EKS-TAR-00246

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00246

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CASK	536.2	3.0E-161	12	276	265

Status

Unreviewed

Ensembl Protein

ENSTRUP00000029457

UniProt Accession

H2TXP5;

Protein Name

Protein Synonyms/Alias

Gene Name

CASK

Gene Synonyms/Alias

CASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000011655	ENSTRUP00000029458	ENSTRUT00000029575
ENSTRUG00000011655	ENSTRUP00000029457	ENSTRUT00000029574
ENSTRUG00000011655	ENSTRUP00000029459	ENSTRUT00000029576
ENSTRUG00000011655	ENSTRUP00000029460	ENSTRUT00000029577
ENSTRUG00000011655	ENSTRUP00000029454	ENSTRUT00000029571
ENSTRUG00000011655	ENSTRUP00000029461	ENSTRUT00000029578
ENSTRUG00000011655	ENSTRUP00000029462	ENSTRUT00000029579
ENSTRUG00000011655	ENSTRUP00000029456	ENSTRUT00000029573
ENSTRUG00000011655	ENSTRUP00000029463	ENSTRUT00000029580
ENSTRUG00000011655	ENSTRUP00000029455	ENSTRUT00000029572

Organism

Takifugu rubripes

Functional Description

Protein Length

902

Protein Sequence
(FASTA)

MADDDVLFED VYELCEVIGK GPFSVVRRCI NRDTGQQFAV KIVDVASFTS SPGLSTEDLK 60

REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120

YMRQILEALR YCHDNNVIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180

GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEAI IKGKYKMNPR 240

QWAHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300

RRKLKGAVLA AVSSHKFNSY YGDPPEELHD FSDDPTSSGL LAAERAVSQV LDSLEEIHAL 360

TDCSEKDMDF LHSVFQDQHL HTLLDLYDKI NTRSSPQIRN PPSDGVQRAK EVLETIACYP 420

ENMEAKELRR ILTQPHFMAL LQTHDVVAHE VYSDEALRVT PPPTSPYLNG DSPDSTNGDM 480

DLENVTRVRL VQFQKNTDEP MGITLKMNDL NHCIVARIMH GGMIHRQGTL HVGDEIREIN 540

GISVANQTVE QLQKMLREMR GSITFKIVPS YRSQSMSCED LPSTIQPKGR QIYVRAQFEY 600

DPAKDDLIPC KEAGIRFRVG DIIQIISKDD HNWWQGKLEN TKNGTAGLIP SPELQEWRVA 660

CIAMEKTKQE QQASCTWFGK KKKQYKDKYL AKHNAVFDQL DLVTYEEVVK LPSFKRKTLV 720

LLGAHGVGRR HIKNTLIAKH PDRFAYPIPH TTRPPKKDEE NGKNYYFVSH DQMMQDISNN 780

DYLEYGSHED AMYGTRLETI RQIHAQGMIS ILDVEPQALK ILRTAEFAPY VVFIAAPTIT 840

PGMTEDESLQ RLQKESEMLQ RTYAHYFDQT IINNEIDDTI RWEEAVDLVS TTPQWVPVSW 900

VY 902

Nucleotide Sequence
(FASTA)

