EKS-TAR-00049

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00049

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	281.7	1.5E-83	847	1116	270

Status

Unreviewed

Ensembl Protein

ENSTRUP00000022931

UniProt Accession

H2TE39;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000009121	ENSTRUP00000022937	ENSTRUT00000023033
ENSTRUG00000009121	ENSTRUP00000022936	ENSTRUT00000023032
ENSTRUG00000009121	ENSTRUP00000022935	ENSTRUT00000023031
ENSTRUG00000009121	ENSTRUP00000022934	ENSTRUT00000023030
ENSTRUG00000009121	ENSTRUP00000022933	ENSTRUT00000023029
ENSTRUG00000009121	ENSTRUP00000022932	ENSTRUT00000023028
ENSTRUG00000009121	ENSTRUP00000022931	ENSTRUT00000023027

Organism

Takifugu rubripes

Functional Description

Protein Length

1136

Protein Sequence
(FASTA)

RNMSRSSSKR SKGDLFPGTV QPPRCKGIHV YLFCTKEGGT YLSHTSGDVT AEELCFLAAK 60

AVGITPLCHV LFALYNPLAT CWYSPSHTFT TEVHSTLVLH YCMRYYFRNW HGLNENEPTV 120

SRYPLKSKTE KELLSLFDVR SLDYLFSQAK YEFVNKIVHM EDMKTEEEIS SFKNESLGMA 180

VLHMSHQALQ TGSTLQEVAK KHSYLDCIPK CFAKHISKDN FLTKIRIRRV FADFVQTFQE 240

HTVENGRLDT QKIMYKYIST LERLEPNFGI EIFHVSHLNL RETWEESGSL PNKTHPQCDC 300

RAPATHEIMV NGNKGISWRI STQKAQSPQP DTPNDWTAFC DFPEIAHIAI TETNVCISTQ 360

DNHCMEVQMS STQEAHSFIS LLDGYYRLTA DAHNYLCHDL APPRVLLNEA NGLHGPMHGC 420

FALQKLKKEA AEEGAYLICW SAVNYENLVL IVHNKNKNGS AQNHKQFQIK LKGSKFCLDG 480

WDLQYSSVRE LMDSLKNFVL MSGSESFTVK KCCLPRHGEL SNLLVMRTPF QPSSKTSRVQ 540

VPYIPDKDLV QGQHLGSGPI TNIYRGLLLV HGGGDNGEED KFNNNASSQT GIPVVLKILN 600

PNHDELSLTF IESVGTMSQV SHRHLVHVHG LSVKEHQHIM VEEFVKFGPL DVFLHKEKAS 660

ISGRWKFIVA IQLASALSYL ENKQLIHGNV CARNILLARC GLDTGTAPFI KLSDPGIPIS 720

ALEREERLER IPWIAPECID GGESNQSATD QWSFGATFLE ICYNGTLPIS TSSEKERFYQ 780

QKGRLPVLSS QEVSNFINTC LAYDPMDRPS FCIVLRELSE FMNKNLDISP SETLPDTGQG 840

IFNKRFLKEI EDLGEGNFGK VTLCLYDPAN DGSGEHVAVK ALKQENGNIA GWIKEIEVLK 900

SLDHCNIVKY KGCCSERGGQ GLQLIMEFLP QGSLAKYLPK HKPHQSQLLI FAQQICQGMD 960

YLHSKRYVHR DLAARNILLD RNTQVKIGDF GLTKCIPEGA SYYRVSENED SPVYWFAVEC 1020

LKDNKFSFAS DVWAFGVTLY EIFSYCNSKQ SPPKKFNEML EKPSKMSQML LISLLEKQKR 1080

LPCPKNCPLE VRMIMERCWA TEPQQRPAFI SLIENLLPLS NQQSTKTDQL HSQYVC 1136

Nucleotide Sequence
(FASTA)

