EKS-TAR-00335

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00335

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	414.3	4.6E-124	38	290	253

Status

Unreviewed

Ensembl Protein

ENSTRUP00000037778

UniProt Accession

H2ULF6;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000014787	ENSTRUP00000037777	ENSTRUT00000037913
ENSTRUG00000014787	ENSTRUP00000037778	ENSTRUT00000037914

Organism

Takifugu rubripes

Functional Description

Protein Length

588

Protein Sequence
(FASTA)

MSAGIAKPTN PSAHVDPKSA PLKEIPDVLV DPRTMRRYAR GRFLGKGGFA KCYEITDLET 60

KQTFAGKIVP KSLILKQHQR EKMTSEIAIH KSLDHANIVG FHGFFEDDDF VFVVLEICRR 120

RSLLELHKRR KAVTEPEARY YMTQLLKGVH YLHNNRVIHR DLKLGNIFLN DDMEVKIGDF 180

GLATRIEFDG ERKKTLCGTP NYIAPEVLCK KGHSYEVDIW SLGCILYTLL VGKPPFETSC 240

LKETYNRIKK NSYTIPWHIN PAATSLIKRM LHADPTQRPT ISDVQADEFF TSGYVPSRLP 300

TTCLTVPPRF SMGPSAAAEL NQRRPLAAIN NKDIQYPQDL MVKLFFPAGT EKVDVKEEPM 360

QREPEPAENH LKDMLQQLNV LIAAKPSEKA VVCQEEAEDP ACIPIFWISK WVDYSDKYGL 420

GYQLCDNSVG VLFNDYTRLI MYTDGDSLQY IDKTAAESYL NVRSYPPTLN KKITLLKYFR 480

NYMSEHLLKA GANIARREGD ELARLPYLSL WFRTKSAIVL HLSNGTVQIN FFQDHTKLIL 540

CPLMAAVTYI DEKRDFRTYK LSLLEEFGCS KELASRLRYA KLMVEKLL 588

Nucleotide Sequence
(FASTA)

