EKS-TAR-00510
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00510
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR535.61.4E-160566899334
StatusUnreviewed
Ensembl ProteinENSTRUP00000038817
UniProt AccessionH2UPE2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000015193ENSTRUP00000038815ENSTRUT00000038954
ENSTRUG00000015193ENSTRUP00000038816ENSTRUT00000038955
ENSTRUG00000015193ENSTRUP00000038817ENSTRUT00000038956
ENSTRUG00000015193ENSTRUP00000038818ENSTRUT00000038957
ENSTRUG00000015193ENSTRUP00000038813ENSTRUT00000038952
ENSTRUG00000015193ENSTRUP00000038814ENSTRUT00000038953
ENSTRUG00000015193ENSTRUP00000038819ENSTRUT00000038958
OrganismTakifugu rubripes
Functional Description
Protein Length959
Protein Sequence
(FASTA)
VFPGDTKPTI TPAGTYVVVS LNAPLELQCQ GEKAMQWQRE ERPKVRGETK VDGKSTLYIP 60
KAHPAHMGRY ICLEETSQER ASIYIYVKDP DNPFRKSMVS NILSREGDSA SIPCLATDPS 120
LENLQLKTCS SKALASGLHF SPSLEQGIII HNTQKSYEGC YVCTGRLKET NVRSHDYHLT 180
VRPVPVAPPV IMMQAPKRVI LIRDESLYLT CNTTNVNGNI KLKWVAPLGS QPAKVDGSSR 240
ILTENFTQAR SATLHIAAVR IQDTGRYQCE AENEKGVSTQ SVWLDVFEKG FMYSNPVNNG 300
TIQVRAGESL LLSVSIEAYP MPRSASWSFM GRGLHNTSDH VITTRSHEYT FSYSSELKLV 360
RLKMSEGGVY TFQASNGDAS VNHTFTIFVI SKPEIVSHEG PVDGQVRCVA EGFPAPQITW 420
YYCEQPYARC SQQVNATQEE QNVITVTLFS PLFGKTEVES RVNISRGRFS TLECVATVEG 480
EQAFTLFSIS ERTISHDLFS PLLIGSVSAA CILCLILIVL FYKYMQKPKY QIQWKVIEGI 540
HGNNYVYIDP TQLPYDHQWE FPRKNLRFGK TLGSGAFGKV VEATAYGLAN EDSMMTVAVK 600
MLKSSAHSTE KEALMSELKV LIYLGNHINI VNLLGACTVG GPTLVITEYC CFGDLLNFLR 660
RKRESFICFK LEEDCHYRNI MLQREMAGID SLNGYMTMRP SAAGKPSSSS SSEKRRSLRE 720
GSPYVEEDSE SEMFDEDSLS LDTEDLLSFS YQVAKGMEFL TSKNCIHRDL AARNILLTQG 780
RVAKICDFGL ARDINTDSNY VVKGNARLPV KWMSPESIFE CVYTFESDVW SYGILLWEIF 840
SLGNSPYPGM PVDAKFYKLI KEGYRMDAPE FAPSEMYQIM RSCWDADPLN RPPFRKVVER 900
IEQQLSDTTK HIYLNFSSRV PVMPRGREES STHSMASQPF NSAGNNSPPS RPLLLHHEV 959
Nucleotide Sequence
(FASTA)
GTTTTTCCAG GTGACACCAA GCCTACCATT ACCCCTGCCG GCACCTACGT TGTTGTCTCG 60
CTCAACGCCC CCTTGGAGCT GCAGTGTCAG GGCGAGAAAG CGATGCAGTG GCAGCGAGAA 120
GAGCGTCCTA AAGTGCGGGG GGAGACAAAG GTAGATGGGA AGTCGACGCT GTACATTCCC 180
AAGGCTCATC CCGCTCACAT GGGTCGCTAC ATCTGCTTGG AGGAGACCAG CCAGGAGAGA 240
GCCTCCATTT ACATCTATGT GAAAGATCCT GATAATCCTT TCAGAAAATC AATGGTGTCC 300
AACATTCTCA GTCGCGAGGG AGACAGCGCT TCCATTCCCT GCCTGGCAAC AGATCCGAGT 360
CTGGAAAACT TGCAGCTCAA AACATGCTCC AGTAAAGCTC TGGCCTCTGG TCTCCACTTT 420
TCTCCCAGCC TGGAGCAAGG CATCATCATC CACAACACAC AAAAGTCCTA TGAGGGCTGC 480
