EKS-TAR-00416

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00416

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	343.5	1.8E-102	15	272	258

Status

Unreviewed

Ensembl Protein

ENSTRUP00000033542

UniProt Accession

H2U9C4;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K2

Gene Synonyms/Alias

MAP4K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000013185	ENSTRUP00000033540	ENSTRUT00000033666
ENSTRUG00000013185	ENSTRUP00000033541	ENSTRUT00000033667
ENSTRUG00000013185	ENSTRUP00000033539	ENSTRUT00000033665
ENSTRUG00000013185	ENSTRUP00000033543	ENSTRUT00000033669
ENSTRUG00000013185	ENSTRUP00000033538	ENSTRUT00000033664
ENSTRUG00000013185	ENSTRUP00000033542	ENSTRUT00000033668
ENSTRUG00000013185	ENSTRUP00000033537	ENSTRUT00000033663
ENSTRUG00000013185	ENSTRUP00000033545	ENSTRUT00000033671
ENSTRUG00000013185	ENSTRUP00000033544	ENSTRUT00000033670

Organism

Takifugu rubripes

Functional Description

Protein Length

812

Protein Sequence
(FASTA)

MDRIGVSFQD PLDEYELIHR IGCGTYGEVF KARNKETSEL AAIKILKLDP GEDITYIQQE 60

ITMMKECKHK NIVAYFGSYH RNTKLWICME YCGGGSLQDI YYVTGPLKEK QIAYVCRETL 120

QGLHHLHETG KMHRDIKGAN ILLTQRGDVK LADFGVAAEI SASVAKRKSF IGTPYWMAPE 180

VVAVEKKGGY NHLCDIWALG ITAIELAELQ PPLFDLHPMR ALMLMSKSNF QPPRLKDKSK 240

WSSCFQSFVK MAVTKNPRKR PSAETLLQHA FVTQLLTCNL VIELLDMASN PDLHGVHVPN 300

VVDELENGEV TPDKIHSARR RLPAERTRSE EHFFFAAEVR LPLRKITEPH PDLEGRKSAL 360

FSPSSASLPA FTSLASSSED SGLLLRSSCT LKPDGAVAAD SPCPSGAVPH KTSASAPAIQ 420

TRPYSTLQRR AQLPKSKAPI SPEWSSMRRK TADSKANCHG LPPTPHVHMG ACFSKVFNGC 480

PLKIHCAVTW ILPKTRDQYL ILGAEEGIYR LNLNELHEDV LEKLLPHRCT WLYVMNNVLM 540

SVSGKSSQLF SHSLLVLFDQ RHLQRRNDSL SFSSHCSDRI KPRKFAVSVK IPHTKGCRRC 600

SVARNPYTDS TFLCAAVPSG LVLLLWYEPL QKFMHLKFIP ISLPDSLPIF ELLVSTTDEV 660

PQLCVGVRES IKGNPENSRQ FDIVELNNVL WSPTGMPSGA VKVTQIDRDT VLIALEKTVE 720

IVSLQGVPST ELVFGFPIET IVCLQDSVLA FWKHGLKGKS FNSDEVTQEI TDESRVFKVL 780

GTNSDIILQS TPTDDPSAQS NLYILTGHES SY 812

Nucleotide Sequence
(FASTA)

