EKS-TAR-00466

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00466

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	453.5	4.2E-136	271	520	250

Status

Unreviewed

Ensembl Protein

ENSTRUP00000037680

UniProt Accession

H2UL58;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000014739	ENSTRUP00000037680	ENSTRUT00000037816
ENSTRUG00000014739	ENSTRUP00000037679	ENSTRUT00000037815

Organism

Takifugu rubripes

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MGCVQCKDKE AAKLTDDRET SLSHHSGYRY GSDPTPQHYP SFGVTTIPNY NNFHGTASQG 60

VTVFGGVHTS SQSGTLRSRG GTGVTLFVAL YDYEARTEDD LSFRKGERFQ ILNSTEGDWW 120

EARSLTTGGT GYIPSNYVAP VDSIQAEDWY FGKLGRKDAE RQLLSNGNAR GTFLIRESET 180

TKGAYSLSIQ DWDDIKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSARAAGLCC 240

RLIVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGTTKVAVKT 300

LKPGTMSPES FLEEAQIMKK LRHDKLVQLY AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR 360

GLKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGD SLVCKIADFG LARLIEDNEY 420

TARQGAKFPI KWTAPEAALY GKFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 480

RGYRMPCPQD CPTSLHELMV QCWKKDPEER PTFEYLQAFL EDYFTATEPQ YQPGDNL 537

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TCCAATGTAA GGATAAAGAA GCAGCGAAAC TCACCGACGA CCGGGAGACC 60

AGCCTCTCGC ACCATTCGGG CTACCGCTAT GGGTCCGACC CCACGCCGCA GCACTACCCC 120

AGCTTCGGCG TCACCACCAT TCCCAACTAC AACAACTTCC ACGGCACCGC CTCACAGGGG 180

GTGACGGTGT TCGGAGGGGT CCACACGTCC TCACAGTCTG GAACGCTGAG GTCTCGTGGA 240

GGAACAGGGG TGACCCTATT TGTGGCTCTC TATGACTACG AGGCCAGGAC CGAGGATGAC 300

CTCAGCTTCA GGAAGGGGGA GCGGTTCCAG ATCCTTAACA GCACCGAGGG AGACTGGTGG 360

GAGGCTCGTT CTCTCACCAC AGGTGGAACT GGTTACATTC CCAGCAATTA TGTTGCTCCG 420

GTGGACTCGA TCCAAGCTGA GGATTGGTAT TTCGGTAAAC TAGGCCGAAA AGATGCAGAG 480

AGGCAGCTGC TGTCCAACGG CAATGCCAGA GGCACTTTCC TCATCCGTGA AAGTGAAACG 540

ACCAAAGGGG CCTACTCACT CTCCATTCAG GACTGGGATG ATATCAAAGG AGACCACGTC 600

AAGCACTATA AAATTCGCAA ACTGGACAAT GGCGGCTACT ACATCACCAC CAGGGCCCAG 660

TTTGAGACCC TTCAGCAGCT GGTGCAGCAC TACTCTGCCA GGGCTGCTGG GCTGTGCTGC 720

CGGCTGATTG TGCCGTGCCA CAAGGGGATG CCTCGTCTCA CCGACCTGTC CGTCAAAACC 780

AAAGACGTGT GGGAGATCCC GCGGGAGTCG CTGCAGCTCA TCAAACGTCT GGGCAACGGC 840

CAGTTTGGAG AAGTCTGGAT GGGCACGTGG AACGGCACCA CCAAGGTGGC GGTCAAGACG 900

CTGAAGCCTG GCACCATGTC GCCCGAGTCC TTCCTGGAGG AGGCTCAGAT TATGAAGAAG 960

CTCCGACACG ACAAGCTGGT GCAGCTGTAC GCCGTGGTGT CCGAGGAGCC CATCTATATC 1020

GTCACCGAGT ACATGAGCAA AGGCAGTTTG CTTGATTTCC TGAAAGACGG CGAAGGACGA 1080

GGCCTCAAAT TGCCAAATCT AGTGGACATG GCTGCTCAGG TGGCGGCAGG CATGGCGTAC 1140

ATCGAGAGGA TGAACTACAT TCACAGAGAC CTGCGCTCTG CCAACATCCT TGTCGGGGAC 1200

AGTCTGGTGT GTAAGATCGC CGACTTCGGC CTGGCAAGGC TCATCGAAGA CAACGAATAC 1260

ACAGCGAGAC AAGGTGCAAA ATTCCCAATA AAGTGGACCG CCCCCGAGGC CGCCCTCTAC 1320

GGGAAATTCA CCATCAAGTC GGACGTGTGG TCATTTGGCA TTCTGCTGAC AGAGCTGGTG 1380

ACCAAGGGCA GGGTGCCGTA TCCAGGCATG AACAACCGGG AGGTGCTGGA GCAGGTCGAG 1440

CGGGGCTACC GAATGCCGTG CCCTCAGGAC TGCCCCACGT CGCTGCACGA GCTGATGGTG 1500

CAATGCTGGA AGAAGGACCC CGAGGAGAGG CCCACCTTCG AGTACCTGCA GGCCTTTTTG 1560

GAGGACTACT TCACTGCCAC GGAGCCTCAG TACCAGCCGG GGGATAATCT CTGA 1614

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kvavktlk+gt+spe+fleeaqi+kklrh+klv+ly

Q: 271   LQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLY  330

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg+ lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 331   AVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHR  389

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+slv+k+adfGlarlied+eyta++gak+PikWtaPea+ +gkftiksdv

Q: 390   DLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDV  449

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp++l+el+++cwkkdpee

Q: 450   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPTSLHELMVQCWKKDPEE  509

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 510   RPTFEYLQAFL  520

         *******9876

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGTTKVAVKT LKPGTMSPES FLEEAQIMKK LRHDKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR GLKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LRSANILVGD SLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GKFTIKSDVW 180

SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPTSLHELMV QCWKKDPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013