EKS-TAR-00484

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00484

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	319.6	3.5E-95	129	364	236

Status

Unreviewed

Ensembl Protein

ENSTRUP00000022891

UniProt Accession

H2TDZ8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12 (1 of 2)

Gene Synonyms/Alias

MAP3K12 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000009106	ENSTRUP00000022890	ENSTRUT00000022985
ENSTRUG00000009106	ENSTRUP00000022891	ENSTRUT00000022986

Organism

Takifugu rubripes

Functional Description

Protein Length

877

Protein Sequence
(FASTA)

TCIHEPRAPS PSLSGFSTPI SEPLYRRLDG DTPACTPETD LTPTHVLKLH EHEACQCGGG 60

AEAGHSPEAG AVRSQSENIR LQSGSGGFLE GLFGCLKPVW TMIGKAYSTE HKHSNEESWE 120

VPFEEISDLQ WVGSGAQGAV FLGKFHGEEV AVKKVRDIKE TEIKHLRKLK HPNIITFKGV 180

CTQAPCYCIL MEYCAQGQLY EVLRAGRKIT PSLLVDWSMG IAGGMNYLHL HKIIHRDLKS 240

PNMLITHDDL VKISDFGTSK ELSDKSTKMS FAGTVAWMAP EVIRNEPVSE KVDIWSFGVV 300

LWEMLTGEIP YKDVDSSAII WGVGNNSLQL PIPESCPDGF KILLRQCWNC KPRNRPSFRQ 360

ILLHLDIASA DVLSTPQETY FKSQAEWREE VKRHFEKIKS EGTCLHRLDE ELINRRREEL 420

RHALDIREHY ERKLERANNL YMELSAVMLQ LELKEKELQR REQSLDKKYP GLFKHHSSRQ 480

SSSSNTMDKL IKKRNVPQKL PSGKRPDILK SEVIIPKMDS SVMQITIPAC PNRSSTSPSR 540

SRRVKTRHRK PGKGSSGDLA GLKANQSSPN RDSTAQTNGS TTNTSKQLLE PSAALRGLGH 600

EQQQRQLSSS SPDLICTTLK AEAQGATGLD DLTETPPRSD TPSEDAASFP FSSSPDSPCG 660

RGAAARRASL GSPRLLLDGE DKEEGAGAVR MPRGASGGIG SQHLTPSAIL YRAAITRKQR 720

RGVSSEEEEG EVDSEVELPR RRRRPTSITK CQSVSTFSSE NLSVSDGEEG HTTDHSHSGT 780

PDVVSTNTDD RLDDRSDDLL SQGSEIPADN TDPAQASDGL SERDGALGRA KAQLDAGQNP 840

NESRALCDDS DCDSAELDQS GSGEPSRPPS AGAWAPP 877

Nucleotide Sequence
(FASTA)

