EKS-TAR-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	385.2	3.2E-115	114	367	254

Status

Unreviewed

Ensembl Protein

ENSTRUP00000028066

UniProt Accession

H2TTQ8;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000011118	ENSTRUP00000028066	ENSTRUT00000028177

Organism

Takifugu rubripes

Functional Description

Protein Length

715

Protein Sequence
(FASTA)

MDQDTQWLYQ LLADVQLEKF YLRVRDGLNI TRLEHFAYVK ESDLEQIGIS KPAQRRLWEA 60

LKRHKVKSRS WIPKVLSGRS GDAVDQPSGG APSQGQEPVG RALPCLIQDG ELLLGEKLGS 120

GSFGVVRKGE WHTPTGRVLT VAVKTLRNSV SRQTDTLTDF LQEVTTMQAL DHPNIIRLYG 180

VVLTQPLKMV TELASLGSLY DTLRARQFEY PLVRLWLFAT QIASGMDYLE TRRLIHRDLA 240

ARNILLASRE MVKIGDFGLM RGLSQEVDHY VMSAHRRIPF AWCAPESLRV GSFSHSSDVW 300

MFGVTMWEMF TYCEEPWFGL TGRQILWRVE REGERLEKPP DCPQELYVVM RKCWACNPND 360

RPNFSQLGML VAEAKPKEVQ AMRDFSESRK LALAANDFVT LVEHSLEMSE WRGQNQKTLA 420

VGWFPASLTV PTPPAVVPVP AASFISTPLK GSLHHTGHGD VHPDRSWGTP ESLDDSGNLR 480

LPGPVKEKEG TNLQKMAGMS QSLESVLGGH RPRSQTVTTV RVDQQGRLLP PVMAAHSAVM 540

QKDPRRFSEA SIVPPPRPPP PNLKRPIKSQ RRPVALPVPG APWPPHMVMA AQPQLQQSTS 600

NLAKMTQMAR STPQLDDNTD GRERERSRER PPHLQNTRDS LVSQVMEGVH GVTIEEADMA 660

LQRNEWNPVR AQQQLKLEQL YSLSLCSRDD CLRILSKYQW NLQLASRYLI RWSRE 715

Nucleotide Sequence
(FASTA)

