EKS-TAR-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	327.4	1.3E-97	750	1010	261

Status

Unreviewed

Ensembl Protein

ENSTRUP00000037465

UniProt Accession

H2UKJ2;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000014663	ENSTRUP00000037463	ENSTRUT00000037598
ENSTRUG00000014663	ENSTRUP00000037464	ENSTRUT00000037599
ENSTRUG00000014663	ENSTRUP00000037465	ENSTRUT00000037600
ENSTRUG00000014663	ENSTRUP00000037466	ENSTRUT00000037601

Organism

Takifugu rubripes

Functional Description

Protein Length

1044

Protein Sequence
(FASTA)

MDINAWVECF EKRLSTYTGD DPLDQWDKFV DYLEQRIPED DRREMSQVFD SLVQRFLTVE 60

RYSDDIRYVK YCIKCASFYQ DPTALYTHVY SKGVGHRTAA LYVTWAQHFE HRGMYEEADA 120

VYQKAVKNQA QPAETVLNEY SLLWFKRYLS LWHTTVNALE SRNPLQNSHV TNQLMSHQEQ 180

HNKASGDCSF KHPTIETIVT VSRSETSGTI NSSQSSNVQF VSEYLKDELL CEGSELCFEE 240

VRAAKYFRKL EEQQDDQTVD VLFAEEQFMR VEEENFMSMR DALGTIKQAL GGVKSHMGQT 300

AVVETSAAMN INPTQHSTGP PQLSSRRSSR RSLGLRLLTE PTFIHEALAV VPDQYQEERK 360

VTSSDPDERL CHPALTDRRT QRSTLLQPSE SLSWLYRDRE EKESGMWHVS LNPTTDSTVS 420

TPGVSQGGTG NLSHITPNTS LGFVQATPSR VLPSPTVNTR EALDVIMDMF QAPTLLEDPF 480

NKTSAFPSSE VEAEPAPLKH GEQDKLKKLN CKPRAAASFT IFQDEQDKEN ISAAAPHPSL 540

SKSKPIKALA EIRQETPPEL MPDESTMWGA RYNSLNSLAA CPNSTTDFAM LAQCVSTPFA 600

FKTPHSSNFF QDEGTTENSG GGDGDDDEFM RRQPKKLSPI MEQSPAEETA ISHMALPSDR 660

LGTIVGEGLA SAQLCSTSST TLVQAPPPAT PARAAGPPLV SDPWDNDLIS DLLSALTPPL 720

PSHPHYITWS CNMPAISPRM TITMGKASLR VDCILGEGAF ATVYQATNPA TLEKVVLKVQ 780

KPANPWEFYI NTQLDARLQP HTRHLFSNIR SAHLFNNGSV LLAQLHNYGT LLNAVNIYKT 840

LSEKLMPQPL VMYLATCILT MVEQLHAIHI IHADIKPDNF LLGERFLENR CFEPENLDHG 900

LVLIDLGQSI DLDLFPEGTA FTAKCLTSGF QCTEMLSGKP WNYQSDYFGV AGTVHCMLFG 960

TYMQVTNDGG VWKTNGVFRR IPHSDLWQEF FHVLLNVPDC SGLPSLRGLR GKLTSVLQQD 1020

YSNKLGTLKS RLVVQLLERR KAAA 1044

Nucleotide Sequence
(FASTA)

