EKS-TAR-00551

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00551

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	466.5	5.9E-140	67	329	263

Status

Unreviewed

Ensembl Protein

ENSTRUP00000033807

UniProt Accession

H2UA40;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000013281	ENSTRUP00000033805	ENSTRUT00000033931
ENSTRUG00000013281	ENSTRUP00000033806	ENSTRUT00000033932
ENSTRUG00000013281	ENSTRUP00000033807	ENSTRUT00000033933

Organism

Takifugu rubripes

Functional Description

Protein Length

1361

Protein Sequence
(FASTA)

RFEKIDAMLT DPKSEINTDC LLDGLDALVY DLDFPALRKN KSIDNFLNRY KETINKIRDL 60

RMKAEDYEVV KVIGRGAFGE VQLVRHKFTS KVYAMKLLSK FEMIKRSDSA FFWEERDIMA 120

FADSSWVVQL FFAFQDDRYL YMVMEYMPGG DLVNLMSNYD VPEKWARFYT AEVVLALDGI 180

HSMGFIHRDV KPDNMLLDKT GHLKLADFGT CMKMNKDGMV RCDTAVGTPD YISPEVLKSQ 240

GGDGYYGREC DWWSVGVFLY EMLVGDTPFY ADSLVGTYSK IMNHKNALTF PDDSDISNDA 300

KNLICAFLTD REVRLGRNGV DEIKRHPFFK NDQWTWENIR DTAAPVVPEL SSDIDTSNFD 360

DIEEDRGEEE TFPVPKAFVG NQLPFVGFTY YSNQHPLRRP STASKASDKR GSTTKEDKSH 420

LENLQKRIYQ LEEQLHSEMQ LKDELEQKCR ASHTKLEKIM KELDEEANIR KNTEASVSLL 480

EKDKIMLQHR FTEYQRKADQ EAEKRRNLEN EASTLKEQLE DMRKISQNSQ ASNDKIIQLQ 540

NQLEEANDLL RAESDTAARL RKNHTEMAKS MSQLESLNRE LQERSRAIDG EKAQLEKEVL 600

VIQSTLDSER RNYSQGSEEI RELQARMAGL QEDNKSLKLS LSKVEAERKQ AQERSNNLEK 660

EKNNLEIDLN YKLKTLQQRL EQEQTEHRVT RAQLTDKYES IEEAKSAAMN AVQQKMSEEI 720

GARMRAESRV VEVEKQCSML EFDLKQSVQK MEQLMKQKER LEDEVKSLRI QAEQELSKRV 780

LAQSELKSCM QEVDRLRCSE KQLKQEINTA LESKRSLEFQ LAQLTKQYRG NEGQMRELQD 840

QLEAEQYFST LYKTQVKELK EEIEERNRQV QEAHKKMQEL SSERDSLSAQ LDLTVTKAES 900

EQLARALQEE QCFELSQENK KSVARHKMEI IEKEAIISRL EESNKTLTKD AENLSKEKAE 960

LNEKLQTQEQ VMCLFFDRKE DIVNAVKANY EKVLNTERTL KTQAVNKLAE IMNRKDMKLD 1020

TKKKGSTTDL RKKEKENRKL QLELNQEKDK FNHMAIKYQK ELSEMQAQLA EEFSNRNELQ 1080

MQLDSKESDI EQLREKLNDL QQRMDNSSIT SLQTDETDSN IAESRLEGWL SIPNRANIKR 1140

YGWKKQYVVV SSKKILFYND EQNKEQSNPS MVLDIDKLFH VRPVTQGDVY RAETEEIPRI 1200

FQILYANEGE CRKEADMEPV LQGDKTNCLP HKGHEFIPTL YHFPSNCEAC AKPLWHVFKP 1260

PAALECRRCH VKCHKDHLDK KEDVIAPCKV NYDVTSARDM LLLALTQDEQ KKWIGHLGKK 1320

IPKTPPSTFS RASPRSMSTR SGPNQSFRKN PKSNTAERSP A 1361

Nucleotide Sequence
(FASTA)

