EKS-TAR-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	359.9	1.5E-107	22	273	252

Status

Unreviewed

Ensembl Protein

ENSTRUP00000036933

UniProt Accession

H2UJ11;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000014442	ENSTRUP00000036933	ENSTRUT00000037065
ENSTRUG00000014442	ENSTRUP00000036932	ENSTRUT00000037064
ENSTRUG00000014442	ENSTRUP00000036934	ENSTRUT00000037066

Organism

Takifugu rubripes

Functional Description

Protein Length

621

Protein Sequence
(FASTA)

SMVMADSVQK PQIRGPVRVG FYDIERTLGK GNFAVVKLAR HRITKSEVAI KIIDKTQLDA 60

VNLEKIYREV QIMKMLDHPH IIKLYQVMET KNMLYLVTEY AKNGEIFDYL AKHGRLSELE 120

ARRKFWQILS AVEYCHNRNI VHRDLKAENL LLDGHMNIKI ADFGFGNFFQ PGKPLATWCG 180

SPPYAAPEVF EGQQYEGPQL DIWSMGVVLY VLVCGALPFD GPTLPVLRQR VLEGRFRIPY 240

FMTEDCEHLI RRMLVLDPSK RLSVAQIKQH KWMAPYVPVQ RPVLHQQPLS AEGEAGIGEY 300

SEQVLRLMHS LGIDQHKTIE SLQNKSYNHF AAIYYLLVER LKAHRCSFPV EQRLDARQRR 360

PSTIAEQTVV KEIIDCVRIH SIIPKSSILS FSTFGRFIYC RIQSQSFSPF YSTLKVNGCL 420

MDPLPPPTVL RKSSTSSPSN MMETSIDEGI ETEEPDAEED PPHLLSAYQT ARFGQRRHTL 480

SEVTNQPGPS NQGKFFTLGH NPSMGSVDSD MGYDMGSMHS DIGLLEDPPS LSELVSSSTS 540

TQTVTPSPFL SARPPNPAMA ALTSQHRETH NRSPISFREG RRASDTSLTQ GLVAFRQHLQ 600

NLARTKGILE LNKVQMLVEH M 621

Nucleotide Sequence
(FASTA)