ATGGCGGACG ACGACGTGCT GTTCGAGGAT GTCTACGAGC TGTGCGAGGT GATTGGCAAG 60

GGTCCCTTCA GCGTGGTGAG GCGTTGCATC AACAGGGACA CAGGCCAGCA GTTTGCCGTA 120

AAGATCGTGG ATGTGGCGAG TTTCACCTCG AGCCCCGGCT TGAGCACAGA AGACCTGAAG 180

CGTGAGGCCA GCATCTGTCA CATGCTGAAG CACCCCCACA TTGTGGAGCT GCTGGAGACC 240

TACAGCTCTG ATGGCATGCT CTACATGGTC TTTGAATTTA TGGATGGGGC AGATCTGTGT 300

TTTGAAATAG TGAAGCGAGC CGACGCTGGG TTTGTGTACA GCGAAGCTGT AGCCAGCCAT 360

TACATGCGGC AGATTTTGGA GGCGCTCCGC TATTGTCATG ACAACAATGT GATTCATCGT 420

GACGTGAAGC CTCACTGTGT GCTGTTGGCC TCGAAGGAGA ACTCTGCTCC TGTCAAGCTG 480

GGAGGGTTTG GAGTGGCCAT TCAGCTGGGA GAGTCTGGCC TAGTAGCTGG AGGCCGAGTC 540

GGTACACCTC ACTTCATGGC ACCTGAGGTT GTGAAGAGGG AGCCGTACGG TAAACCAGTG 600

GATGTGTGGG GATGTGGAGT CATCCTCTTC ATCCTGCTCT CTGGATGCCT TCCGTTCTAT 660

GGCACCAAGG AACGCTTGTT TGAGGCTATC ATCAAGGGAA AATACAAGAT GAACCCACGT 720

CAATGGGCCC ATATCTCAGA GAGTGCCAAG GACCTGGTGA GACGCATGCT GATGCTGGAC 780

CCTGCTGAGA GGATCACCGT CTATGAGGCG CTCAACCACC CCTGGCTGAA GGAAAGGGAC 840

AGATACGCAT ACAAGATCCA CCTGCCTGAA ACGGTGGAGC AGCTGAGGAA GTTCAATGCA 900

AGGAGGAAGC TGAAGGGGGC AGTACTGGCT GCTGTCTCCA GCCACAAGTT TAATTCTTAT 960

TATGGTGACC CCCCAGAGGA GCTACATGAC TTCTCGGATG ACCCCACCTC ATCAGGACTG 1020

CTAGCTGCTG AAAGAGCAGT ATCGCAAGTT TTGGACAGTC TAGAGGAAAT TCATGCACTG 1080

ACAGACTGCA GTGAGAAAGA CATGGACTTC CTTCACAGCG TCTTCCAGGA TCAGCACCTC 1140

CACACTCTCT TAGATCTTTA TGACAAAATC AACACCAGGT CATCCCCTCA GATCAGGAAT 1200

CCCCCAAGTG ATGGAGTGCA GAGGGCCAAA GAGGTACTGG AAACCATTGC TTGTTATCCG 1260

GAGAACATGG AAGCCAAGGA GCTCAGGAGG ATCCTCACGC AGCCTCATTT TATGGCTCTG 1320

CTCCAGACTC ACGATGTGGT GGCTCACGAG GTCTACAGTG ACGAGGCGCT GAGGGTGACT 1380

CCCCCGCCAA CTTCACCTTA CCTGAACGGA GACTCGCCAG ACAGCACTAA CGGAGACATG 1440

GACCTGGAGA ATGTCACCAG GGTCCGCCTG GTTCAGTTTC AGAAGAACAC TGATGAGCCC 1500

ATGGGCATCA CTCTGAAAAT GAATGACCTT AACCACTGCA TCGTAGCCCG AATTATGCAC 1560

GGAGGAATGA TTCACCGACA AGGTACTCTG CATGTAGGAG ATGAGATCCG TGAGATTAAT 1620

GGCATCAGTG TTGCCAATCA GACAGTGGAG CAGCTCCAAA AGATGCTGAG GGAGATGAGG 1680

GGAAGCATCA CTTTCAAGAT TGTACCCAGT TACCGCTCCC AGTCCATGTC TTGTGAGGAT 1740

CTGCCATCCA CAATCCAGCC TAAAGGTCGA CAGATTTATG TTCGTGCCCA GTTTGAGTAT 1800

GACCCGGCCA AAGATGACCT CATTCCCTGT AAGGAGGCAG GCATTCGCTT TAGAGTGGGC 1860

GACATCATTC AGATCATCTC CAAGGATGAC CACAACTGGT GGCAGGGGAA GCTAGAGAAC 1920

ACTAAGAATG GGACGGCAGG CCTCATTCCA TCACCAGAGC TACAGGAATG GCGGGTTGCA 1980

TGCATAGCAA TGGAGAAGAC CAAACAGGAA CAGCAGGCCA GTTGTACCTG GTTTGGCAAG 2040

AAGAAGAAGC AATACAAAGA CAAGTATCTG GCCAAGCACA ATGCAGTGTT TGACCAACTA 2100

GATCTGGTGA CATATGAGGA GGTGGTCAAA CTCCCATCAT TTAAGAGAAA AACATTGGTC 2160

TTACTTGGAG CACATGGAGT TGGTCGGAGA CACATTAAGA ACACACTCAT TGCCAAGCAC 2220

CCTGATCGCT TCGCCTATCC CATCCCTCAC ACAACTCGGC CTCCAAAGAA GGATGAGGAG 2280

AATGGAAAGA ACTATTACTT TGTGTCTCAT GACCAAATGA TGCAGGACAT CAGCAACAAT 2340

