EKS-TAR-00393
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00393
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR412.11.9E-123675931257
StatusUnreviewed
Ensembl ProteinENSTRUP00000025982
UniProt AccessionH2TMR9;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3 (2 of 2)
Gene Synonyms/Alias ERBB3 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000010319ENSTRUP00000025978ENSTRUT00000026083
ENSTRUG00000010319ENSTRUP00000025980ENSTRUT00000026085
ENSTRUG00000010319ENSTRUP00000025979ENSTRUT00000026084
ENSTRUG00000010319ENSTRUP00000025975ENSTRUT00000026080
ENSTRUG00000010319ENSTRUP00000025981ENSTRUT00000026086
ENSTRUG00000010319ENSTRUP00000025976ENSTRUT00000026081
ENSTRUG00000010319ENSTRUP00000025982ENSTRUT00000026087
ENSTRUG00000010319ENSTRUP00000025977ENSTRUT00000026082
OrganismTakifugu rubripes
Functional Description
Protein Length944
Protein Sequence
(FASTA)
VCPGTQNGLS STGSQENQYN LNKDRYKGCE IIMGNLEITQ IESNWDFSFL KTIREVTGYV 60
LIAMNHFQEI PLGQLRVIRG NSLYERRFAL SVFLNYPKDG PSGLNQLGLM NLTEILDGGV 120
QIINNKYLRY GPWVYWRDII RNNDAPIEIQ FNGERGVCSV CHKSCGNYCW GPGKDQCQIL 180
TKTVCAPQCN DRCFGTSPRD CCHIECAAGC KGPLDTDCFA CRLFNDSGAC VPQCPQTLIY 240
NKQTFQMETN PNAKYQYGSI CVSQCPTHFV VDGSSCVSVC PPDKMEVERG SQRQCELCSG 300
LCPKVCEGTG AEQRQTVDSS NIDSFINCTK IQGSLHFLVT GILGDDFKNV PPLDAKKLEV 360
FRTVREITDI LNIQSWPKEL NDLSVFSSLT TIQGRSLFKR FSLMVMRIPT LTSLGLRSLR 420
EISDGSVYIS QNAHLCYHHT VNWTQLFRGS RVRANSLNSN RPMAECVADG RVCDPLCSDS 480
GCWGPGPDQC LSCRNYSRHG TCVAGCHFNS GIPREFAGLN GVCVACHPEC KPQTGKASCT 540
GPGADECMAC TKFRDGPYCM SSCPAGVNDG EKGLIFKFPN REGHCEPCHQ NCTQGCSGPG 600
LNDCLEAARL TISSVMLISV SAVVRLQGML YHRGLAIRRK RAMRRYLESG ESFEPLGPGE 660
KGTKVHARIL KPSDLRKIKP LGSGVFGTVS KGFWIPEGET VKIPVAIKTI QDSSGRQTFT 720
EITDHLLSMG SLDHPYIVRL LGICPGTCLQ LVTQLSSHGS LLEHIRQHKT SLDPQRLLNW 780
CVQIAKGMYY LEEHRVVHKN LAARNILLKN DYQVQISDYG VADLLYPDDK KYVYSETKTP 840
IKWMALESIL FRRYTHQSDV WSYGVTVWEM MSFGAEPYAS VQPQEVPSVL EKGERLSQPA 900
ICTIDVYMVM VKCWMIDENI RPTFKELASD FTRMARDPPR YLVI 944
Nucleotide Sequence
(FASTA)
GTGTGTCCCG GGACGCAGAA CGGACTGAGC TCCACAGGCT CCCAGGAGAA TCAGTACAAT 60
CTGAATAAAG ACCGTTACAA AGGCTGCGAG ATCATCATGG GCAACCTGGA GATCACTCAG 120
ATTGAGAGCA ACTGGGACTT CTCCTTCCTC AAGACCATTC GTGAGGTGAC CGGATATGTC 180
CTCATCGCAA TGAATCACTT TCAGGAGATT CCTCTGGGAC AATTACGAGT CATCAGAGGA 240
AACAGCCTTT ACGAGAGGCG ATTTGCCCTC TCTGTCTTCT TGAACTACCC CAAGGACGGC 300