AGCATGGTCA TGGCTGACAG CGTCCAGAAG CCGCAGATCC GGGGTCCTGT CCGAGTCGGG 60

TTCTACGACA TCGAGCGCAC TTTAGGAAAG GGCAATTTTG CCGTCGTGAA GCTCGCCAGA 120

CACCGCATAA CCAAGAGCGA GGTGGCCATT AAGATCATTG ACAAGACCCA GCTGGATGCT 180

GTGAACCTGG AGAAGATCTA CAGGGAAGTT CAGATCATGA AGATGCTGGA CCATCCCCAC 240

ATCATCAAAC TCTATCAGGT GATGGAGACG AAGAACATGC TTTACTTGGT CACGGAGTAC 300

GCGAAGAACG GGGAGATCTT TGACTACCTG GCAAAACACG GCCGCCTGAG CGAGCTGGAG 360

GCCCGGAGGA AGTTCTGGCA GATCCTGTCG GCGGTGGAGT ATTGTCACAA CCGCAACATC 420

GTCCACAGGG ACCTGAAGGC GGAGAACCTG TTACTGGACG GACACATGAA CATCAAGATC 480

GCAGATTTTG GATTTGGGAA TTTCTTTCAA CCTGGGAAGC CTCTTGCCAC ATGGTGTGGC 540

AGCCCACCTT ATGCTGCTCC AGAGGTCTTT GAAGGCCAGC AGTATGAGGG TCCACAGCTG 600

GACATCTGGA GTATGGGGGT GGTGCTGTAC GTGCTGGTGT GTGGTGCGTT ACCATTTGAT 660

GGACCAACTC TGCCTGTACT CCGACAGAGA GTCCTGGAAG GAAGGTTCCG TATCCCTTAC 720

TTCATGACTG AAGACTGTGA GCACCTGATT CGCAGGATGC TGGTGCTGGA CCCATCAAAG 780

CGCCTCTCTG TGGCCCAGAT CAAGCAGCAC AAGTGGATGG CTCCGTACGT TCCCGTGCAG 840

AGGCCGGTTC TACACCAGCA GCCTCTATCT GCTGAGGGTG AAGCAGGCAT CGGGGAGTAC 900

AGCGAACAAG TTCTCCGCCT GATGCATAGT CTTGGCATTG ACCAGCACAA AACTATAGAG 960

TCTTTGCAGA ACAAAAGCTA CAACCACTTT GCTGCTATCT ACTACCTGCT GGTCGAGCGG 1020

CTCAAGGCCC ATCGTTGCAG CTTCCCCGTG GAACAGCGGC TCGACGCCCG CCAGCGACGA 1080

CCAAGCACCA TTGCTGAACA GACAGTTGTC AAGGAAATAA TTGACTGTGT GAGGATCCAT 1140

TCAATTATAC CTAAATCAAG CATCCTCAGC TTCTCAACTT TTGGGAGATT TATCTACTGC 1200

AGAATACAGA GTCAATCTTT CTCCCCCTTT TATTCGACCC TCAAGGTGAA CGGCTGTCTG 1260

ATGGACCCTC TACCTCCCCC CACCGTCCTC CGCAAATCCT CCACGTCATC ACCAAGCAAC 1320

ATGATGGAGA CTTCAATTGA TGAGGGCATC GAGACCGAGG AGCCCGATGC TGAGGAGGAC 1380

CCACCCCATT TGTTGTCTGC TTATCAGACG GCACGGTTTG GCCAGCGAAG GCACACCCTC 1440

TCTGAGGTGA CCAACCAGCC AGGTCCTTCA AATCAAGGTA AATTTTTCAC TCTTGGTCAC 1500

AATCCCTCCA TGGGTAGCGT GGACTCGGAC ATGGGCTACG ACATGGGCTC CATGCACAGC 1560

GACATTGGCC TGCTGGAGGA TCCGCCCTCT CTCAGTGAAC TGGTCTCATC AAGCACCTCC 1620

ACCCAAACCG TCACCCCTTC ACCCTTCTTA AGCGCACGGC CTCCGAACCC AGCCATGGCT 1680

GCCCTCACCT CCCAGCACAG GGAGACGCAC AACCGTTCTC CTATCAGCTT CAGAGAAGGA 1740

CGGCGCGCTT CCGACACCTC CCTCACTCAA GGTCTTGTCG CATTTCGACA GCACCTCCAG 1800

AACCTCGCAA GGACCAAAGG CATCCTGGAG CTTAACAAGG TCCAGATGCT GGTGGAGCAT 1860

ATG 1863

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 22    YDIERTLGKGNFAVVKLARHRITKSEVAIKIIDKTQLDAVNLEKIYREVQIMKMLDHPHI  81

         899*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e ear+ f q++sav+Y+h+++iv

Q: 82    IKLYQVMETKNMLYLVTEYAKNGEIFDYLAKHGRLSELEARRKFWQILSAVEYCHNRNIV  141

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld ++nikiaDFG++n+f++gk l t+cGsppYaaPe+++g++Yegp++D

Q: 142   HRDLKAENLLLDGHMNIKIADFGFGNFFQPGKPLATWCGSPPYAAPEVFEGQQYEGPQLD  201

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +++++e+L+r++Lv dp+kR

Q: 202   IWSMGVVLYVLVCGALPFDGPTLPVLRQRVLEGRFRIPYFMTEDCEHLIRRMLVLDPSKR  261

         ************************************************************

S: 241   atieeilkhewl  252

         +++ +i++h+w+

Q: 262   LSVAQIKQHKWM  273

         ***********8

Domain Sequence
(FASTA)

YDIERTLGKG NFAVVKLARH RITKSEVAIK IIDKTQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK NMLYLVTEYA KNGEIFDYLA KHGRLSELEA RRKFWQILSA VEYCHNRNIV 120

HRDLKAENLL LDGHMNIKIA DFGFGNFFQP GKPLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPVLRQRV LEGRFRIPYF MTEDCEHLIR RMLVLDPSKR 240

LSVAQIKQHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013