EKS-TAR-00520

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00520

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	460.1	4.5E-138	14	275	262

Status

Unreviewed

Ensembl Protein

ENSTRUP00000040496

UniProt Accession

H2UU72;

Protein Name

Protein Synonyms/Alias

Gene Name

DAPK1

Gene Synonyms/Alias

DAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000015844	ENSTRUP00000040496	ENSTRUT00000040638

Organism

Takifugu rubripes

Functional Description

Protein Length

1444

Protein Sequence
(FASTA)

MTIFNQENVE EFYDIGNELG SGQFAVVRRC RHRSTGVEYA AKFIKKRRSK SSRRGVSRED 60

IEREVSILKE IQHPNIITLH EVFENKAEVI LILELVAGGE LFDFLAEKES LSEEEATQFL 120

KQILDGVFYL HSKQIAHFDL KPENIMLLNR SVPHPRIKII DFGLAHKIDF SNDFKNIFGT 180

PEFVAPEVVN YEPLGLEADM WSVGVITYIL LSGASPFLGD NKQETLANVS AVDYTFDEEF 240

FSNTSILAKD FIARLLIKDP KKRMTIQDSL QHPWIKPKDT QQALSRKESA VNMEKFKKFA 300

ARRKWKQSVR LISLCNRLSR SFLSRSNISV ARSDDTLDEE DSFVMKAIIH AINDDNVPGL 360

THLLGSLNSY DVNQPNKHGT PPLLIAAGCG NIQIIEVLMR KGAEIQAGDK SGANAIYYAA 420

RHGHVETLKF LHEKKCPLDI QDKSGETALH VAARYGNVDV VSYLCSIRAN PDLADREQET 480

PLHCAAWHGY STVARALCQA GCHVNAKNRE GESPLLTASA RGFVDIVECL VEHRATLEAS 540

DKDGHTALHL AVRRCQVDVV RCLLRHHCHL DQQDRHGNTP LHIACKDGNL AIVMAICSAK 600

ANLDLPNKYG RTSLHLAASN GSLEVVRHLC LAGVNIDAVT NDGKTAEELA SVDHHDHIVS 660

LLVRLKKDNH KLSYIQQLRP TQTIQPRIKL KLFGHSGAGK STLLESLKCG ILRSFFRRRR 720

TRMTNTARHP NSPINSKPPV SVSISNLYPG CENVSVRSRS MMFEPSLTKG VLEVFSPVHS 780

ALSTADEQAT KAIDIQHANI HSVGDFSVWE FSGNPVYHCS YDYFAANDST AIHLVLFSLE 840

EPYETQLSHV TYWLNLLKAL TLPQDNIAFG GRIQQPLVVV LVATHADLAD IPRAFSGEFT 900

YDKEKVLLKE VRNRFGVDLQ ISEKLFVMDA GASNSKDVKL LRNHLQELRS SIISKCSPMT 960

QLTERLLTTL PSWRKLSGPN QLTSWQQFVS DVQEHINPLV SQDHLRTLTM QLHSMGEINI 1020

MQSETVQDVV LLEPRWLCSG ILGKLLSVEA PKAIHHYRGR YRLEEVQALV PESDVEELLQ 1080

ILDAMDICAR DASNPFMVDV PALIKTSGLH RSWTEEDEED EVLIYGGIRL VPAEHLTPFP 1140

CGLFHKLQVN LCRWSHQQKS EEEGGEDFDG DIHLWTNGAK VSQAGVEAII LLVNHGQGVE 1200

VQVRGHDSER AKCYTLLDTI CSITENLLTS TLPGLLTAKY YLSPQQLREH HAPIMIYQPK 1260

DFFRAQAQRE SSLTNTMGGY RESFSSILSF GCAEVYQQGT LGTDIHISDV PLLARRKLCR 1320

MLDPPDAMGK DWCLLAMNLG LTDLVAKHSS GTNGAAEPDS PQAAQQPSPT AALLQEWSSR 1380

ADSTVGVLMA KLRELGRRDA ADFLLKASPV FRVNAEAVGG AANGYPAICN GGTSYNSISS 1440

VVSR 1444

Nucleotide Sequence
(FASTA)

