EKS-TAR-00221

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00221

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	472.0	1.3E-141	340	598	259

Status

Unreviewed

Ensembl Protein

ENSTRUP00000041514

UniProt Accession

H2UX35;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

PRKCA (2 of 2)

Gene Synonyms/Alias

PRKCA (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016241	ENSTRUP00000041513	ENSTRUT00000041657
ENSTRUG00000016241	ENSTRUP00000041515	ENSTRUT00000041659
ENSTRUG00000016241	ENSTRUP00000041514	ENSTRUT00000041658

Organism

Takifugu rubripes

Functional Description

Protein Length

673

Protein Sequence
(FASTA)

GEAFPAQTTY YNDSAGVGNR FARKGALRQK NVHEVKNHKF TARFFKQPTF CSHCTDFIWG 60

FGKQGFQCQV CCFVVHKRCH EFVTFSCPGA DKGPDTDDPR SKHKFKIHTY GSPTFCDHCG 120

SLLYGLIHQG MKCDTCDMNV HKQCVVNVPS LCGTDHTERR GRLFLKIEVK LDRLHVTVGE 180

ARNLIPMDPN GLSDPYVKLK ITPDPKNETK QKTRTIRSSL NPCWNESFTF KLKPSDKDRR 240

LSVEVWDWDR TTRNDFMGSM SFGVSELIKA PHCGWYKLLS QEEGEYYNVP IPEVDDVNLE 300

LRQKFEKAKL GQGKKVITPS DHRRFSLPSG NMDRVRLNDF NFLALLGKGS FGKVMLAEMK 360

STDELYAIKI LKKDVVIQDD DVECTMVEKR VLAQRDKPPF LTQLHSCFQT VDRLYFVMEY 420

INGGDLMYHI QRMGKFKEPQ AVFYAAEIAV GLFFLHRKGI IYRDLKLDNV MLDSEGHIKI 480

ADFGMCKESM YEGMTTRTFC GTPDYIAPEI IAYQPYGKSV DWWAYGVLLY EMLAGQPPFD 540

GEDEDELFQS IMEHNVSYPK SMSKEAVSIC KGLMTKHPSK RLGCGPEGEM DIREQAFFRR 600

IDWDRLANRE IQPPFKPKVG GKGAENFDKF FTRTQPVLTP PDQLVIANID QSEFAGFSYV 660

NPQFVPPSLH SVV 673

Nucleotide Sequence
(FASTA)

