EPS-TAR-00055

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TAR-00055

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	589.9	2.2E-177	179	489	311

Status

Unreviewed

Ensembl Protein

ENSTRUP00000040967

UniProt Accession

H2UVJ0;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016020	ENSTRUP00000040968	ENSTRUT00000041110
ENSTRUG00000016020	ENSTRUP00000040967	ENSTRUT00000041109

Organism

Takifugu rubripes

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

VPSMVRGSDN GSEKMAEGDN SAELLKEKAN QYFKEKDYEN AIKYYSEALE LNPTNAIYYS 60

NRSLAYLRTE CYGYALADAT KALEIDKNYI KGYYRRATSN MALGKFKAAL KDYETVVRVR 120

PNDKDARMKY QECNKIVKQK AFERAIASDE TKKSVVDSLD IENMTIEDDY AGPKLENGKV 180

TLAFMKEMMD WFEDQKKLHR KCAYQILVQV KEVLSKLPSL IEIALKETEK ITICGDTHGQ 240

YYDLLNIFKL NGLPSETNPY LFNGDFVDRG SFSLEVILTL FGFKLLYPDN FHLLRGNHET 300

DNMNQMYGFE GEIKAKYTAQ MFQLFSEVFQ WLPLAQCINN KVLVMHGGLF SEDGVTLEDL 360

RKIERNRQPP DSGPMCDLLW SDPQPQNGRS ISKRGVSCQF GPDVTERFLN QNKLDFIVRS 420

HEVKAEGYEV THSGKCITVF SAPNYCDQMG NKGAYIHLRG SDLKPEFHQF TAVPHPNVKP 480

MAYANTLMQM GLM 493

Nucleotide Sequence
(FASTA)

