EKS-TAR-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	370.0	1.9E-110	213	505	293

Status

Unreviewed

Ensembl Protein

ENSTRUP00000033551

UniProt Accession

H2U9D4;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2 (1 of 2)

Gene Synonyms/Alias

TGFBR2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000013188	ENSTRUP00000033551	ENSTRUT00000033677
ENSTRUG00000013188	ENSTRUP00000033550	ENSTRUT00000033676

Organism

Takifugu rubripes

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

VILSWNRFTS SPGNIMNQLC KFCDVESSNC SGTGTCTSNC SITAICSSAE EICVALWRKN 60

ETGFSIETLC HDPSKSLYGM MLDDFNSSAC LMKEKNTTGG MVQVCSCTGD ECNNFLIFSP 120

VVDPSPDDPL VSVVLVSLLP LLVMGIAGMF YWYRVHRPRL RSQEWKSSIK KRKPKSGGLD 180

CSDVCVIMMD DDRSDSSSTD ANNLNHNTEP LPIELDQLVG KGRFAQVYKA KLKQAASDQF 240

ETVAVKIFPY EEYASWKNEK DIFSNSDLRH ENVLHFLTAE EKKAQRQYWL ITAFHTRGNL 300

QEHLTHNIIS WEELKILGSS LARGVSHLHS DRLPCGRPKV AIVHRDLKSS NILVKNDLTC 360

CLCDFGLGLQ LDSSLSVDDL ANSGQVGTAR YMAPEVLEAR LNLENIESFK QADIYSMALV 420

LWEMTSRCEA VGEVKDYEPA YGSKVREHPC VESMKDNVLR DRGRPEIPDT WLRHQGVAMM 480

CGTIMECWDH DPEARLTAHC VAERISEMED EMDKLSSHSS S 521

Nucleotide Sequence
(FASTA)