ATGGATATCA ACGCCTGGGT CGAATGTTTT GAAAAAAGGT TGAGCACGTA TACGGGAGAT 60

GATCCACTGG ATCAATGGGA TAAGTTTGTA GATTATCTTG AGCAGAGGAT ACCTGAGGAC 120

GACCGTCGTG AGATGTCTCA GGTGTTTGAC AGCCTTGTGC AGAGGTTTTT GACTGTTGAG 180

AGATACTCGG ACGACATCAG ATATGTGAAG TACTGCATCA AATGTGCGAG TTTTTACCAG 240

GACCCCACTG CTCTGTACAC CCATGTTTAC AGTAAAGGGG TTGGCCACAG GACTGCTGCC 300

CTCTACGTGA CCTGGGCACA GCACTTTGAA CACAGAGGGA TGTATGAAGA GGCAGATGCC 360

GTCTACCAGA AAGCTGTGAA GAACCAAGCC CAGCCAGCTG AGACTGTTCT CAATGAATAC 420

AGTTTGTTAT GGTTTAAGAG ATATTTATCT TTATGGCACA CGACTGTTAA TGCTTTAGAA 480

AGCAGAAACC CTTTACAAAA TTCTCATGTA ACCAATCAGC TGATGTCTCA CCAAGAGCAA 540

CATAACAAGG CCTCTGGGGA CTGTTCTTTC AAACATCCCA CCATTGAAAC CATTGTCACA 600

GTTTCCCGCT CTGAGACTTC TGGGACCATT AACTCCAGCC AGAGCTCCAA CGTTCAGTTT 660

GTGTCCGAGT ACCTGAAGGA TGAGCTGCTC TGTGAGGGGT CCGAGTTGTG TTTCGAGGAG 720

GTCCGAGCGG CGAAATACTT CCGTAAACTG GAGGAGCAAC AGGATGATCA GACAGTAGAT 780

GTTTTGTTTG CAGAAGAGCA GTTTATGAGG GTGGAGGAGG AGAACTTCAT GAGCATGAGA 840

GATGCACTGG GGACGATCAA GCAGGCTCTG GGGGGTGTAA AGAGCCACAT GGGGCAGACA 900

GCTGTAGTGG AAACATCTGC TGCCATGAAC ATTAATCCTA CTCAGCATTC CACCGGGCCT 960

CCTCAGTTAT CCAGTCGGCG CAGCAGCCGG CGCTCGCTCG GTTTGAGGCT GCTCACTGAG 1020

CCCACCTTCA TCCACGAGGC CCTTGCTGTC GTCCCTGACC AATATCAGGA GGAGAGAAAG 1080

GTCACATCCT CTGACCCTGA TGAGAGACTG TGTCATCCAG CTCTAACTGA CAGGAGGACC 1140

CAGAGATCAA CACTGCTGCA GCCCAGTGAG TCATTATCCT GGTTATACCG TGACAGGGAG 1200

GAGAAAGAAT CTGGGATGTG GCATGTCTCC CTGAACCCGA CGACAGACTC AACAGTAAGT 1260

ACACCAGGTG TGTCACAGGG TGGGACCGGT AACCTTTCTC ACATTACTCC CAACACATCA 1320

CTGGGTTTTG TTCAGGCCAC ACCATCACGG GTGCTGCCGT CTCCTACAGT CAACACACGG 1380

GAAGCTCTGG ATGTTATCAT GGACATGTTC CAGGCGCCAA CCCTCCTCGA GGACCCGTTC 1440

AACAAAACAT CGGCTTTTCC CTCGTCAGAG GTGGAGGCAG AACCGGCCCC ACTTAAACAT 1500

GGGGAACAAG ATAAGCTGAA AAAGTTGAAC TGTAAGCCCC GCGCTGCTGC CTCGTTTACT 1560

ATCTTCCAGG ATGAACAAGA CAAAGAAAAC ATCAGTGCCG CTGCTCCTCA TCCTTCACTC 1620

AGCAAATCTA AACCAATCAA AGCTCTGGCT GAGATACGGC AGGAGACGCC TCCTGAGCTG 1680

ATGCCGGACG AGAGCACCAT GTGGGGGGCC CGCTACAACT CCCTCAACTC CCTGGCAGCG 1740

TGTCCCAACA GCACCACCGA CTTCGCCATG TTGGCCCAGT GTGTGTCCAC ACCGTTCGCA 1800

TTCAAGACGC CTCACAGCAG CAACTTCTTC CAGGATGAAG GTACAACAGA GAACAGCGGT 1860

GGTGGTGACG GTGATGACGA CGAATTTATG AGACGTCAAC CGAAAAAACT CAGCCCCATC 1920

ATGGAGCAGA GTCCAGCTGA AGAAACTGCC ATCAGTCACA TGGCCCTGCC CTCTGACAGG 1980

CTCGGGACCA TTGTAGGTGA GGGTCTTGCC TCAGCCCAGC TCTGCTCGAC CTCCTCCACC 2040

ACCCTGGTGC AGGCTCCGCC CCCTGCAACG CCGGCACGTG CGGCCGGCCC ACCACTGGTG 2100

TCTGACCCAT GGGACAATGA TCTGATCTCA GATTTGCTGT CGGCACTCAC TCCGCCGCTA 2160

CCCTCTCACC CTCATTACAT CACCTGGTCC TGCAACATGC CCGCCATCAG CCCGCGGATG 2220

ACCATCACCA TGGGTAAAGC ATCTCTAAGA GTCGACTGCA TCCTTGGAGA AGGAGCCTTC 2280