GACTATCTGG AGTATGGAAG CCATGAGGAT GCCATGTATG GAACTAGATT GGAGACCATA 2400

AGGCAGATCC ATGCACAGGG CATGATCTCT ATACTGGATG TGGAACCCCA GGCGCTAAAG 2460

ATCCTCAGGA CAGCTGAGTT TGCTCCCTAT GTCGTCTTCA TCGCAGCGCC CACCATCACC 2520

CCAGGCATGA CTGAGGACGA GTCTCTCCAG CGGCTCCAGA AGGAATCGGA GATGCTTCAG 2580

CGGACCTACG CTCACTACTT TGATCAGACC ATCATCAATA ATGAGATCGA TGACACCATC 2640

CGCTGGGAGG AAGCCGTAGA CTTGGTGTCA ACCACTCCTC AGTGGGTCCC CGTCTCCTGG 2700

GTCTACTGA 2709

Domain Profile

S: 1     yelcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkh  60

         yelcevigkGpfsvvrr+i+r+++q+favkivdva ftsspGlstedlkreasichmlkh

Q: 12    YELCEVIGKGPFSVVRRCINRDTGQQFAVKIVDVASFTSSPGLSTEDLKREASICHMLKH  71

         89**********************************************************

S: 61    pyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealry  120

         p+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealry

Q: 72    PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY  131

         ************************************************************

S: 121   chdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapev  180

         chdn+++hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapev

Q: 132   CHDNNVIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEV  190

         ****************************************.*******************

S: 181   vkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesak  240

         vkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+w +isesak

Q: 191   VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEAIIKGKYKMNPRQWAHISESAK  250

         ************************************************************

S: 241   dlvrrmlaadpakrisvkealnhewl  266

         dlvrrml++dpa+ri+v+ealnh+wl

Q: 251   DLVRRMLMLDPAERITVYEALNHPWL  276

         *************************7

Domain Sequence
(FASTA)

YELCEVIGKG PFSVVRRCIN RDTGQQFAVK IVDVASFTSS PGLSTEDLKR EASICHMLKH 60

PHIVELLETY SSDGMLYMVF EFMDGADLCF EIVKRADAGF VYSEAVASHY MRQILEALRY 120

CHDNNVIHRD VKPHCVLLAS KENSAPVKLG GFGVAIQLGE SGLVAGGRVG TPHFMAPEVV 180

KREPYGKPVD VWGCGVILFI LLSGCLPFYG TKERLFEAII KGKYKMNPRQ WAHISESAKD 240

LVRRMLMLDP AERITVYEAL NHPWL 265

Keyword

Complete proteome; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR008144	; Guanylate_kin.
IPR008145	; Guanylate_kin/L-typ_Ca_channel.
IPR020590	; Guanylate_kinase_CS.
IPR011009	; Kinase-like_dom.
IPR004172	; L27.
IPR014775	; L27_C.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.

Pfam

PF00625	; Guanylate_kin; 1.
PF02828	; L27; 2.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00072	; GuKc; 1.
SM00569	; L27; 2.
SM00228	; PDZ; 1.
SM00220	; S_TKc; 1.
SM00326	; SH3; 1.

Prosites

PS00856	; GUANYLATE_KINASE_1; 1.
PS50052	; GUANYLATE_KINASE_2; 1.
PS51022	; L27; 2.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50002	; SH3; 1.

Prints

Created Date

20-Feb-2013