EKS-TAR-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/Trio	297.2	2.5E-88	112	365	254

Status

Unreviewed

Ensembl Protein

ENSTRUP00000036005

UniProt Accession

H2UGD5;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000014074	ENSTRUP00000036006	ENSTRUT00000036136
ENSTRUG00000014074	ENSTRUP00000036005	ENSTRUT00000036135

Organism

Takifugu rubripes

Functional Description

Protein Length

1433

Protein Sequence
(FASTA)

IQVPHEDLCV EPGQPVTFTA IITGRPAPKI EWYKDEEELL ANENVKLAQH GARCSVTIVC 60

PEGEDSGIYT CFAYNDSGHE SCQAQLTVEE GPLEHREREV ELGKRRKLFS VYDVHDEIGR 120

GTFGVVKRVV HRRTGEVFAA KFLPVRSSTR TRAFQERDLL SRLAHPRVAC LLDFFCTRRT 180

LVLITEMCCS HGLLDHLLLK GSVSEREVRS FIQQILEGLG HIHSMNILHL DMKPDNILMV 240

YPPRDEIKIC DFGFCQEIDT SRHQYSMLGT PEFVAPEIVH LEPVTVATDI WSVGVIAYIC 300

LVCRCPFVGE TDRATLLRVG EGTLNWDAPD VTCRSPEAQN FLHILLQPDP EKRPSAFESL 360

SHEWFQDELA GEDTDEINTR NLKAFISKRK WQRSLTCIGS VLTLRPIPEL LDAPLRETAA 420

TVPREPQEHS SSSLSSGSSS EYDEADSWDF FQHYSQTEEE EETEDDYDPL MERARIPEPF 480

PRHHLDTEEE EVTLGDEEGG DVERRSVLER SMSRQSAASS ETSCQRTPQR ERRLSKDSSP 540

SLHLSDGDEG SGSEGGRIPR GSVIRSTFYS TSHQLSPMSA RHMTLRDKFQ AKKQERGRKP 600

IRRSLSGRLS EPLIEYVEDE TDAARGQRRV SVQPAMQKSC SFDSGVGLVH GNVPPHRRSR 660

SLDGFSRLSP GSPICSKSGE EEGSQSLKED FTDDEGTARN LLSIPQRPTR RRGSVAPVRG 720

IPLQVGSALP SRLLAGDRAL SKLDQEPTQG GAFTGSQGSL AESFHLEHGG SDSSSRLGSY 780

EELSHDHRRG RSRSGCSEGY NDQGEPLISS SPFSFTEVKS VSSFPQAPPR NRTRSNPNLT 840

TYQRGQLGTP LTASPSPSSR EASQGQGQEG PQGPPKTCVS SSPGTPATCR KITKAGVPEH 900

LPEAVLDWSA ILPAGKPRVW THAWRDHEPR YSYHVFEEEN ESISLQPDQT VFQVFKQRGC 960

QQRKGPIVKV SPEVGGFTGP ESPKKRTTKL LPSFKMPVFK RTKGRVFLIC PPLFPGLLVR 1020

PSKPEVLQLD GGGVLLVWKP VHSSDPVTYC VQYCTDATGG DWTLLSEEVA DSCYVVKDLP 1080

RGASYVFRVS CITKTGAGPF SDASVPVVMA THPEVQTESP GSKVIGLDQQ THQKTYSFLS 1140

EINRGRFSII TMCRDVETSQ VFAAKVTPYK AEQRQLVLRE YQLLKKLHHP HLVQLHTAYL 1200

TSSYLVLVEE LCPGKELLHS LAARELYSET HVAELLVQIL SAVDYLHGRR VIHLDLKSDN 1260

MLVDDCNHLK IVDLGSAQLF TPGQPLNIEH IQGLSESRAP EILEGHGVGP ETDIWAVGVL 1320

SFIMLSADSP FHAELDSEQD RNIKKGKIQF GRCYPGLSEG ALNFMKSSMN NKSWGRPTAA 1380

ECLHSPWLRA HRASHRGRQS KVCFSTDKLK EFLTQKEEKR DQIDPKSNRS LIP 1433

Nucleotide Sequence
(FASTA)

