EKS-TAR-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	438.2	2.4E-131	1024	1284	261

Status

Unreviewed

Ensembl Protein

ENSTRUP00000035732

UniProt Accession

H2UFL0;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R (1 of 2)

Gene Synonyms/Alias

MST1R (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000013975	ENSTRUP00000035729	ENSTRUT00000035857
ENSTRUG00000013975	ENSTRUP00000035730	ENSTRUT00000035858
ENSTRUG00000013975	ENSTRUP00000035734	ENSTRUT00000035862
ENSTRUG00000013975	ENSTRUP00000035733	ENSTRUT00000035861
ENSTRUG00000013975	ENSTRUP00000035732	ENSTRUT00000035860
ENSTRUG00000013975	ENSTRUP00000035731	ENSTRUT00000035859
ENSTRUG00000013975	ENSTRUP00000035738	ENSTRUT00000035866
ENSTRUG00000013975	ENSTRUP00000035737	ENSTRUT00000035865
ENSTRUG00000013975	ENSTRUP00000035736	ENSTRUT00000035864
ENSTRUG00000013975	ENSTRUP00000035735	ENSTRUT00000035863

Organism

Takifugu rubripes

Functional Description

Protein Length

1305

Protein Sequence
(FASTA)

WTTSSTPAPS PVNFSVVYTM PFFQAGGPIQ NIVNNSFYQE VYVASQNVIE AVNQSLEKVW 60

ELRTGPVGSP ECKICDLCNT DKDPSFLEDT NNEVLLLDTL FMYLYTCGSS QYGVCYFHQL 120

NSTGEPPSLS KCLYRKKSNS AAYCPDCVAS SLGTKVTMVE EGQTVYFFVA TTVNDSVTQR 180

YGRKSLSVRR PLATEDGFYS DVRGLTVLPS LRNTYHIEYV YSFFTQEFVF FLSVQRESPD 240

QESSPFQTRL GRLPRNEWEM KRYREVILEC RFEPKRRRRT VGSEPYKDVV YNVVQAAHFG 300

KAGRELAEEL GAEEEDDILY GVFAVTDDNG VTEHDSALCA FPVDNVNKAI ADGVDDCCQS 360

GPEQLSRGLC HFQPCESCPH ESMENNATCR DQPTMVSKPY YRVDLFNRQM TDVLLTSLLV 420

TTIENKTVAH IGTSTGRLLQ LVLTRSSPII FANYSLVENQ RVSSIAAVYS SEYLLFVVGD 480

KMIQVPQRGP GCQHFLTCAV CLTAPKFVGC GWCSGVCSWE SDCDHHWRND SCPPGITGFF 540

PRTAPPDGQT ELTVFGWEFQ SPLRPAITSR THQVRLGQTA CTVLPAKSNN SQMFMSNNLL 600

QNNLVCKIRI GTMELFRPVN ITVEVHEGKA EGRYSIDGKA EMSGFTFVIP NITEIQPNYG 660

PRIGGTLITV TGSHLDSGKT RKVTLNEVLC PIKRVTQPKG NVSSIICLSQ HISEVRDVPL 720

SVFIDKSPIL TTKVFYYKEN PTITAVLPDC SFDRGSKIVI EGENLDSVYR TIVRFKPNES 780

HLKPVTRECV GNSSPTKMEC FTPEFPRDET EEGELSFDMD GALGLWNKEF SYHPYGQPIP 840

FETEGHVLSL YPGFDEVSLH HQKLNLVSSC MTIVMTMAGV NCDAKVLDNE ITCRIPKNMS 900

IPSEGLPVKI SINGQIHNVG TVVRVSNHYM VGIVLGILAA LVAGAVLAFL VMKHLRKKKK 960

VATLNPPTPL SGSAGFPSLA YATGSIDPTL TPLIPPDKIS ISNFRPELLE EVKDVLIPAE 1020

MLVVQHHRII GKGHFGTVYH GYFADCNSRE IHCAVKSLNR ITDAEEVEQF LKEGIIMKGF 1080

HHCNVLSLLG ILLPQEGLPL VVLPYMKHGD LRHFIRCDKR NPTVKDLIGF GLQVATGMEY 1140

LAQKKFVHRD LAARNCMLDE SYTVKVADFG MARDVLDKEY YSVQNHRKAK LPVKWMAIES 1200

LQTQKFTSKS DVWSFGVLIW EMLTRGASPY PDVDPYDITH YLLRGRRLPQ PQFCPDPLYR 1260

IMLQCWDPDP ELRPSFATLV SAVSVILSNL EGEHYISLNV TYVNL 1305

Nucleotide Sequence
(FASTA)