CGATTCGAAA AAATCGATGC CATGCTGACT GATCCAAAGT CGGAAATAAA CACGGATTGT 60

CTTCTGGACG GCTTGGACGC ACTGGTGTAT GATCTGGACT TCCCAGCCCT GCGGAAAAAC 120

AAGAGCATCG ACAACTTTTT GAATAGATAT AAAGAAACCA TCAATAAAAT CCGGGATCTG 180

CGCATGAAAG CAGAGGACTA TGAGGTTGTC AAAGTTATAG GGAGGGGAGC GTTTGGAGAG 240

GTCCAACTGG TGAGGCACAA ATTCACAAGC AAGGTTTATG CGATGAAGCT ACTAAGTAAG 300

TTTGAGATGA TCAAGAGGTC GGACTCCGCT TTCTTTTGGG AGGAAAGGGA CATCATGGCT 360

TTTGCAGACA GCTCCTGGGT GGTACAGCTC TTTTTTGCAT TCCAAGATGA CCGCTACCTC 420

TACATGGTGA TGGAGTACAT GCCAGGGGGT GACTTGGTGA ATCTGATGAG CAACTATGAT 480

GTCCCAGAGA AATGGGCGCG CTTTTACACT GCTGAGGTGG TGCTGGCTCT GGATGGAATC 540

CACTCCATGG GCTTCATCCA CAGGGACGTG AAGCCTGATA ACATGTTGTT AGACAAAACA 600

GGCCACTTAA AACTGGCTGA CTTTGGGACC TGCATGAAAA TGAACAAGGA CGGTATGGTA 660

CGATGTGACA CGGCAGTGGG AACTCCAGAT TATATTTCAC CGGAGGTACT GAAGTCCCAG 720

GGAGGCGATG GATATTACGG CAGAGAGTGT GACTGGTGGT CAGTGGGAGT ATTCCTCTAT 780

GAAATGCTAG TCGGCGACAC GCCCTTTTAT GCAGACTCTC TGGTGGGAAC CTACAGCAAA 840

ATTATGAACC ACAAGAATGC CCTGACCTTC CCCGATGACA GCGACATATC CAATGACGCC 900

AAGAATCTCA TCTGTGCTTT TCTCACTGAC AGGGAGGTTC GACTTGGTCG TAACGGCGTA 960

GATGAGATAA AGAGGCATCC TTTCTTCAAG AATGACCAGT GGACCTGGGA AAACATCCGA 1020

GACACGGCCG CCCCAGTCGT GCCTGAACTG AGCAGTGACA TCGACACCAG TAACTTTGAT 1080

GACATCGAGG AGGATCGGGG TGAAGAGGAG ACCTTCCCGG TACCAAAGGC ATTTGTGGGA 1140

AACCAGCTCC CCTTTGTAGG CTTCACTTAC TACAGCAATC AGCACCCTTT GCGGAGGCCC 1200

AGCACTGCCT CAAAGGCCAG TGACAAACGC GGCAGTACTA CAAAAGAGGA CAAGAGTCAT 1260

CTGGAGAACC TGCAGAAAAG GATCTACCAG CTGGAGGAGC AGCTTCACAG CGAGATGCAG 1320

CTGAAGGATG AGTTGGAGCA GAAATGCAGG GCATCACACA CCAAGCTTGA AAAGATCATG 1380

AAGGAACTGG ACGAAGAGGC AAACATTAGA AAAAATACAG AGGCCAGCGT GTCTTTGCTG 1440

GAGAAGGACA AGATCATGCT GCAGCACCGA TTCACCGAGT ACCAAAGAAA AGCTGACCAG 1500

GAGGCAGAGA AGAGACGCAA CTTGGAAAAT GAGGCGTCAA CTTTAAAGGA GCAGCTTGAA 1560

GATATGAGAA AGATCAGCCA AAACTCACAG GCCTCAAATG ACAAAATTAT CCAACTGCAG 1620

AATCAGTTGG AAGAGGCCAA CGACCTCCTG CGCGCGGAGT CAGACACGGC AGCAAGATTA 1680

CGGAAAAACC ACACGGAAAT GGCCAAGTCC ATGAGCCAGC TGGAGAGCTT GAACCGGGAG 1740

CTGCAGGAGA GGAGCCGTGC CATAGATGGA GAAAAGGCCC AGTTGGAGAA GGAGGTCCTG 1800

GTGATTCAAA GCACCCTCGA CTCGGAGAGG AGGAACTACA GCCAGGGATC TGAGGAGATC 1860

AGGGAGCTTC AAGCAAGGAT GGCTGGGTTA CAAGAGGACA ACAAAAGTCT GAAGCTCAGC 1920

CTGTCAAAAG TGGAAGCCGA ACGCAAACAA GCCCAGGAGA GGAGCAACAA CCTGGAGAAG 1980

GAAAAGAACA ACTTGGAAAT TGACCTGAAC TACAAACTGA AGACTTTGCA ACAGCGTCTG 2040

GAGCAGGAAC AGACGGAGCA CCGGGTGACG CGGGCGCAGC TCACCGACAA ATATGAGTCC 2100

ATCGAAGAAG CCAAATCAGC CGCCATGAAT GCCGTTCAGC AGAAGATGTC TGAAGAAATT 2160

GGAGCCCGAA TGCGAGCCGA GAGTCGGGTA GTGGAAGTGG AGAAGCAGTG CTCCATGTTG 2220

GAGTTTGACC TCAAGCAGTC TGTTCAGAAG ATGGAGCAGC TGATGAAGCA AAAGGAACGA 2280

CTGGAAGACG AGGTGAAGAG CCTGCGAATA CAGGCAGAAC AGGAGCTGAG CAAGCGCGTG 2340

CTGGCTCAGA GCGAGCTGAA GAGCTGCATG CAGGAGGTGG ACCGCCTCAG GTGTTCTGAG 2400

AAGCAGCTCA AACAGGAGAT CAACACGGCG CTAGAGAGCA AACGCTCACT GGAGTTTCAG 2460

TTGGCACAAC TGACAAAACA ATATAGAGGC AATGAAGGAC AGATGAGGGA ACTTCAGGAC 2520

CAGCTTGAAG CTGAACAGTA TTTTTCCACG CTTTACAAAA CTCAGGTCAA GGAGCTAAAG 2580