CGAAACATGT CTCGAAGTTC CTCCAAGCGT TCAAAGGGAG ACCTATTTCC GGGTACGGTC 60

CAACCTCCTC GGTGCAAAGG TATCCATGTT TACCTCTTCT GTACAAAGGA AGGGGGCACA 120

TATTTGTCCC ACACCAGCGG AGACGTGACA GCAGAGGAGC TTTGCTTCTT GGCTGCCAAG 180

GCTGTAGGCA TCACTCCCCT GTGCCATGTT TTGTTTGCTC TGTACAATCC ACTGGCAACC 240

TGCTGGTACA GTCCCAGTCA CACCTTCACC ACAGAAGTTC ACTCCACTCT TGTACTCCAC 300

TACTGTATGA GATATTATTT TCGGAATTGG CATGGACTTA ATGAAAATGA GCCAACTGTA 360

TCCCGGTATC CTCTCAAATC AAAGACGGAA AAAGAGCTCT TGTCTTTATT TGATGTCAGA 420

TCCTTGGACT ATCTGTTCTC CCAGGCTAAA TATGAATTTG TCAACAAAAT AGTTCACATG 480

GAAGACATGA AAACGGAGGA GGAAATTAGC AGCTTCAAAA ATGAGAGCCT GGGGATGGCT 540

GTCCTTCACA TGTCACACCA GGCATTACAA ACAGGCAGCA CACTACAGGA AGTTGCTAAA 600

AAACACAGCT ACTTAGACTG CATCCCAAAG TGTTTCGCCA AACATATTTC CAAAGACAAC 660

TTCCTTACAA AAATAAGGAT TCGGCGGGTG TTTGCAGATT TTGTGCAGAC ATTTCAGGAG 720

CACACTGTGG AAAATGGGCG ACTGGATACC CAAAAGATCA TGTATAAGTA CATCTCTACC 780

CTTGAACGTT TGGAGCCGAA TTTCGGCATA GAGATCTTCC ACGTATCCCA TCTGAACTTA 840

AGAGAAACCT GGGAAGAAAG TGGCTCTTTG CCCAACAAAA CGCATCCACA GTGTGACTGT 900

AGAGCACCTG CGACGCATGA AATAATGGTG AATGGCAACA AAGGGATCTC GTGGCGAATA 960

TCCACTCAAA AGGCACAGTC GCCACAACCT GACACACCCA ATGATTGGAC TGCCTTCTGT 1020

GATTTCCCAG AAATTGCACA CATAGCCATT ACTGAGACTA ATGTGTGCAT TAGCACTCAG 1080

GACAATCACT GCATGGAGGT TCAAATGAGC TCAACCCAAG AGGCCCATTC CTTCATCTCC 1140

CTCCTAGATG GATACTACCG GCTGACTGCA GACGCCCACA ACTATCTTTG TCATGATCTG 1200

GCTCCCCCAA GGGTACTGCT GAATGAAGCA AATGGACTGC ACGGACCTAT GCATGGTTGT 1260

TTTGCGCTTC AAAAGCTGAA AAAGGAGGCA GCTGAGGAGG GGGCTTACCT CATATGTTGG 1320

AGTGCTGTAA ATTATGAAAA CCTTGTCCTG ATTGTCCATA ACAAAAATAA GAATGGCTCA 1380

GCACAAAACC ACAAGCAGTT TCAGATTAAG CTCAAGGGTT CGAAGTTCTG TCTGGATGGT 1440

TGGGACTTAC AGTACTCCAG TGTGAGGGAG CTCATGGACA GTCTCAAGAA CTTTGTGCTC 1500

ATGTCTGGTT CAGAAAGCTT CACTGTCAAG AAATGCTGTT TGCCACGGCA TGGAGAGCTA 1560

TCCAATCTTT TGGTGATGAG GACTCCCTTT CAACCTTCCT CAAAGACATC CCGGGTACAA 1620

GTACCCTATA TCCCAGACAA AGATCTTGTG CAGGGACAAC ATTTGGGCAG TGGGCCGATT 1680

ACAAACATAT ATAGAGGATT GTTGCTTGTT CACGGGGGAG GAGACAATGG TGAGGAGGAT 1740

AAATTCAACA ACAACGCCAG TAGCCAAACA GGGATCCCGG TGGTTCTTAA GATCCTAAAT 1800

CCAAACCATG ATGAACTGTC ACTCACCTTT ATTGAAAGTG TAGGTACCAT GAGCCAGGTA 1860

TCCCACAGGC ACTTGGTGCA TGTACATGGT CTGTCAGTCA AAGAACATCA ACATATCATG 1920

GTGGAAGAGT TTGTGAAATT TGGTCCTCTT GATGTTTTCC TTCATAAAGA AAAGGCCTCA 1980

ATCTCTGGTC GCTGGAAATT CATCGTTGCA ATACAACTTG CCAGTGCTTT GAGTTACCTT 2040

GAGAACAAAC AGCTGATTCA TGGAAATGTA TGTGCAAGGA ACATTTTGTT GGCACGTTGT 2100

GGCCTAGATA CAGGTACTGC ACCTTTCATC AAGCTGAGTG ACCCAGGAAT CCCCATCAGT 2160

GCCCTTGAAC GGGAAGAACG TCTGGAGCGT ATCCCATGGA TTGCCCCAGA GTGTATTGAC 2220

GGTGGTGAAT CCAACCAAAG TGCCACTGAT CAGTGGAGTT TTGGAGCAAC ATTCCTTGAA 2280

ATATGCTATA ACGGAACTCT GCCCATCAGC ACATCATCTG AGAAAGAGCG CTTTTACCAG 2340

CAAAAAGGAC GCCTGCCTGT CCTCTCCTCC CAGGAGGTGT CCAACTTCAT CAACACCTGC 2400

