EKS-TAR-00212

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00212

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	508.0	9.8E-153	358	616	259

Status

Unreviewed

Ensembl Protein

ENSTRUP00000026640

UniProt Accession

H2TPN4;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000010554	ENSTRUP00000026640	ENSTRUT00000026747

Organism

Takifugu rubripes

Functional Description

Protein Length

668

Protein Sequence
(FASTA)

MSDLDEDFAK ILLLKEERIR DLERRLADRE DEIQELKRKL HKCQSVLPSA QLIGPRTRRA 60

QGISAEPQTH QDLSRQTFRK YAKSDWSKDL IKEAILDNDF MKNLELSQIQ EIVDCMYPVE 120

YGKDSCIIKE GDVGSLVYVM EDGKVEVTKE SLKLCTMGPG KVFGELAILY NCTRTATVKT 180

LTNVKLWAID RQCFQTIMMR TGLIKQTEYM EFLKSVPTFQ GLQEDILSKL ADVLEETHYE 240

DGEYIIRQGA RGDTFFIISK GKVNVTREDS PSGEPVYLRS LGKGDWFGEK ALQGEDIRTA 300

NVIAAEAVTC LVIDRDSFKH LIGGLEEVSS KGHEDADAKA KYEAENAFFF NLNLADFNII 360

DTLGVGGFGR VELVQLKSDE NKTFAMKILK KRHIVDTRQQ EHIRSEKLIM QEAHSDFIVR 420

LYRTFKDSKY LYMLMEACLG GELWTILRDR GSFEDSTTRF YTACVVEAFA YLHSKGIIYR 480

DLKPENLILD HRGYAKLVDF GFAKKIGFGK KTWTFCGTPE YVAPEIILNK GHDISADYWS 540

LGILMFELLT GSPPFSGPDP MKTYNIILRG IDMIEFPKKI TKNAANLIKK LCRDNPSERL 600

GNLKNGVKDI QKHKWFEGFN WEGLKKGTLT PPIIPTVTSA VDISNFDNFP EDKEDPPPDD 660

NSGWDVDF 668

Nucleotide Sequence
(FASTA)

ATGAGCGACC TGGACGAAGA CTTCGCCAAG ATCCTGCTGC TTAAAGAGGA GAGGATACGA 60

GACTTGGAGA GGCGTCTGGC GGACAGGGAG GACGAGATCC AGGAACTGAA GAGAAAATTG 120

CACAAATGTC AGTCTGTTCT GCCCAGCGCG CAACTTATCG GACCGAGGAC CCGCAGGGCG 180

CAGGGCATCT CCGCGGAGCC GCAGACGCAC CAGGACCTGT CGCGGCAAAC CTTTCGGAAA 240

TATGCCAAGT CCGACTGGTC CAAGGATCTG ATCAAGGAGG CCATCTTGGA CAACGACTTC 300

ATGAAGAACC TGGAGCTGTC CCAGATCCAA GAGATTGTGG ACTGCATGTA TCCTGTGGAG 360

TATGGAAAAG ACAGCTGCAT CATCAAGGAA GGCGACGTGG GCTCGCTGGT CTACGTCATG 420

GAAGACGGGA AGGTGGAGGT GACGAAGGAG AGCCTGAAAC TTTGCACCAT GGGGCCCGGG 480

AAGGTGTTCG GGGAGCTGGC TATTCTCTAC AACTGCACCA GGACCGCCAC TGTCAAGACT 540

CTTACAAATG TGAAGCTGTG GGCCATCGAC CGGCAGTGTT TCCAGACCAT CATGATGAGG 600

ACCGGGCTCA TCAAGCAGAC CGAGTACATG GAGTTTTTGA AAAGCGTCCC CACGTTCCAA 660

GGCCTGCAGG AAGACATTCT GAGCAAGCTT GCAGATGTCC TTGAGGAGAC ACATTACGAA 720

GATGGAGAGT ACATCATTAG ACAGGGAGCC AGAGGAGACA CCTTCTTCAT CATCAGTAAA 780

GGAAAGGTTA ATGTGACGAG GGAAGACTCG CCCAGCGGAG AGCCCGTCTA CCTGCGGAGC 840

CTCGGGAAAG GAGACTGGTT CGGAGAGAAA GCTCTGCAAG GGGAGGACAT CAGGACGGCC 900

AACGTCATCG CGGCAGAGGC GGTCACCTGT CTGGTCATCG ACAGAGATTC TTTCAAGCAC 960

CTGATTGGAG GTTTAGAGGA AGTATCCAGC AAAGGCCACG AGGACGCTGA CGCCAAAGCC 1020

AAGTATGAAG CAGAGAACGC CTTTTTCTTC AACCTCAACC TGGCCGACTT CAACATCATC 1080

GACACTCTGG GGGTTGGAGG CTTTGGCCGC GTCGAGCTGG TTCAGCTCAA GAGCGACGAA 1140

AACAAAACCT TTGCCATGAA GATCCTGAAA AAGCGGCACA TAGTGGACAC GAGACAGCAG 1200

GAGCACATTC GTTCGGAGAA ACTCATCATG CAGGAGGCCC ACTCTGATTT CATCGTTAGG 1260

CTGTATCGAA CATTTAAGGA CAGCAAGTAC CTCTATATGC TGATGGAAGC TTGCTTAGGA 1320

GGAGAGCTCT GGACCATCCT CCGAGATCGG GGCTCCTTTG AGGACTCCAC GACCAGGTTT 1380

TACACAGCTT GTGTGGTGGA GGCCTTCGCC TACCTGCATT CCAAAGGAAT CATCTACAGA 1440

GACCTCAAAC CAGAGAACCT TATACTGGAC CACAGGGGCT ATGCTAAACT GGTCGACTTT 1500

GGCTTTGCGA AGAAGATCGG GTTTGGGAAG AAGACGTGGA CCTTCTGCGG GACGCCGGAG 1560

TATGTAGCAC CAGAGATCAT CTTGAACAAA GGCCACGACA TCTCAGCCGA CTACTGGTCC 1620

CTGGGAATCC TCATGTTTGA GCTCTTAACT GGCAGCCCTC CGTTCTCTGG CCCCGATCCG 1680

ATGAAAACCT ACAACATCAT CCTGAGAGGT ATTGACATGA TTGAATTCCC AAAGAAAATT 1740

ACCAAAAATG CTGCCAACCT TATCAAAAAG CTATGCAGGG ATAATCCTTC GGAAAGACTA 1800

GGAAACTTGA AAAATGGTGT CAAAGACATC CAAAAGCACA AATGGTTTGA GGGCTTTAAC 1860

TGGGAGGGAC TGAAGAAGGG GACGCTGACA CCTCCCATCA TCCCTACCGT CACATCAGCA 1920

GTCGACATAA GCAACTTTGA CAACTTCCCA GAGGACAAGG AAGACCCGCC CCCGGACGAC 1980

AACTCTGGCT GGGACGTGGA TTTTTGA 2007

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ksde+k+fa+kilkk+hivdt+qqeh++sek i++ea+sdf

Q: 358   NIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDF  417

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 418   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  477

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 478   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  537

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil++elltg+ppfsg+dp+ktyn+il+gid++e+p+kitk+a++likklcrdnp+

Q: 538   YWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPS  597

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 598   ERLGNLKNGVKDIQKHKWF  616

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SDENKTFAMK ILKKRHIVDT RQQEHIRSEK LIMQEAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMFE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKITKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013