GTGCCGTCAA TGGTTCGCGG ATCGGATAAC GGCAGTGAGA AGATGGCGGA GGGAGATAAC 60

AGTGCAGAGC TACTGAAGGA GAAGGCAAAT CAGTACTTTA AAGAGAAAGA CTATGAAAAT 120

GCAATCAAGT ACTACTCAGA AGCCCTGGAG CTCAATCCAA CCAATGCCAT CTATTATAGC 180

AACCGAAGCC TGGCATACCT GCGCACAGAG TGCTATGGCT ATGCCCTGGC AGATGCAACG 240

AAGGCCCTGG AGATAGACAA AAACTACATT AAGGGATATT ATCGTCGTGC CACCTCCAAC 300

ATGGCACTGG GCAAGTTCAA GGCTGCACTT AAGGACTATG AAACAGTAGT AAGAGTTCGA 360

CCAAATGACA AGGATGCAAG GATGAAGTAT CAAGAATGTA ACAAGATTGT GAAGCAGAAG 420

GCTTTTGAGA GAGCAATTGC CAGTGATGAG ACAAAAAAAT CTGTTGTTGA CTCTCTGGAC 480

ATTGAAAATA TGACCATTGA GGATGACTAT GCAGGCCCAA AACTTGAAAA TGGTAAAGTG 540

ACATTGGCAT TCATGAAAGA GATGATGGAT TGGTTCGAAG ATCAGAAGAA ACTCCACAGA 600

AAGTGCGCTT ACCAGATTTT GGTGCAAGTT AAAGAAGTTC TGTCAAAACT ACCAAGTCTG 660

ATTGAAATCG CATTAAAAGA AACAGAAAAA ATAACAATTT GTGGCGACAC TCATGGACAA 720

TACTATGATC TCCTCAACAT TTTTAAGTTG AACGGCCTTC CGTCAGAGAC CAACCCATAT 780

CTGTTTAACG GAGACTTTGT AGATCGCGGT TCTTTCTCTC TTGAAGTTAT TCTTACCCTC 840

TTCGGATTCA AGCTGCTCTA TCCTGACAAC TTTCACTTGC TTCGAGGTAA CCATGAGACA 900

GACAATATGA ACCAGATGTA TGGTTTTGAA GGAGAAATCA AAGCTAAGTA CACCGCCCAG 960

ATGTTCCAGC TCTTCAGTGA GGTCTTCCAG TGGTTGCCTC TTGCACAGTG TATCAACAAC 1020

AAAGTACTGG TGATGCATGG TGGTCTGTTC AGTGAAGATG GCGTCACATT AGAAGACCTT 1080

AGAAAGATTG AGAGGAACAG ACAACCTCCT GACTCAGGTC CAATGTGTGA CCTGCTCTGG 1140

TCTGATCCAC AGCCTCAGAA TGGCCGTTCC ATCAGCAAGC GAGGAGTGAG CTGTCAGTTC 1200

GGGCCAGATG TGACGGAACG CTTTCTCAAC CAGAACAAGC TGGACTTCAT TGTGCGAAGT 1260

CATGAGGTCA AGGCAGAGGG CTATGAGGTC ACTCATTCAG GGAAGTGCAT CACCGTGTTT 1320

TCAGCGCCCA ATTACTGTGA TCAGATGGGA AACAAAGGAG CTTATATTCA CCTCAGGGGA 1380

TCAGACCTCA AGCCAGAGTT TCACCAGTTC ACTGCTGTGC CTCATCCAAA TGTCAAGCCC 1440

ATGGCATATG CCAACACGCT AATGCAGATG GGACTGATGT AG 1482

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+  f+k++++++ ++kkl+rk+a++ilv+v++vl+kl  ++e ++ke++kit+cGdth

Q: 179   KVTLAFMKEMMDWFEDQKKLHRKCAYQILVQVKEVLSKLPSLIEIALKETEKITICGDTH  238

         7999********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         Gq+ydllnif+lnGlpse+npylfnGdfvdrGsfs eviltlfg+kllyPd+f+llrGnh

Q: 239   GQYYDLLNIFKLNGLPSETNPYLFNGDFVDRGSFSLEVILTLFGFKLLYPDNFHLLRGNH  298

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn++yGfege+kakyta++++lf+evf+wlPlaq+in+kvlvmhGGlfsedgvtl+

Q: 299   ETDNMNQMYGFEGEIKAKYTAQMFQLFSEVFQWLPLAQCINNKVLVMHGGLFSEDGVTLE  358

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         d+rkiern+qPP++G++c+llWsdPq++nGr++skrGv++qfGpdvt+rfl++nkld+i+

Q: 359   DLRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTERFLNQNKLDFIV  418

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++gk++tvfsapnycd++gn++++ih+r++dl++ +++f+av+hp+v

Q: 419   RSHEVKAEGYEVTHSGKCITVFSAPNYCDQMGNKGAYIHLRGSDLKPEFHQFTAVPHPNV  478

         ************************************************************

S: 302   kpmaysngllg  312

         kpmay+n+l++

Q: 479   KPMAYANTLMQ  489

         ********998

Domain Sequence
(FASTA)

KVTLAFMKEM MDWFEDQKKL HRKCAYQILV QVKEVLSKLP SLIEIALKET EKITICGDTH 60

GQYYDLLNIF KLNGLPSETN PYLFNGDFVD RGSFSLEVIL TLFGFKLLYP DNFHLLRGNH 120

ETDNMNQMYG FEGEIKAKYT AQMFQLFSEV FQWLPLAQCI NNKVLVMHGG LFSEDGVTLE 180

DLRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSISKRGVSC QFGPDVTERF LNQNKLDFIV 240

RSHEVKAEGY EVTHSGKCIT VFSAPNYCDQ MGNKGAYIHL RGSDLKPEFH QFTAVPHPNV 300

KPMAYANTLM Q 311

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0003676	; F:nucleic acid binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.
IPR006612	; Znf_C2CH.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF05485	; THAP; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00692	; DM3; 1.
SM00156	; PP2Ac; 1.
SM00980	; THAP; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.
PS50950	; ZF_THAP; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013