EKS-TAR-00334

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00334

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	419.9	8.8E-126	38	290	253

Status

Unreviewed

Ensembl Protein

ENSTRUP00000033670

UniProt Accession

H2U9Q2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000013228	ENSTRUP00000033668	ENSTRUT00000033794
ENSTRUG00000013228	ENSTRUP00000033669	ENSTRUT00000033795
ENSTRUG00000013228	ENSTRUP00000033670	ENSTRUT00000033796
ENSTRUG00000013228	ENSTRUP00000033671	ENSTRUT00000033797

Organism

Takifugu rubripes

Functional Description

Protein Length

576

Protein Sequence
(FASTA)

MCEPTQRSCE PRRKRADERN APPEMARIIT DPATGKCYCR GKVLGKGGFA KCYEMTDLST 60

NKVYAAKIIP HARVSKPHQR EKIDREIELH RILHHKNIVH FYHHFEDKEN IYILLEYCSR 120

KSLAHILKAR KVLTEPEVRY YLRQIVSGLR YLHEQEILHR DLKLGNFFVN ESMELKVGDF 180

GLAAKLEPAG NRRKTICGTP NYLSPEVLNK QGHGCESDIW ALGCVMYTML LGRPPFETTN 240

LKETYRCIRE ARYSLPSSLS AQAKQLITNL LAKTPEDRPN LDLLLRHDFF TQGFSPERLP 300

ASCCHSAPDF HVSSPAKSFF KKAAAALFGG RREKVKYYET LNKLTKEEEE IYQLQHDLER 360

TAITQQRNQK VSESSLSPFP PPPPADNIPK GSNSCNLQWV TKWVDYSNKY GFGYQLSDHT 420

VGVLFNNGTH MSLLPDRKTI HYYAELGQRS VFPTCEVPEH FVGQVTVLKY FSHYMEENLM 480

DGGDLGSMTD ANMPRLYLLQ WLKSDRALMM LFNDGTFQVN FYHDHTKIVL CCQRDEYMLT 540

YINEDRVSKT FKLSSLLTSG CTADLQERMA YSLNML 576

Nucleotide Sequence
(FASTA)

