EKS-TAR-00547

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00547

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Syk	440.3	4.3E-132	329	576	248

Status

Unreviewed

Ensembl Protein

ENSTRUP00000024631

UniProt Accession

H2TIX3;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

SYK

Gene Synonyms/Alias

SYK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000009800	ENSTRUP00000024636	ENSTRUT00000024736
ENSTRUG00000009800	ENSTRUP00000024633	ENSTRUT00000024733
ENSTRUG00000009800	ENSTRUP00000024628	ENSTRUT00000024728
ENSTRUG00000009800	ENSTRUP00000024632	ENSTRUT00000024732
ENSTRUG00000009800	ENSTRUP00000024627	ENSTRUT00000024727
ENSTRUG00000009800	ENSTRUP00000024635	ENSTRUT00000024735
ENSTRUG00000009800	ENSTRUP00000024634	ENSTRUT00000024734
ENSTRUG00000009800	ENSTRUP00000024630	ENSTRUT00000024730
ENSTRUG00000009800	ENSTRUP00000024631	ENSTRUT00000024731
ENSTRUG00000009800	ENSTRUP00000024629	ENSTRUT00000024729

Organism

Takifugu rubripes

Functional Description

Protein Length

592

Protein Sequence
(FASTA)

IMDDKVNTLP FFYGEITREE AEDYLQQAGM VNGLYLLRQS RNNLGGFALS VSFSDRCYHY 60

SIERRANETY AIPGGKTHRH PVDVIDYHSQ VTDGLVSLLK RPCNRPKNMR PKVGLFEDMK 120

EKLIREYVQQ TWNLQGAALE QAIISQRPKL EKLIATTAHE KMSWFHGAIT REDSEPRLQN 180

GVRPNGKFLV RQRDQSSYAL CIIHEGQVMH YRIDQDQIGK LSIPDGKKFD TLWQLVEHYS 240

YKPDGLLHIL TEPCPRHAGE NGFPLLVEEL IHSSENSPRF PHGGIIHQTC VSPAEQTYAM 300

PMDTEVYESP YADPDELRSS TVDRSQLILE DGELGSGNFG TVMKGIYKMR KTEKSVAVKI 360

LKNDDNNASV REEMLREANV MQQLDNPYIV RMIGICEAES LMLVMELADL GPLHKFLQKH 420

KQISMKNITE LVHQVSMGMR YLEEHKFVHR DLAARNVLLV TQHYAKISDF GLSKAVAEEK 480

NYYKAKGHGK WPVKWYAPEC INYFKFSSKS DVWSFGVLMW EAFSYGQKPY KGMKGNEVMQ 540

MIESGQRMDA PVNCPSEMYD LMRACWTYKV EGRPEFTVVE PRLREYYYDI SH 592

Nucleotide Sequence
(FASTA)

