EKS-TAR-00381

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00381

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/DDR	429.5	1.4E-128	592	879	288

Status

Unreviewed

Ensembl Protein

ENSTRUP00000030974

UniProt Accession

H2U208;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000012234	ENSTRUP00000030974	ENSTRUT00000031092
ENSTRUG00000012234	ENSTRUP00000030973	ENSTRUT00000031091
ENSTRUG00000012234	ENSTRUP00000030969	ENSTRUT00000031087
ENSTRUG00000012234	ENSTRUP00000030972	ENSTRUT00000031090
ENSTRUG00000012234	ENSTRUP00000030971	ENSTRUT00000031089
ENSTRUG00000012234	ENSTRUP00000030967	ENSTRUT00000031085
ENSTRUG00000012234	ENSTRUP00000030970	ENSTRUT00000031088
ENSTRUG00000012234	ENSTRUP00000030968	ENSTRUT00000031086

Organism

Takifugu rubripes

Functional Description

Protein Length

880

Protein Sequence
(FASTA)

AHCRYALGME DGRIPDEAIT ASSQWYETTG PQYARLNQEK GDGAWCPEPS DSQYLQVDLG 60

KLTFLTVVGT QGRYVQNSGK EFARAYRLNY SRDGLLWKSW RNRLGNEVIE GNKNTYASVI 120

NDLHPPIITR YIRLLPVTKL SPTVCMRVEL YGCPWEDGLI SYSAPEGQLM MPPASPNACL 180

NDSTYDGVHE RRRVEPRHCI PVPRWLCLTA VVSRRRLFGG MGQLTDGVIG LDDFLMTRQY 240

HVWPGYDYFG WKNDSLGTQG YVEMEFVFDK QRNFTSMKVH SNNMFSRGVK IFSSVSCWFK 300

PRLISSWEAA PVVFNTVLDD KNPSARYVTV PLNRRAAKSL RCRFFFADMW MMFSEISFQD 360

TSNSTLLTSG LFPAAASPSA SYPQEDSNTP ILIGCLVTII LLLVIIIFLI LWCQYVCKVL 420

EKAPRRILDE EVTVRLSSCS DTIILQTPPV PPRSSHAPSG LANSDPHYER VFLLDPQYQN 480

PAALRNKLPE LSQSAEASAL LLGNPLYDLL LLTSCHMTSG WLRACGGGYA EPDVTQCTPH 540

QCFHNSAPHY AETDIVRLQG VTGSNMYAVP ALTVDSLTRK DISAAEFPRQ QLIFREKLGE 600

GQFGEVHLCE AEGLPEFLGE GSPLPERNGC SVLVAVKQLR ADATSQARND FLKEIKIMSR 660

LNDPNIIRLL CVCVSSDPLC MVTEYMENGD LNMFLSQREI ESTLTHANNI PSVSLSDLLH 720

MAVQISSGMK YLASLNFVHR DLATRNCLLD RRLTIKIADF GMSRNLYSSD YYRIQGRAVL 780

PIRWMAWESI LLGKFTTASD VWAFGVTLWE IFTLCKEQPY SLLSDEQVIE NTGEFFRNQG 840

RQIFLYAPPL CPPSLFELMM RCWGRDISDR PTFEGLYQAL 880

Nucleotide Sequence
(FASTA)

