EKS-TAR-00502

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00502

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	468.9	1.0E-140	474	738	265

Status

Unreviewed

Ensembl Protein

ENSTRUP00000025168

UniProt Accession

H2TKG3;

Protein Name

Protein Synonyms/Alias

Gene Name

TYRO3

Gene Synonyms/Alias

TYRO3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000010003	ENSTRUP00000025167	ENSTRUT00000025270
ENSTRUG00000010003	ENSTRUP00000025168	ENSTRUT00000025271

Organism

Takifugu rubripes

Functional Description

Protein Length

846

Protein Sequence
(FASTA)

FTKHPANQTV SQGNSIQLGC AVQGVTEPDI VWMKDGEKLY STDQMFITVG EQHWETFHSV 60

KSVHQHDAGQ YWCEVEHQGQ MLSSNSAWIT VEGVPHFIQE PRDVSVFPNV PFNLTCAAVG 120

PPGPVEVLWW FGGAQVGEPR PSPSVLLVQG VNDSLKFYCE AKNTRGISVS RTGTVHIKVL 180

PAAPVQLQVL STVDNVTLSW KPGFNGHSEL SACNIQVSLS LRVELPQQKV LVPPHLHVLS 240

GINSHSNYSV RVSCVNEVGA SPFSHWLQFQ TPESVPSEAP RNLTFELSDD QLLLSWAVLQ 300

QEELHGNLLA YKVQWTLGGE AQEPLLFKEN LAHLSGGGRF FNSSFQVSAC TSVGCGPWST 360

PVMVLPTSGK QAFVQLQGQR SHMWVGLLFG VLVATVVGLL LSVLARHRGK DTPFGNRKRS 420

AFKAPGPESL VSFTAARSFN RTCSEPQDST LDSLGINNDL KNKLQDVLIP ERLLTLGHML 480

GKGEFGSVRE AFLKLDDSSV QKVAVKVLKS DITSSGDIEQ CLKEAAYMKD FDHPNVIKLT 540

GVSLQRRPGQ RLPVPMVVLP FMKHGDLHTF LLLSRLGEQP FDLNLQTLLH FMLDVARGMA 600

YLSSRSIIHR DLAARNCMLN ENMSVCVADF GLSKKIYSGD YYRQGSVSKL PVKWIALESL 660

ADNVYTTQSD VWAFGVTMWE IITRGQTPYP GVENSEIYEF LIKGERLKKP AECRDDIYEL 720

MHSCWSPVPK CRPSFQQLVL QLEALAHSLS PTPPLREPLH YVNLEDNETE MESGPRVPPS 780

EEEARLGAGT LSCAAHAIGG DYRYIIGPCG VPGEEEQQNG RAGLMREESG NGLQEDVKDE 840

DDDVII 846

Nucleotide Sequence
(FASTA)

