EKS-TAR-00508
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00508
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR577.42.7E-173590943354
StatusUnreviewed
Ensembl ProteinENSTRUP00000038529
UniProt AccessionH2UNK8;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRALPHA
Gene Synonyms/Alias PDGFRALPHA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000015076ENSTRUP00000038532ENSTRUT00000038671
ENSTRUG00000015076ENSTRUP00000038528ENSTRUT00000038667
ENSTRUG00000015076ENSTRUP00000038530ENSTRUT00000038669
ENSTRUG00000015076ENSTRUP00000038529ENSTRUT00000038668
ENSTRUG00000015076ENSTRUP00000038531ENSTRUT00000038670
OrganismTakifugu rubripes
Functional Description
Protein Length1083
Protein Sequence
(FASTA)
RLPTPQSALA KRCRVAVGKP SMFPPSSAPL LLPQLEELVV PLHTAFTLTC QGEATIAWDV 60
PLDVPEKTQE DNSGLFVTTI SVDSASAMHT GYYRCFYRRN ATEDADEAMQ SIYVYVPDPD 120
VPFVPLVVPF GNHVLSDHEE MEIQCRVSDP SANVTLINVD TQQPVPCMYD SKRGALGVFT 180
AGTYVCKAVV NGAEHYSEDY IVHGWIGGSG LHVELTAKHT VLLVGDTITV NCLAQGSEIL 240
EDHWKYPGKV ANRAIKTVHE NKKDQEILYT LTVPQASVKD TGIYSCSITD VVTNMSQTKQ 300
IAIRVYASEF MSIQPKFGEY ESAELDEVCE FRAEITSFPT ASVTWFKDSV PLSNVTAEIS 360
TSLQKLSETS YMSVLTLIRA KEEDSGNYTM RVKNGDQSRT VSLILEVKVP AVIVDLMDIH 420
HGSATGQSVV CITRGQPTPL VEWFVCKNIK HCANDTSSWV PLPVNSTEVT MDSRFDEDNN 480
LETQVIFGHL ENTLAVRCLA RNEMAAVSRE IKLVSNGPHP ELTVAAAVLV LLVIVIISLI 540
VLVVIWKQKP RYEIRWRVIE SVSPDGHEYI YVDPMQLPYD SRWEFPRDRL VLGRILGSGA 600
FGKVVEGTAY GLSRSQPVMK VAVKMLKPTA RSSEKQALMS ELKIMTHLGP HLNIVNLLGA 660
CTKSGPIYII TEYCFYGDLV NYLHKNRESF LNPKPEKSNK KELDIFGINP ADESSRSYVI 720
LSFESKGDYM DMKQADNTQY VPMLEISNAS KYSDLQGSNY DHPPSQKGSN DGEMDQLLSD 780
NMSEGLTTND LLSFTYQVAK GMEFLASKNC VHRDLAARNV LLSQGKIVKI CDFGLARDIM 840
HDNNYVSKGS TFLPVKWMAP ESIFDNLYTT LSDVWSYGIL LWEIFSLGGT PYPGMIVDSS 900
FYNKIKSGYR MSKPEHAPQD VYDMMMKCWN SEPEKRPSFL GLSDTIASLL PSSYKRHYER 960
VNHEFLKSDH PAVTRVCVDN DDAYIGITYK NQGKLKDRES GFDEQRLSSD SGYIIPLPDL 1020
DPISDEEYGK RNRHSSQTSE ESAIETGSSS STFAKREGET LEDITLLDEM CLDCSDLVED 1080
SFL 1083
Nucleotide Sequence
(FASTA)
CGCCTACCCA CCCCCCAAAG TGCACTGGCT AAAAGATGCC GAGTCGCTGT CGGAAAACCG 60
TCGATGTTCC CGCCCTCCTC GGCTCCGTTG CTGCTGCCAC AGTTGGAGGA GCTGGTGGTT 120
CCCCTCCACA CCGCCTTCAC TTTAACATGT CAGGGGGAGG CGACAATAGC CTGGGACGTG 180
CCGCTGGACG TGCCGGAGAA GACGCAGGAG GACAACAGCG GCCTCTTCGT CACCACTATC 240
AGCGTGGACT CCGCCAGCGC CATGCACACC GGCTACTACA GGTGCTTCTA CAGAAGAAAC 300
GCCACGGAGG ACGCGGACGA AGCGATGCAG AGTATCTACG TCTACGTGCC AGACCCTGAC 360
GTCCCCTTTG TTCCGTTGGT GGTGCCTTTC GGCAACCACG TCCTGTCCGA CCACGAGGAG 420
