EKS-TAR-00227

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00227

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	434.1	4.8E-130	360	614	255

Status

Unreviewed

Ensembl Protein

ENSTRUP00000026881

UniProt Accession

H2TQC3;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCD (2 of 2)

Gene Synonyms/Alias

PRKCD (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000010650	ENSTRUP00000026880	ENSTRUT00000026989
ENSTRUG00000010650	ENSTRUP00000026881	ENSTRUT00000026990

Organism

Takifugu rubripes

Functional Description

Protein Length

687

Protein Sequence
(FASTA)

MAPFLRIAFS SYELGVLPPL ADPPFCAIKL KEALTTERGK TLVQRKPTMY PAWKASFDAH 60

IYEGRVLEVL LMKTAEEPLA EVSVGVSVLA ERCKKANGRA EFWVDLHPSG KVMMVVQYFL 120

EGGDTGKKSK HSVKEEEAPT LNRRRGAIKQ AKIHFIKNHE FIATFFRQPT FCSVCREFVW 180

GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTVF QKERFKIDMP HRFKSHNYMS 240

PTFCDHCGSL LWGLVKQGLK CEDCAMNVHH KCQDKVANLC GINQKLLAEA LTQVSQKSST 300

RRSDPCLPNL PDIGIYDEVS KLAELDINGP TGTYGQIWQG TSPRPQSRIT HLTRLNVDSF 360

VFHKVLGKGS FGKVLLAELK GRGEYFAVKA LKKDVVLMDD DVECTMVEKR VLALAWENPF 420

LTHLYSTFQT KEHLFFVMEY LNGGDLMFHI QEKGRFDLHR ATFYSAEISC GLQFLHSKGI 480

IYRDLKLDNV MLDYEGHIKI ADFGMCKENV FGENRATTFC GTPDYIAPEI LLGQKYSFSV 540

DWWSFGVLLY EMLIGQSPFH GDDEDELFES IRMDTPHYPR WINKEAKDLI ERFFERDPTR 600

RLGIVGDIRL HPFFKMIDWP ALERREVEPP FKPKVKAPND CSNFDREFLC EKPCLSYSEK 660

NFIDSMDQSA FSGFSFINPK MEHLLDK 687

Nucleotide Sequence
(FASTA)