ATGACTATTT TCAACCAGGA AAATGTCGAG GAATTTTATG ACATTGGAAA CGAGCTGGGG 60

AGTGGGCAGT TTGCCGTGGT CAGAAGATGC CGGCACAGAA GCACAGGTGT GGAGTACGCT 120

GCCAAGTTTA TCAAGAAGAG ACGCAGCAAA TCGAGCCGTC GGGGGGTGTC CAGGGAGGAC 180

ATTGAGCGCG AGGTCAGCAT CCTTAAGGAA ATCCAGCACC CAAACATCAT AACCCTTCAT 240

GAGGTGTTTG AAAACAAGGC GGAGGTCATC CTGATCCTGG AGCTTGTTGC TGGTGGGGAG 300

CTCTTCGATT TCCTGGCAGA GAAAGAGTCA CTGAGCGAGG AGGAAGCCAC TCAGTTTCTA 360

AAGCAGATCC TGGATGGAGT ATTTTACCTG CACTCCAAAC AAATTGCTCA CTTTGACCTT 420

AAGCCAGAGA ACATCATGCT GCTGAACCGT TCAGTGCCTC ACCCACGCAT CAAAATCATT 480

GACTTTGGCC TGGCCCACAA GATAGACTTC AGCAATGACT TTAAAAACAT TTTTGGAACT 540

CCAGAATTTG TTGCTCCTGA AGTCGTCAAC TATGAACCCT TGGGCCTGGA GGCAGACATG 600

TGGAGTGTTG GTGTGATAAC CTACATCCTT TTGAGCGGCG CATCTCCGTT CCTGGGGGAC 660

AACAAGCAGG AGACACTGGC CAACGTCTCG GCTGTGGACT ACACGTTTGA TGAGGAGTTC 720

TTCAGCAACA CCAGTATCCT GGCCAAAGAC TTCATAGCAA GGCTGCTCAT TAAAGACCCC 780

AAAAAGAGAA TGACAATTCA GGACAGCCTA CAACACCCTT GGATTAAGCC AAAAGATACT 840

CAACAAGCAC TGAGTAGAAA GGAGTCAGCA GTCAACATGG AAAAGTTCAA GAAGTTTGCA 900

GCTCGAAGAA AATGGAAACA ATCCGTCCGA CTTATCTCCT TATGTAACCG TCTGTCCCGC 960

TCCTTCCTGT CCAGGAGCAA CATAAGCGTG GCACGCAGTG ATGACACTTT GGATGAGGAA 1020

GACTCCTTTG TGATGAAGGC CATCATCCAT GCCATAAATG ATGACAACGT CCCCGGTCTC 1080

ACGCATTTAC TCGGCTCCTT AAACAGTTAC GATGTCAATC AGCCCAACAA GCATGGGACT 1140

CCGCCCCTTC TGATTGCGGC TGGCTGTGGC AACATTCAGA TCATCGAGGT GCTGATGAGA 1200

AAAGGTGCCG AGATTCAGGC CGGCGATAAG AGTGGAGCCA ATGCCATCTA CTACGCAGCA 1260

AGACACGGCC ATGTGGAGAC CCTGAAATTC CTCCACGAGA AGAAATGCCC TCTGGATATC 1320

CAAGATAAGT CTGGGGAAAC TGCTCTCCAT GTGGCAGCTC GCTATGGCAA CGTGGACGTG 1380

GTGAGCTATC TGTGCAGCAT TCGTGCCAAT CCAGATCTGG CCGACAGGGA GCAGGAGACC 1440

CCGCTGCATT GTGCTGCATG GCACGGATAT TCCACAGTGG CCCGAGCACT CTGCCAGGCG 1500

GGCTGCCACG TCAACGCAAA GAACCGAGAG GGCGAGAGCC CATTGCTGAC TGCATCTGCT 1560

CGGGGTTTCG TGGACATCGT CGAGTGCCTG GTGGAGCATC GGGCCACTCT CGAAGCCAGT 1620

GACAAGGATG GACACACAGC CCTCCACCTG GCCGTACGGA GGTGTCAAGT TGACGTGGTC 1680

CGTTGCCTCC TTAGACACCA CTGTCACCTT GACCAACAGG ATCGCCATGG TAACACCCCA 1740

CTACACATCG CGTGCAAGGA TGGAAACCTT GCCATTGTCA TGGCTATTTG CAGTGCCAAG 1800

GCCAACCTTG ACCTCCCTAA CAAGTATGGC CGGACTTCTC TTCACCTGGC TGCCAGCAAC 1860

GGAAGCCTGG AGGTGGTTCG TCACCTGTGT CTTGCTGGAG TTAACATTGA TGCTGTCACC 1920

AATGATGGGA AGACGGCAGA GGAACTCGCC AGCGTTGATC ACCACGACCA TATCGTTTCT 1980

TTATTGGTGA GGTTAAAAAA GGACAACCAC AAACTGAGCT ACATCCAGCA GCTACGGCCC 2040