ATGGACAGGA TAGGGGTGTC CTTCCAGGAC CCTTTGGACG AGTACGAGTT GATTCACCGA 60

ATCGGGTGTG GCACTTATGG AGAAGTGTTT AAGGCACGTA ACAAAGAGAC ATCAGAACTG 120

GCAGCCATCA AGATCCTCAA GCTGGATCCT GGTGAAGACA TCACCTATAT CCAGCAGGAG 180

ATCACCATGA TGAAGGAGTG CAAGCACAAA AATATTGTGG CCTACTTCGG CAGCTACCAC 240

AGGAACACCA AGCTGTGGAT TTGTATGGAG TACTGTGGTG GAGGATCACT CCAGGATATT 300

TATTATGTAA CAGGCCCATT GAAGGAGAAG CAGATAGCGT ATGTGTGCAG AGAAACCCTC 360

CAGGGTTTAC ATCACTTACA TGAAACAGGC AAAATGCACA GAGACATTAA GGGAGCGAAC 420

ATCCTGTTGA CACAGCGCGG GGATGTGAAA CTGGCTGATT TTGGGGTGGC TGCGGAGATC 480

AGTGCCTCAG TAGCCAAAAG GAAGTCTTTC ATCGGAACCC CCTACTGGAT GGCTCCGGAG 540

GTAGTAGCGG TGGAGAAGAA GGGCGGCTAC AACCACCTGT GTGACATCTG GGCCCTCGGC 600

ATTACCGCCA TCGAACTGGC CGAGCTTCAG CCGCCCCTGT TTGACCTCCA TCCAATGAGA 660

GCGCTGATGC TGATGTCCAA GAGCAACTTC CAGCCTCCGA GGCTGAAAGA CAAATCCAAG 720

TGGTCTTCAT GCTTCCAAAG CTTTGTGAAA ATGGCTGTTA CGAAAAACCC CCGGAAAAGG 780

CCGTCAGCTG AGACGCTGCT GCAGCATGCG TTCGTGACAC AACTTTTGAC CTGTAATCTG 840

GTTATTGAGT TACTGGACAT GGCCAGCAAC CCCGACTTAC ACGGCGTCCA CGTTCCCAAC 900

GTGGTGGACG AGCTGGAGAA CGGTGAAGTG ACTCCGGATA AAATCCACTC GGCACGGAGA 960

CGGCTGCCGG CAGAGAGGAC ACGGTCTGAA GAACACTTTT TCTTTGCAGC TGAAGTCAGG 1020

CTGCCATTGA GGAAAATCAC TGAGCCTCAC CCTGATCTGG AGGGAAGGAA GAGTGCTTTG 1080

TTCAGCCCAT CTTCAGCATC TTTGCCAGCC TTCACCTCTT TGGCCTCCAG CAGCGAGGAC 1140

AGTGGTCTGT TGCTTCGATC CAGCTGCACG CTAAAGCCTG ACGGCGCCGT CGCTGCCGAC 1200

TCCCCTTGTC CTTCAGGTGC TGTGCCACAC AAGACATCAG CCAGTGCTCC AGCGATCCAA 1260

ACCCGCCCCT ACAGCACGCT GCAACGCAGA GCGCAACTTC CCAAAAGCAA GGCCCCGATA 1320

TCACCGGAGT GGAGCAGCAT GAGGAGGAAA ACTGCTGATT CTAAAGCCAA TTGTCATGGT 1380

CTTCCTCCAA CTCCACATGT CCATATGGGT GCCTGCTTCT CCAAAGTCTT CAATGGTTGT 1440

CCTCTGAAAA TTCACTGTGC TGTCACATGG ATTTTGCCAA AGACGAGAGA TCAGTATCTG 1500

ATACTTGGGG CAGAGGAGGG CATCTACAGG CTCAATCTAA ATGAACTCCA CGAAGATGTT 1560

TTAGAGAAGC TTCTCCCTCA TCGATGCACA TGGTTGTACG TTATGAATAA TGTACTGATG 1620

TCTGTATCAG GGAAGTCCTC CCAGCTCTTT TCCCACAGTC TCCTGGTGCT GTTTGACCAA 1680

AGACATCTGC AGAGGAGAAA CGACAGCCTG TCTTTCAGCA GCCACTGCAG CGACAGGATC 1740

AAACCCAGGA AGTTCGCTGT GTCGGTGAAG ATTCCGCATA CCAAAGGCTG CCGAAGGTGT 1800

AGTGTGGCGA GGAACCCTTA CACGGACAGT ACTTTTCTCT GTGCCGCTGT CCCGTCTGGC 1860

TTGGTTCTAC TGCTTTGGTA TGAGCCTCTG CAGAAATTCA TGCACCTAAA GTTCATACCG 1920

ATCAGCCTTC CAGATTCTCT GCCAATATTC GAGCTACTGG TGTCGACAAC AGATGAAGTG 1980

CCCCAGTTGT GTGTCGGTGT AAGAGAGTCC ATAAAAGGGA ATCCGGAAAA CAGCCGACAG 2040

TTTGATATCG TCGAACTGAA CAACGTGCTG TGGTCGCCGA CGGGTATGCC ATCTGGTGCA 2100

GTGAAAGTAA CTCAAATTGA CAGGGACACT GTTCTGATTG CACTGGAAAA AACTGTTGAG 2160

ATTGTGAGTC TCCAAGGAGT TCCATCCACA GAGCTGGTCT TTGGTTTCCC CATTGAGACA 2220

ATAGTCTGCT TGCAGGATAG CGTTTTGGCT TTCTGGAAGC ATGGACTTAA AGGGAAAAGT 2280

TTTAATTCAG ATGAGGTAAC ACAGGAAATT ACAGATGAGA GTAGAGTATT TAAAGTTTTG 2340

GGGACAAACA GTGACATTAT CCTTCAGAGC ACGCCAACGG ATGACCCTTC GGCTCAAAGC 2400

AATCTGTACA TTCTGACAGG ACATGAAAGC AGCTACTAA 2439

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         yel+++ig G++g+v++ar+k+t+el+aik+++l+  e+++ +q+ei+++k++kh+niv+

Q: 15    YELIHRIGCGTYGEVFKARNKETSELAAIKILKLDPGEDITYIQQEITMMKECKHKNIVA  74

         99**********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+ ++++lw++mey+ gGsl+d++   ++ +lkE+qiay++re+l++L++lH+ +++

Q: 75    YFGSYHRNTKLWICMEYCGGGSLQDIYY--VTGPLKEKQIAYVCRETLQGLHHLHETGKM  132

         ***************************9..9*****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgvaa+++++++krk+++gtpywmAPEv+a+e + gY++

Q: 133   HRDIKGANILLTQRGDVKLADFGVAAEISASVAKRKSFIGTPYWMAPEVVAVEkKGGYNH  192

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw+lGItaielae +pP++dl+p++al++++k++  pp+lk+k+k+s+ f++fv+ +

Q: 193   LCDIWALGITAIELAELQPPLFDLHPMRALMLMSKSNfqPPRLKDKSKWSSCFQSFVKMA  252

         ******************************999999888*********************

S: 238   lqknpekRpsasellkhkFl  257

         ++knp+kRpsa++ll+h+F+

Q: 253   VTKNPRKRPSAETLLQHAFV  272

         *******************7

Domain Sequence
(FASTA)

YELIHRIGCG TYGEVFKARN KETSELAAIK ILKLDPGEDI TYIQQEITMM KECKHKNIVA 60

YFGSYHRNTK LWICMEYCGG GSLQDIYYVT GPLKEKQIAY VCRETLQGLH HLHETGKMHR 120

DIKGANILLT QRGDVKLADF GVAAEISASV AKRKSFIGTP YWMAPEVVAV EKKGGYNHLC 180

DIWALGITAI ELAELQPPLF DLHPMRALML MSKSNFQPPR LKDKSKWSSC FQSFVKMAVT 240

KNPRKRPSAE TLLQHAFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Caenorhabditis elegans"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Gasterosteus aculeatus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Rattus norvegicus"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013