TGGACCACCT CCTCCACACC GGCGCCCAGC CCCGTCAACT TCTCTGTGGT TTACACCATG 60

CCTTTCTTCC AAGCGGGAGG CCCCATCCAG AACATAGTCA ACAACTCCTT TTACCAGGAG 120

GTTTATGTGG CTTCTCAGAA TGTGATCGAA GCTGTCAACC AGAGTTTGGA GAAGGTATGG 180

GAGCTCCGCA CCGGGCCGGT GGGAAGCCCT GAGTGTAAGA TATGTGATTT ATGCAACACA 240

GACAAGGATC CCAGCTTCTT AGAGGACACA AACAATGAAG TTTTGCTGCT GGATACTCTG 300

TTTATGTATT TGTACACTTG TGGAAGCTCT CAGTATGGCG TTTGCTATTT CCACCAACTT 360

AACTCGACCG GAGAGCCGCC GTCTCTGTCC AAGTGTTTGT ATCGAAAGAA ATCAAACTCT 420

GCTGCCTACT GTCCCGACTG TGTGGCCAGT TCTCTGGGCA CCAAGGTCAC GATGGTCGAA 480

GAAGGTCAGA CGGTCTACTT CTTTGTTGCC ACCACCGTCA ACGACAGTGT GACGCAACGC 540

TACGGAAGGA AGTCCTTGTC AGTGCGCCGA CCACTGGCCA CGGAGGACGG CTTCTACAGC 600

GATGTGCGTG GCCTCACCGT CCTCCCAAGC TTGAGGAATA CTTATCATAT CGAATATGTC 660

TACAGCTTCT TCACCCAGGA GTTTGTCTTT TTTCTCTCGG TTCAAAGAGA GAGCCCCGAT 720

CAGGAGTCAT CTCCGTTTCA GACCCGCCTG GGCCGTCTCC CCCGGAATGA ATGGGAGATG 780

AAGCGGTACC GTGAGGTGAT CTTGGAGTGC CGGTTTGAAC CAAAACGCAG GAGGAGGACT 840

GTGGGTAGTG AACCCTATAA AGATGTGGTC TACAATGTGG TCCAGGCAGC CCACTTTGGC 900

AAAGCAGGAA GGGAGCTGGC AGAGGAGTTG GGGGCAGAGG AGGAGGATGA TATCCTCTAT 960

GGGGTGTTTG CTGTTACAGA TGACAATGGT GTTACCGAAC ACGACTCGGC CCTTTGCGCC 1020

TTCCCCGTGG ACAACGTGAA CAAAGCCATC GCAGACGGTG TGGACGACTG CTGCCAGTCT 1080

GGGCCAGAGC AGCTCTCCAG GGGGCTCTGC CATTTCCAGC CTTGTGAGAG CTGCCCACAC 1140

GAGAGCATGG AGAACAACGC CACCTGCAGA GACCAGCCCA CCATGGTGTC AAAGCCGTAC 1200

TACAGGGTGG ATCTCTTCAA CAGGCAGATG ACAGACGTCC TGCTCACGTC TCTACTGGTC 1260

ACCACCATTG AGAACAAGAC GGTCGCCCAT ATCGGCACCT CCACTGGACG CCTGCTACAG 1320

CTTGTTCTAA CAAGATCCAG CCCCATTATC TTTGCTAATT ACTCTCTTGT GGAGAACCAG 1380

AGGGTCTCAT CGATCGCTGC TGTTTACTCA TCAGAGTATC TTCTCTTTGT GGTTGGAGAC 1440

AAGATGATCC AAGTGCCCCA GAGAGGACCA GGCTGCCAGC ACTTCCTCAC CTGTGCCGTG 1500

TGCCTGACGG CGCCTAAGTT CGTGGGCTGT GGCTGGTGCT CTGGCGTGTG TTCCTGGGAG 1560

AGCGACTGCG ACCATCACTG GAGGAACGAT TCCTGTCCTC CTGGAATCAC GGGGTTCTTC 1620

CCCCGGACTG CTCCTCCTGA CGGTCAGACA GAGCTGACGG TGTTCGGTTG GGAGTTTCAG 1680

