EKS-TAR-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	440.3	5.1E-132	13	297	285

Status

Unreviewed

Ensembl Protein

ENSTRUP00000031949

UniProt Accession

H2U4T7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5 (1 of 2)

Gene Synonyms/Alias

CDKL5 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000012621	ENSTRUP00000031949	ENSTRUT00000032072

Organism

Takifugu rubripes

Functional Description

Protein Length

896

Protein Sequence
(FASTA)

MKNPNIGDVM NKFEVLGIVG EGAYGVVLKC RHKETNEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EELPNGVPTD KARSYIYQLI 120

RAIHWCHKHD IVHRDIKPEN LLISSDDVLK LCDFGFARSL SEGTDANYTE YVATRWYRSP 180

ELLLGAPYGK AVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYN 240

NPRFHGLRFP AVNHHQTLER RYLGIIGGGL LDLLKNLLLL NPTERFLTEQ CLNHHAFQTL 300

RLVERSGPPT PTPVRSSKRK PHHGDNTTPS RSSHGGKSSG GHRSSSRECS SLPRHEDLHP 360

NTEGFLNGSI TAAINLSPTL HPKNYQPQIY NHSTSCSMDL ASSNLPHLLS PGEAKSKCDF 420

DLNLGSKVPD GPGAKYLNSN FRSQQNRHSF VEGKTSTLQS GDKHSRHAYM EAHSSTPSAK 480

FAYLNLSKSY GTLSDAKSVG NLNDVHLYAD EPTSRYFPSS CLDLTAPSSP AARRMDRLGL 540

GRRRRWRQRE SNTLDSSHRR SSIRLKASEE AKSPDGLDPG DSGIERSHAH SLSSPRDPLS 600

YGQGYTSPFS SQQRPHRHSM YVRRDHQRTH GAEEGLAVGQ GLPTRASSLQ LLSPQLSEQT 660

PTEVTHSRPP IRDSTRDNTA SFHTQRQKSE VGLYHDQQTE DGGSSKENRN IYSESMPRRV 720

GSFYRVPSPR PDNSFHDSRG QSRDSGLSSD GTRLTNHSKR QPGFDPWTGP DTVVLNPSEP 780

SKEKEKQGFF RAIKKKKKKS QMVTSQKSSR SSGHQSSRHR TRSKSRDRDK ERDQAKDWPH 840

EKLSDSHSPS QPLKSLRKLL HLTSSSSSQA APPDMHYQPL PNPASAQGGF TESRTH 896

Nucleotide Sequence
(FASTA)