TTTACGAAAC ATCCAGCCAA TCAGACGGTG TCTCAGGGCA ACTCGATCCA GCTCGGCTGC 60

GCTGTCCAGG GAGTGACAGA ACCTGACATT GTGTGGATGA AAGATGGAGA GAAGCTGTAC 120

AGCACCGACC AGATGTTCAT CACAGTGGGA GAGCAGCACT GGGAGACGTT TCACAGTGTG 180

AAGTCGGTCC ACCAGCATGA TGCTGGTCAG TACTGGTGTG AGGTGGAACA TCAAGGTCAG 240

ATGCTCTCCT CTAATTCGGC CTGGATTACA GTGGAAGGAG TCCCTCACTT CATCCAGGAA 300

CCACGGGATG TGTCGGTCTT TCCCAACGTT CCCTTCAACC TCACCTGTGC TGCTGTAGGT 360

CCTCCAGGGC CTGTGGAGGT GCTGTGGTGG TTCGGTGGAG CCCAGGTGGG GGAACCGAGA 420

CCATCACCGT CTGTTCTCCT TGTCCAAGGT GTGAATGACA GCCTGAAGTT TTACTGTGAA 480

GCTAAAAACA CCAGAGGAAT TTCAGTGTCC AGAACAGGAA CAGTTCACAT CAAAGTCTTG 540

CCAGCAGCTC CAGTGCAGCT TCAGGTTCTG AGCACAGTGG ACAACGTCAC ATTGTCATGG 600

AAACCAGGAT TCAACGGGCA CTCCGAGCTG TCTGCCTGCA ACATTCAGGT CTCACTCTCT 660

CTGAGAGTGG AGCTTCCTCA GCAGAAGGTT CTGGTTCCTC CTCACCTGCA TGTTCTATCG 720

GGCATAAACA GCCACTCCAA CTACAGCGTT CGGGTGTCCT GTGTCAACGA GGTGGGCGCG 780

TCTCCCTTCT CTCATTGGCT GCAATTCCAG ACACCCGAGT CAGTTCCCTC GGAGGCACCT 840

AGGAACCTGA CGTTTGAGCT GTCGGATGAC CAGCTGCTTC TGAGCTGGGC AGTGCTGCAG 900

CAGGAGGAGC TCCATGGAAA CCTGCTGGCT TATAAGGTGC AGTGGACCCT GGGAGGAGAA 960

GCACAGGAAC CTCTGTTGTT TAAGGAGAAC CTGGCTCACC TCTCAGGAGG AGGACGCTTT 1020

TTTAATTCCT CCTTCCAAGT GTCTGCGTGT ACCAGCGTAG GTTGTGGACC CTGGAGCACC 1080

CCGGTGATGG TTCTGCCCAC CTCAGGTAAG CAGGCTTTTG TCCAGCTCCA GGGCCAGCGG 1140

AGCCACATGT GGGTGGGCCT GCTATTCGGG GTGCTTGTGG CCACTGTAGT GGGCCTGCTG 1200

CTGTCTGTCC TTGCTCGCCA CCGAGGAAAA GACACTCCGT TTGGAAACAG GAAAAGGTCG 1260

GCCTTTAAAG CTCCTGGCCC AGAGAGTTTG GTTTCTTTCA CAGCAGCTCG ATCCTTCAAC 1320

AGAACCTGTT CTGAGCCGCA GGACTCCACC TTGGACAGTC TTGGAATCAA CAACGACCTG 1380

AAGAATAAAC TCCAGGACGT CCTGATTCCA GAGCGGCTGC TCACACTGGG ACACATGCTG 1440

GGGAAAGGGG AGTTTGGATC AGTGCGCGAG GCCTTTCTGA AGCTGGACGA CTCGTCTGTC 1500

CAGAAGGTGG CAGTTAAAGT GCTGAAATCT GACATTACAT CATCGGGAGA CATTGAACAA 1560

TGTCTTAAAG AAGCTGCCTA CATGAAGGAC TTTGACCATC CAAATGTCAT CAAGCTGACG 1620

GGAGTGAGTC TGCAGCGGCG CCCGGGCCAG CGGTTGCCGG TCCCGATGGT GGTCCTCCCA 1680

TTCATGAAGC ACGGAGATCT GCACACGTTT CTGCTTCTGT CACGACTGGG AGAACAGCCC 1740

TTTGACCTCA ACCTGCAGAC ACTCCTGCAC TTCATGTTGG ACGTTGCTCG TGGGATGGCG 1800

TACCTGAGCA GCCGCAGCAT CATCCACAGA GACCTCGCTG CTAGAAACTG CATGTTGAAT 1860

GAGAACATGA GTGTGTGTGT TGCAGACTTT GGCCTCTCCA AGAAGATCTA CAGTGGAGAT 1920

TATTACAGAC AGGGTTCAGT GTCCAAACTG CCTGTGAAGT GGATCGCTCT GGAGAGTTTG 1980

GCTGACAACG TGTACACCAC GCAGAGTGAT GTGTGGGCAT TTGGTGTGAC GATGTGGGAG 2040

ATCATAACCC GAGGTCAAAC TCCATACCCG GGCGTGGAGA ACTCTGAGAT CTACGAGTTC 2100

CTGATCAAAG GAGAACGTCT GAAGAAGCCT GCAGAGTGTC GAGATGACAT ATATGAACTC 2160

ATGCACAGCT GTTGGAGTCC AGTCCCCAAA TGTCGTCCCA GTTTTCAGCA GCTCGTGCTC 2220

CAGCTGGAAG CGCTGGCCCA CAGCCTGAGC CCCACCCCTC CGCTGAGGGA ACCGCTGCAT 2280

TACGTTAACC TGGAAGACAA CGAGACCGAG ATGGAGTCGG GGCCCAGAGT GCCCCCCTCA 2340

GAGGAGGAGG CCAGGCTTGG GGCCGGGACC CTGAGCTGCG CCGCACATGC TATTGGAGGA 2400

GACTACCGGT ACATCATTGG CCCCTGTGGA GTTCCTGGGG AGGAGGAGCA GCAGAATGGA 2460

AGAGCAGGGC TGATGAGGGA GGAGTCTGGA AATGGACTCC AGGAAGACGT CAAGGATGAG 2520

GATGATGATG TCATCATC 2538

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lg++lg+gefgsv+e+ lk +d+s++kvavk+lk di+++ +ie+ l+eaa mk+fdh

Q: 474   LTLGHMLGKGEFGSVREAFLKLDDSSVQKVAVKVLKSDITSSGDIEQCLKEAAYMKDFDH  533

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnvi+l gvsl+ +  +rlp p+v+lpfmk+gdlh+fll srlge+p+ l+lqtl++fm+

Q: 534   PNVIKLTGVSLQRRPGQRLPVPMVVLPFMKHGDLHTFLLLSRLGEQPFDLNLQTLLHFML  593

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         d+a gm ylssr +ihrdlaarncml+e+m+vcvadfglskkiysgdyyrqg ++klpvk

Q: 594   DVARGMAYLSSRSIIHRDLAARNCMLNENMSVCVADFGLSKKIYSGDYYRQGSVSKLPVK  653

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wia+eslad+vyt++sdvwafgvtmwei+trgqtpy+gven+eiy++l++g+rlk+p++c

Q: 654   WIALESLADNVYTTQSDVWAFGVTMWEIITRGQTPYPGVENSEIYEFLIKGERLKKPAEC  713

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvl  265

          d++y+lm++cw+  pk rpsf +l

Q: 714   RDDIYELMHSCWSPVPKCRPSFQQL  738

         **********************887

Domain Sequence
(FASTA)

LTLGHMLGKG EFGSVREAFL KLDDSSVQKV AVKVLKSDIT SSGDIEQCLK EAAYMKDFDH 60

PNVIKLTGVS LQRRPGQRLP VPMVVLPFMK HGDLHTFLLL SRLGEQPFDL NLQTLLHFML 120

DVARGMAYLS SRSIIHRDLA ARNCMLNENM SVCVADFGLS KKIYSGDYYR QGSVSKLPVK 180

WIALESLADN VYTTQSDVWA FGVTMWEIIT RGQTPYPGVE NSEIYEFLIK GERLKKPAEC 240

RDDIYELMHS CWSPVPKCRP SFQQL 265

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013