EKS-TAR-00395
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00395
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk515.37.6E-155184453270
StatusUnreviewed
Ensembl ProteinENSTRUP00000025271
UniProt AccessionH2TKR1;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameALK
Gene Synonyms/Alias ALK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000010044ENSTRUP00000025268ENSTRUT00000025371
ENSTRUG00000010044ENSTRUP00000025269ENSTRUT00000025372
ENSTRUG00000010044ENSTRUP00000025266ENSTRUT00000025369
ENSTRUG00000010044ENSTRUP00000025267ENSTRUT00000025370
ENSTRUG00000010044ENSTRUP00000025270ENSTRUT00000025373
ENSTRUG00000010044ENSTRUP00000025271ENSTRUT00000025374
ENSTRUG00000010044ENSTRUP00000025272ENSTRUT00000025375
OrganismTakifugu rubripes
Functional Description
Protein Length481
Protein Sequence
(FASTA)
MDYELGQQGR NGKSYAAGGN TSVENNPKHD GDDGTSFLSP DVVPFLSVPL KGMEGDGEVI 60
IGPVQNCSHC ESGECYDVKD SIVCYCDEDL ILAPDRVSCI NATVTACSRV PPTSALIAAL 120
LLAVSGVMIR IHSKGLSHLE LQSPDCKLSK LRASTIMTDY NPNYCFAGKT ASVNDLKEVP 180
RRNISLTRGL GHGAFGEVYE GLAVGIPGEP SPLQVAVKTL PEVCSEQDEL DFLMEALIIS 240
KFSHQNIVRC VGVSLQAMPR FILLELMTGG DLKTFMRETR PRPEHPSSLT MVDLLNIARD 300
IAKGCQYLEE NQFIHRDIAA RNCLLTCKGA GRVAKIGDFG MARDIYRASY YRKGGRAMLP 360
VKWMPPEAFM EGIFTSKTDT WSFGVLLWEI FSLGYMPYPS RSNQEVLEFV TNGGRMDPPK 420
NCPGPVYRIM TQSWQHQPED RPNFSTILER IDYCLQDPDV VTMPLPVQYG PIPEEEEAAA 480
M 481
Nucleotide Sequence
(FASTA)
ATGGACTATG AATTAGGCCA ACAAGGACGC AATGGGAAAT CGTACGCTGC AGGTGGCAAC 60
ACCTCCGTAG AAAACAACCC CAAGCACGAC GGCGATGACG GCACATCCTT CCTCAGCCCA 120
GACGTAGTGC CCTTTCTGTC CGTTCCACTG AAAGGCATGG AGGGGGATGG CGAGGTGATC 180
ATAGGGCCTG TGCAGAACTG CAGCCACTGT GAGAGTGGGG AATGCTATGA TGTCAAGGAC 240
AGCATCGTCT GCTACTGTGA CGAAGACCTG ATCCTGGCGC CGGACAGAGT CTCCTGCATC 300
AACGCCACAG TAACTGCATG TTCTCGCGTG CCACCGACTT CGGCCCTCAT CGCCGCGCTG 360
TTGCTGGCTG TGTCCGGAGT CATGATCAGA ATCCACTCTA AAGGGTTGAG TCATCTGGAG 420
CTTCAGAGCC CGGACTGCAA GCTCAGTAAG CTGCGGGCCT CCACCATCAT GACCGACTAC 480
AACCCCAACT ATTGCTTCGC TGGCAAGACG GCATCAGTAA ACGACCTGAA AGAAGTCCCC 540
CGCCGGAACA TCTCCCTCAC CAGGGGTCTG GGCCACGGTG CTTTCGGGGA AGTCTATGAA 600
GGATTGGCAG TGGGAATACC AGGGGAACCC AGCCCGCTGC AAGTGGCGGT CAAGACGCTT 660
CCTGAGGTTT GCTCTGAGCA GGATGAGCTG GACTTCCTCA TGGAGGCTTT AATCATCAGT 720
AAATTTAGTC ACCAGAACAT TGTGAGATGC GTCGGAGTCA GCCTGCAGGC TATGCCCAGG 780
TTTATCCTGC TGGAACTGAT GACCGGAGGA GACCTCAAAA CCTTCATGAG GGAGACCAGA 840
CCGCGCCCGG AGCACCCTTC CAGCCTGACG ATGGTGGACC TTCTCAACAT AGCTCGGGAC 900
ATCGCAAAGG GTTGCCAGTA CCTGGAAGAG AACCAGTTTA TACACAGGGA CATTGCAGCT 960
