EKS-TAR-00413

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00413

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	344.9	6.8E-103	11	268	258

Status

Unreviewed

Ensembl Protein

ENSTRUP00000023057

UniProt Accession

H2TEG0;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K5

Gene Synonyms/Alias

MAP4K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000009167	ENSTRUP00000023050	ENSTRUT00000023146
ENSTRUG00000009167	ENSTRUP00000023049	ENSTRUT00000023145
ENSTRUG00000009167	ENSTRUP00000023058	ENSTRUT00000023154
ENSTRUG00000009167	ENSTRUP00000023057	ENSTRUT00000023153
ENSTRUG00000009167	ENSTRUP00000023056	ENSTRUT00000023152
ENSTRUG00000009167	ENSTRUP00000023055	ENSTRUT00000023151
ENSTRUG00000009167	ENSTRUP00000023054	ENSTRUT00000023150
ENSTRUG00000009167	ENSTRUP00000023053	ENSTRUT00000023149
ENSTRUG00000009167	ENSTRUP00000023052	ENSTRUT00000023148
ENSTRUG00000009167	ENSTRUP00000023051	ENSTRUT00000023147

Organism

Takifugu rubripes

Functional Description

Protein Length

828

Protein Sequence
(FASTA)

EIQRRNPHQD FELIQRVGSG TYGDVYKARN IKTGELAAVK IIKLEPGDDF SIIQQEIFMV 60

KECTHKNIVA YFGSYLCREK LWICMEYCGG GSLQDIYHVT GPLSELQIAY VCRETIQGLG 120

YLHSMGKMHR DIKGANILLT DKGDVKLADF GVAAKITATI AKRKSFIGTP YWMAPEVAAV 180

EKNGGYNQLC DIWAVGITSI ELAELQPPMF DLHPMRALFL MSKSSFQPPK LKDKNKWSTS 240

FHNFVKVSLT KNPKKRPTAE KLLSHVFVAQ TGLTWRLAVD LLDKMNNPDN HQPYSEVDDD 300

DLEPLSAVRH TIRSTNKHAR AERTRSEIDF DKLQFEPPLR KETEDVSKDN DFPSPWSPFA 360

EGGITTRSLL KSVEDELFQR GHVTHLEDAF ELDEIVLNDD RILTVRRFPN YENGPSQASR 420

RQSTPEQGHK VENSSPDYLS ASVSSPGLLS HASDPDNDSD DDKPAINGLP PTPKVLMGAC 480

FSKVFDGCPL KINCATSWIH PDTKDQYLIF GTEDGIYTLN LNELHEATME QLFPRKCTWL 540

YVINNNLMSL SGKTFQLYSH NLIGLFEQLR KPGLAAQFQT HRFPDRILPR RFALTTKIPD 600

TKGCHKCCIV RNPYTGHKYL CGALQSGIVL LQWYEPMQRF MLLKLFDFPL PSPLKVFEML 660

VVPEQEYPLV CVAISQGSDP SQVVRFETIN LNSCSSWFTE IGTNNQQVDA IHVTQLERDT 720

VLVCLDQNLK IVNLQGRLKS NKKLASELSF DFSIECVVCL QDSVLAFWKH GMQGKSFKSN 780

EVTQEISDPS RVFHLLGSDR VVVLESRPTD NPTALSNLYI LAGHENSY 828

Nucleotide Sequence
(FASTA)

