EKS-TAR-00390
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00390
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR490.91.8E-147690947258
StatusUnreviewed
Ensembl ProteinENSTRUP00000029912
UniProt AccessionH2TYZ9;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR (1 of 2)
Gene Synonyms/Alias EGFR (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000011834ENSTRUP00000029907ENSTRUT00000030024
ENSTRUG00000011834ENSTRUP00000029908ENSTRUT00000030025
ENSTRUG00000011834ENSTRUP00000029914ENSTRUT00000030031
ENSTRUG00000011834ENSTRUP00000029915ENSTRUT00000030032
ENSTRUG00000011834ENSTRUP00000029912ENSTRUT00000030029
ENSTRUG00000011834ENSTRUP00000029913ENSTRUT00000030030
ENSTRUG00000011834ENSTRUP00000029911ENSTRUT00000030028
ENSTRUG00000011834ENSTRUP00000029910ENSTRUT00000030027
ENSTRUG00000011834ENSTRUP00000029909ENSTRUT00000030026
OrganismTakifugu rubripes
Functional Description
Protein Length963
Protein Sequence
(FASTA)
AVCQGITNRL NLLGSREDHY ANMLKTYSNC TVVLENLEIT YMEEDRDLSF LRSIEEVGGY 60
VLIALNTVSK IRLDNLRIIR GHSLYEKKFA LSVIANFNKS TGQGTSELLL NSLTEILKGG 120
IKISGKVLCN VETIQWYDIV NVETKPVMEL PVASNNPQCQ KCDSSCFNGS CWAPGPQNCQ 180
TLTKLNCAQQ CSKRCKGTSP IDCCNEHCAA GCTGPRPTDC LACRDFQDDG VCKDSCPGLM 240
RYDPNLHQLV PNPHGKYNFG ATCVKTCPHN YVVTDHGACV RTCSGNTYEV DEGGMRKCAK 300
CEGLCPKVCN GLGTGELTNA MSINATNIES FRNCTKINGN IAIIRTSIHG DAYTKTPKMH 360
PSQLDVFKTV KEITGYLLIQ TWPDNISSLS PFENLEIIRG RTKRGSRSLM VANLGITSLG 420
LRSLKEISDG DVIIMKNKNL CYTSKSHWKK LFKSDSQHPT IDENADAATC AQRNNSCDRK 480
CTAEGCWGSG PDMCFACSNY SRGGSCVDSC NILEGEPREA VVDKTCVECH PECERMNGTA 540
TCIAPGSGNC TRCANSQDGL FCVSRCPQGV PGEDETLVWK YADNNKVCQL CHKNCTQGCT 600
GPGLAGCQNK SFCLSFSTSG FSMIAAGVVG GLLAALIAGL SVFVLLRRRH IKRKRTMRRL 660
LQERELVEPL TPSGEAPNQA LLRILKEPEF KKIKVLGSGA FGTVYKGLWV PEGEDVKIPV 720
AIKVLREATS PKANKEILDE AYVMASVEHP HVCRLLGICL TSTVQLITQL MPYGCLLDYV 780
KENRDNIGSQ YLLNWCVQIA KKGMNYLEER HLVHRDLAAR NVLVKTPQHV KITDFGLAKL 840
LNADEKEYHA DGGKVPIKWM ALESILNRTY THQSDVWSYG VTVWELMTFG TKPYDGIPAS 900
EIAGILEKGE RLPQPPICTI DVYMIMVKCW MIDADSRPRF RELIAEFTKM ARDPSRYLVI 960
QRE 963
Nucleotide Sequence
(FASTA)
GCAGTATGTC AAGGCATCAC CAATCGTTTA AACCTGTTGG GTTCCAGAGA GGACCATTAT 60
GCAAACATGC TGAAGACTTA CAGCAACTGC ACTGTAGTTC TGGAGAACCT GGAGATCACT 120
TATATGGAGG AGGATCGTGA CCTGTCCTTC CTCAGGTCTA TTGAAGAAGT GGGCGGATAT 180
GTGCTGATTG CTCTCAACAC GGTGTCCAAG ATTCGCCTGG ATAACCTCCG AATCATCCGC 240
GGTCATTCGC TTTACGAAAA GAAGTTTGCC CTGTCGGTGA TTGCCAACTT CAACAAGAGT 300