CCCAGTGGCC TGAACCAGCT CGGTCTCATG AATCTAACGG AAATTCTCGA TGGAGGAGTG 360
CAAATAATCA ACAACAAGTA CCTGAGATAC GGCCCCTGGG TCTACTGGCG GGATATCATC 420
AGGAACAACG ATGCTCCCAT TGAAATCCAG TTTAATGGAG AGAGGGGTGT GTGTAGCGTG 480
TGTCACAAGT CCTGTGGAAA CTACTGCTGG GGCCCGGGCA AGGACCAGTG TCAGATCTTG 540
ACAAAGACGG TGTGCGCTCC GCAGTGCAAC GACCGCTGTT TCGGGACGAG CCCGAGGGAC 600
TGCTGTCACA TAGAATGTGC GGCAGGATGT AAAGGCCCTC TGGATACTGA CTGTTTTGCG 660
TGTCGACTTT TCAATGACTC TGGCGCCTGC GTTCCTCAGT GTCCTCAGAC TCTGATCTAT 720
AACAAGCAGA CGTTTCAAAT GGAAACTAAC CCAAATGCTA AATACCAGTA CGGATCCATT 780
TGTGTTTCCC AGTGCCCCAC TCATTTTGTG GTGGATGGAA GTTCCTGTGT GAGTGTTTGT 840
CCTCCGGACA AGATGGAGGT GGAGCGAGGA AGCCAGAGGC AGTGTGAACT TTGCAGTGGA 900
CTCTGCCCAA AAGTGTGTGA AGGCACTGGT GCAGAGCAAA GACAGACCGT GGACTCCAGC 960
AACATTGACA GTTTCATCAA CTGCACCAAG ATCCAGGGCA GCCTCCACTT CCTGGTCACG 1020
GGGATTCTGG GAGATGATTT TAAAAACGTT CCACCTCTGG ATGCCAAAAA GCTAGAGGTA 1080
TTCCGCACAG TCAGGGAGAT AACAGATATA TTAAACATCC AGTCGTGGCC CAAAGAGCTG 1140
AATGATCTGT CTGTTTTTTC AAGTCTCACC ACCATTCAAG GAAGGTCTCT GTTCAAGCGA 1200
TTTTCCCTCA TGGTGATGCG CATCCCCACT CTGACCTCAC TGGGTCTGCG CTCCCTGCGG 1260
GAGATCAGCG ATGGCAGCGT GTACATCAGT CAGAACGCCC ACCTGTGCTA CCACCACACG 1320
GTGAACTGGA CACAGCTGTT CAGGGGCAGC AGAGTCCGGG CCAACAGCCT CAACAGCAAC 1380
AGGCCAATGG CAGAATGTGT TGCAGACGGC CGCGTGTGTG ACCCGCTGTG TTCGGACTCT 1440
GGCTGTTGGG GCCCTGGGCC TGATCAGTGT CTCTCCTGTA GGAACTACAG TCGCCATGGC 1500
ACGTGTGTTG CCGGTTGTCA TTTTAACTCT GGAATTCCAA GGGAATTTGC AGGACTTAAT 1560
GGCGTATGTG TCGCCTGCCA TCCAGAATGT AAGCCTCAGA CTGGGAAAGC CAGCTGTACT 1620
GGACCGGGTG CAGATGAGTG TATGGCATGC ACCAAGTTTC GAGATGGCCC CTACTGCATG 1680
TCGTCTTGTC CGGCTGGTGT CAATGATGGC GAGAAGGGGC TGATCTTTAA ATTCCCCAAC 1740
AGGGAGGGTC ACTGTGAGCC ATGCCACCAA AACTGCACGC AGGGATGTTC AGGCCCTGGG 1800
TTAAATGACT GTTTGGAGGC AGCGAGGTTG ACCATTAGTA GTGTGATGCT AATATCTGTC 1860
TCTGCAGTGG TCAGATTACA GGGCATGCTG TACCATCGTG GTCTAGCCAT TCGCCGCAAG 1920
AGAGCCATGA GGAGGTATCT GGAGAGTGGA GAGAGCTTTG AGCCACTGGG GCCTGGAGAG 1980
AAAGGAACCA AAGTTCACGC CCGCATATTG AAGCCCTCAG ACTTGAGGAA AATCAAACCC 2040
CTGGGCTCAG GAGTTTTTGG TACAGTCAGC AAGGGGTTTT GGATACCAGA GGGAGAAACC 2100
GTGAAGATCC CTGTGGCCAT TAAGACTATC CAGGACAGCT CAGGTCGACA GACCTTCACT 2160
GAGATCACTG ATCATTTGCT GTCCATGGGC AGTCTGGACC ACCCATACAT TGTTAGACTG 2220
CTGGGGATAT GTCCAGGTAC CTGTCTGCAA CTGGTGACGC AGCTCAGTTC ACATGGTTCC 2280
