EKS-TAR-00419
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00419
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20341.11.0E-10116273258
StatusUnreviewed
Ensembl ProteinENSTRUP00000033305
UniProt AccessionH2U8N3;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K3
Gene Synonyms/Alias MAP4K3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000013107ENSTRUP00000033306ENSTRUT00000033432
ENSTRUG00000013107ENSTRUP00000033297ENSTRUT00000033423
ENSTRUG00000013107ENSTRUP00000033304ENSTRUT00000033430
ENSTRUG00000013107ENSTRUP00000033298ENSTRUT00000033424
ENSTRUG00000013107ENSTRUP00000033305ENSTRUT00000033431
ENSTRUG00000013107ENSTRUP00000033299ENSTRUT00000033425
ENSTRUG00000013107ENSTRUP00000033302ENSTRUT00000033428
ENSTRUG00000013107ENSTRUP00000033303ENSTRUT00000033429
ENSTRUG00000013107ENSTRUP00000033300ENSTRUT00000033426
ENSTRUG00000013107ENSTRUP00000033301ENSTRUT00000033427
OrganismTakifugu rubripes
Functional Description
Protein Length814
Protein Sequence
(FASTA)
MNSSVDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 60
EIIMMKDCKH SNIVAYFGSY LRRDKLWISM EYCGGGSLQD IYHVTGPLSE SQIAYMSRET 120
LQGLYYLHNK GKMHRDIKGA NILLTDSGYV KLADFGVSAQ ITATLAKRKS FIGTPYWMAP 180
EVAAVERKGG YNQLCDIWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKL 240
KWTNNFHHFV KLALTKNPKK RPTAEKLLQH PFVSQPLSRT LAIELLDKAN NPDHSTYNDF 300
DDDDPEPESP VSVPHRIRST SRSTREGKTL SEINFGQVKF DPPLRKETEP HHEPWMSKNS 360
LNDKEKLHLS LLKSVEEELQ QSSSQQKHED SQSHSEDDGG GTIKRCPGPE MPSPAKTASN 420
VPPRPPPPKL PPHRRSSLGN ESPKVKSLHK PISNGLPPTP KVHMGACFTK VFNGCPLKIH 480
CATSWINPDT RDQYLIFGAE EGIYTLNLNE LHETSMEQLF PRRCTWLYVM NNCLLSISGK 540
ASQLYSHNLS GLFEQARQLQ KLPVAIPTHK LPDKMIPRKF AVSNKIPDTK GCQKCCVVRN 600
PYTGHKYLCG AFQSSVMLLE WVESMQRFML IKNIDFPLPC PLEVFEMLVV PEHTYPLICV 660
AVSKGTELNQ VVRFGTINPN CTSSWFTEAD TPQTCVIHIT QLERDTILVC LDRCIKIVNL 720
QGRLKSSRKL SAELTFNFQI EATVCLQDSV LAFWRHGMQG RSFKTNEITQ EISDSTRIFR 780
LLGSDRVVVL ESRPTDNPTA DSNLYILAGH ENSY 814
Nucleotide Sequence
(FASTA)
ATGAACTCCA GTGTCGACCT ATCTCGGCGG AATCCGCAGG AGGATTTCGA ACTGATCCAG 60
AGGATAGGAA GCGGCACTTA CGGAGATGTG TACAAGGCTC GCAATGTAAA CACGGGAGAA 120
CTGGCTGCTA TCAAAGTCAT CAAACTGGAA CCGGGTGAAG ATTTTGCTGT CGTCCAGCAG 180
GAGATTATAA TGATGAAGGA CTGTAAACAC TCAAACATCG TAGCCTATTT TGGCAGCTAT 240
CTCCGGAGAG ATAAGCTGTG GATCAGTATG GAGTACTGTG GAGGAGGTTC TCTGCAGGAT 300
ATCTATCATG TGACCGGGCC TTTGTCAGAG TCCCAGATAG CATATATGTC AAGAGAGACC 360
CTGCAGGGGT TATACTACCT GCACAATAAA GGCAAAATGC ACAGAGACAT TAAGGGCGCC 420
AACATCCTCC TGACAGACAG TGGATACGTT AAACTGGCTG ACTTTGGTGT TTCAGCGCAA 480
ATTACAGCAA CTCTTGCAAA GAGGAAGTCA TTTATTGGAA CTCCATACTG GATGGCTCCA 540
GAGGTCGCAG CGGTTGAAAG AAAAGGAGGT TACAACCAGC TCTGTGACAT TTGGGCTGTG 600
GGCATTACTG CAATAGAACT GGCTGAACTA CAGCCCCCTA TGTTTGACCT GCACCCCATG 660
AGGGCTCTCT TCTTAATGAC AAAGAGTAAT TTTCAGCCAC CTAAGTTGAA AGATAAACTC 720
AAGTGGACAA ATAACTTCCA CCATTTTGTC AAGCTGGCCC TGACCAAGAA TCCAAAAAAG 780
AGACCCACAG CTGAGAAACT GCTGCAGCAC CCTTTTGTGT CTCAGCCCCT CAGCAGAACT 840
TTGGCCATAG AGCTGCTGGA CAAAGCCAAC AACCCCGACC ACAGCACCTA CAACGACTTT 900
GATGATGACG ATCCTGAACC GGAGTCTCCA GTCTCTGTTC CTCATCGAAT TCGCTCTACC 960
AGCAGGAGCA CCAGGGAAGG AAAGACACTG TCAGAGATCA ACTTTGGTCA GGTGAAGTTT 1020
GATCCTCCAC TCAGAAAGGA GACTGAACCC CATCATGAAC CGTGGATGAG TAAAAATTCT 1080
CTAAATGATA AAGAAAAATT ACATTTGAGT CTTCTCAAAT CTGTGGAGGA AGAGCTGCAG 1140
CAGAGCTCAT CCCAACAGAA GCATGAGGAC AGCCAGTCGC ACAGTGAGGA CGACGGCGGG 1200