GTCATTTTAT CCTGGAATCG CTTCACCAGT AGCCCAGGAA ACATAATGAA CCAGCTCTGT 60

AAGTTCTGCG ATGTTGAATC CTCTAACTGC AGCGGGACGG GGACGTGCAC ATCCAACTGC 120

TCCATCACAG CCATCTGCTC CTCCGCTGAA GAAATCTGCG TGGCCCTCTG GAGGAAGAAC 180

GAGACAGGAT TCTCCATCGA GACTCTGTGT CACGACCCTT CAAAGTCACT TTACGGCATG 240

ATGCTGGATG ATTTCAACAG CTCCGCCTGC TTGATGAAGG AGAAGAACAC GACCGGTGGA 300

ATGGTTCAGG TCTGCTCCTG CACGGGGGAT GAGTGTAACA ACTTTCTGAT CTTCTCTCCC 360

GTGGTGGATC CGAGTCCCGA CGACCCCCTG GTGTCCGTGG TGCTGGTGAG CCTCCTCCCT 420

CTGCTGGTGA TGGGCATCGC AGGAATGTTC TACTGGTACC GAGTGCACCG GCCACGCCTG 480

CGCAGCCAAG AGTGGAAGAG CAGCATCAAG AAACGCAAAC CGAAAAGCGG AGGCCTGGAC 540

TGCAGTGACG TCTGCGTCAT CATGATGGAC GACGACAGAT CTGACAGCAG CTCCACGGAC 600

GCCAACAACC TGAACCACAA CACGGAACCG CTGCCAATAG AACTCGATCA GCTGGTGGGG 660

AAGGGTCGCT TCGCCCAGGT CTACAAGGCT AAGTTGAAGC AGGCCGCCTC CGATCAGTTT 720

GAAACGGTGG CCGTGAAGAT CTTCCCGTAC GAGGAATACG CTTCCTGGAA GAATGAGAAG 780

GACATCTTCT CCAATTCAGA CCTGCGGCAC GAGAACGTCC TCCACTTCCT TACAGCCGAG 840

GAGAAAAAGG CTCAGAGGCA GTACTGGCTC ATCACTGCCT TCCACACCAG AGGAAACCTG 900

CAGGAACACC TGACGCATAA CATCATCAGC TGGGAGGAGC TTAAGATTCT GGGGAGCTCG 960

TTAGCTCGGG GCGTCTCTCA CCTCCACAGT GACCGCCTCC CCTGCGGACG CCCAAAGGTT 1020

GCCATCGTCC ACCGTGACCT CAAGAGCTCC AACATCCTGG TGAAGAACGA CCTGACCTGC 1080

TGCCTGTGCG ACTTCGGGCT GGGCTTGCAG CTGGACAGCA GCCTGTCTGT GGATGATCTG 1140

GCCAATAGTG GACAGGTGGG TACGGCCCGT TACATGGCTC CTGAGGTACT GGAGGCCCGG 1200

CTGAACCTGG AAAACATTGA GTCCTTCAAG CAGGCCGATA TCTACTCCAT GGCGCTGGTG 1260

CTTTGGGAGA TGACGTCGAG GTGCGAAGCT GTTGGAGAGG TGAAGGACTA TGAGCCTGCC 1320

TATGGCTCCA AAGTGCGAGA GCACCCCTGT GTGGAGAGCA TGAAGGACAA CGTGCTGAGA 1380

GACAGAGGAA GGCCTGAGAT CCCCGACACC TGGCTCAGAC ACCAGGGCGT GGCCATGATG 1440

TGCGGCACCA TCATGGAATG CTGGGACCAC GACCCCGAGG CCCGGCTCAC GGCCCACTGC 1500

GTCGCCGAGC GCATCTCCGA GATGGAGGAC GAGATGGACA AACTGTCCAG CCACAGCTCG 1560

TCC 1563

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr+++V+kakl++      e+vAvKif++e+ aswk+Ek+i+++  lrhen

Q: 213   IELDQLVGKGRFAQVYKAKLKQaasdqfETVAVKIFPYEEYASWKNEKDIFSNSDLRHEN  272

         67899*****************99*999********************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         +l+f++a++k+   + +++l+t++h +g+L+++L+++++++eel  l +sla+G++hLH+

Q: 273   VLHFLTAEEKK--AQRQYWLITAFHTRGNLQEHLTHNIISWEELKILGSSLARGVSHLHS  330

         ********987..568********************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + +  +g+ K ai+HRDlks Nilvk+dltcc++D+GL l+l+++ ++ dla++ qvGt

Q: 331   D-RLPCGRPKVAIVHRDLKSSNILVKNDLTCCLCDFGLGLQLDSSLSVDDLANSGQVGTA  389

         *.577899****************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle +lnl+++e+fk+aD+Ys++LvlWE++sRce+  +ev++y++++ ++v+++

Q: 390   RYMAPEVLEARLNLENIESFKQADIYSMALVLWEMTSRCEA-VGEVKDYEPAYGSKVREH  448

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         P++e+mk+ v++++ rP+ip++w +++ +++++ ++ ecWd+dpeaRlta++v++r+

Q: 449   PCVESMKDNVLRDRGRPEIPDTWLRHQGVAMMCGTIMECWDHDPEARLTAHCVAERI  505

         *****************************************************9985

Domain Sequence
(FASTA)

IELDQLVGKG RFAQVYKAKL KQAASDQFET VAVKIFPYEE YASWKNEKDI FSNSDLRHEN 60

VLHFLTAEEK KAQRQYWLIT AFHTRGNLQE HLTHNIISWE ELKILGSSLA RGVSHLHSDR 120

LPCGRPKVAI VHRDLKSSNI LVKNDLTCCL CDFGLGLQLD SSLSVDDLAN SGQVGTARYM 180

APEVLEARLN LENIESFKQA DIYSMALVLW EMTSRCEAVG EVKDYEPAYG SKVREHPCVE 240

SMKDNVLRDR GRPEIPDTWL RHQGVAMMCG TIMECWDHDP EARLTAHCVA ERI 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013