ATCATGGATG ACAAAGTGAA CACATTACCC TTCTTCTATG GTGAAATCAC AAGGGAAGAA 60

GCAGAGGACT ACCTGCAGCA GGCCGGCATG GTCAACGGCC TGTACCTCCT ACGACAGAGC 120

CGAAACAACC TGGGAGGGTT TGCGCTCTCT GTCTCCTTCT CAGACCGCTG CTACCATTAC 180

AGCATTGAAA GACGAGCCAA TGAAACATAC GCTATTCCTG GGGGGAAGAC CCACAGGCAC 240

CCTGTGGATG TGATTGATTA CCATTCCCAG GTGACGGATG GCCTGGTGTC GTTGCTGAAG 300

AGGCCCTGCA ACAGGCCCAA GAACATGAGA CCAAAGGTTG GACTGTTTGA GGACATGAAG 360

GAGAAGCTGA TCCGAGAGTA TGTGCAGCAG ACATGGAACC TGCAGGGTGC AGCTCTGGAG 420

CAGGCTATTA TCAGCCAAAG GCCTAAGCTG GAGAAGTTGA TTGCCACCAC CGCACATGAA 480

AAGATGTCTT GGTTTCATGG AGCAATAACG CGAGAAGACT CTGAGCCCAG GCTTCAAAAT 540

GGCGTCCGCC CCAATGGAAA GTTCCTGGTT CGTCAGAGGG ACCAGAGCTC ATATGCTCTG 600

TGTATCATCC ACGAAGGACA GGTCATGCAT TACCGCATTG ACCAGGACCA AATAGGCAAA 660

CTGTCCATAC CAGATGGAAA GAAGTTTGAC ACCCTGTGGC AGCTAGTTGA ACATTATTCA 720

TACAAGCCCG ATGGTCTGCT GCACATTCTA ACAGAACCCT GTCCAAGACA CGCTGGAGAG 780

AACGGTTTTC CCTTGTTAGT GGAGGAGCTC ATCCACAGCT CAGAGAACTC TCCACGGTTC 840

CCACATGGAG GAATAATCCA TCAGACATGT GTCAGTCCTG CAGAGCAAAC ATATGCAATG 900

CCAATGGATA CAGAGGTGTA TGAGAGCCCC TATGCAGACC CAGACGAGCT GAGGAGCTCC 960

ACAGTGGATC GTAGTCAGCT TATCCTGGAG GATGGAGAAC TGGGCTCTGG GAACTTTGGT 1020

ACCGTTATGA AAGGCATCTA CAAAATGAGG AAGACGGAGA AGTCAGTGGC TGTCAAAATC 1080

CTGAAGAACG ATGACAACAA CGCATCAGTG CGTGAGGAGA TGCTGCGAGA AGCCAACGTC 1140

ATGCAGCAGC TGGACAACCC CTACATCGTT AGAATGATCG GAATCTGTGA GGCCGAGAGC 1200

CTCATGCTGG TCATGGAGCT GGCTGATCTG GGACCACTGC ATAAGTTCCT GCAGAAACAC 1260

AAGCAAATCA GCATGAAGAA CATCACCGAG CTGGTCCACC AGGTGTCTAT GGGGATGAGG 1320

TACCTGGAGG AACATAAGTT TGTCCACAGG GACCTCGCTG CCAGGAACGT CCTGCTGGTT 1380

ACGCAGCACT ATGCCAAGAT CAGCGACTTC GGCCTGTCCA AAGCTGTTGC TGAGGAGAAG 1440

AACTACTACA AGGCTAAGGG TCATGGGAAG TGGCCAGTCA AATGGTACGC TCCCGAATGC 1500

ATCAACTACT TCAAGTTTTC ATCCAAAAGT GATGTTTGGA GCTTTGGGGT GCTGATGTGG 1560

GAAGCCTTCT CCTACGGCCA GAAACCTTAC AAGGGAATGA AAGGAAATGA GGTGATGCAG 1620

ATGATTGAAA GTGGACAGCG GATGGATGCT CCTGTCAACT GTCCATCAGA GATGTACGAC 1680

CTGATGCGGG CCTGCTGGAC ATACAAGGTG GAGGGCAGAC CTGAGTTCAC CGTGGTGGAG 1740

CCCAGATTAC GGGAATATTA CTACGACATC TCCCATTAA 1779

Domain Profile

S: 2     vedkelGsGnfGsvkkGyyrmkkkrlevaikvlk.eadekadkdellreasvmqqldnky  60

         +ed elGsGnfG+v kG+y+m+k+++ va+k+lk + ++ + ++e+lrea+vmqqldn+y

Q: 329   LEDGELGSGNFGTVMKGIYKMRKTEKSVAVKILKnDDNNASVREEMLREANVMQQLDNPY  388

         79********************************556667789*****************

S: 61    ivrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleeknf  120

         ivr+iGi++ae+lmlvmela+lGpl+k+l+++++ i+ kn+ elvhqv+mGm+ylee++f

Q: 389   IVRMIGICEAESLMLVMELADLGPLHKFLQKHKQ-ISMKNITELVHQVSMGMRYLEEHKF  447

         ******************************9999.*************************

S: 121   vhrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkfs  180

         vhrdlaarnvllv++hyakisdfGlska+  +++yyka+ +Gkwpvkwyapecin+ kfs

Q: 448   VHRDLAARNVLLVTQHYAKISDFGLSKAVAEEKNYYKAKGHGKWPVKWYAPECINYFKFS  507

         ************************************************************

S: 181   sksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscwk  240

         sksdvwsfGv++weafsyGqkpyk++kg ev++++e+G+r+++p +cp+e+y+lm+ cw+

Q: 508   SKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVMQMIESGQRMDAPVNCPSEMYDLMRACWT  567

         ************************************************************

S: 241   ykvedrpdf  249

         ykve rp+f

Q: 568   YKVEGRPEF  576

         ********9

Domain Sequence
(FASTA)

LEDGELGSGN FGTVMKGIYK MRKTEKSVAV KILKNDDNNA SVREEMLREA NVMQQLDNPY 60

IVRMIGICEA ESLMLVMELA DLGPLHKFLQ KHKQISMKNI TELVHQVSMG MRYLEEHKFV 120

HRDLAARNVL LVTQHYAKIS DFGLSKAVAE EKNYYKAKGH GKWPVKWYAP ECINYFKFSS 180

KSDVWSFGVL MWEAFSYGQK PYKGMKGNEV MQMIESGQRM DAPVNCPSEM YDLMRACWTY 240

KVEGRPEF 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR023420	; Kinase_SYK/ZAP-70_inter-SH2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR012234	; Tyr_kinase_non-rcpt_SYK/ZAP70.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 2.

SMARTs

SM00252	; SH2; 2.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 2.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013