ATCCAGGTGC CCCACGAGGA CCTGTGTGTA GAACCGGGCC AGCCGGTTAC GTTCACTGCC 60

ATCATCACGG GGAGACCTGC ACCAAAAATT GAGTGGTACA AGGATGAAGA GGAGCTGCTA 120

GCTAATGAGA ATGTAAAGCT AGCGCAGCAT GGCGCCCGTT GCTCTGTGAC CATAGTGTGC 180

CCCGAGGGTG AGGACAGCGG AATATACACT TGCTTTGCCT ACAACGACTC TGGTCACGAG 240

TCCTGCCAGG CCCAGCTGAC GGTCGAGGAA GGCCCTCTGG AGCACCGGGA GAGAGAGGTG 300

GAGCTTGGAA AGAGGAGGAA GTTGTTCTCT GTTTATGACG TCCATGATGA AATTGGAAGG 360

GGCACCTTCG GGGTAGTGAA GCGCGTCGTT CACAGGAGGA CAGGTGAGGT GTTTGCCGCC 420

AAGTTTCTAC CCGTGCGGAG CAGTACGCGG ACCAGAGCGT TCCAGGAGAG GGACTTGCTG 480

TCCCGCCTGG CCCACCCCAG AGTCGCCTGT CTGCTGGACT TCTTTTGCAC CAGACGCACT 540

CTGGTGTTGA TCACAGAAAT GTGCTGTTCC CATGGACTTC TGGACCATCT CCTTCTTAAA 600

GGCTCAGTTT CTGAGCGAGA GGTCCGGTCG TTCATCCAGC AGATCCTGGA AGGCCTCGGT 660

CACATTCACA GCATGAACAT TTTGCACCTG GATATGAAAC CTGATAATAT CCTGATGGTG 720

TATCCACCGA GAGATGAGAT CAAGATCTGC GACTTTGGCT TCTGCCAAGA AATAGACACG 780

TCCAGGCACC AGTACAGCAT GCTGGGAACG CCGGAGTTTG TTGCCCCAGA GATTGTTCAC 840

CTTGAGCCCG TCACTGTGGC CACCGACATT TGGTCTGTCG GGGTTATAGC CTACATATGT 900

CTTGTGTGCC GCTGCCCCTT CGTGGGTGAG ACAGACCGAG CCACACTGCT CAGAGTTGGG 960

GAAGGAACCC TGAACTGGGA CGCCCCCGAT GTCACCTGTA GGAGCCCAGA GGCCCAGAAC 1020

TTTCTTCACA TCCTCCTCCA GCCAGATCCA GAGAAACGGC CATCTGCCTT TGAGTCCTTG 1080

AGCCACGAAT GGTTCCAGGA TGAACTTGCT GGAGAAGACA CTGATGAAAT CAACACAAGG 1140

AATTTAAAAG CATTCATCTC CAAAAGGAAA TGGCAGCGCT CGCTGACTTG CATCGGGTCA 1200

GTTCTCACTC TCAGGCCCAT CCCAGAGCTG CTGGATGCTC CTCTCAGGGA AACCGCTGCT 1260

ACCGTTCCCC GTGAGCCTCA GGAACACAGC AGCAGCTCTC TGAGCAGCGG CTCGTCGTCC 1320

GAGTACGACG AAGCCGACTC CTGGGACTTC TTCCAGCACT ACAGCCAGAC TGAGGAGGAG 1380

GAGGAAACCG AGGACGACTA CGATCCTCTG ATGGAGAGAG CGCGGATCCC CGAACCATTC 1440

CCCAGACACC ATTTAGACAC CGAGGAGGAG GAGGTCACAT TGGGAGATGA AGAGGGTGGA 1500

GATGTTGAGA GGAGGAGTGT GCTGGAGCGG AGTATGAGCA GGCAGTCAGC TGCGTCATCA 1560

GAGACGTCCT GCCAAAGGAC ACCTCAGAGG GAACGTAGGC TCAGCAAAGA CAGCAGCCCC 1620

TCCCTCCACC TCTCTGATGG AGATGAGGGT TCGGGGAGCG AGGGGGGCCG CATCCCACGT 1680

GGAAGCGTCA TCAGAAGCAC TTTCTACAGC ACCTCGCACC AGCTGTCCCC CATGTCTGCC 1740

AGACACATGA CTTTGCGGGA TAAATTTCAA GCCAAAAAGC AGGAGAGGGG CCGCAAACCA 1800

ATACGGAGAA GCCTTTCCGG GCGGCTTAGC GAGCCCCTGA TCGAATACGT GGAGGATGAG 1860

ACGGATGCCG CCCGCGGCCA GAGGCGAGTG TCCGTCCAAC CCGCGATGCA GAAGTCCTGC 1920

TCGTTCGACA GTGGCGTCGG CCTCGTCCAC GGCAATGTCC CACCTCACAG GAGGAGCAGG 1980

TCTCTTGACG GGTTCTCTCG GCTGTCTCCC GGCTCACCCA TCTGCTCCAA GTCAGGTGAG 2040

GAAGAGGGTT CCCAGAGCCT GAAGGAGGAT TTCACAGATG ACGAAGGGAC GGCAAGAAAC 2100