TCCCCTTTGA GACCTGCCAT CACTTCCAGA ACCCACCAAG TGCGACTGGG ACAAACCGCC 1740

TGCACCGTGC TTCCTGCCAA AAGCAATAAC AGCCAAATGT TCATGTCCAA TAATTTACTC 1800

CAGAATAATC TGGTTTGTAA GATTCGCATA GGGACGATGG AGCTGTTCAG ACCCGTCAAC 1860

ATAACAGTGG AAGTGCACGA GGGCAAAGCG GAGGGACGCT ACTCTATTGA CGGGAAGGCG 1920

GAAATGTCGG GATTCACATT TGTGATACCC AACATCACTG AAATCCAGCC CAATTACGGG 1980

CCCCGTATTG GGGGAACACT CATCACAGTG ACTGGATCAC ACCTGGATTC TGGGAAGACC 2040

AGGAAGGTCA CGCTCAATGA AGTGCTTTGT CCGATAAAGA GAGTCACGCA GCCCAAAGGC 2100

AACGTGTCCT CCATCATTTG TCTGTCCCAG CACATCTCAG AGGTCAGGGA TGTTCCGCTG 2160

AGCGTCTTCA TCGACAAGTC CCCCATTCTT ACCACAAAGG TGTTTTATTA TAAAGAAAAC 2220

CCAACGATCA CAGCCGTCCT GCCCGACTGT AGCTTTGATA GGGGTTCGAA GATTGTGATT 2280

GAGGGGGAGA ACCTGGACTC TGTTTATCGC ACTATCGTCC GCTTCAAACC CAATGAGAGC 2340

CATTTAAAGC CTGTGACAAG GGAGTGTGTT GGGAATTCCT CTCCAACGAA GATGGAGTGT 2400

TTCACGCCAG AGTTTCCCAG GGACGAGACG GAGGAAGGAG AGCTTTCCTT CGACATGGAC 2460

GGGGCTTTGG GACTTTGGAA TAAGGAGTTT TCCTACCACC CCTACGGCCA GCCCATACCG 2520

TTTGAAACAG AGGGACACGT GCTGAGTTTG TACCCGGGGT TTGATGAAGT ATCGCTACAT 2580

CATCAGAAGC TGAATCTGGT GAGCTCCTGC ATGACCATCG TCATGACCAT GGCTGGTGTC 2640

AACTGTGATG CTAAAGTCCT GGACAATGAG ATCACCTGCA GGATCCCCAA AAACATGAGC 2700

ATCCCCAGTG AAGGGCTGCC AGTGAAGATT TCCATCAATG GCCAGATCCA CAACGTGGGC 2760

ACGGTGGTGA GGGTCAGCAA CCACTACATG GTGGGCATCG TCCTGGGGAT CCTGGCTGCT 2820

CTGGTGGCAG GGGCGGTGCT GGCCTTTCTG GTCATGAAGC ACCTCAGGAA GAAGAAGAAA 2880

GTGGCGACCC TGAATCCTCC CACGCCCCTG TCTGGATCGG CGGGCTTCCC AAGCTTGGCT 2940

TATGCTACTG GCAGCATCGA TCCCACTCTC ACCCCTCTCA TTCCCCCAGA CAAAATCTCC 3000

ATCTCAAATT TTAGGCCGGA ATTGTTGGAA GAGGTGAAAG ATGTTCTAAT TCCTGCAGAG 3060

ATGCTTGTTG TGCAGCACCA TCGAATCATA GGAAAAGGTC ATTTCGGAAC TGTCTATCAC 3120

GGCTACTTTG CAGACTGCAA CAGCAGAGAA ATCCACTGTG CTGTCAAGTC TTTAAATAGA 3180

ATAACAGATG CGGAGGAAGT GGAGCAGTTC CTGAAGGAGG GCATCATCAT GAAGGGCTTC 3240

CATCACTGTA ACGTGCTCTC TCTTCTCGGG ATCCTTCTGC CTCAAGAAGG GCTCCCTCTA 3300

GTGGTGCTGC CCTACATGAA ACACGGGGAC CTGCGGCACT TCATCCGCTG TGATAAGAGG 3360