GAGGAGATTG AAGAAAGGAA TCGGCAGGTG CAGGAGGCTC ATAAAAAGAT GCAGGAGCTG 2640

AGCAGTGAAA GGGACTCGCT ATCTGCTCAG CTGGATCTGA CCGTGACCAA AGCTGAATCG 2700

GAGCAGCTCG CCCGTGCTCT TCAGGAGGAG CAGTGCTTTG AGCTCAGCCA GGAGAATAAG 2760

AAGTCAGTGG CGAGACATAA GATGGAGATT ATTGAAAAAG AGGCTATTAT CTCACGGCTC 2820

GAGGAATCCA ATAAAACTCT AACCAAAGAT GCTGAAAACC TCAGCAAAGA GAAGGCGGAG 2880

TTAAATGAGA AACTTCAGAC TCAAGAACAA GTTATGTGTC TCTTTTTTGA CAGAAAAGAA 2940

GACATTGTAA ATGCAGTTAA GGCCAATTAT GAAAAGGTCC TAAACACAGA ACGCACGCTG 3000

AAGACTCAGG CTGTAAACAA GCTGGCAGAG ATCATGAATC GCAAGGACAT GAAGCTGGAC 3060

ACGAAGAAGA AGGGCAGCAC CACCGACCTG CGGAAGAAAG AGAAGGAGAA CCGCAAGCTT 3120

CAACTGGAAC TGAACCAGGA GAAGGACAAG TTTAATCACA TGGCCATCAA GTACCAGAAG 3180

GAGCTAAGCG AGATGCAGGC GCAATTAGCA GAGGAGTTTA GTAACCGCAA CGAGCTTCAA 3240

ATGCAGCTGG ACAGCAAGGA GAGTGACATC GAGCAGCTCC GAGAGAAGCT GAACGACCTG 3300

CAGCAGCGCA TGGACAACTC CAGCATCACC AGTCTGCAGA CAGATGAGAC GGACAGCAAC 3360

ATAGCAGAGT CCAGATTGGA GGGTTGGCTG TCCATTCCTA ACCGCGCTAA TATCAAGCGA 3420

TATGGATGGA AGAAGCAGTA TGTGGTGGTG AGCAGTAAGA AGATTCTCTT CTACAATGAT 3480

GAGCAGAATA AGGAACAGTC CAACCCCTCA ATGGTACTAG ATATCGACAA ATTATTTCAT 3540

GTGAGACCAG TTACACAAGG AGATGTATAC AGAGCTGAGA CAGAGGAGAT TCCCAGGATA 3600

TTCCAGATTC TCTACGCCAA CGAGGGAGAG TGCAGGAAGG AGGCGGACAT GGAGCCGGTC 3660

CTCCAGGGCG ACAAAACCAA CTGTCTCCCG CACAAAGGCC ACGAGTTCAT CCCCACGCTA 3720

TATCACTTTC CTTCCAACTG CGAGGCCTGT GCCAAACCCC TGTGGCACGT CTTCAAGCCG 3780

CCGGCGGCAT TAGAGTGTCG CCGCTGCCAC GTCAAGTGCC ACAAGGACCA CCTCGACAAA 3840

AAGGAGGACG TTATAGCTCC TTGCAAAGTA AACTACGATG TGACCTCTGC CCGAGACATG 3900

CTTCTACTGG CCCTCACCCA AGATGAGCAG AAGAAATGGA TCGGCCACCT CGGAAAGAAG 3960

ATCCCCAAAA CGCCACCCTC CACGTTTTCA CGAGCCTCAC CTCGTTCCAT GTCCACTCGC 4020

TCCGGACCAA ACCAGTCCTT CCGCAAGAAC CCTAAAAGCA ATACAGCAGA GCGCAGTCCA 4080

GCC 4083

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k t+kvyamk+l+k+e++kr++saff+eerd++++ads+w

Q: 67    YEVVKVIGRGAFGEVQLVRHKFTSKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFADSSW  126

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql++afqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald +h++g

Q: 127   VVQLFFAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDGIHSMG  184

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk+Gh+kladfG+c+k+n+dg+v++++avGtpdyispevlk+++ g+

Q: 185   FIHRDVKPDNMLLDKTGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQG-GD  243

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+ l+fp+d+++s++ak+l

Q: 244   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPDDSDISNDAKNL  303

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g++++k+hpff

Q: 304   ICAFLTDREVRLGRNGVDEIKRHPFF  329

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KFTSKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFADSSW 60

VVQLFFAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDGIHSMGFI 120

HRDVKPDNML LDKTGHLKLA DFGTCMKMNK DGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN ALTFPDDSDI SNDAKNLICA 240

FLTDREVRLG RNGVDEIKRH PFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013