EKS-TAR-00415

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00415

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	344.1	1.2E-102	255	506	252

Status

Unreviewed

Ensembl Protein

ENSTRUP00000041501

UniProt Accession

H2UX21;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK2 (1 of 2)

Gene Synonyms/Alias

PAK2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016233	ENSTRUP00000041502	ENSTRUT00000041646
ENSTRUG00000016233	ENSTRUP00000041501	ENSTRUT00000041645
ENSTRUG00000016233	ENSTRUP00000041500	ENSTRUT00000041644

Organism

Takifugu rubripes

Functional Description

Protein Length

530

Protein Sequence
(FASTA)

MCDNGESEDK PPAPPVRMSS TIFSTGSGKD SLSANHSSKP LPSVPEERKP RNKIISIFSG 60

AEKSGRKKDR DKERPEISPP SDFEHTIHVG FDAVTGEFTG MPEQWARLLQ TSNITKSEQK 120

KNPQAVLDVL KFYDSTGNGR QKYLSFSSSA DSSPLSNNGI DMSSCTEPSS ANIKDIDDDD 180

DDETPPPVVA PRPEHTKSVY TRSVIDPIPA PNPCVDGDVA SKAADRQKKK GKMSDEEIMD 240

KLRTIVSIGD PKKKYTRYEK IGQGASGTVF TAIDVATGQE VAIKQINLQK QPKKELIINE 300

ILVMKELKNP NIVNFLDSFL MGEELFVVME YLAGGSLTDV VTETCMDEAQ IAAVCRECLQ 360

ALDFLHANQV IHRDIKSDNV LLGMDGSVKL TDFGFCAQIT PEQSKRSTMV GTPYWMAPEV 420

VTRKAYGPKV DIWSLGIMAI EMVEGEPPYL NENPLRALYL IATNGTPELQ NPEKLSPVFR 480

DFLNCCLEMD VEKRGGSKEL LQHPFLKLAK PLSSLTPLIL AAKEAMKGNR 530

Nucleotide Sequence
(FASTA)

ATGTGCGATA ACGGCGAATC TGAGGATAAA CCCCCCGCCC CTCCGGTCCG CATGAGCAGC 60

ACCATCTTCA GCACCGGTTC CGGCAAAGAC TCCCTCTCGG CCAACCACAG CTCCAAACCG 120

CTGCCGTCTG TGCCCGAGGA GAGAAAACCT CGGAACAAAA TCATCTCAAT CTTTTCTGGA 180

GCCGAAAAAA GTGGTAGGAA GAAGGATCGG GACAAGGAGC GACCGGAGAT TTCGCCGCCT 240

TCAGACTTTG AACACACCAT ACACGTTGGC TTTGACGCCG TCACTGGGGA GTTCACTGGC 300

ATGCCGGAGC AATGGGCCCG ACTGCTCCAG ACGTCAAACA TCACCAAGTC GGAGCAGAAG 360

AAAAACCCAC AGGCTGTGCT GGACGTTCTC AAATTTTACG ACTCGACAGG CAACGGTCGG 420

CAGAAGTACC TCAGCTTTTC CTCCTCTGCG GATTCTTCTC CCCTGAGCAA CAATGGGATC 480

GATATGAGCT CATGCACCGA ACCCTCCTCT GCAAATATCA AAGACATCGA CGATGACGAC 540

GACGACGAAA CTCCTCCTCC TGTCGTGGCA CCGAGACCGG AGCACACAAA GAGTGTGTAC 600

ACTCGCTCGG TGATCGATCC GATCCCTGCC CCAAATCCCT GCGTGGACGG CGACGTGGCT 660

TCCAAGGCTG CAGACAGGCA GAAAAAGAAG GGCAAGATGT CTGATGAGGA AATCATGGAT 720

AAACTGAGAA CCATCGTGAG CATCGGAGAC CCCAAGAAGA AATACACCAG ATACGAAAAA 780

ATTGGTCAGG GTGCATCTGG AACCGTCTTC ACAGCCATCG ATGTGGCTAC TGGCCAGGAG 840

GTGGCCATTA AACAGATCAA CCTTCAGAAG CAGCCCAAGA AGGAGCTGAT CATCAATGAG 900

ATTCTGGTGA TGAAGGAGCT GAAGAACCCC AACATCGTCA ACTTCTTAGA CAGTTTCCTG 960

ATGGGGGAGG AGCTGTTTGT GGTGATGGAG TACCTGGCCG GCGGGTCGCT GACAGATGTG 1020

GTCACGGAGA CCTGCATGGA CGAGGCCCAG ATCGCTGCTG TCTGCCGAGA GTGTTTACAA 1080

GCCTTGGATT TCCTGCACGC CAACCAGGTC ATTCACAGAG ACATCAAAAG TGACAATGTG 1140

TTACTCGGAA TGGACGGTTC TGTCAAGCTG ACCGACTTCG GCTTCTGCGC CCAGATCACT 1200

CCAGAGCAAA GCAAACGCAG CACCATGGTA GGAACGCCTT ACTGGATGGC TCCTGAGGTG 1260

GTGACCCGGA AGGCTTACGG GCCCAAAGTC GACATTTGGT CACTGGGTAT TATGGCCATT 1320

GAGATGGTGG AAGGAGAGCC CCCCTACCTG AACGAGAACC CGCTACGAGC GTTGTACCTG 1380

ATTGCCACAA ATGGCACGCC CGAGCTCCAG AACCCAGAGA AGCTGTCCCC GGTGTTCAGA 1440

GACTTCCTCA ACTGTTGCCT GGAGATGGAC GTAGAGAAAC GAGGCGGCAG CAAAGAGCTG 1500

CTCCAGCATC CTTTCCTGAA GCTGGCGAAG CCCCTCTCCA GTCTCACACC TCTCATCCTG 1560

GCCGCCAAGG AGGCCATGAA GGGCAATCGT TAA 1593

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+v++a ++ tg+ vaik+inl+kq+k+e++++ei v+k+lk+pniv+

Q: 255   YTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN  314

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l+sfl+ eel++vmeylagGsl+d+v+   ++ ++E qia+++re+l+aL++lH+++vi

Q: 315   FLDSFLMGEELFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALDFLHANQVI  371

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++n+Ll ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 372   HRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  429

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f++ cl+

Q: 430   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFRDFLNCCLEM  489

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR  ++ell+h+Fl

Q: 490   DVEKRGGSKELLQHPFL  506

         ****************7

Domain Sequence
(FASTA)

YTRYEKIGQG ASGTVFTAID VATGQEVAIK QINLQKQPKK ELIINEILVM KELKNPNIVN 60

FLDSFLMGEE LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALDF LHANQVIHRD 120

IKSDNVLLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPVFRDFLN CCLEMDVEKR 240

GGSKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013