EKS-TAR-00485

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00485

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	317.0	2.2E-94	133	368	236

Status

Unreviewed

Ensembl Protein

ENSTRUP00000028362

UniProt Accession

H2TUK2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12 (2 of 2)

Gene Synonyms/Alias

MAP3K12 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000011230	ENSTRUP00000028361	ENSTRUT00000028473
ENSTRUG00000011230	ENSTRUP00000028362	ENSTRUT00000028474

Organism

Takifugu rubripes

Functional Description

Protein Length

846

Protein Sequence
(FASTA)

MALIHEPRAP SPSLSGFNTP LSDPPSFRRL DAETPCTPEM DLTPTHILKL HDHSGNPGLT 60

EGEGQDLDGS MVRSQAGDGR LQCQSTAGGF LEGLFGCLRP VWTMIGKAYS TEHKHDLDAS 120

EAWEVPFEEI SDLQWVGSGA QGAVFLGKLH GQEVAVKKVR NIKETDIKHL RKLKHPNIIT 180

FKGICTQAPC YCIIMEYCAQ GQLYEVLRAG RKIQPCLLMD WAMGIAGGMN YLHLHKIIHR 240

DLKSPNMLIT YDDSVKISDF GTSKELSDKS TKMSFAGTVA WMAPEVIRNE PVSEKVDIWS 300

FGVVLWEMLT GEVPYKDVDS SAIIWGVGNN SLHLPVPESC PDSFKLLLRQ CWNCKPRNRP 360

SFRQILLHLD IASADILSTP QETYFQSQVE WRDEVRHHFE KIKSEGTCLH RLDEELIKRR 420

REELRHALDI REHYERKLER ANNLYMELNA IMLQLEIKEK ELHKREQSLD KKYQGCFKHH 480

SSRQSASSNS MEKLMKKRNI PQKLPSHSKR PDLLKSEVIL PKLDSSMTQV TINNKGSTSP 540

GRSRRGKPRY RKAGKGSTGD LAQLKATLSS SLAIVNSTTS VPSSKQRLDP SAAIRGLQHD 600

LLLKKMYSSS PDLISTTVEA EGRRKDVGTE DLAGIPPRSD TPSEDAASIP FSSSPDSPCG 660

RGAAVGRTSV LGNSRVSHEG EEKEEGTVIT RSPRSQRLTP AALLYRAAVT RSQRRGVSSE 720

EEEGEVDSEV ELPRRRRTVS MTKCQSLSTF SSENLSVSDG EEGNTTDHSH SGTPDVVSTN 780

TDERLDDKSD DLLSQGSEIP ADPSDLTQLG SVAPSFVFPP HQGLYDDSDC DSTELDHSGS 840

AEPNQP 846

Nucleotide Sequence
(FASTA)

