EKS-TAR-00446

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00446

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	346.6	2.6E-103	601	1020	420

Status

Unreviewed

Ensembl Protein

ENSTRUP00000035789

UniProt Accession

H2UFR9;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK4

Gene Synonyms/Alias

EIF2AK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000013993	ENSTRUP00000035789	ENSTRUT00000035917

Organism

Takifugu rubripes

Functional Description

Protein Length

1661

Protein Sequence
(FASTA)

LPCRRMSSQL TPADRTDERT TQQDNELEAL ASIFGDDFQD LRNSDPWKVK RPPEVYLCLR 60

PNGLNNGQGC YATVDLQVKC PPSYPDVPPE LELKNAKGLS NEKLQNLQSE LNKLAASRCG 120

EVMIYELADH IQGFLSEHNK PPPCSFHDEM LKNQQRQQEK RAQEEQQRMD QLRKKEEEME 180

KEIMAEIQRR EEEKREEKRR KEMAKLERLE SIDQSLSANS NLLGKSPPTP GKTPPELTDA 240

RKAVGNRRRT TSNSRHSRVH RRDTCNEDTH RLQEVLHFSS STFGELLVHR GKSLGVSQHL 300

GRDVYNGFET NSGEFAVIYE WTLHWNKKMG KFFTTQEKAK IESCKKQIHA AENEFNSLLK 360

LNHPNLVHYM ALSTTEKEDC LVVNLLVEHV SGTNLNQSLT THGPVPLDKL CHYTAQLLAA 420

LDYLHSNSVV HKRLCASSVL VDSEGTVHLT DYSLSKRFAD ICKEDIFEQA HVRFTEGTAM 480

PTKLGKKGDV WNLGLMLLAL SQGKEVKEYP VTVPSSLPPD FQDFLNKCVC LNDVDRWTPQ 540

QLLDHSFLKP PSPKNLPQYQ EASPEDLAVD FASTVIPRSH ILDAPFISGV QRQFSRYFNE 600

FEELQLLGKG AFGAVIKVQN KLDGCYYAVK RIQVNPASKH FRRIKGEVTL LSRLNHENIV 660

RYYNAWIERH EKPCTGVPSN TDSSEPQSPD KSPHGKKPPQ RLNELGLPDN VEDAAPPPAL 720

SSSVEWSTSI ERSSSAKCRG HQSSDEEDDD EEEEEEDVFS ASFLPSDSHS RSDIIFDNGD 780

ESPDEMSQVE PSKRPTSDTE ETTDSERSLL VAHYLYIQME YCEKSTLRDT IDHGLYQDQN 840

RLWRLFREIL DGLAYIHQQG MIHRDLKPVN IFLDSQDHVK IGDFGLATDH PASVAAGKYE 900

VEEHSTGLVP KSDPTDNMTG MVGTALYVSP EVQGNTKATY NQKVDLFSLG IILFEMSYRP 960

MTTGAERISV LGQLRGEPIV FPQDFCTNEI STQMKVIEWL LNHDPALRPT AQEVLKSELL 1020

PLPQMEESEL HEVLQHTMAN VNGKAYRTMV GQLFAQDTSP VMDYTYDIDL HRGNFSFNGA 1080

KLQQHVHETI IRILKKHGAV RLQTPLLFPR NKKLYDGSEL ACFMDHSGML VTLPYDLRMA 1140

FARFVARNNI THLKRYSIDR VFRPRKLDRA HPRELLECAF DIITPVTNSL LPDAEAIYAI 1200

SEIIQEFPIL QERNYHIYLN HTSLLKAILL HSGIPEDKLS QASIILCDSM SEKLTKREVE 1260

AKFCNFSLST KSLQTLYKYI EQKGELQELL PLLTTLTKHK TAVSQHAKQG IKDLEEVTGL 1320

LNKLGVKLQV VINLGLVYKV QHHTGVIFQF VAFINKRKKM VPDIIAAGGR YDHLIVEFRG 1380

PASIVPVPSA VGASLALEKV CVALAGMEEP PSVSSCDVLV VPVGHSSMTR AINVVQKLWS 1440

TGISADITYD VSQSQETLLE HCRLAGINCT ALVSDKEGSY VKVKSFEKDR QYEKRIPDWD 1500

LVDHIIQKCR NKFFEERNIR EVPDSMALQN PKGSLLSSSG SSEPHGSSSI VNVNVISPEK 1560

VSASVRRRYE TQIQTRLQNL GSNLQNKSND IEVLAVDLQR ETLINFLSLE FDRRLKTLLS 1620

RLPKQRYLQS ICDELHRFKI AKKVGVVVLY SYRDDYYKIL V 1661

Nucleotide Sequence
(FASTA)

