EPS-TAR-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TAR-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	139.8	1.3E-40	137	281	145

Status

Unreviewed

Ensembl Protein

ENSTRUP00000029672

UniProt Accession

H2TYB3;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000011751	ENSTRUP00000029672	ENSTRUT00000029789

Organism

Takifugu rubripes

Functional Description

Protein Length

882

Protein Sequence
(FASTA)

NGSGEDAHQT APVVEEEVAP EGEMSVHGIQ SRYLRCPSPR FSMISGSDAA SIFMEPIHLS 60

SAVAAKKIIN EELPPRGPRE ESVPESMLET AEQLMVEDLY NRVRDIIDDR SPYNTPCVLD 120

IQRAMVQDRL EAPFNPVDEV WPNIFITEKS VAVNKARLKR MGITHVLNTA HGTGVYTGES 180

FYSGMNVQYM GIELDDFPDA DISVHFRPTA EFLDEALLTH KGKVLVVSMM GVSRSAILVA 240

AYLMIFQNMT IMEALTSIRK KRPINPNEGF LKQLREFNEN LMEERDDDDE TLSQCSVIDA 300

RARARIFGEG GDDDDDDTDK EEEQSTFEAK ARSIMMEEEE DGESVMSSVA SSAAAAALGS 360

GLTGAQNGPD DQGVSQEIVL PDRQGGDEDE GLSSMIHDWQ RRNERYQNED WWEAQLNSDD 420

EDGDGLEEVE SITSEDVRAV KDRVKRRTKR PPVDAMSTST STSYSDLWKQ RLREIEEEAA 480

ARYRRKEDEE LSESTNTDAA EERGKKIDDE VESILSDGTS MYNFCQKNKE NLTPLERWRV 540

KRIQFGWNKK DREDGEKSSV GEGENGEGET RTPSLQDVNL TAYQSWKLRQ QKRFGEENKD 600

EILELSRGED SKTVKRRQRR EEILERCKKT LEESQSMCGW DTESCVSGGT VPLSAFWAGA 660

GVTGPPSVAN DDNVSVLSGR SSASGLGLNP VAPVPPLVPV PCVQGPGGEP MVNLSSIQNW 720

IANVVSETIK QKQSEMSLPP PSRAGSEFNF GGAASLISGY SKDDDKASLL SGASYTSALS 780

QGRSKAASVL SGGGSSSISG LTGKGSTYSS NLSAKKNKIT TTSVPLFSLF QDEVDIGKLN 840

AMDKEIKSEM RGKMAVYEKK KILEDNKRST LFKKKKPKED ED 882

Nucleotide Sequence
(FASTA)