TTATTGGAAC ACATCAGACA GCACAAGACC AGCCTGGACC CCCAGCGTCT GCTCAACTGG 2340
TGCGTCCAGA TCGCCAAAGG CATGTACTAC CTGGAGGAGC ACCGCGTGGT CCACAAGAAC 2400
CTGGCTGCTC GCAACATCCT GCTGAAGAAT GACTACCAGG TCCAGATCTC CGACTACGGC 2460
GTGGCGGACC TCCTTTATCC AGATGACAAG AAATACGTCT ACAGTGAAAC GAAGACACCC 2520
ATAAAATGGA TGGCGCTTGA AAGCATTTTA TTTCGAAGAT ACACTCATCA AAGTGATGTT 2580
TGGAGTTATG GAGTGACGGT GTGGGAGATG ATGTCATTTG GGGCAGAGCC ATATGCATCC 2640
GTGCAGCCTC AAGAGGTACC GAGTGTGCTG GAGAAGGGCG AGAGACTCTC ACAACCTGCC 2700
ATCTGTACCA TAGATGTATA CATGGTTATG GTTAAATGCT GGATGATCGA TGAAAACATC 2760
AGGCCAACTT TTAAAGAGCT AGCCAGTGAC TTTACTCGTA TGGCAAGAGA CCCGCCGAGA 2820
TATCTGGTGA TC 2832
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+k lGsG+fGtv kG wipege+vkipvaik +++++g+++++e++d+ l ++sldh
Q: 675   LRKIKPLGSGVFGTVSKGFWIPEGETVKIPVAIKTIQDSSGRQTFTEITDHLLSMGSLDH  734
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         +++vrllg+c  + lqlvtql  +G+ll+++r+hk +l +q llnwcvqiakGm+ylee+
Q: 735   PYIVRLLGICPGTCLQLVTQLSSHGSLLEHIRQHKTSLDPQRLLNWCVQIAKGMYYLEEH  794
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         r+vh++laarn+l+k+  +v+i+d+G+a+ll  d+k++ ++++k+pikw+alesil+r+y
Q: 795   RVVHKNLAARNILLKNDYQVQISDYGVADLLYPDDKKYVYSETKTPIKWMALESILFRRY  854
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwe+++fGa+py++++ +e+p++lekGerl+qp ictidvymv+vkcw
Q: 855   THQSDVWSYGVTVWEMMSFGAEPYASVQPQEVPSVLEKGERLSQPAICTIDVYMVMVKCW  914
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela++f
Q: 915   MIDENIRPTFKELASDF  931
         **************998
Domain Sequence
(FASTA)
LRKIKPLGSG VFGTVSKGFW IPEGETVKIP VAIKTIQDSS GRQTFTEITD HLLSMGSLDH 60
PYIVRLLGIC PGTCLQLVTQ LSSHGSLLEH IRQHKTSLDP QRLLNWCVQI AKGMYYLEEH 120
RVVHKNLAAR NILLKNDYQV QISDYGVADL LYPDDKKYVY SETKTPIKWM ALESILFRRY 180
THQSDVWSYG VTVWEMMSFG AEPYASVQPQ EVPSVLEKGE RLSQPAICTI DVYMVMVKCW 240
MIDENIRPTF KELASDF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00281
EKS-ANC-00291
EKS-BOT-00299
EKS-CAJ-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-EQC-00291
EKS-FEC-00285
EKS-GAM-00190
EKS-GAA-00372
EKS-ICT-00282
EKS-LAC-00311
EKS-LOA-00310
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-ORN-00390
EKS-ORC-00282
EKS-ORL-00361
EKS-OTG-00305
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-SAH-00281
EKS-TEN-00389
EKS-TUT-00065
EKS-XET-00373
EKS-XIM-00380
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013