GAAATCCAGA GGAGGAACCC TCATCAAGAC TTTGAGCTCA TCCAGAGGGT TGGAAGTGGC 60

ACCTATGGAG ACGTGTACAA GGCTCGGAAC ATAAAAACAG GGGAGCTAGC TGCTGTGAAG 120

ATCATAAAGC TGGAACCAGG GGATGACTTT TCCATCATCC AGCAGGAAAT CTTCATGGTG 180

AAGGAATGCA CACACAAGAA TATTGTTGCC TACTTCGGGA GCTACCTCTG TCGCGAGAAG 240

CTGTGGATAT GTATGGAGTA CTGCGGCGGA GGATCTCTGC AGGACATCTA CCACGTGACG 300

GGCCCTCTGT CGGAGCTCCA GATAGCCTAC GTCTGCAGAG AGACTATACA GGGTTTGGGA 360

TATCTGCACA GCATGGGCAA GATGCACCGC GACATTAAGG GTGCAAACAT TCTTCTAACA 420

GACAAAGGAG ATGTAAAATT AGCCGACTTT GGAGTCGCGG CCAAAATTAC AGCTACTATT 480

GCGAAACGAA AGTCTTTTAT TGGGACACCT TATTGGATGG CTCCAGAAGT AGCCGCGGTG 540

GAGAAGAACG GTGGCTACAA CCAGCTGTGT GACATCTGGG CTGTCGGGAT CACGTCGATA 600

GAGCTGGCCG AGCTGCAGCC GCCGATGTTT GACCTTCACC CCATGAGAGC TTTGTTCCTG 660

ATGTCAAAGA GCAGCTTCCA GCCTCCAAAG CTAAAAGACA AAAACAAATG GTCCACCAGC 720

TTCCATAACT TTGTCAAAGT GTCCCTCACC AAGAACCCAA AGAAGAGGCC CACAGCAGAA 780

AAGCTTTTAT CACATGTGTT TGTGGCCCAG ACTGGTTTGA CCTGGCGGCT CGCTGTCGAT 840

CTCCTGGATA AGATGAACAA CCCAGACAAC CACCAGCCTT ACAGCGAGGT GGACGACGAC 900

GACCTGGAGC CTCTGTCTGC AGTCCGACAC ACCATCCGCT CCACCAACAA ACATGCCCGA 960

GCTGAGAGGA CGCGCTCGGA GATCGACTTC GACAAGCTGC AGTTTGAACC TCCACTCCGG 1020

AAGGAAACAG AGGATGTGAG TAAAGATAAT GACTTTCCTT CCCCCTGGAG TCCGTTTGCA 1080

GAGGGAGGAA TAACAACCAG GAGCCTTCTC AAAAGCGTTG AAGACGAGTT GTTCCAACGG 1140

GGACACGTAA CCCACCTTGA AGATGCATTT GAGTTAGATG AAATCGTTCT GAACGATGAT 1200

AGAATCCTGA CGGTCCGGAG GTTCCCAAAC TACGAGAACG GGCCGAGCCA GGCGTCCCGG 1260

AGGCAGAGCA CGCCAGAGCA GGGCCACAAG GTGGAGAACT CCTCCCCCGA TTACCTGTCT 1320

GCCAGCGTCA GCAGCCCTGG CCTCCTGTCT CACGCCTCAG ATCCAGATAA CGACTCGGAC 1380

GATGACAAAC CAGCTATCAA CGGTCTGCCC CCCACTCCTA AAGTCCTGAT GGGAGCCTGC 1440

TTCTCCAAAG TGTTCGACGG ATGTCCGCTG AAGATCAACT GTGCCACGTC ATGGATCCAT 1500

CCTGACACCA AAGATCAGTA CCTCATCTTT GGGACTGAGG ATGGCATCTA CACGCTGAAC 1560

CTGAATGAGC TGCATGAGGC CACAATGGAG CAGCTCTTCC CGAGGAAGTG CACGTGGCTC 1620

TACGTCATCA ACAACAACCT GATGTCTCTC TCTGGAAAAA CCTTCCAGCT GTACTCGCAC 1680

AACCTCATCG GGCTGTTTGA GCAGCTGAGG AAACCCGGCC TGGCGGCTCA GTTCCAGACT 1740

CACCGCTTCC CAGACAGGAT ATTACCCAGG AGGTTTGCCT TGACAACCAA GATCCCCGAC 1800

ACCAAGGGCT GTCACAAATG CTGCATCGTG AGAAATCCCT ACACGGGCCA CAAGTATCTG 1860

TGTGGAGCGC TGCAGTCTGG GATCGTCCTG CTGCAGTGGT ACGAGCCCAT GCAGAGGTTC 1920

ATGCTCCTCA AGCTCTTTGA CTTCCCGCTC CCCAGCCCCC TGAAGGTGTT TGAGATGCTG 1980

GTGGTCCCGG AGCAGGAGTA TCCTCTGGTG TGCGTGGCCA TCAGCCAGGG CTCAGACCCC 2040

AGCCAGGTGG TCCGCTTCGA GACCATCAAC CTCAACTCTT GCTCGTCCTG GTTCACAGAG 2100

ATCGGAACAA ATAATCAACA GGTGGACGCG ATCCACGTCA CCCAGCTGGA GAGGGACACG 2160

GTGTTGGTGT GTTTGGACCA AAATTTAAAG ATTGTGAACC TCCAGGGCAG ACTGAAGTCC 2220

AACAAGAAGC TGGCTTCTGA ACTGAGCTTT GACTTCTCCA TCGAATGTGT TGTGTGTCTT 2280

CAGGACAGCG TCCTGGCCTT CTGGAAACAC GGCATGCAGG GAAAGAGCTT CAAGTCTAAT 2340

GAGGTGACCC AGGAGATCTC TGATCCGAGC AGAGTCTTTC ACCTCCTGGG ATCTGACAGG 2400

GTGGTGGTTT TGGAGAGTCG ACCTACGGAC AACCCCACGG CCCTGAGCAA CCTCTACATC 2460

CTGGCAGGTC ACGAGAACAG TTACTGA 2487

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +el++++g+G++g+vy+ar++ktgel+a+k+i+le  ++ + +q+ei ++k+++h+niv+

Q: 11    FELIQRVGSGTYGDVYKARNIKTGELAAVKIIKLEPGDDFSIIQQEIFMVKECTHKNIVA  70

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E qiay++re++++L ylHs++++

Q: 71    YFGSYLCREKLWICMEYCGGGSLQDIYH--VTGPLSELQIAYVCRETIQGLGYLHSMGKM  128

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++

Q: 129   HRDIKGANILLTDKGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQ  188

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw++GIt+ielae +pP++dl+p++al++++k++  ppklk+k+k+s++f++fv+

Q: 189   LCDIWAVGITSIELAELQPPMFDLHPMRALFLMSKSSfqPPKLKDKNKWSTSFHNFVKVS  248

         ***********************************9998*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h F+

Q: 249   LTKNPKKRPTAEKLLSHVFV  268

         ******************97

Domain Sequence
(FASTA)

FELIQRVGSG TYGDVYKARN IKTGELAAVK IIKLEPGDDF SIIQQEIFMV KECTHKNIVA 60

YFGSYLCREK LWICMEYCGG GSLQDIYHVT GPLSELQIAY VCRETIQGLG YLHSMGKMHR 120

DIKGANILLT DKGDVKLADF GVAAKITATI AKRKSFIGTP YWMAPEVAAV EKNGGYNQLC 180

DIWAVGITSI ELAELQPPMF DLHPMRALFL MSKSSFQPPK LKDKNKWSTS FHNFVKVSLT 240

KNPKKRPTAE KLLSHVFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013