GGGACCATCA AGCGTTGTCC AGGTCCAGAG ATGCCAAGCC CTGCAAAGAC CGCCTCTAAC 1260
GTCCCCCCGC GGCCTCCTCC CCCGAAGCTG CCACCCCACC GTCGCAGTAG CCTAGGTAAC 1320
GAGAGCCCCA AAGTAAAATC TTTACATAAG CCAATCAGTA ATGGTCTCCC CCCAACGCCC 1380
AAAGTCCATA TGGGGGCGTG TTTCACCAAG GTGTTCAATG GCTGTCCATT AAAAATCCAC 1440
TGTGCCACCT CTTGGATCAA TCCTGACACC AGAGACCAAT ATTTGATATT TGGAGCCGAG 1500
GAGGGAATCT ACACTCTAAA CCTTAATGAA CTCCATGAGA CGTCAATGGA GCAGCTCTTT 1560
CCTCGGCGGT GTACATGGCT ATATGTCATG AACAACTGTC TTCTTTCCAT ATCTGGGAAA 1620
GCCTCACAGT TGTACTCCCA TAATCTGAGC GGCCTGTTTG AACAAGCCAG ACAGCTGCAA 1680
AAGCTACCAG TAGCCATTCC AACACACAAG CTGCCTGACA AGATGATTCC CAGGAAGTTT 1740
GCTGTGTCCA ATAAAATTCC AGACACTAAG GGGTGCCAAA AGTGCTGCGT AGTGCGTAAC 1800
CCATACACAG GGCATAAATA CCTGTGTGGA GCTTTTCAAT CCAGTGTCAT GTTGTTGGAG 1860
TGGGTGGAGT CCATGCAGAG GTTTATGCTC ATTAAGAACA TTGATTTCCC GCTGCCATGT 1920
CCATTGGAGG TCTTTGAAAT GTTGGTGGTC CCTGAACACA CCTACCCTCT AATCTGTGTG 1980
GCAGTCAGTA AAGGCACTGA ACTCAATCAG GTGGTCCGAT TCGGTACCAT CAACCCCAAC 2040
TGTACCTCCT CCTGGTTCAC AGAAGCAGAC ACACCACAGA CATGTGTGAT TCACATCACT 2100
CAGTTAGAGA GAGACACTAT CCTGGTCTGC CTGGACAGAT GTATAAAGAT TGTAAATCTC 2160
CAGGGGAGGT TGAAATCCAG CAGGAAGTTA TCAGCAGAAC TCACCTTCAA TTTTCAGATA 2220
GAAGCCACAG TCTGCCTTCA GGACAGTGTC CTGGCCTTCT GGAGGCACGG AATGCAGGGA 2280
CGGAGCTTTA AGACGAATGA GATCACGCAG GAGATCTCTG ACAGCACACG GATATTCAGA 2340
CTACTAGGAT CAGACAGGGT GGTGGTGCTG GAGAGTAGGC CTACAGACAA CCCTACAGCT 2400
GACAGTAACC TCTACATCCT GGCAGGCCAT GAAAACAGCT ACTGA 2445
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +el+++ig+G++g+vy+ar+++tgel+aik+i+le  e+ + +q+ei ++k++kh+niv+
Q: 16    FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHSNIVA  75
         899*********************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s+l++++lw+ mey+ gGsl+d+++  ++ +l+E+qiay+ re+l++L ylH+k+++
Q: 76    YFGSYLRRDKLWISMEYCGGGSLQDIYH--VTGPLSESQIAYMSRETLQGLYYLHNKGKM  133
         ****************************..******************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179
         Hrdik++niLlt++g VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++
Q: 134   HRDIKGANILLTDSGYVKLADFGVSAQITATLAKRKSFIGTPYWMAPEVAAVErKGGYNQ  193
         ****************************************************98889***
S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237
          +Diw++GItaielae +pP++dl+p++al++++k++  ppklk+k k++++f++fv+ +
Q: 194   LCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKLKWTNNFHHFVKLA  253
         ******************************999999888*********************
S: 238   lqknpekRpsasellkhkFl  257
         l+knp+kRp+a++ll+h+F+
Q: 254   LTKNPKKRPTAEKLLQHPFV  273
         *******************7
Domain Sequence
(FASTA)
FELIQRIGSG TYGDVYKARN VNTGELAAIK VIKLEPGEDF AVVQQEIIMM KDCKHSNIVA 60
YFGSYLRRDK LWISMEYCGG GSLQDIYHVT GPLSESQIAY MSRETLQGLY YLHNKGKMHR 120
DIKGANILLT DSGYVKLADF GVSAQITATL AKRKSFIGTP YWMAPEVAAV ERKGGYNQLC 180
DIWAVGITAI ELAELQPPMF DLHPMRALFL MTKSNFQPPK LKDKLKWTNN FHHFVKLALT 240
KNPKKRPTAE KLLQHPFV 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Cavia porcellus"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-CAP-00353
EKS-CII-00179
EKS-DIO-00040
EKS-DRM-00155
EKS-GAA-00395
EKS-ICT-00315
EKS-LAC-00337
EKS-MEG-00257
EKS-MOD-00308
EKS-ORN-00417
EKS-ORL-00400
EKS-PES-00285
EKS-PEM-00168
EKS-SUS-00279
EKS-TEN-00413
EKS-VIP-00037
EKS-XET-00383
EKS-XIM-00407
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013