TTGGCTTACG ACCCCATGGA CAGGCCTTCT TTTTGCATTG TGCTCAGAGA ACTCTCAGAG 2460

TTCATGAACA AAAATCTTGA TATATCACCA AGTGAAACCC TCCCCGACAC GGGTCAGGGT 2520

ATATTCAATA AACGCTTTCT GAAAGAGATT GAAGACTTAG GAGAGGGTAA CTTTGGAAAG 2580

GTGACTCTCT GCTTGTATGA CCCAGCCAAT GATGGTTCTG GAGAGCATGT GGCAGTAAAA 2640

GCTTTGAAGC AAGAAAATGG TAACATTGCG GGCTGGATAA AGGAAATAGA AGTTCTGAAG 2700

TCACTCGATC ATTGCAACAT TGTGAAGTAC AAAGGATGTT GTAGTGAAAG AGGTGGACAA 2760

GGGCTGCAGC TAATCATGGA GTTCCTTCCA CAAGGGAGCC TGGCAAAGTA CCTTCCCAAG 2820

CACAAGCCTC ACCAGTCCCA GTTGCTGATA TTTGCTCAGC AGATCTGTCA GGGTATGGAT 2880

TATCTGCATT CCAAGCGATA TGTCCATCGA GACCTTGCTG CCCGAAATAT ATTGTTGGAC 2940

AGAAACACTC AAGTCAAGAT TGGAGATTTT GGTCTCACGA AATGCATCCC TGAAGGAGCA 3000

TCGTATTACC GTGTCTCTGA GAATGAGGAC AGTCCTGTGT ACTGGTTTGC AGTTGAGTGT 3060

TTGAAGGATA ACAAATTTTC CTTCGCCTCT GATGTTTGGG CCTTTGGAGT CACATTATAT 3120

GAGATCTTCT CTTACTGCAA CTCTAAACAG AGCCCTCCAA AGAAATTTAA TGAAATGTTG 3180

GAAAAACCTT CAAAAATGAG TCAAATGCTT CTCATTAGTC TGTTGGAGAA GCAAAAGCGA 3240

CTGCCTTGTC CCAAAAACTG CCCGCTGGAG GTGAGGATGA TAATGGAGCG ATGTTGGGCT 3300

ACTGAGCCGC AACAGCGACC AGCATTCATT TCCCTGATTG AAAATCTATT GCCACTTTCG 3360

AATCAACAAT CTACAAAAAC TGACCAGTTG CACTCACAAT ATGTCTGT 3408

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk ie+Lg+g+f+kv ++ +d+ +d ++e va+k+Lk + + +++++ +e+e+l++l+h

Q: 847   LKEIEDLGEGNFGKVTLCLYDPANDGSGEHVAVKALK-QENGNIAGWIKEIEVLKSLDHC  905

         6889*********************************.6777889***************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kg+c + g +  +l+me++++GsL +yL+k+k+  + s+ll +a+q++++m+YL+

Q: 906   NIVKYKGCCSERGGQglQLIMEFLPQGSLAKYLPKHKP--HQSQLLIFAQQICQGMDYLH  963

         ***********99999********************77..5789999*************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k++vhrd+aarn+L++r+ +      vk++d+gl+k ++++  Yy v e+ ds+++w a

Q: 964   SKRYVHRDLAARNILLDRNTQ------VKIGDFGLTKCIPEGaSYYRVSENEDSPVYWFA  1017

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp...........lrseslerklell  225

         +ecl+++k +s asdvW+Fgvtlye+++ c++++sp            +++++  ++ ll

Q: 1018  VECLKDNK-FSFASDVWAFGVTLYEIFSyCNSKQSPpkkfnemlekpSKMSQM-LLISLL  1075

         ********.***************************99998886654444444.499***

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265

         e+++rlp+pk cp e+ ++m++c+++ep+qrp+F  ++e+l

Q: 1076  EKQKRLPCPKnCPLEVRMIMERCWATEPQQRPAFISLIENL  1116

         **********************************9999876

Domain Sequence
(FASTA)

LKEIEDLGEG NFGKVTLCLY DPANDGSGEH VAVKALKQEN GNIAGWIKEI EVLKSLDHCN 60

IVKYKGCCSE RGGQGLQLIM EFLPQGSLAK YLPKHKPHQS QLLIFAQQIC QGMDYLHSKR 120

YVHRDLAARN ILLDRNTQVK IGDFGLTKCI PEGASYYRVS ENEDSPVYWF AVECLKDNKF 180

SFASDVWAFG VTLYEIFSYC NSKQSPPKKF NEMLEKPSKM SQMLLISLLE KQKRLPCPKN 240

CPLEVRMIME RCWATEPQQR PAFISLIENL 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013