ATGGAGATCC AGTGCCGGGT GTCGGATCCC AGCGCCAACG TCACGCTGAT AAATGTCGAC 480
ACCCAGCAGC CCGTGCCTTG CATGTACGAT AGCAAGAGGG GCGCTCTGGG CGTGTTCACG 540
GCTGGGACGT ATGTCTGCAA GGCCGTGGTC AACGGAGCGG AGCACTACAG CGAGGATTAC 600
ATCGTCCATG GCTGGATAGG GGGCTCCGGG CTGCACGTTG AGCTGACGGC CAAACATACG 660
GTTCTGCTGG TGGGAGACAC CATCACGGTC AATTGTTTGG CTCAGGGATC TGAGATTTTG 720
GAGGACCACT GGAAATATCC CGGGAAAGTG GCTAATCGTG CTATTAAGAC GGTTCACGAG 780
AACAAAAAGG ATCAGGAGAT TCTTTACACC CTCACAGTCC CGCAGGCTTC CGTCAAGGAC 840
ACTGGCATTT ACTCCTGTTC CATCACCGAT GTAGTAACCA ACATGAGTCA GACCAAGCAG 900
ATCGCCATTC GCGTTTACGC GAGCGAGTTC ATGTCCATCC AGCCAAAGTT CGGAGAGTAC 960
GAATCGGCCG AGCTGGACGA GGTCTGCGAG TTCAGGGCCG AGATCACCTC TTTCCCGACC 1020
GCTAGCGTCA CGTGGTTTAA AGACAGCGTC CCGCTCAGCA ACGTGACGGC GGAGATTTCT 1080
ACCAGCCTCC AGAAGCTCAG CGAGACCAGC TACATGAGTG TCCTGACCCT GATCCGAGCC 1140
AAGGAGGAGG ACAGCGGGAA CTACACCATG CGGGTGAAGA ACGGAGATCA GAGTCGCACC 1200
GTCAGCCTGA TCCTGGAGGT TAAAGTGCCG GCAGTCATCG TGGACCTGAT GGACATCCAC 1260
CACGGCTCAG CTACAGGCCA GTCCGTGGTG TGCATCACCA GAGGTCAGCC CACTCCTCTG 1320
GTGGAGTGGT TCGTCTGCAA GAACATCAAG CACTGCGCCA ATGACACCTC ATCCTGGGTG 1380
CCCCTCCCCG TCAACTCCAC GGAGGTCACC ATGGATTCGC GCTTCGACGA GGACAATAAT 1440
CTGGAGACCC AGGTCATATT TGGGCACCTG GAGAACACGC TGGCGGTGCG CTGCCTGGCC 1500
AGGAACGAAA TGGCCGCCGT CAGCAGGGAG ATCAAGCTGG TGTCCAATGG CCCTCATCCA 1560
GAGCTGACTG TCGCGGCGGC TGTGTTGGTG CTCCTGGTCA TTGTCATCAT CTCACTCATT 1620
GTCTTGGTTG TGATCTGGAA ACAGAAACCG CGATATGAAA TCCGCTGGAG GGTCATCGAG 1680
TCTGTAAGCC CGGATGGACA CGAGTACATC TACGTGGATC CAATGCAGCT TCCCTACGAC 1740
TCCAGATGGG AGTTCCCCCG GGACAGACTT GTGTTGGGTC GCATCCTGGG CTCTGGAGCC 1800
TTTGGGAAAG TGGTGGAGGG CACCGCCTAT GGGCTCAGCC GCTCTCAGCC TGTCATGAAG 1860
GTGGCAGTAA AGATGCTCAA ACCCACAGCG CGCTCCAGCG AAAAACAGGC CCTGATGTCT 1920
GAGCTGAAGA TCATGACCCA CCTGGGACCG CACCTCAACA TTGTTAACCT GCTGGGCGCC 1980
TGCACCAAGT CAGGCCCCAT ATACATCATC ACTGAGTACT GTTTCTACGG CGATCTGGTC 2040
AACTACCTGC ACAAGAACCG GGAGAGCTTC CTCAACCCGA AGCCAGAGAA GAGCAACAAG 2100
AAAGAGTTGG ACATTTTTGG AATCAACCCC GCGGACGAGA GCAGCAGAAG TTATGTGATC 2160
CTGTCCTTCG AGAGCAAAGG CGACTACATG GACATGAAGC AGGCCGACAA CACTCAGTAT 2220
GTGCCCATGC TGGAGATAAG CAATGCCTCC AAGTACTCTG ACCTCCAGGG CTCCAACTAC 2280
GACCACCCGC CCTCGCAGAA AGGATCAAAT GACGGCGAGA TGGATCAACT GCTGTCGGAC 2340
AACATGAGCG AGGGCCTCAC CACCAATGAC CTGCTGAGTT TCACTTACCA GGTGGCTAAA 2400
GGAATGGAGT TCCTGGCTTC AAAAAATTGT GTCCACCGAG ATCTGGCCGC CAGGAACGTC 2460
CTGCTCTCTC AGGGCAAGAT AGTGAAGATC TGCGACTTTG GACTGGCGCG AGACATCATG 2520
CATGACAACA ACTACGTCTC CAAAGGAAGC ACGTTCCTAC CAGTGAAGTG GATGGCTCCC 2580