ATGGACCAGG ACACTCAGTG GCTCTACCAG CTCCTCGCCG ACGTCCAGTT GGAGAAGTTC 60

TACCTCCGCG TCAGAGATGG CCTCAACATC ACCCGCTTGG AGCATTTCGC CTACGTCAAG 120

GAGTCCGACC TGGAGCAGAT CGGGATCAGC AAGCCCGCTC AAAGGAGATT ATGGGAGGCT 180

CTGAAACGGC ACAAAGTCAA ATCACGCTCG TGGATTCCCA AGGTGTTGAG CGGTCGAAGC 240

GGCGACGCGG TGGACCAGCC GAGCGGCGGC GCCCCCTCCC AGGGTCAGGA GCCCGTGGGT 300

CGGGCTCTGC CGTGTCTGAT ACAGGACGGC GAGCTGCTGC TGGGCGAGAA GCTGGGCTCC 360

GGCTCCTTCG GTGTGGTGAG GAAGGGAGAG TGGCACACAC CCACCGGAAG AGTGTTGACT 420

GTTGCGGTAA AGACGTTACG GAACAGCGTG TCCAGACAGA CGGACACGCT GACGGACTTC 480

CTCCAGGAGG TGACCACCAT GCAGGCGCTG GACCACCCCA ACATCATCAG GCTTTACGGC 540

GTGGTGCTCA CGCAACCCCT GAAGATGGTG ACGGAACTGG CCTCTCTGGG ATCGCTGTAC 600

GACACCCTGC GTGCCCGTCA GTTCGAGTAC CCTCTGGTCC GCCTTTGGCT CTTCGCGACT 660

CAGATAGCGT CGGGTATGGA TTACCTGGAG ACCAGGAGGT TGATCCACAG GGATCTGGCT 720

GCCAGAAACA TCCTTCTTGC TTCCAGGGAG ATGGTCAAGA TCGGGGATTT TGGCCTCATG 780

CGAGGATTGA GCCAAGAGGT GGATCATTAC GTGATGTCGG CTCACAGAAG GATCCCGTTT 840

GCATGGTGTG CTCCAGAGAG CCTCCGCGTG GGCTCCTTCT CCCACTCCTC AGATGTGTGG 900

ATGTTTGGAG TCACCATGTG GGAGATGTTC ACCTACTGTG AGGAGCCCTG GTTCGGCCTG 960

ACAGGCAGAC AGATCTTGTG GCGCGTGGAA CGGGAGGGCG AGCGTCTGGA GAAGCCGCCG 1020

GATTGCCCTC AGGAGCTGTA CGTGGTCATG CGGAAGTGCT GGGCCTGCAA CCCCAACGAC 1080

AGGCCAAACT TCTCGCAGCT CGGCATGTTG GTAGCAGAGG CTAAACCAAA GGAAGTACAA 1140

GCCATGAGAG ACTTTTCTGA GTCCCGAAAA CTCGCACTCG CAGCCAACGA CTTTGTGACC 1200

CTGGTAGAGC ACAGCCTGGA GATGTCCGAG TGGAGGGGCC AGAACCAGAA AACCCTGGCG 1260

GTGGGCTGGT TTCCCGCGAG CCTCACCGTG CCAACGCCAC CTGCCGTCGT TCCAGTGCCC 1320

GCTGCCTCCT TCATCTCCAC TCCACTGAAG GGCAGCCTGC ATCACACCGG ACACGGAGAC 1380

GTCCACCCAG ACCGCAGCTG GGGGACGCCG GAGAGCCTGG ATGACAGTGG GAACTTGAGG 1440

CTACCGGGTC CTGTCAAAGA GAAGGAAGGC ACCAATTTGC AAAAAATGGC AGGTATGTCC 1500

CAGAGCCTGG AGTCCGTTTT AGGTGGACAT CGACCGCGGT CTCAGACTGT AACCACAGTC 1560

AGAGTGGATC AGCAGGGCCG ACTCCTCCCT CCTGTCATGG CCGCCCACAG TGCGGTTATG 1620

CAAAAAGACC CGCGGCGGTT CAGCGAGGCC AGCATCGTCC CGCCCCCTCG ACCGCCACCT 1680

CCCAATCTCA AACGCCCAAT TAAGTCCCAG AGGAGGCCAG TAGCCCTCCC CGTCCCAGGC 1740

GCCCCGTGGC CTCCGCACAT GGTCATGGCG GCGCAGCCTC AGCTGCAGCA GAGCACCTCT 1800

AACCTGGCAA AAATGACACA GATGGCGCGC TCGACCCCGC AGCTGGACGA CAACACGGAC 1860

GGCAGGGAGC GAGAGCGCAG CCGAGAGAGG CCGCCCCACT TGCAGAACAC CAGGGACAGC 1920

CTCGTCTCAC AGGTCATGGA GGGGGTGCAC GGCGTGACCA TCGAAGAGGC CGACATGGCC 1980

CTCCAACGCA ACGAGTGGAA CCCAGTACGA GCTCAGCAAC AGCTCAAGTT GGAGCAGCTG 2040

TACTCGCTGA GCCTCTGCTC CAGGGACGAC TGCCTCCGGA TCCTCTCCAA GTACCAGTGG 2100

AACCTGCAGC TGGCCAGCCG CTACCTGATC CGGTGGTCAC GTGAA 2145

Domain Profile

S: 3     lleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllklehe  61

         l+eklG+Gsfgvv++geW++p+g++++vavk+l++ +  +t++  dfl+ev+++++l+h+

Q: 114   LGEKLGSGSFGVVRKGEWHTPTGRVLTVAVKTLRNSVSRQTDTlTDFLQEVTTMQALDHP  173

         789*******************************9999999988****************

S: 62    nlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayles  121

         n++rlyGvvltqplk+vtela+lgsl+d+lr+++   ++++ +l+ +a+qia+g+ yle+

Q: 174   NIIRLYGVVLTQPLKMVTELASLGSLYDTLRARQF--EYPLVRLWLFATQIASGMDYLET  231

         ********************************999..7999*******************

S: 122   krlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrtr  181

         +rl+hrdlaarn+llas+++vki+dfGl+r l++e d+yv++ ++++PfaWcaPeslr

Q: 232   RRLIHRDLAARNILLASREMVKIGDFGLMRGLSQEVDHYVMSAHRRIPFAWCAPESLRVG  291

         ************************************************************

S: 182   kfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediyslll  241

          fs++sdvW+fGvt+Wemf+y eePW gl+g qil ++++e+erlekP++cp+++y ++

Q: 292   SFSHSSDVWMFGVTMWEMFTYCEEPWFGLTGRQILWRVEREGERLEKPPDCPQELYVVMR  351

         ************************************************************

S: 242   kcWakkpadrpkfsal  257

         kcWa +p+drp+fs+l

Q: 352   KCWACNPNDRPNFSQL  367

         **************98

Domain Sequence
(FASTA)

LGEKLGSGSF GVVRKGEWHT PTGRVLTVAV KTLRNSVSRQ TDTLTDFLQE VTTMQALDHP 60

NIIRLYGVVL TQPLKMVTEL ASLGSLYDTL RARQFEYPLV RLWLFATQIA SGMDYLETRR 120

LIHRDLAARN ILLASREMVK IGDFGLMRGL SQEVDHYVMS AHRRIPFAWC APESLRVGSF 180

SHSSDVWMFG VTMWEMFTYC EEPWFGLTGR QILWRVEREG ERLEKPPDCP QELYVVMRKC 240

WACNPNDRPN FSQL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Danio rerio"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF09027	; GTPase_binding; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013