CTGCCATGTA GAAGAATGAG CAGTCAGCTC ACTCCAGCGG ACAGGACGGA CGAGCGCACC 60

ACCCAGCAGG ACAACGAGCT TGAGGCGCTC GCCTCTATCT TTGGAGATGA CTTCCAGGAT 120

CTGCGAAACA GCGACCCGTG GAAGGTTAAA AGGCCTCCGG AGGTGTACCT CTGCCTGCGG 180

CCCAACGGGC TGAATAACGG CCAGGGTTGC TACGCGACGG TGGACCTGCA GGTCAAATGT 240

CCACCTTCAT ACCCAGATGT GCCTCCAGAG CTGGAGCTAA AGAACGCCAA AGGTCTGTCC 300

AATGAAAAGC TTCAGAACCT CCAGAGTGAG CTCAACAAGC TGGCAGCGTC ACGATGTGGT 360

GAGGTGATGA TTTACGAACT AGCGGACCAC ATCCAGGGGT TCCTCAGTGA GCATAACAAA 420

CCCCCACCGT GTTCCTTCCA CGACGAGATG CTCAAGAACC AGCAGAGACA GCAGGAGAAA 480

CGAGCACAGG AGGAGCAGCA GAGGATGGAT CAGCTGCGCA AGAAGGAGGA GGAGATGGAA 540

AAAGAAATCA TGGCTGAAAT CCAAAGACGA GAAGAGGAGA AACGGGAGGA AAAGCGACGG 600

AAGGAGATGG CAAAACTGGA GAGACTTGAG AGTATCGATC AGTCATTAAG TGCAAACTCC 660

AACCTGCTTG GAAAGAGCCC CCCCACACCT GGAAAAACTC CTCCTGAACT GACCGATGCC 720

AGGAAAGCAG TTGGTAACCG CCGTCGGACT ACCTCAAACT CTCGCCACAG TCGCGTCCAT 780

AGACGCGATA CGTGTAACGA AGACACCCAT CGTTTGCAAG AGGTCCTCCA CTTCAGCAGC 840

AGCACGTTTG GAGAGCTGCT CGTTCACAGA GGGAAGAGTT TAGGTGTGAG CCAGCACCTG 900

GGCCGCGATG TTTACAACGG GTTCGAGACA AACTCCGGGG AGTTTGCTGT GATTTATGAG 960

TGGACTCTCC ACTGGAACAA GAAAATGGGC AAGTTCTTCA CCACTCAGGA GAAAGCCAAA 1020

ATTGAGAGCT GCAAGAAACA GATCCACGCA GCAGAGAATG AATTTAACTC CCTCTTGAAG 1080

TTGAATCATC CAAACTTGGT TCATTACATG GCGCTGAGCA CCACTGAGAA GGAAGACTGC 1140

CTGGTGGTGA ACCTGCTGGT GGAGCATGTG TCCGGCACCA ATCTCAACCA AAGCTTAACC 1200

ACCCACGGGC CGGTTCCCCT GGACAAGCTG TGCCACTACA CAGCCCAGCT GCTGGCGGCT 1260

CTCGACTACC TTCACTCCAA CTCGGTGGTC CACAAACGGC TGTGTGCGTC CAGCGTGCTG 1320

GTGGACTCCG AGGGCACCGT TCATCTGACT GATTACAGCC TGTCGAAGAG ATTCGCTGAC 1380

ATCTGCAAGG AGGATATTTT TGAGCAAGCC CACGTGCGTT TCACAGAGGG GACGGCCATG 1440

CCGACTAAAC TGGGCAAGAA GGGGGACGTG TGGAACCTGG GGCTGATGCT GCTGGCTCTG 1500

AGTCAGGGGA AGGAGGTGAA GGAGTATCCA GTGACGGTGC CTTCCAGCCT GCCTCCCGAT 1560

TTCCAGGATT TCCTCAACAA GTGCGTCTGC CTGAACGACG TGGACCGTTG GACACCTCAG 1620

CAGCTCCTGG ACCACTCTTT TCTCAAGCCG CCATCGCCTA AGAACCTACC ACAGTATCAG 1680