GCACACTGTC GCTATGCCTT GGGTATGGAG GATGGGCGGA TTCCAGACGA GGCCATCACA 60

GCATCCAGCC AATGGTACGA GACCACTGGA CCCCAATATG CGAGGCTGAA TCAAGAGAAA 120

GGAGATGGCG CTTGGTGTCC GGAGCCTTCA GACAGTCAGT ACTTGCAGGT GGACCTGGGC 180

AAGCTGACCT TCCTGACTGT GGTCGGGACT CAGGGACGAT ACGTCCAGAA CTCTGGAAAA 240

GAATTTGCCA GGGCGTACCG CCTCAACTAC AGCCGGGATG GACTGTTGTG GAAGTCTTGG 300

AGAAACCGTC TGGGAAATGA GGTGATAGAG GGCAACAAAA ACACGTATGC TTCAGTCATC 360

AACGACCTTC ACCCTCCCAT TATCACACGT TACATCAGGC TGCTTCCTGT CACCAAACTG 420

TCGCCCACAG TCTGCATGAG GGTAGAGCTG TACGGCTGTC CGTGGGAGGA TGGACTGATC 480

TCTTACAGCG CCCCAGAGGG CCAGCTCATG ATGCCCCCCG CTTCTCCCAA CGCCTGCCTC 540

AATGACTCCA CCTACGATGG GGTCCACGAG AGAAGGCGAG TGGAGCCGCG CCACTGCATC 600

CCTGTTCCGC GCTGGCTGTG TCTGACTGCT GTTGTGTCAC GCAGGAGGCT GTTTGGAGGG 660

ATGGGGCAGC TGACGGACGG CGTGATCGGC TTGGACGACT TCCTCATGAC TCGTCAGTAC 720

CACGTGTGGC CGGGCTACGA CTACTTTGGC TGGAAGAACG ACTCGCTGGG CACTCAGGGA 780

TACGTGGAGA TGGAGTTTGT CTTCGACAAA CAGCGGAACT TCACCTCCAT GAAGGTTCAC 840

AGTAACAACA TGTTTAGCCG TGGCGTGAAG ATCTTCTCCT CCGTCTCCTG TTGGTTTAAG 900

CCCCGCCTCA TTTCCAGCTG GGAGGCGGCG CCGGTGGTTT TCAACACAGT GCTGGACGAC 960

AAGAACCCGA GTGCTCGCTA CGTGACCGTG CCGCTCAATC GCCGCGCGGC GAAATCCCTC 1020

CGCTGTCGCT TTTTCTTCGC TGACATGTGG ATGATGTTCA GTGAGATCTC CTTTCAGGAC 1080

ACTTCAAACT CCACCCTCCT CACATCTGGT CTCTTTCCTG CAGCTGCCAG TCCATCAGCC 1140

AGTTACCCGC AGGAGGACAG CAACACGCCC ATTCTGATTG GCTGCCTCGT GACCATCATC 1200

CTGCTCTTGG TCATCATCAT CTTCCTCATC CTCTGGTGCC AATATGTCTG CAAGGTACTG 1260

GAGAAGGCTC CACGGCGGAT CCTGGATGAG GAGGTGACAG TCCGGCTCTC TTCCTGCAGC 1320

GACACCATAA TCCTTCAGAC GCCGCCGGTG CCCCCTCGCT CCAGCCACGC CCCCTCAGGC 1380

CTCGCCAACA GCGATCCTCA CTATGAGCGA GTTTTCCTGC TGGATCCACA GTACCAGAAC 1440

CCAGCGGCCC TGAGGAACAA GCTGCCAGAG CTGTCACAAA GCGCGGAGGC CTCAGCTCTC 1500

CTGCTCGGCA ATCCTCTCTA TGACCTCCTC CTGCTGACAT CCTGTCACAT GACATCAGGC 1560

TGGTTGCGTG CCTGTGGGGG AGGCTACGCC GAGCCGGACG TCACCCAGTG CACGCCTCAC 1620

CAGTGTTTCC ACAACAGTGC GCCGCACTAC GCAGAGACGG ACATCGTGAG GCTACAAGGC 1680

GTCACTGGCA GCAACATGTA TGCTGTTCCC GCCCTCACTG TGGACTCCCT CACCAGGAAG 1740

GACATCTCAG CCGCTGAGTT CCCGCGGCAA CAGCTGATCT TCAGGGAGAA GCTGGGGGAG 1800

GGACAGTTCG GAGAGGTCCA CCTGTGTGAG GCCGAAGGTC TCCCAGAATT CCTGGGTGAG 1860

GGGTCGCCCC TTCCTGAGAG AAATGGGTGT TCAGTTCTGG TGGCTGTGAA GCAGCTGAGG 1920

GCTGATGCCA CCAGCCAGGC CAGGAACGAC TTCCTGAAGG AAATCAAGAT CATGTCCCGC 1980

CTGAACGACC CCAACATCAT CCGGCTGCTG TGCGTGTGCG TGTCCTCCGA CCCGTTGTGC 2040

ATGGTGACTG AGTACATGGA GAACGGAGAC CTCAACATGT TCCTTTCGCA GCGAGAGATC 2100

GAGAGCACGC TGACACACGC CAACAACATC CCCTCCGTCA GTCTGTCTGA CCTCCTTCAC 2160

ATGGCGGTGC AGATCTCATC GGGGATGAAA TACCTGGCGT CTCTGAACTT TGTGCACCGC 2220

GACCTGGCAA CCAGAAACTG CCTGCTGGAC CGACGCCTCA CCATCAAGAT CGCCGATTTC 2280

GGGATGAGCC GGAACCTGTA CAGCAGCGAC TACTACCGCA TCCAGGGCCG GGCGGTGCTC 2340