GAGAGCATTT TCGACAACCT GTACACCACG CTGAGCGACG TCTGGTCGTA CGGCATCCTG 2640
CTGTGGGAGA TATTCTCTTT AGGCGGCACG CCATACCCAG GTATGATTGT GGATTCCAGC 2700
TTCTATAACA AGATCAAGAG TGGCTACAGG ATGTCCAAAC CAGAGCACGC GCCTCAGGAT 2760
GTGTATGACA TGATGATGAA GTGCTGGAAC AGCGAGCCGG AGAAGAGGCC CTCTTTCCTG 2820
GGTCTCAGTG ACACCATCGC CTCTTTGCTG CCCTCCAGCT ACAAGCGGCA TTACGAGAGG 2880
GTGAACCACG AGTTCCTGAA GAGTGACCAC CCTGCCGTGA CCCGAGTGTG CGTAGATAAC 2940
GATGACGCCT ACATCGGGAT CACCTACAAA AACCAGGGAA AGTTAAAGGA CAGGGAAAGT 3000
GGATTTGATG AGCAGCGGCT CAGCTCCGAC AGTGGCTACA TCATCCCCCT GCCTGACCTG 3060
GACCCCATTT CTGATGAGGA ATACGGGAAG AGGAACAGAC ACAGCTCTCA AACGTCCGAG 3120
GAGAGCGCCA TCGAGACGGG GTCCAGCAGC TCCACTTTCG CAAAGCGCGA GGGCGAGACG 3180
CTGGAGGACA TCACGCTTTT GGACGAGATG TGTCTGGACT GTAGTGACCT GGTGGAGGAC 3240
AGCTTTCTGT GA 3252
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 590   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  649
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++resfl+ + ek   +++eld+++
Q: 650   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRESFLNPKPEK--SNKKELDIFG  707
         ******************************************988887..6788899999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         + +ad+s rs+++ls+es+++y+d+k++                +sd++ s++d++ s+k
Q: 708   InPADESSRSYVILSFESKGDYMDMKQAdntqyvpmleisnaskYSDLQGSNYDHPPSQK  767
         999************************99***************************9998
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
             ++ e+ + l+++ se+l+ +dllsf+yqvakGmeflaskncvhrdlaarnvll++G
Q: 768   --GSNDGEMDQLLSDNMSEGLTTNDLLSFTYQVAKGMEFLASKNCVHRDLAARNVLLSQG  825
         ..5677888889************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+d nyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 826   KIVKICDFGLARDIMHDNNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  885
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlv  341
         slG+tpypg++vds fy++ik+Gyrm++p++a++++y++m kcw++epekrpsf  l+
Q: 886   SLGGTPYPGMIVDSSFYNKIKSGYRMSKPEHAPQDVYDMMMKCWNSEPEKRPSFLGLS  943
         ******************************************************8876
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRES FLNPKPEKSN KKELDIFGIN 120
PADESSRSYV ILSFESKGDY MDMKQADNTQ YVPMLEISNA SKYSDLQGSN YDHPPSQKGS 180
NDGEMDQLLS DNMSEGLTTN DLLSFTYQVA KGMEFLASKN CVHRDLAARN VLLSQGKIVK 240
ICDFGLARDI MHDNNYVSKG STFLPVKWMA PESIFDNLYT TLSDVWSYGI LLWEIFSLGG 300
TPYPGMIVDS SFYNKIKSGY RMSKPEHAPQ DVYDMMMKCW NSEPEKRPSF LGLS 354
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013