ACTGGCCAGG GCACCAGCGA GCTGCTTCTG AACAGCCTCA CAGAGATTCT TAAGGGAGGA 360
ATCAAAATTT CAGGCAAAGT GCTCTGCAAT GTGGAAACCA TCCAGTGGTA TGACATTGTC 420
AATGTTGAGA CCAAACCCGT CATGGAGCTT CCAGTAGCCA GCAACAATCC ACAGTGCCAG 480
AAATGTGACT CGAGTTGCTT TAATGGTTCA TGCTGGGCAC CTGGTCCTCA AAACTGTCAG 540
ACCTTAACAA AGCTGAACTG TGCACAGCAG TGTTCTAAGA GATGCAAAGG AACCTCACCC 600
ATTGATTGCT GTAATGAGCA CTGTGCTGCT GGCTGCACCG GGCCGCGGCC CACCGACTGT 660
CTGGCATGTC GGGACTTCCA GGACGACGGG GTGTGTAAGG ACTCATGCCC AGGTCTTATG 720
CGCTACGACC CCAACCTTCA CCAACTCGTA CCCAATCCTC ATGGAAAGTA CAACTTTGGG 780
GCCACCTGTG TCAAAACCTG TCCACATAAT TATGTTGTGA CGGATCACGG AGCGTGCGTG 840
CGTACATGCA GCGGGAACAC ATATGAGGTG GATGAGGGCG GAATGAGGAA GTGCGCCAAA 900
TGTGAAGGAC TATGCCCAAA AGTGTGTAAC GGGCTCGGGA CAGGAGAACT GACGAACGCT 960
ATGTCCATCA ATGCCACCAA CATCGAATCC TTTAGAAATT GCACAAAAAT CAATGGTAAC 1020
ATTGCTATCA TCCGCACATC AATTCATGGC GACGCATATA CCAAAACGCC AAAGATGCAC 1080
CCTTCCCAAC TAGATGTGTT CAAGACAGTT AAAGAAATTA CTGGATATTT GTTGATTCAA 1140
ACATGGCCAG ACAACATAAG CTCACTGAGC CCTTTTGAGA ACCTGGAGAT CATTCGGGGC 1200
CGAACAAAAC GTGGTAGCCG TAGTTTGATG GTGGCTAATC TTGGGATCAC ATCACTGGGC 1260
CTTCGCTCCT TGAAAGAAAT CAGTGATGGA GATGTGATCA TCATGAAAAA CAAGAACCTG 1320
TGCTACACCA GTAAAAGCCA CTGGAAAAAG CTCTTCAAGT CGGACAGCCA ACATCCCACC 1380
ATAGATGAAA ACGCTGATGC TGCCACATGT GCCCAAAGGA ACAACAGTTG TGACAGGAAG 1440
TGCACTGCAG AAGGCTGCTG GGGCTCCGGC CCGGACATGT GTTTTGCCTG CAGTAACTAC 1500
AGCCGCGGTG GGAGTTGTGT TGACTCCTGC AACATCCTGG AGGGTGAACC ACGGGAGGCT 1560
GTTGTGGATA AAACCTGCGT GGAGTGTCAC CCCGAGTGTG AACGCATGAA CGGGACCGCA 1620
ACCTGCATTG CTCCTGGTAG TGGAAACTGT ACAAGGTGTG CCAACTCTCA GGATGGACTG 1680
TTCTGCGTGT CTCGGTGTCC CCAAGGTGTG CCAGGGGAAG ATGAGACACT CGTGTGGAAA 1740
TACGCAGACA ACAATAAAGT GTGCCAACTG TGCCACAAAA ACTGCACTCA AGGGTGCACT 1800
GGTCCTGGTC TTGCAGGTTG CCAAAATAAA AGTTTCTGCC TGTCTTTCAG CACGTCTGGT 1860
TTTTCAATGA TTGCGGCTGG TGTTGTTGGC GGGCTGCTAG CTGCTCTTAT AGCGGGCCTG 1920
TCTGTTTTTG TGTTACTACG CCGACGCCAC ATCAAGAGGA AGCGAACCAT GCGCCGACTT 1980
CTCCAAGAGA GAGAGTTGGT TGAACCTTTG ACACCAAGCG GGGAGGCACC AAACCAGGCT 2040
CTGTTGCGTA TCCTGAAAGA GCCCGAATTC AAGAAAATCA AAGTGCTCGG ATCAGGGGCT 2100
TTCGGCACAG TTTACAAGGG CCTGTGGGTT CCAGAGGGAG AGGATGTGAA GATCCCAGTG 2160
GCCATCAAGG TTTTACGAGA GGCAACATCA CCAAAAGCAA ACAAGGAGAT TTTGGATGAG 2220
GCGTATGTGA TGGCCAGCGT GGAACACCCG CATGTTTGCC GCCTGCTTGG CATCTGCCTG 2280
ACCTCAACTG TGCAGCTCAT CACCCAGCTG ATGCCCTACG GCTGCCTTCT GGACTACGTC 2340
AAAGAGAACA GGGATAATAT CGGCTCCCAG TACTTGCTCA ACTGGTGTGT GCAGATAGCT 2400
