLsmSLVMEYLPYGSLIGYLENNRHKVNTRRMLLFASQICKGMEYLQ  956
         ***********9998889******************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         + ++vhrd+aarn+Lv++es       vk++d+gl+k ++ + eYy v ++++s+i+w+a
Q: 957   SLRFVHRDLAARNILVASESL------VKIGDFGLTKIIPCNkEYYRVTQPGESPIFWYA  1010
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224
         pe+++e++ +s +sdvWsFgv+l+el++ c+ +++p    +++++++        ++ ++
Q: 1011  PESITESR-FSHESDVWSFGVVLHELFSyCDINSNPkrlfMQEIGHNmqtpsislHLANI  1069
         ********.***************************9988555555577788889*****
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
         l+++ rlp+p+ cp +++ +m++c++y+ ++rp F+ + +
Q: 1070  LKNNWRLPAPPdCPPKVYGMMKECWQYNFTERPCFSLLGN  1109
         ***********************************87755
Domain Sequence
(FASTA)
LRYISLLGKG NFGSVELCCY DPLGDNTGEL VAVKKLQPSK QSSMDDFKKE VKTLSVLHCE 60
YIVKYKGVCY SMGRLSMSLV MEYLPYGSLI GYLENNRHKV NTRRMLLFAS QICKGMEYLQ 120
SLRFVHRDLA ARNILVASES LVKIGDFGLT KIIPCNKEYY RVTQPGESPI FWYAPESITE 180
SRFSHESDVW SFGVVLHELF SYCDINSNPK RLFMQEIGHN MQTPSISLHL ANILKNNWRL 240
PAPPDCPPKV YGMMKECWQY NFTERPCFSL LGN 273
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Danio rerio"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-DAR-00044
EKS-GAM-00014
EKS-GAA-00050
EKS-ORN-00050
EKS-ORL-00047
EKS-TEN-00054
EKS-XIM-00048
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013