GAAGCCAGCC CAGAAGATCT GGCCGTGGAC TTTGCTTCGA CAGTCATTCC AAGGAGTCAC 1740

ATCCTCGATG CTCCCTTCAT CTCAGGGGTG CAGAGGCAGT TTTCTCGCTA CTTCAACGAG 1800

TTCGAAGAGC TGCAGCTGCT TGGAAAGGGC GCCTTTGGTG CCGTTATCAA GGTTCAGAAC 1860

AAGCTAGACG GTTGCTATTA TGCCGTGAAG CGCATCCAGG TCAACCCGGC CAGCAAACAT 1920

TTCCGCCGAA TTAAAGGCGA GGTGACGCTG CTGTCCCGCC TCAACCACGA GAACATCGTC 1980

CGCTACTACA ACGCCTGGAT CGAACGACAC GAGAAGCCCT GCACCGGGGT GCCGAGCAAC 2040

ACCGACAGCT CGGAGCCGCA GAGCCCTGAC AAGTCTCCTC ACGGCAAAAA GCCTCCACAG 2100

CGCCTGAACG AGCTGGGCCT CCCCGACAAC GTGGAGGACG CCGCTCCGCC TCCCGCCCTG 2160

TCCAGCTCCG TGGAGTGGTC CACCTCCATT GAGAGGTCCT CCAGTGCGAA ATGCAGAGGA 2220

CACCAGTCGA GTGATGAAGA GGATGATGAT GAGGAGGAGG AGGAGGAGGA CGTGTTTAGT 2280

GCTTCATTTT TGCCATCGGA TAGTCACTCC AGGAGTGACA TCATCTTTGA CAACGGCGAC 2340

GAAAGCCCAG ATGAGATGTC CCAGGTCGAG CCGAGCAAAA GGCCAACCAG CGACACTGAA 2400

GAGACGACGG ACTCGGAGAG ATCGCTCCTC GTAGCACATT ACCTGTACAT CCAAATGGAA 2460

TACTGTGAAA AAAGCACTTT AAGGGACACA ATAGATCACG GGCTGTACCA GGACCAGAAC 2520

CGCTTATGGA GACTCTTCAG GGAAATCCTG GACGGACTCG CTTACATCCA TCAGCAGGGT 2580

ATGATTCACA GGGACCTGAA ACCTGTCAAC ATCTTCCTGG ACTCGCAGGA CCACGTGAAG 2640

ATTGGAGACT TTGGCCTGGC TACAGACCAT CCTGCTAGTG TGGCTGCAGG TAAATATGAA 2700

GTGGAAGAGC ACAGCACAGG ATTAGTGCCC AAATCAGACC CAACAGATAA CATGACAGGT 2760

ATGGTTGGCA CTGCCCTTTA CGTCAGCCCC GAGGTTCAGG GAAACACCAA AGCCACCTAC 2820

AACCAAAAAG TGGACCTGTT TAGTTTAGGC ATCATCCTCT TTGAGATGTC CTATCGGCCC 2880

ATGACCACCG GCGCCGAGCG GATTTCTGTC CTGGGCCAGC TTCGTGGGGA GCCCATCGTC 2940

TTTCCTCAGG ACTTCTGTAC CAATGAGATA AGTACGCAGA TGAAAGTGAT TGAGTGGCTG 3000

CTGAACCACG ACCCAGCCCT GCGGCCCACC GCCCAGGAGG TGCTGAAGAG CGAATTGCTG 3060

CCTTTGCCTC AGATGGAGGA GTCTGAGCTT CACGAGGTGC TCCAGCACAC CATGGCCAAC 3120

GTCAATGGCA AAGCCTATCG CACCATGGTG GGCCAGCTGT TTGCCCAGGA CACCTCTCCT 3180

GTCATGGACT ACACATATGA TATCGACCTG CACAGGGGCA ACTTCAGCTT TAACGGTGCA 3240

AAATTGCAGC AGCATGTGCA CGAAACAATC ATAAGGATCT TGAAGAAGCA CGGTGCGGTG 3300

CGTCTCCAAA CCCCACTGCT CTTCCCCAGA AACAAGAAGC TGTACGATGG TAGCGAGCTG 3360