ATGAAGAACC CCAACATCGG TGATGTGATG AATAAATTTG AAGTCCTTGG GATCGTGGGT 60

GAAGGTGCTT ACGGTGTTGT TTTGAAGTGT CGTCACAAGG AGACCAATGA AATTGTGGCC 120

ATTAAGAAAT TTAAGGACAG TGAAGAAAAT GAGGAGGTTA AGGAAACCAC GCTGCGGGAG 180

CTTAAGATGC TCCGCACCCT CAAGCAGGAG AACATCGTGG AGCTGAAGGA GGCCTTCCGC 240

AGACGAGGGA AGCTCTACCT CGTCTTTGAG TATGTGGAGA AGAACATGCT GGAGCTGCTG 300

GAGGAGCTGC CAAATGGCGT ACCAACCGAC AAAGCGCGCA GCTATATCTA CCAGCTAATC 360

AGAGCAATTC ACTGGTGCCA CAAGCACGAC ATAGTCCACC GGGACATAAA GCCTGAAAAC 420

CTTCTCATCA GCTCTGACGA TGTTCTCAAA TTGTGTGACT TTGGCTTCGC GCGCAGTCTC 480

TCAGAGGGAA CTGATGCTAA TTACACCGAG TACGTGGCCA CTAGATGGTA CCGCTCTCCA 540

GAGCTCCTGC TCGGGGCTCC GTATGGAAAG GCGGTGGACA TGTGGTCAGT GGGCTGCATA 600

TTAGGAGAGC TGAGCGACGG GCAGCCTCTG TTCCCGGGAG AAAGCGAGAT CGACCAGCTC 660

TTTACCATCC AGAAAGTGTT GGGCCCCCTA CCATCAGAAC AGATGAAGCT CTTCTATAAT 720

AACCCCCGCT TCCACGGGCT GAGGTTTCCT GCAGTGAATC ACCATCAGAC CCTGGAGAGA 780

CGATACCTGG GGATCATTGG TGGAGGCCTC CTGGATCTGC TGAAGAACCT GCTGCTGCTG 840

AACCCGACAG AGCGCTTTCT CACGGAGCAG TGCTTGAATC ACCACGCCTT CCAGACCCTG 900

CGGCTGGTGG AACGGTCCGG CCCACCCACA CCCACACCTG TGCGCTCCTC CAAGAGAAAA 960

CCTCACCATG GAGACAACAC CACCCCCAGC AGGTCGAGCC ACGGGGGGAA GAGCTCAGGA 1020

GGTCACCGCT CGAGCAGCAG AGAATGTTCC AGCCTGCCTC GACACGAAGA CCTCCACCCC 1080

AACACCGAGG GGTTCCTCAA CGGCAGCATC ACGGCGGCGA TTAATCTCAG TCCCACGCTG 1140

CATCCGAAGA ACTACCAGCC GCAGATCTAC AACCACTCCA CCTCGTGCAG CATGGACCTG 1200

GCCAGCAGCA ACCTGCCTCA TCTGCTCAGC CCCGGTGAAG CCAAGAGCAA GTGCGACTTT 1260

GACTTGAACC TGGGGTCGAA GGTTCCCGAC GGCCCGGGAG CCAAGTACCT CAACTCCAAC 1320

TTCCGCTCGC AGCAGAATCG CCATTCCTTT GTGGAGGGGA AGACCAGCAC GCTTCAGTCG 1380

GGTGACAAAC ACAGTCGCCA CGCCTACATG GAAGCCCACA GCTCCACGCC ATCTGCTAAG 1440

TTTGCCTATT TGAACTTGTC CAAGAGCTAC GGAACGCTCA GTGACGCCAA GTCGGTGGGG 1500

AATTTAAACG ACGTGCACCT TTACGCGGAC GAGCCCACAT CTCGCTATTT TCCTTCAAGT 1560

TGTCTGGACC TCACGGCTCC AAGCAGCCCT GCAGCCCGCC GCATGGACAG ACTGGGACTT 1620

GGGCGGCGGC GGCGGTGGCG GCAGAGAGAG AGCAACACGC TGGACTCGTC CCACAGGCGC 1680

TCCTCAATCC GTCTGAAGGC CTCGGAGGAG GCCAAATCGC CAGACGGCCT GGACCCCGGA 1740

GACAGCGGCA TTGAGAGGAG CCACGCTCAC TCGCTGTCAT CGCCGCGTGA CCCTCTGTCT 1800

TACGGTCAGG GGTACACCAG CCCCTTCTCC TCCCAGCAGC GGCCCCATCG CCACTCCATG 1860

TACGTACGGA GAGACCACCA GCGGACACAC GGGGCGGAGG AGGGGCTGGC AGTCGGGCAG 1920

GGCTTGCCTA CTAGAGCCAG CAGCCTCCAG CTGCTCTCTC CGCAGCTGAG CGAGCAGACA 1980

CCCACTGAGG TCACCCACAG CAGACCCCCA ATAAGGGACT CCACAAGGGA CAACACTGCG 2040

TCTTTTCACA CACAGCGGCA AAAAAGCGAG GTGGGCTTGT ATCACGACCA GCAAACAGAA 2100

GATGGGGGCT CCTCGAAAGA GAACCGCAAC ATCTACAGCG AATCCATGCC GAGGAGGGTG 2160

GGCAGCTTCT ACAGAGTTCC TTCTCCCCGG CCAGACAACT CTTTTCATGA CAGCAGAGGT 2220

CAGAGCCGAG ATTCTGGTTT GTCCTCCGAC GGAACCAGAT TGACAAACCA CTCCAAACGT 2280

CAGCCGGGAT TCGACCCCTG GACTGGCCCG GACACGGTGG TGTTGAACCC CTCAGAGCCA 2340

TCCAAAGAAA AAGAAAAGCA GGGTTTCTTC AGAGCCATTA AGAAGAAAAA GAAAAAAAGC 2400

CAAATGGTAA CTTCCCAAAA GTCCTCCAGG TCGTCCGGAC ACCAAAGCAG TCGACACAGG 2460

ACCCGTAGTA AAAGCAGAGA CCGGGATAAA GAGCGGGACC AGGCCAAGGA CTGGCCGCAT 2520

GAGAAACTGT CCGATTCCCA CTCCCCGAGT CAACCCCTGA AGTCTCTGCG TAAGCTCCTA 2580

CACCTCACCT CCTCCTCCTC CAGTCAGGCC GCACCCCCTG ACATGCACTA CCAGCCGCTG 2640

CCTAATCCAG CCTCTGCTCA GGGCGGATTC ACAGAGAGCC GCACTCAC 2688

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEVLGIVGEGAYGVVLKCRHKETNEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le+ pnGv++++ ++++yq+++ai++chk++i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGVPTDKARSYIYQLIRAIHWCHKHDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis ++v+klcdfGfar l+ +++++yt+yvatrwyr+pell+g + yGk+

Q: 133   HRDIKPENLLISSDDVLKLCDFGFARSLSeGTDANYTEYVATRWYRSPELLLG-APYGKA  191

         ****************************978899*******************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYNNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++ ++le++y   +   lldllk++l l+p+er+++e++l+h+ f

Q: 252   VNHHQTLERRYLgIIGGGLLDLLKNLLLLNPTERFLTEQCLNHHAF  297

         ***********9778899*************************987

Domain Sequence
(FASTA)

FEVLGIVGEG AYGVVLKCRH KETNEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE LPNGVPTDKA RSYIYQLIRA IHWCHKHDIV 120

HRDIKPENLL ISSDDVLKLC DFGFARSLSE GTDANYTEYV ATRWYRSPEL LLGAPYGKAV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYNNP RFHGLRFPAV 240

NHHQTLERRY LGIIGGGLLD LLKNLLLLNP TERFLTEQCL NHHAF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013