AATGGGAGTG GAGAGGACGC GCATCAGACG GCTCCTGTTG TGGAGGAGGA GGTGGCGCCA 60

GAGGGGGAGA TGAGCGTCCA CGGAATTCAG TCCCGTTACC TGCGCTGTCC CTCCCCCAGG 120

TTCTCCATGA TCTCCGGCTC GGACGCTGCC AGCATCTTTA TGGAGCCCAT CCACCTGTCG 180

TCTGCCGTCG CCGCCAAGAA GATCATTAAC GAGGAACTCC CTCCTCGCGG TCCACGAGAA 240

GAGTCCGTCC CAGAGTCCAT GCTGGAAACG GCTGAGCAGC TGATGGTGGA GGACCTGTAC 300

AACCGTGTCA GGGACATCAT TGACGACCGC AGCCCCTACA ACACCCCCTG TGTGCTTGAC 360

ATTCAGAGGG CCATGGTTCA GGACCGCCTG GAGGCTCCTT TCAACCCCGT GGATGAGGTG 420

TGGCCCAATA TCTTCATCAC CGAGAAATCC GTGGCGGTAA ACAAGGCCCG GCTGAAGCGC 480

ATGGGCATCA CCCACGTACT CAACACCGCC CACGGCACAG GGGTCTACAC CGGAGAGTCC 540

TTCTATTCTG GCATGAACGT CCAGTACATG GGCATCGAGC TGGACGACTT TCCCGATGCC 600

GACATCTCGG TCCATTTTAG ACCAACCGCC GAATTCTTGG ACGAAGCTCT GCTGACTCAC 660

AAGGGAAAGG TGCTTGTAGT CTCCATGATG GGCGTCAGCC GCTCTGCCAT CCTCGTGGCG 720

GCCTACCTCA TGATCTTCCA GAACATGACG ATCATGGAAG CTTTGACTTC CATTCGCAAA 780

AAACGTCCCA TCAACCCAAA TGAAGGATTC CTGAAGCAGC TGCGGGAGTT CAACGAGAAC 840

CTGATGGAGG AGCGCGACGA TGACGACGAA ACGCTCAGCC AGTGCTCCGT CATCGACGCA 900

CGTGCACGCG CGCGAATCTT CGGCGAGGGT GGGGACGACG ACGACGATGA TACTGATAAG 960

GAGGAAGAGC AAAGCACGTT TGAGGCGAAA GCCCGTTCGA TCATGATGGA GGAGGAGGAG 1020

GATGGAGAGA GCGTGATGAG CAGCGTCGCC TCGTCGGCAG CCGCCGCTGC GCTCGGGAGT 1080

GGACTGACGG GAGCCCAGAA CGGGCCGGAC GACCAAGGAG TGTCCCAAGA GATCGTTTTA 1140

CCCGACAGGC AGGGTGGCGA TGAGGATGAG GGTCTCAGCA GCATGATCCA TGACTGGCAA 1200

CGGAGGAACG AGAGATATCA GAACGAAGAC TGGTGGGAAG CCCAACTGAA CAGCGACGAT 1260

GAGGACGGCG ATGGTTTGGA GGAGGTGGAG AGCATCACCA GTGAAGACGT GCGTGCTGTA 1320

AAAGATCGAG TGAAGCGCCG AACCAAACGA CCGCCCGTCG ACGCCATGTC GACCTCCACC 1380

AGCACGAGTT ACTCCGACCT TTGGAAACAG CGCTTGAGGG AAATCGAGGA GGAAGCCGCG 1440

GCCCGCTACC GCAGGAAGGA GGATGAGGAG CTGAGTGAGA GCACAAACAC AGACGCTGCA 1500

GAAGAAAGAG GGAAGAAGAT TGATGATGAA GTGGAGAGCA TCCTGTCTGA TGGCACCTCC 1560

ATGTACAACT TTTGCCAGAA GAACAAGGAG AACTTGACTC CTTTGGAACG CTGGCGTGTG 1620

AAGAGAATCC AGTTTGGGTG GAACAAGAAG GATCGAGAAG ATGGAGAGAA AAGTTCTGTA 1680

GGTGAGGGAG AGAACGGCGA GGGAGAAACC AGGACACCGT CCCTCCAAGA TGTCAACCTG 1740

ACAGCGTATC AGTCCTGGAA GCTGAGGCAA CAAAAGCGTT TCGGGGAGGA GAACAAAGAT 1800

GAGATTCTAG AGCTCAGTAG AGGTGAGGAC TCTAAAACGG TCAAAAGGAG ACAAAGAAGA 1860

GAGGAGATCC TGGAACGCTG CAAGAAGACT TTAGAAGAGA GTCAGTCCAT GTGTGGCTGG 1920

GACACCGAGA GCTGCGTCAG TGGAGGGACG GTTCCTCTGT CCGCCTTCTG GGCTGGAGCT 1980

GGGGTCACTG GTCCGCCAAG TGTTGCCAAT GATGACAACG TATCTGTGCT CAGCGGGAGG 2040

TCATCTGCCT CAGGACTTGG GCTTAATCCA GTCGCACCAG TTCCTCCTCT TGTTCCAGTT 2100

CCTTGTGTCC AAGGACCTGG AGGGGAACCG ATGGTGAATC TTTCCAGCAT CCAAAACTGG 2160

ATCGCTAATG TCGTCTCTGA AACCATCAAA CAGAAGCAAA GCGAGATGAG TTTGCCCCCA 2220

CCATCGCGTG CTGGCTCAGA GTTCAACTTT GGGGGCGCTG CAAGTCTAAT TTCTGGCTAC 2280

AGCAAAGATG ATGACAAAGC GTCCTTGTTG AGCGGCGCTT CCTACACTAG CGCGCTGTCA 2340

CAGGGGCGCA GCAAAGCAGC ATCAGTTCTC TCCGGAGGCG GATCAAGCAG CATCTCTGGG 2400

TTAACTGGAA AAGGATCCAC TTACAGTTCC AACCTCAGTG CCAAGAAGAA CAAGATCACC 2460

ACTACCAGCG TGCCTCTTTT CAGCCTTTTC CAAGATGAGG TGGACATTGG CAAACTGAAC 2520

GCCATGGACA AAGAGATCAA GTCCGAAATG AGGGGGAAGA TGGCCGTGTA TGAGAAGAAA 2580

AAGATCCTGG AGGACAACAA ACGCAGTACG CTCTTCAAGA AAAAGAAACC AAAGGAGGAC 2640

GAAGAC 2646

Domain Profile

S: 2     vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd  61

         v+e++p+++++++ +a+++  L+++git+v+n+++++    ++ +++  ++++y++i+ d

Q: 137   VDEVWPNIFITEKSVAVNKARLKRMGITHVLNTAHGTGV-YTGESFYSGMNVQYMGIELD  195

         89*********************************8765.7999****************

S: 62    Dsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAi  120

         D ++ d++ +f+++aef+dea  +++gkvlv + +GvsRSa lv aYLm+++++++ +A+

Q: 196   DFPDADISVHFRPTAEFLDEAlLTHKGKVLVVSMMGVSRSAILVAAYLMIFQNMTIMEAL  255

         *********************88999**********************************

S: 121   eavkrkrpsiepnegfleQLlelekkl  147

         + +++kr  i+pnegfl+QL+e++++l

Q: 256   TSIRKKR-PINPNEGFLKQLREFNENL  281

         *******.69*************9877

Domain Sequence
(FASTA)

VDEVWPNIFI TEKSVAVNKA RLKRMGITHV LNTAHGTGVY TGESFYSGMN VQYMGIELDD 60

FPDADISVHF RPTAEFLDEA LLTHKGKVLV VSMMGVSRSA ILVAAYLMIF QNMTIMEALT 120

SIRKKRPINP NEGFLKQLRE FNENL 145

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013