GCTTGCTTCA TGGACCATAG CGGAATGCTG GTTACGCTGC CCTACGACCT GCGCATGGCG 3420

TTCGCAAGAT TTGTCGCTCG CAACAATATC ACCCACCTCA AGAGGTATAG CATCGATCGC 3480

GTCTTCCGCC CCAGGAAGCT GGATCGAGCG CACCCCAGGG AGCTCCTGGA ATGTGCCTTT 3540

GACATCATCA CACCCGTCAC CAACAGCCTG CTCCCTGACG CCGAGGCCAT TTACGCCATC 3600

TCTGAAATAA TCCAGGAATT CCCCATCCTT CAGGAAAGGA ACTATCACAT TTACCTGAAC 3660

CACACCAGCC TGTTGAAGGC CATCCTGCTG CACAGCGGGA TCCCCGAGGA CAAACTGAGC 3720

CAGGCCTCCA TTATCCTGTG TGACTCCATG AGCGAAAAGT TGACCAAACG TGAGGTGGAG 3780

GCAAAGTTCT GCAACTTCTC ACTGTCGACC AAAAGCTTGC AGACGTTGTA CAAGTACATC 3840

GAGCAAAAGG GGGAGCTGCA GGAGCTGCTG CCGCTGCTGA CGACACTGAC CAAACACAAG 3900

ACGGCTGTCA GTCAACACGC CAAGCAGGGG ATCAAGGACC TGGAGGAGGT CACGGGGTTG 3960

CTGAATAAAC TGGGGGTGAA ACTGCAGGTG GTGATTAATT TAGGGCTGGT TTACAAGGTG 4020

CAACATCACA CAGGAGTCAT CTTCCAGTTT GTGGCTTTTA TTAACAAACG CAAGAAAATG 4080

GTGCCGGATA TCATCGCCGC CGGAGGACGC TACGATCACT TGATTGTGGA GTTTCGAGGT 4140

CCAGCATCTA TTGTACCAGT CCCCTCTGCA GTGGGAGCCA GTTTAGCCCT TGAAAAAGTC 4200

TGTGTTGCCC TGGCTGGCAT GGAGGAGCCA CCTTCGGTGA GTTCCTGCGA CGTTCTGGTG 4260

GTCCCGGTCG GACATTCTTC AATGACCAGA GCCATTAATG TTGTCCAGAA GCTGTGGAGC 4320

ACCGGCATCT CTGCAGACAT CACCTACGAC GTCTCACAGT CTCAGGAGAC GTTGCTGGAG 4380

CACTGCAGGC TGGCCGGCAT CAACTGCACG GCCCTGGTCT CTGACAAGGA GGGCAGCTAC 4440

GTGAAGGTCA AATCCTTCGA GAAGGACCGA CAGTATGAAA AGAGGATCCC CGACTGGGAC 4500

TTGGTGGACC ACATCATCCA GAAGTGTCGG AACAAATTCT TTGAGGAAAG AAACATCAGA 4560

GAGGTCCCTG ACAGCATGGC CCTCCAGAAC CCTAAAGGAT CGCTGCTCAG CTCTTCAGGC 4620

TCCTCTGAAC CACACGGCAG CAGCAGCATC GTGAACGTGA ACGTCATCAG CCCGGAGAAG 4680

GTGTCGGCCA GCGTGCGGCG GCGCTACGAG ACTCAGATCC AGACCAGGCT GCAGAACCTG 4740

GGAAGCAATC TGCAGAACAA AAGCAACGAC ATCGAGGTTC TGGCTGTGGA CCTGCAGAGG 4800

GAAACGCTGA TCAACTTCCT GTCTTTGGAG TTCGACAGGC GGTTGAAGAC CCTCCTGTCC 4860

CGGCTGCCCA AGCAGCGCTA CCTGCAGTCC ATCTGCGACG AGCTGCACCG CTTCAAAATC 4920

GCCAAAAAGG TCGGCGTGGT GGTTCTGTAC AGCTACAGGG ACGACTACTA CAAGATCCTG 4980

GTCTGA 4986

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k++nkld+++ya+kri++n a+k++++++ ev++L++l+h+niv