ATGTGTGAGC CGACGCAGAG ATCCTGCGAG CCTCGCAGAA AGAGAGCCGA TGAACGCAAT 60

GCGCCCCCGG AGATGGCCAG GATAATCACC GATCCGGCCA CTGGGAAGTG CTACTGCCGT 120

GGGAAAGTTT TGGGAAAGGG AGGTTTTGCA AAATGCTACG AGATGACGGA CCTCTCCACC 180

AACAAAGTAT ACGCGGCCAA GATAATCCCA CATGCGCGCG TCTCCAAACC TCACCAACGG 240

GAGAAGATTG ACAGAGAGAT CGAGCTGCAC AGAATACTGC ACCATAAAAA CATTGTGCAC 300

TTTTATCACC ATTTCGAGGA CAAGGAAAAC ATCTACATCC TGTTGGAATA CTGCAGCCGC 360

AAATCATTAG CCCATATCCT GAAGGCTCGC AAAGTGCTTA CTGAGCCGGA GGTGCGTTAT 420

TATCTGAGGC AGATCGTCTC GGGACTGAGG TACCTGCACG AGCAAGAGAT CCTTCACAGA 480

GATCTGAAAC TTGGTAACTT CTTTGTGAAT GAGTCGATGG AGCTGAAAGT TGGCGACTTT 540

GGACTGGCTG CCAAGTTGGA GCCGGCAGGA AACAGAAGGA AGACGATCTG TGGAACTCCC 600

AACTACTTGT CCCCCGAGGT CCTCAACAAG CAGGGCCATG GCTGTGAATC AGACATCTGG 660

GCTCTGGGCT GTGTAATGTA CACCATGCTG CTGGGCAGGC CTCCATTTGA AACCACCAAC 720

CTGAAGGAGA CGTATAGGTG CATTAGAGAG GCACGTTACT CCCTGCCCTC CTCTCTCTCA 780

GCACAAGCTA AGCAGCTAAT CACCAATCTG CTAGCTAAGA CACCAGAAGA CCGACCCAAC 840

CTGGACCTCC TTCTAAGACA CGACTTTTTC ACACAGGGCT TCAGTCCAGA GCGTTTGCCG 900

GCAAGCTGTT GTCATTCGGC ACCAGATTTC CACGTCTCCA GTCCTGCAAA GAGCTTCTTC 960

AAGAAAGCTG CTGCTGCACT TTTTGGTGGA AGGCGAGAGA AGGTGAAATA CTACGAGACG 1020

CTGAACAAGC TAACCAAAGA GGAAGAGGAG ATCTACCAAC TGCAGCACGA TCTTGAGAGA 1080

ACAGCTATCA CCCAGCAACG GAACCAAAAA GTTTCTGAGT CCTCTCTCTC TCCATTTCCT 1140

CCCCCTCCCC CAGCGGATAA CATTCCGAAG GGATCAAACA GCTGCAATCT TCAGTGGGTG 1200

ACTAAATGGG TGGACTACTC CAACAAGTAC GGCTTCGGCT ACCAATTGTC TGATCACACC 1260

GTGGGAGTTC TCTTCAACAA CGGCACTCAC ATGAGCCTCC TCCCAGACAG AAAGACCATC 1320

CATTACTATG CAGAGCTGGG TCAGCGCTCC GTCTTCCCAA CATGTGAGGT TCCTGAGCAC 1380

TTTGTTGGCC AGGTGACTGT GCTGAAGTAC TTCTCCCACT ACATGGAGGA GAACCTAATG 1440

GACGGCGGGG ACCTCGGTAG TATGACAGAC GCAAACATGC CCAGACTCTA CCTGCTGCAG 1500

TGGCTCAAAT CTGACCGCGC CCTCATGATG CTTTTCAACG ACGGCACTTT CCAGGTCAAC 1560

TTCTACCACG ACCACACCAA GATCGTTCTT TGTTGTCAGA GGGACGAGTA CATGCTGACC 1620

TACATCAACG AGGACCGTGT CTCCAAAACC TTCAAACTCA GCTCCTTGTT GACGTCGGGC 1680

TGCACCGCCG ACCTGCAGGA ACGAATGGCG TACTCCCTGA ACATGCTT 1728

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl+t++v+a+k++p++++ k++qrek+++eie+hr l+hkn

Q: 38    YCRGKVLGKGGFAKCYEMTDLSTNKVYAAKIIPHARVSKPHQREKIDREIELHRILHHKN  97

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv++y++fedken+y++le+csr+sla++lk+rk+ltepevryylrqivsgl+ylhe++i

Q: 98    IVHFYHHFEDKENIYILLEYCSRKSLAHILKARKVLTEPEVRYYLRQIVSGLRYLHEQEI  157

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla++le++++r+kt+cGtPny++Pevl+k+gh++e+

Q: 158   LHRDLKLGNFFVNESMELKVGDFGLAAKLEPAGNRRKTICGTPNYLSPEVLNKQGHGCES  217

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+yslPssls++ak+li++ll+k+Pe+

Q: 218   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYSLPSSLSAQAKQLITNLLAKTPED  277

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+l+ +l+++f+

Q: 278   RPNLDLLLRHDFF  290

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LSTNKVYAAK IIPHARVSKP HQREKIDREI ELHRILHHKN 60

IVHFYHHFED KENIYILLEY CSRKSLAHIL KARKVLTEPE VRYYLRQIVS GLRYLHEQEI 120

LHRDLKLGNF FVNESMELKV GDFGLAAKLE PAGNRRKTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYSLPS SLSAQAKQLI TNLLAKTPED 240

RPNLDLLLRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013