CCCATTCGGT GGATGGCCTG GGAGAGCATC CTGCTGGGTA AGTTCACCAC AGCCAGCGAC 2400

GTGTGGGCGT TTGGTGTCAC CCTGTGGGAG ATCTTCACCC TGTGTAAGGA GCAGCCCTAC 2460

AGTCTGCTGT CTGACGAACA GGTCATCGAG AACACTGGCG AGTTCTTCAG GAACCAGGGC 2520

AGACAGATCT TCCTTTATGC CCCCCCACTG TGTCCACCCT CTCTATTCGA GCTGATGATG 2580

CGCTGTTGGG GTCGCGACAT ATCCGACCGG CCCACCTTTG AGGGACTTTA CCAAGCCCTG 2640

Domain Profile

S: 1     LlikeklGeGkfgevklCevegledlkekd.....skgsallvavkslredanknarkdf  55

         L+++eklGeG+fgev+lCe egl ++         ++g ++lvavk+lr+da+++ar+df

Q: 592   LIFREKLGEGQFGEVHLCEAEGLPEFLGEGsplpeRNGCSVLVAVKQLRADATSQARNDF  651

         799*******************99998877789989999*********************

S: 56    lkeikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflseheaeds..elakek  113

         lkeiki+srl+dPni+rll vcv  +plc+++ey+enGdln fls++e e++  ++++ +

Q: 652   LKEIKIMSRLNDPNIIRLLCVCVSSDPLCMVTEYMENGDLNMFLSQREIESTltHANNIP  711

         **********************************************99666511566779

S: 114   tlsyellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdy  173

         ++s + l+++a qi sg+kyL+slnfvhrdlatrncl+++ +t+kiadfg+sr+ly++dy

Q: 712   SVSLSDLLHMAVQISSGMKYLASLNFVHRDLATRNCLLDRRLTIKIADFGMSRNLYSSDY  771

         ************************************************************

S: 174   yrvqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvien  233

         yr+qGravlPiRwmawesillgkfttasDvWafgvtlwei+tlc+eqPy+ l+deqvien

Q: 772   YRIQGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPYSLLSDEQVIEN  831

         ************************************************************

S: 234   agelfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkl  281

         +ge+fr+q+r+++l  P++cp +l+el++rCw rd s+RP+fe l++

Q: 832   TGEFFRNQGRQIFLYAPPLCPPSLFELMMRCWGRDISDRPTFEGLYQA  879

         *******************************************99875

Domain Sequence
(FASTA)

LIFREKLGEG QFGEVHLCEA EGLPEFLGEG SPLPERNGCS VLVAVKQLRA DATSQARNDF 60

LKEIKIMSRL NDPNIIRLLC VCVSSDPLCM VTEYMENGDL NMFLSQREIE STLTHANNIP 120

SVSLSDLLHM AVQISSGMKY LASLNFVHRD LATRNCLLDR RLTIKIADFG MSRNLYSSDY 180

YRIQGRAVLP IRWMAWESIL LGKFTTASDV WAFGVTLWEI FTLCKEQPYS LLSDEQVIEN 240

TGEFFRNQGR QIFLYAPPLC PPSLFELMMR CWGRDISDRP TFEGLYQA 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Gallus gallus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007155	; P:cell adhesion
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000421	; Coagulation_fac_5/8-C_type_dom.
IPR008979	; Galactose-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00754	; F5_F8_type_C; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00231	; FA58C; 1.
SM00219	; TyrKc; 1.

Prosites

PS01285	; FA58C_1; 1.
PS01286	; FA58C_2; 1.
PS50022	; FA58C_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013