Q: 601   FEELQLLGKGAFGAVIKVQNKLDGCYYAVKRIQVNPASKHFRRIKGEVTLLSRLNHENIV  660

         89**********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rY++aw+e++e++

Q: 661   RYYNAWIERHEKPCtgvpsntdssepqspdksphgkkppqrlnelglpdnvedaapppal  720

         **************999***9999999999999999999999999999999999999888

S: 75    ..............................tdsseveaeaeleesesseesdtk......  98

                                       +                      +

Q: 721   sssvewstsiersssakcrghqssdeedddE----------------------Eeeeedv  758

         8888887777766665555555444333330......................0333344

S: 99    .......................................................llyiq  103

                                                                +lyiq

Q: 759   fsasflpsdshsrsdiifdngdespdemsqvepskrptsdteettdsersllvahYLYIQ  818

         4455555555566677777777777777777788888888888889999***********

S: 104   melceketLkdwiderkllesrselvmrlfkqllegleylHskgliHrdLkpsniFldsd  163

         me+cek+tL+d+id+  l++++++l+ rlf+++l+gl+y+H++g+iHrdLkp+niFlds+

Q: 819   MEYCEKSTLRDTIDHG-LYQDQNRLW-RLFREILDGLAYIHQQGMIHRDLKPVNIFLDSQ  876

         ****************.9********.*********************************

S: 164   dqvKigDFgLatalaealkedvkqdaqske.........akhtgqvgtklymsPeql..e  212

         d+vKigDFgLat+   +  +   + +++++          + tg+vgt+ly+sPe++  +

Q: 877   DHVKIGDFGLATDHPASVAAGKYEVEEHSTglvpksdptDNMTGMVGTALYVSPEVQgnT  936

         *************887777655555555556777766666*****************999

S: 213   ksqYnkkvDifsLGlilfeLly.pfstemervetltelrd..gkipedfdd.kvpkekkl  268

         k++Yn+kvD+fsLG+ilfe++y p+ t+ er+++l +lr   + +p+df   ++  + k+

Q: 937   KATYNQKVDLFSLGIILFEMSYrPMTTGAERISVLGQLRGepIVFPQDFCTnEISTQMKV  996

         ***************************************9999******5559*******

S: 269   lqkllsrdpkeRpsasellksell  292

         +++ll++dp+ Rp+a+e+lksell

Q: 997   IEWLLNHDPALRPTAQEVLKSELL  1020

         *********************986

Domain Sequence
(FASTA)

FEELQLLGKG AFGAVIKVQN KLDGCYYAVK RIQVNPASKH FRRIKGEVTL LSRLNHENIV 60

RYYNAWIERH EKPCTGVPSN TDSSEPQSPD KSPHGKKPPQ RLNELGLPDN VEDAAPPPAL 120

SSSVEWSTSI ERSSSAKCRG HQSSDEEDDD EEEEEEDVFS ASFLPSDSHS RSDIIFDNGD 180

ESPDEMSQVE PSKRPTSDTE ETTDSERSLL VAHYLYIQME YCEKSTLRDT IDHGLYQDQN 240

RLWRLFREIL DGLAYIHQQG MIHRDLKPVN IFLDSQDHVK IGDFGLATDH PASVAAGKYE 300

VEEHSTGLVP KSDPTDNMTG MVGTALYVSP EVQGNTKATY NQKVDLFSLG IILFEMSYRP 360

MTTGAERISV LGQLRGEPIV FPQDFCTNEI STQMKVIEWL LNHDPALRPT AQEVLKSELL 420

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding
GO:0006446	; P:regulation of translational initiation

KEGG

InterPros

IPR004154	; Anticodon-bd.
IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR008271	; Ser/Thr_kinase_AS.
IPR016255	; Ser/Thr_kinase_GCN2.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013