EKS-TAR-00136
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00136
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec447.33.0E-134179430252
StatusUnreviewed
Ensembl ProteinENSTRUP00000030736
UniProt AccessionH2U1C2;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000012144ENSTRUP00000030733ENSTRUT00000030850
ENSTRUG00000012144ENSTRUP00000030732ENSTRUT00000030849
ENSTRUG00000012144ENSTRUP00000030736ENSTRUT00000030853
ENSTRUG00000012144ENSTRUP00000030735ENSTRUT00000030852
ENSTRUG00000012144ENSTRUP00000030734ENSTRUT00000030851
OrganismTakifugu rubripes
Functional Description
Protein Length435
Protein Sequence
(FASTA)
MTVTAEYNYL PMTTQDLELK KDEEYTILEM SDPNWWRARD KYGRNEGYIP SNYVVEAENG 60
LERFDWFCKN TNRSQAEKLL RTENKDGGFL VRDSSRPGKY TVSLRDTGAS CRHYNICTTP 120
QGHFYLAEKH YFSTIPELIV YHQHNAAGQC LKRKRECDSE RFSQIWFPAG VWEIDPRHLT 180
FIKDLGTGQF GVVKYGKWQG KHDVAIKMIK EGSMSEDDFI EEAKIMMKLH HENLVQLYGV 240
CTTQRPIYIV TEFLSNGCLL TYLREGLKQH PTMVQLLEMC KDVSEGMAYL ESKQYIHRDL 300
AARNCLVDSN GTVKVTDFGL SRYVLDDEYT SSVGAKFPVR WSPPEVLLYC KFSSKSDVWA 360
YGVLLWEVYT LGKLPYERLN NQEIVDKVSS GRRLYRPQLA SEKVYAVMTS CWHEKADERP 420
TFEELVLTVQ DLLDG 435
Nucleotide Sequence
(FASTA)
ATGACCGTCA CAGCAGAGTA TAACTACTTA CCCATGACGA CACAAGACCT GGAGCTGAAG 60
AAGGATGAGG AGTACACCAT CCTGGAGATG TCCGATCCCA ATTGGTGGAG GGCCAGAGAC 120
AAATACGGCA GGAATGAAGG CTACATCCCC AGCAATTATG TTGTGGAAGC TGAAAACGGG 180
CTAGAACGTT TCGACTGGTT TTGTAAGAAC ACAAATCGCA GCCAAGCAGA AAAACTGTTG 240
AGGACCGAGA ACAAAGATGG CGGCTTCTTG GTGCGAGACT CAAGCAGGCC TGGAAAATAC 300
ACAGTGTCTT TAAGAGACAC TGGTGCAAGC TGCAGGCATT ATAACATCTG CACCACTCCA 360
CAGGGACACT TTTACCTGGC TGAGAAGCAT TATTTCAGCA CCATCCCTGA GCTCATCGTC 420
TACCATCAGC ACAATGCAGC AGGTCAATGT CTCAAACGAA AAAGAGAGTG TGATTCTGAA 480
AGGTTCAGTC AAATCTGGTT TCCTGCAGGT GTGTGGGAGA TCGACCCTCG TCACCTCACC 540
TTCATCAAAG ACCTGGGCAC CGGCCAGTTT GGAGTGGTGA AGTACGGGAA GTGGCAGGGC 600
AAACACGACG TGGCCATAAA GATGATAAAA GAGGGCTCCA TGTCTGAGGA TGACTTCATA 660
GAGGAAGCAA AAATCATGAT GAAGCTCCAT CATGAAAACC TGGTCCAGTT GTACGGCGTG 720
TGCACCACAC AAAGACCAAT TTACATCGTG ACTGAGTTTC TGTCCAACGG CTGCTTGCTG 780
ACGTACCTCA GAGAAGGACT GAAGCAGCAC CCGACTATGG TCCAGCTGCT GGAGATGTGT 840
AAGGACGTCT CTGAAGGCAT GGCCTACCTG GAGTCCAAGC AATACATCCA CAGAGACCTG 900
GCTGCCAGGA ATTGTTTGGT AGACAGCAAC GGCACTGTTA AAGTGACAGA TTTTGGCTTA 960
TCGAGGTACG TCTTAGATGA TGAGTACACA AGTTCAGTAG GAGCCAAGTT TCCTGTTCGC 1020
TGGTCCCCTC CAGAGGTCCT CCTCTATTGC AAATTCAGCA GCAAATCAGA CGTCTGGGCT 1080
TATGGGGTCC TCCTGTGGGA GGTGTACACT TTGGGAAAGC TCCCATATGA ACGCCTCAAC 1140
AACCAGGAAA TTGTGGATAA GGTGTCCAGT GGTCGGCGCC TCTACCGTCC CCAGCTGGCC 1200
AGTGAGAAGG TCTACGCTGT CATGACCAGC TGCTGGCATG AGAAAGCAGA TGAGAGGCCT 1260
ACCTTTGAGG AGCTGGTTCT GACTGTTCAG GATCTGCTGG ATGGG 1305
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt++k+lg+gqfgvvk+gkw++k+dvaik+ikeg+mse+dfieeak+mmkl h++lvqly
Q: 179   LTFIKDLGTGQFGVVKYGKWQGKHDVAIKMIKEGSMSEDDFIEEAKIMMKLHHENLVQLY  238
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkkl.ekelllemckdvcegmeylerksfihr  119
         gvc+ q+piyivte+l+ngcll ylre  k+  +  +llemckdv+egm+yle+k++ihr
Q: 239   GVCTTQRPIYIVTEFLSNGCLLTYLREGLKQHpTMVQLLEMCKDVSEGMAYLESKQYIHR  298
         **************************98666515678***********************
S: 120   dlaarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdv  179
         dlaarnclvd++ +vkv+dfgl+ryvldd+y+ssvgakfpv+wsppevl y k+ssksdv
Q: 299   DLAARNCLVDSNGTVKVTDFGLSRYVLDDEYTSSVGAKFPVRWSPPEVLLYCKFSSKSDV  358
         ************************************************************
S: 180   wafgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpee  239
         wa+gvl+wev+++gklpye+ +n+e+v+kvs g rlyrp+las+kvy vm+scw+ek++e
Q: 359   WAYGVLLWEVYTLGKLPYERLNNQEIVDKVSSGRRLYRPQLASEKVYAVMTSCWHEKADE  418
         ************************************************************
S: 240   rptfkellsale  251
         rptf+el+ +++
Q: 419   RPTFEELVLTVQ  430
         *******98775
Domain Sequence
(FASTA)
LTFIKDLGTG QFGVVKYGKW QGKHDVAIKM IKEGSMSEDD FIEEAKIMMK LHHENLVQLY 60
GVCTTQRPIY IVTEFLSNGC LLTYLREGLK QHPTMVQLLE MCKDVSEGMA YLESKQYIHR 120
DLAARNCLVD SNGTVKVTDF GLSRYVLDDE YTSSVGAKFP VRWSPPEVLL YCKFSSKSDV 180
WAYGVLLWEV YTLGKLPYER LNNQEIVDKV SSGRRLYRPQ LASEKVYAVM TSCWHEKADE 240
RPTFEELVLT VQ 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CII-00053
EKS-DAR-00355
EKS-DRM-00050
EKS-EQC-00104
EKS-ERE-00053
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MIM-00047
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TEN-00126
EKS-TUT-00096
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013