TACGTCTGCA CGGGAAGGCT GAAGGAAACA AACGTCAGAT CACACGACTA CCACCTGACA 540
GTGAGGCCAG TTCCTGTCGC TCCCCCTGTC ATCATGATGC AGGCTCCCAA AAGAGTGATT 600
CTGATCCGCG ACGAGAGCCT GTACCTCACC TGCAACACCA CTAATGTCAA TGGAAATATT 660
AAACTAAAGT GGGTGGCGCC GCTTGGCTCG CAACCAGCAA AGGTTGACGG CTCTTCTCGT 720
ATCCTGACGG AGAACTTCAC CCAAGCACGC AGCGCCACGT TGCACATCGC GGCGGTCCGG 780
ATTCAAGACA CTGGGCGGTA CCAGTGTGAA GCCGAGAACG AGAAAGGGGT CAGCACGCAG 840
TCGGTGTGGC TCGATGTTTT CGAAAAAGGC TTCATGTACT CGAATCCCGT TAACAACGGA 900
ACCATCCAAG TGCGTGCCGG CGAGAGCTTA CTCCTCAGTG TCAGCATAGA GGCTTATCCA 960
ATGCCACGCA GTGCCTCTTG GAGCTTCATG GGCCGCGGGC TGCACAACAC CTCCGACCAT 1020
GTCATCACCA CGCGCAGCCA CGAGTACACG TTTAGCTACA GCAGTGAGCT GAAGCTGGTG 1080
CGCCTAAAAA TGTCAGAAGG CGGAGTTTAT ACCTTTCAAG CCTCCAACGG CGACGCTTCA 1140
GTGAACCACA CGTTCACCAT CTTTGTCATC AGTAAACCCG AGATTGTGTC TCACGAGGGC 1200
CCAGTGGACG GACAGGTACG CTGTGTGGCG GAGGGGTTCC CGGCCCCGCA GATCACCTGG 1260
TACTACTGTG AACAGCCCTA CGCCAGGTGT TCCCAGCAGG TCAATGCCAC CCAGGAGGAG 1320
CAGAACGTCA TCACCGTCAC TCTGTTCAGC CCCTTGTTTG GGAAGACCGA GGTGGAGAGC 1380
AGGGTCAACA TCAGCAGAGG AAGGTTCAGC ACTCTGGAAT GTGTGGCCAC GGTCGAGGGC 1440
GAGCAGGCGT TCACGCTCTT CTCTATCAGC GAGAGAACCA TTTCCCATGA TCTGTTCTCC 1500
CCTCTGCTAA TTGGCTCTGT ATCAGCGGCT TGCATCCTGT GCCTCATCCT TATCGTGCTG 1560
TTCTACAAGT ACATGCAGAA ACCCAAATAC CAGATCCAGT GGAAAGTCAT CGAGGGCATC 1620
CATGGAAATA ATTACGTGTA CATCGACCCC ACCCAGCTGC CGTACGACCA TCAGTGGGAG 1680
TTTCCTCGAA AAAACTTGCG TTTCGGGAAG ACGCTGGGAT CTGGCGCGTT TGGAAAAGTT 1740
GTGGAAGCCA CCGCGTATGG ACTCGCCAAC GAAGATTCAA TGATGACGGT GGCTGTGAAA 1800
ATGCTAAAAT CAAGCGCTCA TTCCACAGAG AAAGAGGCAC TGATGTCCGA GCTGAAAGTC 1860
CTCATTTACC TGGGAAACCA CATAAATATC GTCAACCTGC TGGGAGCCTG CACTGTTGGA 1920
GGACCAACGC TGGTGATCAC GGAGTACTGC TGCTTCGGAG ACCTCCTGAA CTTTCTGCGG 1980
CGAAAACGAG AATCTTTCAT CTGCTTTAAG CTGGAGGAAG ACTGCCACTA TCGCAACATC 2040
ATGCTGCAAA GAGAGATGGC CGGAATTGAC AGCTTGAACG GCTACATGAC CATGAGGCCT 2100
TCTGCTGCTG GCAAGCCGTC TTCCAGCTCT TCCTCTGAGA AGCGACGATC TCTCCGCGAA 2160
GGCAGCCCGT ATGTTGAGGA GGATTCTGAA AGCGAGATGT TTGACGAGGA CAGTCTGTCC 2220
CTGGACACCG AAGACCTTCT CAGCTTCTCA TACCAAGTGG CCAAAGGCAT GGAGTTTTTA 2280
ACATCCAAAA ATTGCATCCA CAGAGATCTG GCCGCCAGAA ACATCCTACT AACTCAAGGC 2340
AGAGTTGCAA AGATCTGTGA CTTTGGTCTG GCCCGGGACA TCAACACAGA CTCAAACTAC 2400
GTGGTCAAAG GCAATGCCCG TCTACCGGTC AAATGGATGT CCCCTGAAAG TATCTTTGAG 2460
TGCGTGTACA CATTTGAGAG CGATGTTTGG TCCTATGGCA TTTTGCTGTG GGAAATCTTC 2520