CGGAACTGCT TGTTGACTTG CAAAGGAGCG GGACGCGTGG CCAAAATCGG AGACTTCGGC 1020
ATGGCTCGAG ACATTTACAG GGCGAGCTAT TACAGGAAGG GTGGCCGAGC CATGCTGCCG 1080
GTCAAGTGGA TGCCGCCTGA GGCCTTCATG GAGGGAATCT TTACATCCAA AACAGATACG 1140
TGGTCCTTTG GGGTTTTGCT GTGGGAGATC TTCTCTCTGG GATACATGCC GTATCCAAGT 1200
CGCAGTAACC AGGAAGTGTT AGAGTTTGTT ACCAATGGCG GCAGAATGGA CCCTCCTAAG 1260
AACTGCCCAG GGCCGGTGTA TCGGATAATG ACACAGAGTT GGCAGCATCA GCCTGAAGAC 1320
AGGCCTAACT TTTCAACCAT CCTGGAGAGA ATCGACTACT GCTTACAGGA CCCAGACGTG 1380
GTGACGATGC CCCTGCCTGT GCAGTATGGA CCTATCCCTG AAGAGGAGGA GGCTGCAGCC 1440
ATG 1443
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         i l+r+lG+GafGevyegl  g+pg++s+l+vavktlpe++seqdeldfl+ealiiskf+
Q: 184   ISLTRGLGHGAFGEVYEGLAVGIPGEPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFS  243
         6789********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+nivr++Gvsl+++pr+illel++GGdlk+f+re+rp+pe++ssl+m dll++a+d+ak
Q: 244   HQNIVRCVGVSLQAMPRFILLELMTGGDLKTFMRETRPRPEHPSSLTMVDLLNIARDIAK  303
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gc+yleen+fihrdiaarn+ll++kG++rvaki+dfGmardiyra+yyrkggra+lpvkw
Q: 304   GCQYLEENQFIHRDIAARNCLLTCKGAGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKW  363
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp++snqevle+v++Ggr+d+pk++p
Q: 364   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCP  423
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+ w+h+pedrp+f +iler+++
Q: 424   GPVYRIMTQSWQHQPEDRPNFSTILERIDY  453
         ***************************986
Domain Sequence
(FASTA)
ISLTRGLGHG AFGEVYEGLA VGIPGEPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFS 60
HQNIVRCVGV SLQAMPRFIL LELMTGGDLK TFMRETRPRP EHPSSLTMVD LLNIARDIAK 120
GCQYLEENQF IHRDIAARNC LLTCKGAGRV AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180
MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSRSN QEVLEFVTNG GRMDPPKNCP 240
GPVYRIMTQS WQHQPEDRPN FSTILERIDY 270
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00050
EKS-CAE-00256
EKS-GAA-00374
EKS-ORN-00392
EKS-TEN-00398
EKS-XIM-00390
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0048666; P:neuron development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR008985; ConA-like_lec_gl_sf.
IPR011009; Kinase-like_dom.
IPR002172; LDrepeatLR_classA_rpt.
IPR000998; MAM_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00629; MAM; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00192; LDLa; 1.
SM00219; TyrKc; 1.
Prosites
PS50060; MAM_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013