ACTCAGACTA TCCAGCCCAG GATTAAACTG AAACTGTTCG GACACTCCGG AGCGGGGAAG 2100

AGCACCCTGC TGGAGTCGCT CAAGTGCGGC ATCCTGCGTA GCTTCTTCAG GAGGAGGAGG 2160

ACACGCATGA CTAACACGGC CCGCCACCCC AACTCCCCAA TCAACTCCAA ACCACCTGTC 2220

TCGGTGAGCA TCTCCAATCT GTACCCCGGC TGTGAGAATG TGAGCGTGCG GAGTCGCAGC 2280

ATGATGTTTG AGCCAAGCCT GACCAAAGGA GTTCTGGAGG TCTTCTCCCC CGTCCACAGC 2340

GCCCTGTCCA CGGCCGACGA ACAGGCTACA AAGGCCATCG ACATCCAGCA CGCCAACATC 2400

CACAGCGTGG GCGACTTCAG CGTATGGGAG TTTTCTGGGA ACCCCGTCTA TCACTGCTCC 2460

TACGACTACT TTGCGGCCAA CGACAGCACA GCGATCCACT TGGTCCTGTT CAGCCTGGAG 2520

GAGCCGTACG AGACCCAGCT GAGCCACGTC ACCTACTGGT TGAACCTGCT GAAAGCTCTC 2580

ACTCTGCCAC AGGACAACAT CGCTTTTGGA GGTCGCATCC AGCAGCCCCT GGTGGTCGTG 2640

CTCGTGGCGA CACACGCCGA CCTCGCTGAC ATCCCCAGAG CTTTTTCCGG GGAGTTCACT 2700

TATGACAAGG AGAAAGTGCT TCTCAAGGAA GTCAGGAACA GGTTCGGGGT TGACCTGCAG 2760

ATCAGTGAAA AATTGTTCGT GATGGACGCT GGGGCCTCAA ACTCCAAAGA CGTTAAGCTT 2820

CTGAGGAATC ACCTACAGGA ACTTCGCAGC AGCATCATCT CTAAGTGTAG TCCCATGACG 2880

CAGCTGACAG AGCGCTTGCT GACTACCCTC CCGTCCTGGA GGAAACTGAG CGGACCCAAC 2940

CAGCTGACAT CATGGCAGCA GTTTGTCAGC GATGTCCAGG AGCACATCAA CCCGCTGGTC 3000

AGCCAGGATC ATCTGCGCAC GCTGACCATG CAGCTCCACA GCATGGGCGA GATTAATATC 3060

ATGCAGAGCG AGACGGTGCA GGACGTTGTT CTTCTGGAGC CTCGGTGGCT CTGCAGCGGC 3120

ATCCTGGGCA AATTGCTCTC TGTGGAGGCC CCCAAGGCCA TCCACCACTA CCGGGGGCGC 3180

TACAGGCTGG AGGAGGTGCA GGCTCTTGTT CCAGAAAGCG ACGTAGAGGA GCTGCTCCAG 3240

ATCCTGGATG CCATGGACAT CTGCGCCCGT GACGCCAGCA ACCCCTTCAT GGTGGATGTT 3300

CCCGCTCTCA TCAAGACGAG CGGCCTCCAC CGCTCCTGGA CCGAAGAGGA CGAGGAGGAC 3360

GAGGTGCTGA TCTACGGTGG CATACGCCTC GTCCCTGCGG AGCACCTCAC TCCTTTCCCG 3420

TGTGGCCTGT TCCACAAACT GCAGGTGAAC TTGTGTCGCT GGAGCCACCA GCAGAAGTCT 3480

GAAGAAGAAG GCGGAGAGGA TTTCGACGGC GACATCCATT TGTGGACGAA TGGCGCCAAA 3540

GTCAGCCAGG CAGGAGTGGA GGCTATTATC CTGCTGGTCA ATCACGGGCA GGGGGTGGAG 3600

GTTCAGGTGC GCGGCCATGA CTCGGAGCGG GCCAAGTGCT ACACCTTGTT GGACACCATC 3660

TGTAGTATAA CAGAGAACCT GCTGACCTCC ACTCTTCCTG GACTGCTGAC AGCCAAATAC 3720

TACCTTAGTC CTCAGCAGCT GCGGGAACAT CACGCCCCCA TCATGATCTA CCAGCCCAAA 3780

GACTTTTTCC GTGCCCAAGC GCAGCGGGAA AGCTCCCTCA CCAACACCAT GGGTGGCTAC 3840

AGAGAGAGCT TCAGCAGCAT CCTGTCCTTC GGCTGTGCTG AGGTTTACCA GCAGGGGACC 3900

CTGGGAACGG ACATCCATAT ATCAGATGTA CCCCTGCTGG CTCGCCGGAA GCTGTGTCGC 3960

ATGCTGGACC CGCCCGACGC TATGGGAAAA GACTGGTGTC TGCTGGCTAT GAACCTCGGC 4020