ATGGCACTCA TTCACGAACC TCGCGCTCCT TCCCCTTCCC TGTCGGGCTT CAACACACCC 60

CTCTCTGATC CTCCATCCTT TCGCCGCCTC GATGCCGAAA CACCCTGCAC CCCGGAGATG 120

GACCTCACCC CGACCCACAT CCTGAAGCTC CACGATCACA GTGGAAATCC CGGACTGACG 180

GAGGGAGAGG GCCAGGACCT GGACGGCAGC ATGGTTAGAA GCCAGGCAGG TGACGGCAGG 240

CTTCAGTGCC AGTCCACAGC AGGAGGGTTT CTAGAGGGTT TGTTCGGGTG TCTTCGGCCC 300

GTCTGGACTA TGATTGGCAA AGCATACTCC ACGGAGCATA AACACGACCT GGATGCCTCA 360

GAGGCCTGGG AGGTTCCCTT TGAGGAGATA TCTGACCTGC AGTGGGTGGG CAGTGGCGCT 420

CAGGGAGCTG TCTTCTTGGG CAAGCTACAC GGACAGGAAG TGGCAGTAAA GAAAGTGCGG 480

AACATCAAAG AGACGGACAT CAAGCACCTA CGCAAGCTCA AACACCCCAA CATCATCACT 540

TTCAAAGGTA TTTGCACGCA GGCTCCGTGT TACTGCATCA TCATGGAGTA CTGTGCACAG 600

GGGCAGCTGT ATGAGGTGCT GAGAGCAGGC AGGAAGATCC AACCGTGCCT GCTCATGGAC 660

TGGGCCATGG GCATCGCTGG AGGAATGAAC TACCTGCACC TCCACAAGAT CATCCACAGA 720

GATCTGAAGT CCCCAAACAT GTTGATCACT TACGACGATT CGGTGAAGAT CTCGGATTTC 780

GGCACCTCCA AAGAGCTCAG CGACAAGAGC ACCAAGATGT CCTTTGCTGG TACGGTGGCC 840

TGGATGGCCC CCGAGGTCAT ACGCAATGAA CCTGTCTCGG AGAAGGTGGA TATTTGGTCC 900

TTTGGTGTGG TGCTGTGGGA GATGCTAACA GGAGAGGTGC CCTACAAGGA TGTGGATTCC 960

TCCGCTATCA TCTGGGGAGT TGGCAACAAC AGCCTGCATC TGCCTGTGCC CGAGAGCTGT 1020

CCAGACAGCT TCAAACTGCT GCTGAGGCAG TGCTGGAACT GTAAGCCGAG GAACAGGCCT 1080

TCCTTTCGAC AGATTCTCCT GCATTTGGAC ATTGCTTCAG CAGATATCCT GTCGACTCCT 1140

CAAGAAACAT ACTTTCAATC TCAGGTGGAA TGGAGGGACG AGGTGAGGCA CCACTTTGAG 1200

AAGATCAAAT CCGAGGGCAC GTGTCTTCAC AGGCTGGACG AGGAGCTGAT CAAGCGACGC 1260

AGAGAAGAGC TCAGGCATGC TCTGGACATC CGGGAGCACT ATGAGAGGAA GCTGGAGAGA 1320

GCCAACAACC TGTACATGGA GCTTAATGCC ATTATGCTGC AACTGGAAAT CAAAGAGAAA 1380

GAACTGCACA AGAGGGAGCA GTCACTGGAC AAGAAGTACC AGGGCTGCTT CAAGCATCAC 1440

AGCTCCAGAC AGTCGGCCTC CTCCAATTCC ATGGAGAAAC TCATGAAGAA ACGCAACATA 1500

CCTCAAAAAC TGCCCTCACA CAGCAAGAGG CCGGATTTAC TAAAGTCAGA GGTCATCCTT 1560

CCCAAACTGG ACTCTTCAAT GACTCAGGTC ACAATCAACA ACAAGGGTTC TACCTCCCCT 1620

GGCCGCTCAC GCCGAGGAAA GCCTCGCTAT CGGAAGGCCG GTAAAGGCAG CACCGGCGAC 1680

TTGGCTCAGC TCAAAGCCAC TCTCTCCTCA TCACTAGCGA TCGTCAACTC CACCACATCA 1740

GTTCCCAGTA GCAAGCAGCG CTTAGACCCC AGCGCAGCCA TCAGGGGCCT GCAGCATGAC 1800

CTGCTGCTCA AGAAAATGTA CTCCTCCAGC CCGGATCTCA TTTCCACCAC GGTGGAGGCC 1860

GAGGGACGCA GGAAGGATGT GGGGACTGAG GACCTGGCAG GGATCCCTCC ACGCAGTGAC 1920

ACGCCAAGCG AGGACGCAGC TTCCATTCCA TTCTCAAGTA GTCCCGACTC CCCGTGTGGC 1980

AGGGGAGCAG CCGTGGGAAG GACATCCGTG CTTGGAAACA GTCGCGTTTC ACACGAGGGC 2040

GAGGAGAAGG AGGAGGGGAC GGTGATAACG CGCTCGCCAC GGAGTCAACG CCTCACGCCT 2100

GCAGCACTGC TCTACAGGGC GGCAGTCACG CGCAGTCAGA GACGTGGCGT CTCTTCAGAG 2160

GAAGAAGAAG GAGAGGTGGA CAGTGAAGTA GAGTTACCAA GGAGACGGCG CACCGTGAGC 2220

ATGACCAAGT GCCAGTCCCT GTCCACGTTC AGCTCAGAGA ACTTGTCTGT GTCAGACGGT 2280

GAGGAAGGCA ACACCACCGA CCACTCCCAC AGCGGAACAC CGGATGTTGT CAGCACCAAC 2340

ACCGACGAGC GCCTTGACGA CAAGAGCGAC GACCTGCTCT CTCAGGGTTC AGAGATCCCC 2400

GCCGACCCGT CCGACCTCAC CCAGCTGGGC TCAGTAGCGC CATCTTTTGT CTTTCCTCCC 2460

CACCAGGGTC TGTACGATGA CTCAGACTGT GACAGCACCG AACTGGACCA TTCAGGCAGC 2520

GCAGAACCCA ACCAGCCC 2538

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ +k++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G

Q: 133   LQWVGSGAQGAVFLGKLHGQEVAVKKVRNIKET---------DIKHLRKLKHPNIITFKG  183

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         +c++ p+++++mey+++g+L++vl++   r+i++  l++wa+ iA Gm+YLh +   kii

Q: 184   ICTQAPCYCIIMEYCAQGQLYEVLRA--GRKIQPCLLMDWAMGIAGGMNYLHLH---KII  238

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 239   HRDLKSPNMLI-TYDDSVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  297

         ***********.999***************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWe+lt+evPykd+++ ai+++v++++l+lp+p+scp+++k L+++cwn +p+

Q: 298   IWSFGVVLWEMLTGEVPYKDVDSSAIIWGVGNNSLHLPVPESCPDSFKLLLRQCWNCKPR  357

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 358   NRPSFRQILLH  368

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGKLHGQ EVAVKKVRNI KETDIKHLRK LKHPNIITFK GICTQAPCYC 60

IIMEYCAQGQ LYEVLRAGRK IQPCLLMDWA MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120

DSVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWEMLTGE 180

VPYKDVDSSA IIWGVGNNSL HLPVPESCPD SFKLLLRQCW NCKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013