AACCCTACTG TGAAGGATCT GATCGGCTTC GGGCTGCAGG TTGCCACGGG AATGGAGTAT 3420

TTGGCCCAGA AGAAATTTGT GCACAGAGAT CTCGCTGCAC GCAACTGCAT GCTGGACGAG 3480

TCGTACACGG TCAAGGTGGC AGACTTTGGC ATGGCCAGGG ATGTTTTGGA CAAAGAGTAT 3540

TACAGCGTTC AGAATCACAG GAAGGCGAAG CTGCCCGTCA AGTGGATGGC CATCGAGAGT 3600

CTACAGACCC AAAAATTCAC CTCCAAATCA GATGTGTGGT CCTTTGGTGT TCTGATATGG 3660

GAGATGCTGA CCAGAGGAGC GAGTCCCTAC CCAGACGTGG ACCCATATGA TATAACACAT 3720

TACCTCCTGA GGGGCAGGAG GCTTCCGCAG CCTCAGTTCT GCCCTGACCC TCTGTATCGC 3780

ATCATGCTGC AGTGCTGGGA CCCCGATCCA GAGCTCAGAC CCAGTTTTGC TACTTTAGTG 3840

TCAGCTGTGT CCGTCATTCT GTCCAATCTG GAGGGAGAAC ACTACATCAG CCTGAATGTG 3900

ACCTACGTCA ACCTG 3915

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++++iGkGhfG+vy+g + d +s++i++avksl+ritd e+ve+fl+eg++mk+++h

Q: 1024  VQHHRIIGKGHFGTVYHGYFADCNSREIHCAVKSLNRITDAEEVEQFLKEGIIMKGFHHC  1083

         56789*******************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi l++eglplvvlpymk+Gdl++fir  +rn+tvkdl++f+lqva gmeyla+

Q: 1084  NVLSLLGILLPQEGLPLVVLPYMKHGDLRHFIRCDKRNPTVKDLIGFGLQVATGMEYLAQ  1143

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+lde++tvkvadfG+ardvldke+y+v+++r+a+lpvkw+a+eslqt

Q: 1144  KKFVHRDLAARNCMLDESYTVKVADFGMARDVLDKEYYSVQNHRKAKLPVKWMAIESLQT  1203

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k ft+ksdvwsfGvl+we+ltrga+py++v+++d+t+yl +grrl++p++cpd ly +m

Q: 1204  QK-FTSKSDVWSFGVLIWEMLTRGASPYPDVDPYDITHYLLRGRRLPQPQFCPDPLYRIM  1262

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         l+cw ++p+ rp+f+ lvs +s

Q: 1263  LQCWDPDPELRPSFATLVSAVS  1284

         ******************9876

Domain Sequence
(FASTA)

VQHHRIIGKG HFGTVYHGYF ADCNSREIHC AVKSLNRITD AEEVEQFLKE GIIMKGFHHC 60

NVLSLLGILL PQEGLPLVVL PYMKHGDLRH FIRCDKRNPT VKDLIGFGLQ VATGMEYLAQ 120

KKFVHRDLAA RNCMLDESYT VKVADFGMAR DVLDKEYYSV QNHRKAKLPV KWMAIESLQT 180

QKFTSKSDVW SFGVLIWEML TRGASPYPDV DPYDITHYLL RGRRLPQPQF CPDPLYRIML 240

QCWDPDPELR PSFATLVSAV S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013