TCGCTAGGAA ATAGTCCCTA TCCAGGCATG CCTGTGGACG CCAAATTCTA CAAACTGATT 2580
AAAGAAGGAT ACAGAATGGA TGCTCCAGAA TTCGCACCCA GTGAAATGTA TCAGATTATG 2640
AGGTCCTGCT GGGACGCTGA CCCCTTAAAT CGACCCCCCT TCAGGAAGGT TGTGGAAAGA 2700
ATCGAACAAC AGCTGTCGGA CACAACCAAA CACATCTATC TAAACTTCAG CTCCAGAGTT 2760
CCTGTGATGC CCAGAGGCAG GGAGGAGTCC AGCACTCACA GCATGGCGTC CCAGCCTTTC 2820
AACTCAGCCG GGAACAACAG CCCGCCGTCT CGGCCCTTAC TGCTCCACCA CGAAGTC 2877
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lGsGafGkvveatayGl+++d++++vavkmlks+a+s+ekealmselk+l +lG
Q: 566   LRFGKTLGSGAFGKVVEATAYGLANEDSMMTVAVKMLKSSAHSTEKEALMSELKVLIYLG  625
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact+gGp++viteycc+Gdlln+lrrkresf+  +l      ee++++++
Q: 626   NHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRESFICFKL------EEDCHYRN  679
         ******************************************5444......45778888
S: 121   lladkslrsksslssesseeyvdlkkdvsd..vssskadklasekk.ksalerevkaale  177
         +     + +++   ++s + y+ ++++ +    sss+++k++s ++ + ++e++ ++++ 
Q: 680   I-----MLQREMAGIDSLNGYMTMRPSAAGkpSSSSSSEKRRSLREgSPYVEEDSESEMF  734
         8.....34455677899*********8654113344444555544415699*********
S: 178   eedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardi  237
         +eds +l+ edllsfsyqvakGmefl sknc+hrdlaarn+llt+G+v+kicdfGlardi
Q: 735   DEDSLSLDTEDLLSFSYQVAKGMEFLTSKNCIHRDLAARNILLTQGRVAKICDFGLARDI  794
         ************************************************************
S: 238   mkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvds  297
          +dsnyvvkGnarlpvkwm+pesif+++yt++sdvwsyGillweifslG +pypg++vd+
Q: 795   NTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGNSPYPGMPVDA  854
         ************************************************************
S: 298   kfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         kfyklikeGyrm+ p++a++e+y+im++cw+a+p +rp+f+++ve
Q: 855   KFYKLIKEGYRMDAPEFAPSEMYQIMRSCWDADPLNRPPFRKVVE  899
         *****************************************9986
Domain Sequence
(FASTA)
LRFGKTLGSG AFGKVVEATA YGLANEDSMM TVAVKMLKSS AHSTEKEALM SELKVLIYLG 60
NHINIVNLLG ACTVGGPTLV ITEYCCFGDL LNFLRRKRES FICFKLEEDC HYRNIMLQRE 120
MAGIDSLNGY MTMRPSAAGK PSSSSSSEKR RSLREGSPYV EEDSESEMFD EDSLSLDTED 180
LLSFSYQVAK GMEFLTSKNC IHRDLAARNI LLTQGRVAKI CDFGLARDIN TDSNYVVKGN 240
ARLPVKWMSP ESIFECVYTF ESDVWSYGIL LWEIFSLGNS PYPGMPVDAK FYKLIKEGYR 300
MDAPEFAPSE MYQIMRSCWD ADPLNRPPFR KVVE 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013