EKS-TAR-00070

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00070

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	406.7	1.2E-121	437	693	257

Status

Unreviewed

Ensembl Protein

ENSTRUP00000029375

UniProt Accession

H2TXG3;

Protein Name

Protein Synonyms/Alias

Gene Name

BRAF

Gene Synonyms/Alias

BRAF;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000011625	ENSTRUP00000029374	ENSTRUT00000029491
ENSTRUG00000011625	ENSTRUP00000029375	ENSTRUT00000029492
ENSTRUG00000011625	ENSTRUP00000029372	ENSTRUT00000029489
ENSTRUG00000011625	ENSTRUP00000029373	ENSTRUT00000029490
ENSTRUG00000011625	ENSTRUP00000029378	ENSTRUT00000029495
ENSTRUG00000011625	ENSTRUP00000029376	ENSTRUT00000029493
ENSTRUG00000011625	ENSTRUP00000029377	ENSTRUT00000029494

Organism

Takifugu rubripes

Functional Description

Protein Length

746

Protein Sequence
(FASTA)

ALPEQIWNIK QMIKLTQEHL EALLDKFGGE HNPPTIYLEA YEEYTSKLDA LQQREQQLLE 60

AMVLQTPTDG SRVNPRSPQK PIVRVFLPNK QRTVVSARCG MTVRDSLKKA LTMRGLIPEC 120

CAVYRMQDGE KKPIGWDTDI SWLTLEELHV EVLENVPLTT HNFVRKTFFT LAFCDFCRKL 180

LFQGFRCQTC GYKFHQRCST EVPLMCVNYD QLDLLLVSKF FEHHPFTQEE VSSEGTTPVS 240

EVCPSLPPSD STGSICQSTV SPSKSIPIPP SFRSSEEDHR NQFGQRDRSS SAPNVHINTI 300

EPVNIDEKVP ELCSHTHTDL IRVQGLPRSD GAPPTHPARC LRKHRTRTSS PLLYSYPNDI 360

VFDFEPEPVF QGSTTGLSAT PPASLPGSLT NVKVPQKSPC QQRERKSSSS SEDRSKMKTL 420

GRRDSSDDWE IPEGQITLGQ RIGSGSFGTV FKGKWHGDVA VKMLNVTAPT PQQLQAFKNE 480

VGVLRKTRHV NILLFMGYTT KPQLAIVTQW CEGSSLYHHL HIIETKFEMI KLIDIARQTA 540

QGMDYLHAKS IIHRDLKSNN IFLHEDLTVK IGDFGLATVK SRWSGSHQFE QLSGSILWMA 600

PEVIRLQDKN PYSFQSDVYA FGIVLYELMS GVLPYSNINN RDQIIFMVGR GYLSPDLSKV 660

RSNCPKAMKR LMADCLKKKR EERPLFPQIL ASIELLARSL PKIHRSASEP SLNRAGFQTE 720

DFSLYACASP KTPIQAGGYG EFSAFK 746

Nucleotide Sequence
(FASTA)