CTCACAGATT TGGTCGCCAA ACACAGTAGC GGGACAAATG GCGCCGCTGA GCCGGACTCT 4080

CCGCAGGCGG CTCAGCAGCC CAGCCCGACC GCGGCGCTCC TGCAGGAGTG GAGCAGCCGA 4140

GCGGACAGCA CAGTCGGGGT GCTGATGGCC AAACTGAGGG AGCTGGGTCG CAGAGACGCT 4200

GCCGACTTCC TGCTCAAAGC TTCTCCCGTC TTCAGGGTCA ACGCGGAGGC CGTCGGCGGG 4260

GCCGCTAACG GATACCCAGC GATCTGCAAC GGCGGCACAT CGTACAACTC GATCAGCTCG 4320

GTCGTCTCTC GCTGA 4335

Domain Profile

S: 2     etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs  61

         ++g+elgsG+favvr+cr++stG eyaakf+kkrr+kssrrgvsre+ierev++lkei+

Q: 14    DIGNELGSGQFAVVRRCRHRSTGVEYAAKFIKKRRSKSSRRGVSREDIEREVSILKEIQ-  72

         6799*******************************************************.

S: 62    epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs  121

         +pn+i+lhev+enk++vililelvaGGelfd+laekeslseeeat++lkqil+gv ylhs

Q: 73    HPNIITLHEVFENKAEVILILELVAGGELFDFLAEKESLSEEEATQFLKQILDGVFYLHS  132

         ************************************************************

S: 122   kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye  181

         k+i+h+dlkPeni+ll+++vp+++ik+idfGl++ki+ ++++k+i+GtPefvaPe+vnye

Q: 133   KQIAHFDLKPENIMLLNRSVPHPRIKIIDFGLAHKIDFSNDFKNIFGTPEFVAPEVVNYE  192

         ************************************************************

S: 182   plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi  241

         pl+le+dmws+GvityillsgasPflGd+kqetl+n+sav+++f+ee+fs++s lakdfi

Q: 193   PLGLEADMWSVGVITYILLSGASPFLGDNKQETLANVSAVDYTFDEEFFSNTSILAKDFI  252

         ************************************************************

S: 242   rrllvkdpekrltieeclehswl  264

          rll+kdp+kr+ti+++l+h+w+

Q: 253   ARLLIKDPKKRMTIQDSLQHPWI  275

         **********************8

Domain Sequence
(FASTA)

DIGNELGSGQ FAVVRRCRHR STGVEYAAKF IKKRRSKSSR RGVSREDIER EVSILKEIQH 60

PNIITLHEVF ENKAEVILIL ELVAGGELFD FLAEKESLSE EEATQFLKQI LDGVFYLHSK 120

QIAHFDLKPE NIMLLNRSVP HPRIKIIDFG LAHKIDFSND FKNIFGTPEF VAPEVVNYEP 180

LGLEADMWSV GVITYILLSG ASPFLGDNKQ ETLANVSAVD YTFDEEFFSN TSILAKDFIA 240

RLLIKDPKKR MTIQDSLQHP WI 262

Keyword

ANK repeat; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR000488	; Death.
IPR020676	; Death-assoc_prot_kinase.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00023	; Ank; 2.
PF12796	; Ank_2; 2.
PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 10.
SM00005	; DEATH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 8.
PS50017	; DEATH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013