GCCACCGTGT ATCAGGCCAC CAACCCTGCG ACCTTAGAGA AGGTGGTGTT GAAGGTCCAG 2340

AAACCGGCCA ATCCCTGGGA GTTTTACATC AACACCCAGC TGGACGCTCG GCTGCAGCCC 2400

CACACACGTC ACCTCTTCAG CAACATCCGT TCAGCTCACC TGTTCAATAA CGGCAGCGTT 2460

CTGCTTGCTC AGCTCCACAA TTACGGCACC TTGCTGAATG CAGTGAACAT CTACAAAACC 2520

CTGAGTGAGA AGCTGATGCC GCAGCCGCTT GTTATGTACC TGGCTACCTG CATCCTGACC 2580

ATGGTGGAGC AGCTGCACGC CATCCACATC ATCCACGCTG ACATCAAACC TGACAACTTC 2640

CTACTGGGAG AGAGGTTCCT GGAGAACAGG TGCTTTGAGC CAGAGAACTT GGACCACGGC 2700

CTCGTCCTCA TTGACCTCGG CCAGAGCATC GACCTGGATC TTTTCCCAGA GGGCACCGCG 2760

TTCACTGCCA AGTGCCTGAC ATCAGGCTTC CAGTGCACTG AGATGCTGAG TGGGAAACCA 2820

TGGAATTACC AGTCGGATTA CTTTGGAGTT GCAGGGACGG TTCACTGCAT GCTGTTTGGG 2880

ACCTACATGC AGGTGACAAA TGATGGCGGC GTGTGGAAGA CCAACGGTGT CTTCAGAAGA 2940

ATTCCTCACA GCGACCTGTG GCAGGAGTTC TTCCACGTTC TTCTGAACGT TCCGGACTGT 3000

TCCGGGCTGC CAAGCCTGCG GGGCCTGCGT GGGAAGCTGA CGTCGGTCCT GCAGCAGGAC 3060

TACAGCAACA AACTCGGCAC GTTGAAGAGT CGTCTGGTGG TTCAGCTGCT GGAGCGCCGG 3120

AAAGCAGCCG CA 3132

Domain Profile

S: 2     eiekeigeGayakvykaehdsksgelvalKvekpansWefYIclqlkeRlkeeellksii  61

          ++  +geGa+a+vy+a+ +  + e+v+lKv+kpan+WefYI++ql  Rl+ ++  + +

Q: 750   RVDCILGEGAFATVYQAT-NPATLEKVVLKVQKPANPWEFYINTQLDARLQ-PHTRHLFS  807

         57889*************.899*****************************.779*****

S: 62    eissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiveklHe  121

         +i sa+lf+++s+l+ ++++ygtll+++n +k+ ++k m++ lv++l++ +l++ve+lH+

Q: 808   NIRSAHLFNNGSVLLAQLHNYGTLLNAVNIYKTLSEKLMPQPLVMYLATCILTMVEQLHA  867

         ************************************************************

S: 122   veIiHgDlkPdnfllgnrimdkad..kdkeekglkliDfgrsiDmkllpdgtkfkgkakt  179

         ++IiH+D+kPdnfllg+r+ ++ +   ++ ++gl liD+g+siD+ l+p+gt+f++k+ t

Q: 868   IHIIHADIKPDNFLLGERFLENRCfePENLDHGLVLIDLGQSIDLDLFPEGTAFTAKCLT  927

         **********************98435566799***************************

S: 180   dafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkkelw  239

         ++f+c+eml+gk+w+Yq D+fg+a+++h++lfg+y++v+++gg wk +  ++r ++++lw

Q: 928   SGFQCTEMLSGKPWNYQSDYFGVAGTVHCMLFGTYMQVTNDGGVWKTNGVFRRIPHSDLW  987

         ************************************************************

S: 240   ekiferlLNisdastlpsleelv  262

         +++f++lLN++d+s lpsl  l+

Q: 988   QEFFHVLLNVPDCSGLPSLRGLR  1010

         *******************9987

Domain Sequence
(FASTA)

RVDCILGEGA FATVYQATNP ATLEKVVLKV QKPANPWEFY INTQLDARLQ PHTRHLFSNI 60

RSAHLFNNGS VLLAQLHNYG TLLNAVNIYK TLSEKLMPQP LVMYLATCIL TMVEQLHAIH 120

IIHADIKPDN FLLGERFLEN RCFEPENLDH GLVLIDLGQS IDLDLFPEGT AFTAKCLTSG 180

FQCTEMLSGK PWNYQSDYFG VAGTVHCMLF GTYMQVTNDG GVWKTNGVFR RIPHSDLWQE 240

FFHVLLNVPD CSGLPSLRGL R 261

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013