CTGTTGTCCA TCCCTCAACG GCCCACAAGA AGGAGGGGCT CCGTCGCTCC AGTGCGGGGG 2160

ATTCCTCTGC AGGTGGGATC AGCTCTTCCC TCTCGCCTCC TCGCTGGAGA TAGAGCACTC 2220

TCTAAACTAG ATCAGGAGCC GACACAAGGA GGCGCCTTTA CAGGCTCCCA GGGCTCTCTG 2280

GCTGAATCAT TTCATTTGGA ACACGGTGGC TCAGATTCCT CCAGCAGGCT CGGCTCCTAC 2340

GAGGAGCTGA GTCATGACCA TCGGAGAGGA AGATCCAGAT CAGGTTGCAG CGAAGGCTAC 2400

AACGATCAGG GGGAGCCTCT GATTTCATCT TCCCCATTTT CTTTCACGGA GGTTAAATCC 2460

GTAAGTTCAT TTCCTCAGGC ACCACCGCGG AATCGTACTC GCTCCAACCC CAACCTGACT 2520

ACGTACCAGA GAGGTCAGCT GGGCACTCCT CTAACGGCGA GTCCCAGTCC AAGCTCCAGA 2580

GAGGCCTCCC AGGGCCAAGG ACAAGAAGGA CCTCAGGGGC CTCCAAAGAC ATGCGTCAGC 2640

TCCAGCCCTG GAACTCCAGC CACCTGTAGG AAAATCACCA AAGCTGGGGT TCCTGAACAT 2700

CTTCCGGAGG CAGTCCTGGA CTGGTCAGCC ATACTCCCAG CTGGAAAACC CAGAGTTTGG 2760

ACCCACGCTT GGAGAGATCA TGAGCCCCGA TACTCCTACC ATGTCTTTGA GGAAGAGAAT 2820

GAGAGCATCA GCCTCCAGCC TGACCAAACT GTTTTCCAAG TCTTCAAGCA AAGAGGATGT 2880

CAGCAAAGAA AAGGGCCCAT AGTAAAAGTC TCACCTGAGG TTGGAGGCTT CACCGGTCCT 2940

GAGAGTCCCA AAAAGAGGAC CACCAAGCTC TTACCTTCTT TTAAAATGCC CGTGTTCAAA 3000

AGGACAAAAG GTAGAGTGTT TTTAATCTGC CCCCCTCTGT TTCCAGGTCT GCTGGTGCGA 3060

CCCAGTAAAC CTGAAGTGCT CCAGTTAGAT GGGGGGGGAG TGCTGCTGGT TTGGAAGCCG 3120

GTCCATTCTA GTGACCCTGT GACCTATTGT GTGCAGTACT GTACAGATGC CACAGGTGGG 3180

GACTGGACGC TCCTCTCAGA GGAGGTGGCA GACAGCTGCT ATGTGGTGAA GGATTTGCCC 3240

AGAGGAGCCT CTTACGTGTT CCGGGTGAGC TGCATCACCA AAACAGGCGC CGGACCTTTC 3300

AGTGACGCTT CTGTGCCGGT CGTCATGGCA ACACACCCTG AAGTCCAGAC TGAATCACCG 3360

GGGTCAAAGG TTATCGGATT GGATCAGCAG ACACACCAGA AGACCTACAG TTTCCTCTCG 3420

GAGATTAACA GGGGGCGTTT CAGCATCATC ACCATGTGCA GGGACGTTGA GACCAGTCAG 3480

GTTTTTGCTG CCAAGGTCAC CCCTTACAAG GCCGAGCAGA GGCAGCTGGT GCTGAGGGAA 3540

TATCAGCTCC TGAAGAAGCT TCATCACCCC CACCTGGTGC AGCTGCACAC CGCCTACCTC 3600

ACCAGCAGCT ACCTGGTGTT AGTGGAGGAG CTCTGCCCCG GCAAGGAGCT GCTCCACAGT 3660

CTGGCAGCGA GAGAGCTCTA TTCAGAGACT CACGTTGCAG AGCTGCTGGT TCAGATTCTG 3720

AGCGCCGTGG ACTACCTCCA CGGACGCCGC GTGATCCACC TGGACCTGAA GTCCGACAAC 3780

ATGCTGGTGG ACGACTGCAA CCACCTTAAG ATAGTGGACT TGGGCTCGGC TCAGCTCTTC 3840

ACGCCAGGCC AGCCTCTGAA CATCGAGCAC ATCCAGGGCC TGTCGGAGAG CAGAGCTCCG 3900

GAAATCCTCG AAGGTCACGG CGTCGGCCCT GAAACTGACA TTTGGGCCGT TGGAGTGCTG 3960

TCGTTTATCA TGCTGAGCGC CGACAGCCCG TTCCACGCGG AGCTCGACTC GGAGCAGGAC 4020

CGAAACATCA AGAAAGGGAA GATCCAGTTT GGGCGCTGTT ACCCCGGCCT GTCGGAGGGA 4080

GCCCTGAACT TCATGAAGAG CAGCATGAAT AACAAATCCT GGGGGAGGCC CACGGCAGCG 4140