ACCTGTATCC ATGAGCCCCG TGCCCCTTCC CCCTCCCTCT CAGGCTTCAG CACTCCCATC 60

TCAGAACCGC TCTATCGAAG GCTCGATGGA GATACCCCTG CGTGTACCCC CGAAACGGAC 120

CTGACCCCCA CACACGTGCT AAAACTACAT GAACATGAGG CCTGCCAGTG TGGCGGTGGA 180

GCCGAAGCTG GGCACAGCCC AGAGGCTGGC GCTGTTCGGA GCCAGTCAGA GAACATTCGG 240

CTACAATCAG GAAGCGGAGG TTTTTTGGAG GGACTGTTTG GCTGCCTAAA ACCGGTTTGG 300

ACCATGATCG GAAAGGCCTA CTCCACTGAA CACAAACACA GTAACGAAGA GTCCTGGGAG 360

GTTCCTTTTG AGGAAATCTC TGACTTGCAG TGGGTGGGCA GCGGGGCACA GGGCGCCGTC 420

TTCCTTGGCA AGTTCCACGG AGAGGAGGTG GCCGTGAAGA AAGTGCGGGA CATCAAGGAG 480

ACTGAGATCA AACACCTACG CAAACTCAAG CACCCCAACA TCATCACTTT CAAGGGCGTG 540

TGCACACAGG CTCCCTGTTA CTGTATCCTA ATGGAATACT GTGCTCAAGG CCAGTTGTAT 600

GAGGTGCTGA GGGCGGGTCG TAAAATCACC CCGTCCCTCC TGGTTGACTG GTCTATGGGC 660

ATTGCAGGTG GCATGAACTA CCTCCACCTT CACAAAATCA TCCATCGCGA CCTCAAGTCA 720

CCTAATATGC TGATTACCCA CGATGACCTG GTAAAGATCT CTGACTTTGG AACCTCAAAG 780

GAGCTCAGCG ACAAGAGTAC CAAGATGTCG TTTGCTGGGA CTGTGGCTTG GATGGCCCCT 840

GAGGTCATTC GTAACGAGCC TGTCTCCGAA AAGGTGGACA TCTGGTCCTT TGGAGTGGTG 900

CTGTGGGAGA TGTTGACAGG AGAGATCCCT TATAAAGATG TGGACTCCTC CGCCATCATC 960

TGGGGTGTGG GGAACAACAG CCTCCAGCTG CCGATACCGG AGAGCTGCCC TGACGGCTTC 1020

AAGATCCTCC TCAGACAGTG CTGGAATTGT AAGCCTAGAA ATAGGCCCTC TTTCCGTCAG 1080

ATCCTCCTCC ATTTGGACAT TGCGTCTGCT GATGTGCTGT CCACCCCACA AGAGACGTAC 1140

TTCAAGTCTC AGGCTGAATG GCGAGAAGAG GTGAAACGGC ACTTTGAGAA GATCAAGTCG 1200

GAGGGTACTT GTCTCCACCG GCTTGATGAA GAACTAATCA ACAGACGCAG AGAGGAGCTC 1260

AGGCATGCTT TGGATATTCG TGAGCACTAT GAGAGGAAAC TGGAGAGAGC TAACAATCTC 1320

TACATGGAGC TGAGCGCCGT TATGCTGCAG CTGGAGCTGA AAGAGAAAGA GCTGCAGAGG 1380

AGAGAGCAGT CCCTGGATAA AAAGTACCCA GGTCTGTTCA AGCACCACAG TTCCAGACAG 1440

AGCAGCTCCT CAAACACTAT GGACAAGCTC ATCAAGAAGA GAAATGTTCC ACAGAAGCTT 1500

CCTTCAGGAA AGAGGCCAGA CATCCTCAAA TCTGAGGTAA TCATTCCCAA AATGGATTCT 1560

TCCGTGATGC AAATCACTAT TCCAGCGTGC CCCAACAGAA GCTCCACTTC TCCCAGCCGG 1620

TCCCGAAGGG TAAAGACTCG CCACCGCAAG CCGGGTAAAG GCAGCAGTGG GGACCTGGCT 1680

GGACTTAAGG CAAATCAGTC CTCTCCTAAC AGGGACTCGA CTGCCCAGAC GAATGGCTCC 1740

ACAACCAATA CCTCCAAGCA GCTGCTGGAG CCCTCTGCTG CCCTGCGGGG CCTCGGCCAC 1800

GAGCAGCAGC AGAGGCAGCT GTCCTCCTCC AGCCCAGACC TTATATGCAC CACGCTGAAG 1860

GCAGAGGCCC AGGGGGCGAC TGGTCTCGAC GACCTCACAG AAACTCCCCC GCGCAGCGAC 1920

ACGCCGAGCG AGGACGCCGC GTCGTTCCCG TTCTCCAGCA GCCCGGATTC CCCGTGTGGG 1980

AGAGGGGCAG CAGCCAGAAG AGCATCTCTG GGATCTCCGC GCCTACTACT CGACGGCGAG 2040

GACAAAGAGG AAGGAGCTGG GGCCGTGAGG ATGCCACGGG GGGCGTCGGG GGGCATCGGG 2100

AGTCAGCACC TCACTCCGTC AGCCATTCTG TACAGGGCAG CTATCACACG GAAGCAGAGA 2160

CGCGGAGTGT CATCAGAAGA GGAGGAGGGT GAAGTTGACA GTGAGGTTGA GTTGCCACGG 2220

AGACGCAGAC GTCCGACCAG TATCACCAAG TGCCAGTCGG TCTCGACCTT TAGCTCAGAG 2280

AACCTGTCCG TTTCCGATGG CGAGGAGGGT CACACCACTG ACCACTCCCA CAGCGGCACC 2340

CCTGACGTGG TCAGCACTAA CACGGATGAC AGACTGGACG ACCGCAGCGA CGACCTCCTG 2400

TCTCAGGGTT CGGAGATCCC GGCCGACAAC ACCGATCCCG CGCAAGCGTC CGACGGCCTG 2460

TCGGAGAGAG ACGGAGCGCT GGGCCGGGCT AAAGCTCAGC TGGATGCTGG GCAGAATCCC 2520

AATGAGAGTC GCGCCCTGTG TGATGATTCG GACTGCGACA GCGCTGAGCT GGACCAGTCT 2580

GGCAGCGGAG AACCGAGCCG TCCTCCCAGC GCCGGGGCCT GGGCTCCGCC A 2631

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ +k++++evavKk+r+ +e+         e+k+l+kl+hpnii+++G

Q: 129   LQWVGSGAQGAVFLGKFHGEEVAVKKVRDIKET---------EIKHLRKLKHPNIITFKG  179

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA Gm+YLh +   kii

Q: 180   VCTQAPCYCILMEYCAQGQLYEVLRA--GRKITPSLLVDWSMGIAGGMNYLHLH---KII  234

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 235   HRDLKSPNMLI-THDDLVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  293

         ***********.99999*************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWe+lt+e+Pykd+++ ai+++v++++l+lpip+scp+ +k L+++cwn +p+

Q: 294   IWSFGVVLWEMLTGEIPYKDVDSSAIIWGVGNNSLQLPIPESCPDGFKILLRQCWNCKPR  353

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 354   NRPSFRQILLH  364

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGKFHGE EVAVKKVRDI KETEIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEYCAQGQ LYEVLRAGRK ITPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITHD 120

DLVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWEMLTGE 180

IPYKDVDSSA IIWGVGNNSL QLPIPESCPD GFKILLRQCW NCKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Caenorhabditis elegans"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Petromyzon marinus"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013