ATGAGTGCAG GCATTGCGAA GCCGACGAAC CCGTCGGCAC ATGTCGACCC CAAATCGGCT 60

CCTCTCAAAG AAATCCCAGA TGTTCTGGTA GATCCACGCA CCATGAGAAG ATACGCAAGG 120

GGACGGTTCC TGGGGAAAGG TGGTTTCGCC AAATGCTACG AAATCACCGA CCTGGAGACG 180

AAGCAGACGT TCGCCGGGAA GATTGTGCCA AAGTCCCTGA TCCTGAAGCA ACACCAGAGG 240

GAGAAGATGA CTTCCGAAAT CGCCATTCAC AAAAGTCTCG ACCATGCCAA CATCGTGGGG 300

TTTCACGGCT TTTTCGAGGA CGACGACTTC GTTTTTGTCG TCCTGGAGAT CTGCAGGAGA 360

AGGTCCTTGT TGGAGCTGCA CAAGCGTCGC AAGGCTGTGA CGGAGCCTGA AGCCCGCTAC 420

TACATGACCC AGCTTCTGAA GGGAGTCCAT TACCTGCACA ACAACAGAGT CATTCACAGA 480

GACCTGAAGC TGGGGAACAT CTTCCTCAAT GACGACATGG AGGTCAAGAT CGGGGATTTT 540

GGTTTGGCCA CCAGGATTGA GTTCGATGGT GAGAGGAAGA AGACTCTGTG TGGCACGCCC 600

AACTACATTG CACCGGAGGT GCTTTGCAAG AAAGGCCACA GCTATGAAGT GGACATTTGG 660

TCTCTTGGGT GTATATTGTA TACATTGTTG GTGGGTAAGC CCCCCTTTGA GACTTCCTGT 720

CTGAAGGAGA CCTACAATCG CATAAAGAAG AACAGCTACA CCATCCCCTG GCACATCAAC 780

CCAGCGGCAA CGTCCCTCAT CAAGAGGATG TTGCATGCCG ACCCGACTCA GAGGCCGACC 840

ATTTCTGACG TGCAGGCAGA TGAGTTCTTT ACATCGGGCT ACGTCCCCTC ACGCCTGCCC 900

ACTACTTGCC TCACGGTGCC GCCTCGTTTT TCAATGGGGC CGTCCGCCGC GGCGGAGCTG 960

AACCAGAGAC GCCCTCTCGC CGCCATTAAC AACAAGGATA TTCAGTATCC ACAGGATTTA 1020

ATGGTGAAGC TCTTCTTTCC AGCAGGCACA GAAAAGGTGG ACGTGAAGGA GGAGCCCATG 1080

CAAAGGGAGC CCGAGCCAGC AGAAAACCAC CTGAAGGACA TGTTGCAGCA GCTGAACGTT 1140

CTCATTGCAG CCAAACCCTC CGAGAAGGCC GTCGTCTGCC AAGAAGAGGC AGAGGACCCC 1200

GCCTGTATTC CCATCTTCTG GATCAGCAAA TGGGTCGACT ACTCTGATAA ATATGGTTTA 1260

GGCTACCAGC TGTGTGACAA CAGCGTAGGC GTCCTGTTTA ACGACTACAC GCGTCTCATC 1320

ATGTACACCG ATGGAGACAG TCTGCAGTAC ATTGACAAGA CGGCTGCTGA ATCCTACCTC 1380

AACGTCCGCT CGTACCCTCC AACTCTCAAC AAGAAGATAA CGCTGCTGAA ATATTTCCGC 1440

AATTACATGA GCGAGCACCT GCTGAAGGCC GGCGCCAACA TCGCACGGCG GGAAGGAGAC 1500

GAGCTGGCGA GGCTGCCCTA TCTGTCCCTC TGGTTCAGAA CCAAGAGCGC CATTGTCCTG 1560

CACCTGAGCA ACGGCACCGT CCAGATCAAC TTCTTCCAGG ACCACACCAA GCTGATCCTG 1620

TGCCCCCTCA TGGCTGCGGT GACCTACATT GACGAGAAAC GAGACTTCCG CACCTACAAA 1680

CTGTCTCTGC TGGAGGAGTT TGGCTGCAGT AAGGAGCTGG CCAGCCGCCT TCGCTACGCC 1740

AAGCTGATGG TGGAGAAGCT GCTG 1764

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakcye++dletk++fa k+vpksl+ k++qrek+++ei+ih+sl+h n

Q: 38    YARGRFLGKGGFAKCYEITDLETKQTFAGKIVPKSLILKQHQREKMTSEIAIHKSLDHAN  97

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv ++ ffed+++v++vle+c+rrsl el+krrka+tepe+ryy++q+++g++ylh++r+

Q: 98    IVGFHGFFEDDDFVFVVLEICRRRSLLELHKRRKAVTEPEARYYMTQLLKGVHYLHNNRV  157

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgn+fln+++evkigdfGlatr+e ++erkktlcGtPnyiaPevl kkghs+ev

Q: 158   IHRDLKLGNIFLNDDMEVKIGDFGLATRIEFDGERKKTLCGTPNYIAPEVLCKKGHSYEV  217

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diWslGcilytllvGkPPfet++lkety++ikk++y++P +++++a+sli+++l+++P++

Q: 218   DIWSLGCILYTLLVGKPPFETSCLKETYNRIKKNSYTIPWHINPAATSLIKRMLHADPTQ  277

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp++++v  def+

Q: 278   RPTISDVQADEFF  290

         **********998

Domain Sequence
(FASTA)

YARGRFLGKG GFAKCYEITD LETKQTFAGK IVPKSLILKQ HQREKMTSEI AIHKSLDHAN 60

IVGFHGFFED DDFVFVVLEI CRRRSLLELH KRRKAVTEPE ARYYMTQLLK GVHYLHNNRV 120

IHRDLKLGNI FLNDDMEVKI GDFGLATRIE FDGERKKTLC GTPNYIAPEV LCKKGHSYEV 180

DIWSLGCILY TLLVGKPPFE TSCLKETYNR IKKNSYTIPW HINPAATSLI KRMLHADPTQ 240

RPTISDVQAD EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013