GAGTGTCTGC ACAGCCCCTG GCTGAGGGCC CATCGCGCCT CACACAGAGG CCGCCAGTCC 4200

AAAGTGTGTT TCTCTACAGA CAAGCTCAAA GAGTTCCTGA CGCAGAAGGA GGAGAAGCGC 4260

GACCAGATTG ATCCTAAGTC TAACAGAAGC CTCATACCT 4299

Domain Profile

S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60

         y+v++eigRG F+vvk+v+++ t+  +aakf+p ++ +++++ +E+++L rL Hp+++ l

Q: 112   YDVHDEIGRGTFGVVKRVVHRRTGEVFAAKFLPVRSSTRTRAFQERDLLSRLAHPRVACL  171

         99**********************************************************

S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120

         +d + t+r+lvli+E+c ++ LLd l  k+s+sE ev+ +++q+le+l  +H+ ++lHLD

Q: 172   LDFFCTRRTLVLITEMCCSHGLLDHLLLKGSVSEREVRSFIQQILEGLGHIHSMNILHLD  231

         ************************************************************

S: 121   ikpenllvlaaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatDiW  180

         +kp+n+l++  +++++ki+D+g+ qe++++ +q+++lgtpEfvaPEi++ epv+ atDiW

Q: 232   MKPDNILMVYPPRDEIKICDFGFCQEIDTSRHQYSMLGTPEFVAPEIVHLEPVTVATDIW  291

         ************************************************************

S: 181   avGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqedpr  240

         +vGv+ay++L ++ Pf++e +r+tll++ +g++++  +  +  s eA++Fl+ +Lq dp

Q: 292   SVGVIAYICLVCRCPFVGETDRATLLRVGEGTLNWDAPDVTCRSPEAQNFLHILLQPDPE  351

         ************************************************************

S: 241   kRPsaaecLqhpWl  254

         kRPsa e+L+h+W+

Q: 352   KRPSAFESLSHEWF  365

         *************8

Domain Sequence
(FASTA)

YDVHDEIGRG TFGVVKRVVH RRTGEVFAAK FLPVRSSTRT RAFQERDLLS RLAHPRVACL 60

LDFFCTRRTL VLITEMCCSH GLLDHLLLKG SVSEREVRSF IQQILEGLGH IHSMNILHLD 120

MKPDNILMVY PPRDEIKICD FGFCQEIDTS RHQYSMLGTP EFVAPEIVHL EPVTVATDIW 180

SVGVIAYICL VCRCPFVGET DRATLLRVGE GTLNWDAPDV TCRSPEAQNF LHILLQPDPE 240

KRPSAFESLS HEWF 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Danio rerio"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005089	; F:Rho guanyl-nucleotide exchange factor activity
GO:0035023	; P:regulation of Rho protein signal transduction

KEGG

InterPros

IPR000219	; DH-domain.
IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR020682	; Obscurin-myosin_light-ch_kin.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 3.
PF00069	; Pkinase; 2.
PF00621	; RhoGEF; 1.

SMARTs

SM00060	; FN3; 1.
SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00233	; PH; 1.
SM00220	; S_TKc; 2.

Prosites

PS50010	; DH_2; 1.
PS50853	; FN3; 1.
PS50835	; IG_LIKE; 3.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013