GCCCTTCCAG AGCAGATCTG GAACATCAAA CAGATGATAA AGCTGACACA GGAACACTTG 60

GAGGCACTCC TGGATAAATT TGGAGGAGAG CACAACCCTC CCACCATATA CCTGGAGGCC 120

TACGAGGAGT ACACCAGTAA ACTGGATGCC CTGCAGCAGA GGGAGCAGCA GTTGTTGGAG 180

GCTATGGTCC TGCAGACGCC CACCGACGGC AGCCGAGTCA ACCCTCGTTC CCCTCAGAAG 240

CCCATCGTAC GAGTTTTCCT GCCCAACAAG CAAAGGACGG TGGTGTCAGC TCGCTGTGGA 300

ATGACTGTGA GGGACTCCCT GAAGAAGGCG CTGACCATGC GAGGCCTCAT TCCTGAATGT 360

TGTGCCGTCT ACAGAATGCA AGACGGAGAG AAGAAGCCGA TTGGCTGGGA TACCGACATT 420

TCCTGGCTCA CTTTAGAGGA GCTCCACGTG GAGGTTTTAG AGAATGTCCC GCTCACCACT 480

CACAACTTTG TGAGGAAGAC CTTCTTCACG TTGGCCTTCT GTGACTTCTG CAGAAAGCTG 540

CTGTTCCAGG GCTTTCGCTG TCAGACCTGT GGCTACAAGT TCCACCAGCG CTGCAGCACA 600

GAGGTTCCTC TCATGTGTGT CAACTATGAC CAGCTAGATT TGTTGTTGGT CTCCAAGTTC 660

TTCGAACATC ATCCCTTCAC CCAGGAGGAA GTGTCATCAG AGGGAACCAC CCCCGTGTCC 720

GAGGTCTGTC CCTCTCTGCC CCCGTCAGAC TCCACTGGGT CTATCTGCCA GTCTACTGTG 780

TCCCCGTCCA AGTCCATTCC CATTCCCCCC AGTTTTCGCT CCAGTGAGGA GGACCACCGA 840

AACCAGTTTG GCCAGCGGGA TCGTTCCTCC TCGGCCCCAA ATGTCCACAT TAATACGATC 900

GAGCCCGTCA ACATTGATGA AAAGGTTCCA GAGCTTTGCT CACACACACA CACAGACCTG 960

ATTCGAGTCC AGGGGCTTCC AAGATCAGAT GGAGCCCCCC CGACCCACCC TGCCCGCTGC 1020

TTGAGGAAGC ACCGAACACG GACCTCAAGC CCCCTCCTAT ACTCCTACCC CAATGACATA 1080

GTCTTTGATT TTGAGCCTGA GCCTGTTTTC CAAGGTTCCA CCACAGGACT GTCGGCCACT 1140

CCTCCTGCCT CTCTTCCAGG ATCCTTGACT AATGTTAAGG TTCCACAGAA ATCGCCCTGT 1200

CAGCAGAGGG AGCGCAAGTC GTCGTCCTCC TCTGAGGACC GCAGTAAGAT GAAAACCTTG 1260

GGCCGAAGGG ACTCCAGTGA TGACTGGGAA ATCCCAGAGG GTCAGATCAC TCTGGGTCAG 1320

AGGATAGGTT CTGGCTCTTT TGGAACTGTC TTCAAGGGAA AGTGGCACGG AGACGTAGCC 1380

GTAAAGATGT TAAACGTCAC CGCTCCGACG CCGCAACAGC TCCAGGCCTT CAAGAATGAA 1440

GTGGGAGTCC TCAGGAAAAC CCGTCACGTC AACATCCTGC TCTTCATGGG CTACACCACC 1500

AAGCCTCAGC TGGCCATCGT CACCCAGTGG TGCGAAGGCT CCAGCCTCTA CCACCACCTG 1560

CACATCATCG AAACCAAGTT TGAGATGATC AAGCTGATCG ACATAGCCCG GCAGACGGCT 1620

CAAGGCATGG ATTACCTTCA CGCCAAGTCC ATCATCCACA GGGACCTGAA GAGCAACAAT 1680

ATTTTCCTCC ATGAGGATCT GACGGTGAAG ATCGGTGACT TTGGTCTGGC CACGGTCAAG 1740

TCTCGCTGGA GTGGCTCCCA CCAGTTTGAG CAGTTGTCCG GCTCCATATT GTGGATGGCC 1800

CCAGAGGTGA TCCGGCTGCA GGACAAGAAC CCGTACAGCT TCCAGTCTGA CGTCTATGCC 1860

TTTGGCATCG TGCTGTATGA GCTAATGTCA GGGGTGCTGC CCTACTCCAA CATCAACAAC 1920

AGAGACCAGA TCATATTTAT GGTGGGCAGA GGGTACCTGT CTCCTGACCT CAGTAAGGTA 1980

CGCAGCAACT GTCCCAAGGC CATGAAGAGA CTGATGGCTG ACTGTCTGAA GAAGAAGCGA 2040

GAGGAGCGAC CGCTCTTCCC TCAGATCTTG GCTTCGATTG AACTGCTGGC TCGCTCCCTA 2100

CCCAAAATCC ACCGCAGCGC CTCAGAACCT TCATTAAATC GAGCCGGCTT CCAGACAGAG 2160

GACTTTAGTT TATACGCCTG TGCCTCTCCC AAAACCCCCA TCCAGGCCGG CGGCTACGGG 2220

GAGTTTTCAG CATTTAAGTA A 2241

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         +l+++iGsG+fGtv++gkwhGdvavk+lnv++++++ql+aFk+ev +++ktRh+ni+LFm

Q: 437   TLGQRIGSGSFGTVFKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM  496

         6899********************************************************

S: 62    GyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkDl  121

         Gy +kp+laivt++c+gssLy++lh  etk+++ klidiarq+aqgmdYLhak+i+h+Dl

Q: 497   GYTTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDL  556

         ************************************************************

S: 122   ksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleqd  181

         ks+ni+l+e+l+v+i+DFgl++vk+++sg  ++q+e+ +g+il++apevir       qd

Q: 557   KSNNIFLHEDLTVKIGDFGLATVKSRWSG--SHQFEQLSGSILWMAPEVIRL------QD  608

         *****************************..*********************......**

S: 182   elpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpkel  239

         ++p+s++sDvyafGivlyel+++ lpy++ +++dqi+f+vgrG l+pdlskv+s++pk++

Q: 609   KNPYSFQSDVYAFGIVLYELMSGVLPYSNiNNRDQIIFMVGRGyLSPDLSKVRSNCPKAM  668

         ************************************************************

S: 240   kellleClkfekeeRPlftqilkkl  264

         k+l+++Clk+++eeRPlf+qil+++

Q: 669   KRLMADCLKKKREERPLFPQILASI  693

         *********************9875

Domain Sequence
(FASTA)

TLGQRIGSGS FGTVFKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRK TRHVNILLFM 60

GYTTKPQLAI VTQWCEGSSL YHHLHIIETK FEMIKLIDIA RQTAQGMDYL HAKSIIHRDL 120

KSNNIFLHED LTVKIGDFGL ATVKSRWSGS HQFEQLSGSI LWMAPEVIRL QDKNPYSFQS 180

DVYAFGIVLY ELMSGVLPYS NINNRDQIIF MVGRGYLSPD LSKVRSNCPK AMKRLMADCL 240

KKKREERPLF PQILASI 257

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005057	; F:receptor signaling protein activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR003116	; Raf-like_ras-bd.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF07714	; Pkinase_Tyr; 1.
PF02196	; RBD; 1.

SMARTs

SM00109	; C1; 1.
SM00455	; RBD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50898	; RBD; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013