ATGGCTCCTT TCCTGAGGAT TGCCTTCAGT TCCTACGAGC TGGGTGTCTT GCCTCCACTG 60

GCTGATCCTC CCTTCTGTGC CATCAAACTA AAGGAGGCCT TAACGACTGA AAGAGGTAAA 120

ACCTTGGTCC AGAGGAAGCC CACCATGTAC CCTGCCTGGA AAGCCAGTTT TGATGCACAT 180

ATCTATGAGG GTCGTGTGCT GGAGGTGCTG CTGATGAAAA CAGCAGAGGA GCCGCTGGCG 240

GAGGTCTCGG TCGGGGTGTC TGTCCTTGCA GAGCGGTGTA AAAAAGCTAA CGGGCGCGCT 300

GAGTTCTGGG TGGATCTTCA TCCTTCTGGG AAGGTGATGA TGGTGGTGCA GTATTTCCTA 360

GAAGGAGGAG ACACGGGTAA AAAGAGCAAA CATTCTGTAA AGGAGGAAGA GGCCCCCACC 420

CTGAACCGTA GGCGAGGGGC CATCAAGCAG GCCAAGATCC ACTTCATAAA GAACCACGAG 480

TTCATCGCCA CCTTCTTCAG GCAGCCCACT TTCTGCTCCG TGTGCAGAGA ATTTGTCTGG 540

GGACTTAACA AGCAAGGCTA CAAATGCAGA CAATGCAATG CAGCCATCCA CAAGAAATGC 600

ATAGACAAAA TCATCGGCAG ATGCACCGGT ACTGCGGCCA ACAGTCGGGA TACTGTGTTC 660

CAGAAGGAGC GCTTCAAAAT CGACATGCCG CACCGCTTCA AGTCGCACAA CTACATGAGT 720

CCCACTTTCT GCGACCACTG TGGGAGCCTG CTGTGGGGTC TGGTCAAGCA GGGCCTCAAG 780

TGTGAAGATT GTGCAATGAA CGTCCATCAT AAGTGTCAAG ACAAAGTAGC CAATCTTTGT 840

GGGATCAACC AGAAACTTCT GGCTGAAGCA CTTACACAAG TCAGCCAGAA ATCCTCCACC 900

CGTCGTTCTG ACCCCTGCCT GCCCAACCTT CCTGATATCG GAATCTACGA TGAAGTTAGC 960

AAGCTTGCTG AGCTGGACAT CAATGGACCC ACAGGAACCT ATGGTCAAAT TTGGCAGGGG 1020

ACCAGCCCAC GACCGCAGTC TCGCATCACT CATCTGACCC GCCTCAATGT GGACAGCTTT 1080

GTCTTCCACA AGGTCTTGGG AAAAGGCAGC TTTGGCAAGG TTCTCCTAGC GGAGCTGAAG 1140

GGTCGCGGAG AGTACTTTGC GGTGAAGGCG CTTAAAAAAG ACGTGGTTCT GATGGACGAC 1200

GATGTGGAGT GCACTATGGT GGAAAAGAGA GTCCTGGCTC TAGCCTGGGA AAACCCTTTC 1260

CTCACGCACC TTTACTCAAC ATTCCAGACC AAGGAACATC TGTTCTTCGT TATGGAGTAT 1320

TTGAATGGAG GAGACCTGAT GTTTCACATA CAGGAGAAGG GCCGTTTTGA CCTCCATAGA 1380

GCCACGTTCT ACTCAGCTGA GATCAGCTGT GGGCTCCAGT TTTTACACTC CAAAGGGATC 1440

ATCTACAGAG ACTTAAAGTT AGACAATGTG ATGCTGGACT ACGAGGGACA CATAAAGATT 1500

GCAGATTTTG GCATGTGCAA GGAAAATGTG TTTGGAGAGA ATCGTGCTAC CACCTTCTGC 1560

GGCACTCCTG ACTACATTGC TCCAGAGATC CTGCTGGGAC AGAAATACTC CTTCTCTGTT 1620

GACTGGTGGT CATTCGGAGT GCTGCTGTAT GAAATGCTGA TTGGTCAGTC ACCGTTCCAC 1680

GGAGATGATG AGGATGAGTT GTTTGAGTCC ATCCGCATGG ATACTCCCCA TTACCCTCGC 1740

TGGATCAACA AGGAGGCCAA GGACCTGATT GAGCGGTTCT TTGAGAGGGA CCCCACTCGC 1800

AGACTAGGGA TTGTGGGTGA CATCCGTTTA CATCCCTTCT TTAAGATGAT TGACTGGCCA 1860

GCCTTGGAGA GGAGAGAGGT TGAACCCCCC TTCAAGCCCA AAGTGAAAGC ACCAAACGAC 1920

TGCAGCAACT TTGATCGTGA GTTCCTCTGT GAGAAGCCGT GTCTCTCCTA CAGTGAGAAG 1980

AACTTCATTG ACTCCATGGA TCAGTCAGCA TTCTCTGGGT TTTCCTTCAT CAACCCAAAG 2040

ATGGAGCATC TTTTAGACAA GTGA 2064

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f ++kvlGkGsfgkvllaelk++ e++a+k lkkdvvl+dddve+t+vekrvlala+++p

Q: 360   FVFHKVLGKGSFGKVLLAELKGRGEYFAVKALKKDVVLMDDDVECTMVEKRVLALAWENP  419

         889*********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++l+s+fqt+++lffv+ey+nGGdlmfhiq++++++ +ra+fy+aei+++l+flh+kg

Q: 420   FLTHLYSTFQTKEHLFFVMEYLNGGDLMFHIQEKGRFDLHRATFYSAEISCGLQFLHSKG  479

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld eGhik+adfG+cke+++ +++++tfcGtPdyiaPeil +++y++s

Q: 480   IIYRDLKLDNVMLDYEGHIKIADFGMCKENVFGENRATTFCGTPDYIAPEILLGQKYSFS  539

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+dedelfesi++++++yP++++kea+++++ ++++dp+

Q: 540   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRMDTPHYPRWINKEAKDLIERFFERDPT  599

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         +rlG+   g  di+ h+ff

Q: 600   RRLGI--VG--DIRLHPFF  614

         ****9..45..89999998

Domain Sequence
(FASTA)

FVFHKVLGKG SFGKVLLAEL KGRGEYFAVK ALKKDVVLMD DDVECTMVEK RVLALAWENP 60

FLTHLYSTFQ TKEHLFFVME YLNGGDLMFH IQEKGRFDLH RATFYSAEIS CGLQFLHSKG 120

IIYRDLKLDN VMLDYEGHIK IADFGMCKEN VFGENRATTF CGTPDYIAPE ILLGQKYSFS 180

VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRMDTPHYP RWINKEAKDL IERFFERDPT 240

RRLGIVGDIR LHPFF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013