AAGAAGGGTA TGAACTACCT AGAGGAGCGT CACCTGGTAC ACCGCGACTT GGCGGCCAGA 2460
AATGTCCTCG TCAAGACCCC GCAACATGTC AAGATCACAG ACTTCGGTCT GGCCAAGCTC 2520
CTCAATGCGG ATGAGAAAGA GTACCATGCA GATGGCGGGA AGGTGCCAAT AAAATGGATG 2580
GCTCTTGAAT CCATCCTGAA CAGGACGTAC ACACACCAGA GTGATGTTTG GAGTTATGGC 2640
GTGACAGTGT GGGAGCTGAT GACATTTGGG ACCAAACCAT ATGATGGGAT CCCAGCCAGT 2700
GAGATAGCTG GGATCCTGGA GAAAGGCGAG AGGCTGCCTC AACCACCAAT CTGTACCATA 2760
GATGTCTATA TGATAATGGT GAAGTGTTGG ATGATTGATG CTGACAGCCG GCCTCGTTTC 2820
CGGGAACTAA TAGCCGAGTT TACAAAGATG GCTCGAGATC CTTCTCGCTA TCTTGTCATA 2880
CAGAGAGAA 2889
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+w+pege+vkipvaikvl+e+t++kanke+ldea+v+as++h
Q: 690   FKKIKVLGSGAFGTVYKGLWVPEGEDVKIPVAIKVLREATSPKANKEILDEAYVMASVEH  749
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqia.kGmsylee  119
         ++++rllg+cl+st+ql+tql+p+Gclldyv+e++d++Gsq+llnwcvqia kGm+ylee
Q: 750   PHVCRLLGICLTSTVQLITQLMPYGCLLDYVKENRDNIGSQYLLNWCVQIAkKGMNYLEE  809
         **************************************************955*******
S: 120   krlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrk  179
         ++lvhrdlaarnvlvk+p+hvkitdfGlakll+adeke++a+ggkvpikw+alesil+r+
Q: 810   RHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILNRT  869
         ************************************************************
S: 180   ythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkc  239
         ythqsdvwsyGvtvwel+tfG+kpydgipa+ei  +lekGerl+qppictidvym++vkc
Q: 870   YTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGERLPQPPICTIDVYMIMVKC  929
         ************************************************************
S: 240   wmidaesrpkfkelaeef  257
         wmida+srp+f+el++ef
Q: 930   WMIDADSRPRFRELIAEF  947
         ****************99
Domain Sequence
(FASTA)
FKKIKVLGSG AFGTVYKGLW VPEGEDVKIP VAIKVLREAT SPKANKEILD EAYVMASVEH 60
PHVCRLLGIC LTSTVQLITQ LMPYGCLLDY VKENRDNIGS QYLLNWCVQI AKKGMNYLEE 120
RHLVHRDLAA RNVLVKTPQH VKITDFGLAK LLNADEKEYH ADGGKVPIKW MALESILNRT 180
YTHQSDVWSY GVTVWELMTF GTKPYDGIPA SEIAGILEKG ERLPQPPICT IDVYMIMVKC 240
WMIDADSRPR FRELIAEF 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00290
EKS-BOT-00297
EKS-CAF-00304
EKS-CAP-00333
EKS-DAR-00652
EKS-EQC-00289
EKS-FEC-00283
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-NOL-00274
EKS-ORN-00386
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00358
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-POA-00289
EKS-RAN-00314
EKS-TAG-00314
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013