EPS-TAR-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TAR-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	276.5	6.3E-82	23	290	268

Status

Unreviewed

Ensembl Protein

ENSTRUP00000026488

UniProt Accession

H2TP82;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000010499	ENSTRUP00000026488	ENSTRUT00000026595

Organism

Takifugu rubripes

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MGAFLDKPKM EKYNSCGEGN NLRYGLSSMQ GWRVEMEDAH TAVIGLPHAL DHWSFFAVYD 60

GHAGSQVAKY CCEHLLEHIT SNSDFQRALQ EDPSVDNVKN GIRTGFLQID EHMRTISEKK 120

HGVDRSGSTA VGVMISPSHI YFINCGDSRG LLSRGGAVHF FTQDHKPNNP LEKERIQKAG 180

GSVMIQRVNG SLAVSRALGD FDYKCVHGKG PTEQLVSPEP EVYAIERCEG EDEFIILACD 240

GIWDVMGNEQ LCDFVRSRLE VTDDLERVSN EIVDTCLYKG SRDNMSVVLI CFPGAPKVSP 300

DAVKKEADLD KYLEGKVEEI IKKQGDEGVP DLVHVMRTLA SESIPNLPPG GELASKRTVI 360

EAMYNKLNPY RSDDTDSAST DDMW 384

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTCTGGACAA ACCAAAGATG GAAAAGTACA ATTCCTGTGG TGAAGGTAAT 60

AACCTGAGGT ATGGGCTCAG TAGCATGCAA GGCTGGCGAG TGGAGATGGA AGACGCACAC 120

ACGGCCGTGA TCGGCCTGCC TCACGCCCTC GACCACTGGT CTTTCTTTGC TGTTTATGAC 180

GGCCATGCTG GCTCTCAGGT GGCCAAATAT TGCTGCGAGC ACTTGCTGGA GCACATCACC 240

AGCAATTCAG ACTTCCAGCG AGCGCTGCAG GAGGACCCGT CGGTGGATAA TGTGAAAAAC 300

GGGATCCGCA CGGGGTTCCT ACAGATCGAC GAGCACATGC GAACCATCTC GGAGAAGAAG 360

CACGGCGTGG ACCGGAGCGG CTCCACGGCG GTGGGCGTGA TGATTTCCCC GAGTCATATC 420

TACTTTATTA ACTGCGGCGA CTCCCGGGGA CTCCTCAGTC GGGGCGGAGC CGTGCACTTC 480

TTTACACAAG ATCACAAACC CAACAACCCT CTGGAGAAGG AAAGGATCCA GAAAGCCGGC 540

GGCTCGGTCA TGATTCAGCG AGTTAACGGC TCCCTGGCTG TGTCTCGGGC TTTGGGGGAC 600

TTTGACTACA AATGTGTGCA CGGAAAAGGC CCGACGGAGC AGCTGGTGTC TCCCGAGCCT 660

GAAGTTTATG CAATCGAGAG ATGTGAGGGA GAAGACGAGT TCATCATATT GGCATGTGAC 720

GGCATCTGGG ACGTCATGGG CAACGAGCAG CTGTGTGACT TCGTCAGGTC CAGACTAGAG 780

GTGACGGACG ACCTCGAGAG AGTCAGCAAC GAGATCGTCG ACACCTGTTT ATACAAGGGA 840

AGCCGAGACA ATATGAGCGT GGTGTTGATC TGCTTCCCCG GAGCCCCGAA GGTCTCCCCA 900

GACGCCGTGA AGAAGGAGGC AGATCTGGAT AAATATCTGG AGGGAAAAGT AGAAGAGATT 960

ATTAAGAAGC AGGGGGACGA AGGTGTTCCT GATCTGGTCC ACGTTATGAG GACGTTAGCA 1020

TCCGAGTCCA TCCCCAACCT TCCTCCTGGA GGCGAGCTGG CAAGCAAACG AACTGTTATC 1080

GAAGCGATGT ACAACAAACT GAACCCCTAC CGGAGCGATG ACACAGACTC TGCATCCACA 1140

GACGACATGT GGTAA 1155

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   ++  p + d+++ff+vyDGh+gs+vak+c e+l e++

Q: 23    RYGLSSMQGWRVEMEDAHTA---VIGLPHALDHWSFFAVYDGHAGSQVAKYCCEHLLEHI  79

         69****************97...6677777888***************************

S: 62    aeele.....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsk  116

         + + +     +++++ ++vk+ ++++Fl++de+++ ++ek++  d+sGstav ++i++s+

Q: 80    TSNSDfqralQEDPSVDNVKNGIRTGFLQIDEHMRTISEKKHGVDRSGSTAVGVMISPSH  139

         ***9999*999999**********************************************

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsR  176

         +y++n+GdSr +L+r+g ++  ++dHkp+++ E+eRi++aggsv+ +   Rv+G+LavsR

Q: 140   IYFINCGDSRGLLSRGGAVHFFTQDHKPNNPLEKERIQKAGGSVMIQ---RVNGSLAVSR  196

         ***********************************************...**********

S: 177   alGdlylk.........pyvtpePevtshrl.tsedefliLasDGlwdvvsneeavslvr  226

         alGd+++k         ++v+pePev+ +++ + edef+iLa+DG+wdv+ ne+++++vr

Q: 197   ALGDFDYKcvhgkgpteQLVSPEPEVYAIERcEGEDEFIILACDGIWDVMGNEQLCDFVR  256

         *******************************677888***********************

S: 227   dvlekkeaeqeaakkLvklalargskdnvsaivv  260

         ++le +++++ +++++v+++l +gs+dn+s++++

Q: 257   SRLEVTDDLERVSNEIVDTCLYKGSRDNMSVVLI  290

         *****************************99875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPHALDH WSFFAVYDGH AGSQVAKYCC EHLLEHITSN 60

SDFQRALQED PSVDNVKNGI RTGFLQIDEH MRTISEKKHG VDRSGSTAVG VMISPSHIYF 120

INCGDSRGLL SRGGAVHFFT QDHKPNNPLE KERIQKAGGS VMIQRVNGSL AVSRALGDFD 180

YKCVHGKGPT EQLVSPEPEV YAIERCEGED EFIILACDGI WDVMGNEQLC DFVRSRLEVT 240

DDLERVSNEI VDTCLYKGSR DNMSVVLI 268

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013