EKS-TAR-00576

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00576

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	414.4	5.3E-124	64	359	296

Status

Unreviewed

Ensembl Protein

ENSTRUP00000033127

UniProt Accession

H2U861;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000013056	ENSTRUP00000033127	ENSTRUT00000033253

Organism

Takifugu rubripes

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MSRHFLYNCS QPILDVKIAF CQGFGQQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60

LKRYQNLKPI GSGAQGIVCA GYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120

KNIISLLNVF TPQKSLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180

HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240

KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPSPEFMKKL QPTVRNYVEN 300

RPKYAGLTFP KLFPDCLFPA DSEHNKLKAS QARDLLSKML IIDPAKRISV DEALQHPYIN 360

VWYDPAEVEA PPPQIYDKQL DEREHSIDEW KELIYKEVMN FEERTKNGVV KGQPSPSGAA 420

VNSSESPPPS SSINDISSMS TDQTLASDTD SSLETSAGPL GCCR 464

Nucleotide Sequence
(FASTA)

ATGAGCAGAC ATTTCTTATA TAACTGCAGC CAACCGATCC TGGATGTGAA GATTGCCTTT 60

TGTCAGGGTT TTGGACAACA AGTGGATGTA TCATATATTG CCAAACATTA CAACATGAGC 120

AAAAGCAAAG TGGACAACCA GTTTTACAGC GTGGAGGTGG GGGACTCCAC CTTCACGGTC 180

TTAAAACGCT ACCAGAATTT GAAGCCCATC GGCTCTGGAG CTCAGGGAAT TGTCTGCGCG 240

GGCTACGATG CCGTCCTAGA CAGAAATGTG GCCATCAAGA AGCTGAGCAG ACCCTTCCAG 300

AACCAGACCC ATGCCAAGAG GGCATACCGG GAGCTCGTGC TCATGAAATG CGTCAATCAC 360

AAAAACATCA TCAGTTTATT AAATGTCTTC ACACCACAGA AATCATTAGA GGAATTCCAG 420

GATGTCTATC TAGTCATGGA GCTGATGGAC GCCAACCTCT GCCAGGTGAT TCAGATGGAG 480

CTCGACCATG AGAGAATGTC CTACCTGCTC TACCAAATGT TGTGTGGGAT CAAACATCTG 540

CACTCAGCCG GCATTATCCA CAGGGACCTC AAACCGAGCA ACATAGTGGT AAAGTCGGAC 600

TGCACCCTGA AAATCCTGGA CTTTGGCCTG GCTCGGACTG CAGGCACCAG CTTCATGATG 660

ACCCCCTACG TGGTGACGAG ATACTACAGA GCCCCAGAGG TGATCCTCGG CATGGGCTAC 720

AAGGAGAACG TGGATATTTG GTCGGTGGGG TGCATTATGG GAGAAATGGT GCGCCACAAA 780

ATCCTCTTCC CCGGGCGGGA CTACATCGAC CAGTGGAACA AGGTGATCGA GCAGCTGGGA 840

ACACCCTCTC CAGAGTTCAT GAAGAAGCTT CAGCCCACAG TGAGGAACTA CGTCGAGAAC 900

CGGCCGAAGT ACGCCGGCCT CACCTTTCCC AAACTGTTCC CCGACTGCCT TTTCCCTGCT 960

GACTCGGAGC ACAACAAACT CAAAGCCAGC CAGGCCAGAG ACCTGCTGTC CAAGATGCTG 1020

ATTATCGACC CTGCTAAAAG AATATCGGTG GATGAGGCCT TGCAGCACCC CTACATCAAT 1080

GTGTGGTACG ATCCAGCTGA AGTGGAGGCG CCCCCTCCAC AGATCTATGA CAAACAGCTG 1140

GATGAAAGAG AACACTCCAT TGATGAATGG AAAGAACTAA TTTACAAAGA GGTGATGAAC 1200

TTTGAGGAGA GAACGAAGAA TGGCGTTGTG AAGGGACAGC CTTCACCTTC AGGTGCAGCC 1260

GTGAACAGCA GCGAAAGCCC CCCTCCCTCC TCCTCCATCA ACGACATCTC CTCCATGTCC 1320

ACCGACCAGA CCCTGGCATC CGACACTGAC AGCAGCCTGG AGACCTCTGC AGGACCACTG 1380

GGGTGTTGCA GGTGA 1395

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++ +d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 64    YQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  123

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 124   ISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  182

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 183   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  239

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtps ef+kk++  ++rny+

Q: 240   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQP-TVRNYV  298

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+L++dp kRisv+eaL+hpY

Q: 299   ENRPKYAGLTFPKLFPDclfpadsehnklKASQARDLLSKMLIIDPAKRISVDEALQHPY  358

         *****************************99*****************************

S: 289   l  289

Q: 359   I  359

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAGYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPS PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDCLFPADSE HNKLKASQAR DLLSKMLIID PAKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013