GGAGAAGCCT TTCCAGCTCA GACCACTTAT TATAACGACT CGGCCGGGGT CGGGAACCGG 60

TTTGCCCGGA AAGGCGCTTT GCGGCAGAAA AATGTGCACG AAGTGAAAAA CCACAAGTTT 120

ACTGCCAGGT TCTTTAAGCA GCCGACGTTC TGCAGCCATT GCACGGATTT TATATGGGGA 180

TTTGGGAAAC AAGGATTCCA ATGCCAAGTC TGCTGTTTTG TGGTCCACAA ACGGTGCCAT 240

GAATTCGTCA CCTTCTCCTG TCCCGGCGCC GACAAGGGTC CAGACACAGA CGACCCCAGG 300

AGCAAGCACA AGTTTAAGAT CCACACCTAC GGCAGCCCCA CCTTCTGCGA CCACTGTGGA 360

TCTCTGCTGT ACGGCCTCAT TCACCAGGGC ATGAAATGTG ACACCTGCGA CATGAACGTG 420

CACAAGCAGT GTGTGGTGAA CGTGCCCAGC CTGTGCGGTA CCGACCACAC GGAGCGCCGC 480

GGTCGCCTCT TCCTGAAGAT CGAGGTGAAG CTGGACAGGC TGCATGTCAC AGTGGGTGAA 540

GCCAGGAACC TGATCCCCAT GGACCCCAAC GGTTTATCAG ACCCATATGT CAAACTCAAG 600

ATCACCCCCG ACCCCAAAAA TGAGACCAAA CAGAAGACCA GGACCATCCG TTCGTCTCTC 660

AACCCTTGCT GGAACGAGTC CTTCACCTTC AAGCTGAAAC CATCAGACAA GGACCGCCGT 720

CTGTCTGTGG AGGTGTGGGA TTGGGACCGT ACCACCAGGA ACGACTTCAT GGGCTCCATG 780

TCGTTTGGCG TGTCAGAGCT GATCAAAGCG CCTCACTGTG GATGGTACAA GCTGCTGAGC 840

CAGGAGGAGG GGGAGTACTA CAACGTCCCC ATCCCCGAGG TGGACGACGT GAACCTGGAG 900

CTGCGGCAGA AGTTCGAGAA GGCCAAACTT GGCCAGGGCA AGAAAGTGAT CACGCCGTCG 960

GACCACCGGC GATTCAGCCT GCCGTCGGGG AACATGGACC GGGTCCGACT GAACGACTTC 1020

AACTTCCTGG CCCTGTTGGG GAAGGGCAGC TTCGGCAAGG TCATGCTGGC GGAGATGAAG 1080

TCGACGGATG AGTTGTACGC CATCAAGATC CTGAAGAAGG ACGTGGTCAT CCAGGACGAC 1140

GACGTGGAAT GCACCATGGT GGAGAAGAGG GTGCTGGCTC AGAGGGACAA GCCGCCCTTC 1200

CTCACGCAGC TCCACTCCTG CTTCCAGACT GTGGATCGGC TTTACTTCGT GATGGAGTAC 1260

ATCAACGGCG GAGACCTGAT GTATCACATC CAACGCATGG GCAAATTCAA GGAGCCGCAG 1320

GCAGTCTTTT ACGCCGCCGA GATCGCCGTC GGTTTGTTTT TCTTGCACCG GAAGGGAATC 1380

ATCTACAGGG ATCTGAAGTT GGACAACGTG ATGCTGGACT CCGAGGGCCA CATCAAGATC 1440

GCCGACTTCG GCATGTGCAA GGAGAGCATG TACGAAGGCA TGACCACGCG CACCTTCTGC 1500

GGGACCCCCG ACTACATCGC ACCGGAGATT ATAGCGTACC AGCCTTACGG GAAGTCAGTG 1560

GACTGGTGGG CTTACGGGGT TCTGCTGTAT GAGATGCTGG CAGGACAGCC GCCGTTCGAT 1620

GGGGAGGATG AAGACGAGCT CTTCCAGTCC ATCATGGAGC ACAACGTGTC GTACCCCAAG 1680

TCCATGTCGA AAGAAGCCGT GTCCATCTGC AAAGGACTGA TGACCAAGCA TCCGTCCAAG 1740

CGTCTCGGCT GTGGACCAGA GGGCGAGATG GACATCAGGG AGCAGGCCTT CTTCAGACGC 1800

ATCGACTGGG ATCGGCTGGC GAACCGAGAG ATCCAGCCGC CGTTTAAACC CAAAGTGGGT 1860

GGCAAAGGAG CAGAAAATTT CGACAAGTTT TTCACGCGCA CGCAGCCCGT GCTGACGCCT 1920

CCCGACCAGC TGGTCATCGC CAACATCGAC CAGAGCGAGT TCGCGGGATT CTCCTACGTG 1980

AACCCTCAGT TCGTCCCTCC GTCCCTGCAC AGCGTGGTAT GA 2022

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l +lGkGsfgkv+lae+k+tdelyaik+lkkdvv+qdddve+t+vekrvla+ +k+p

Q: 340   FNFLALLGKGSFGKVMLAEMKSTDELYAIKILKKDVVIQDDDVECTMVEKRVLAQRDKPP  399

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt drl+fv+ey+nGGdlm+hiq+++k+ke++a+fyaaei+++l+flh+kg

Q: 400   FLTQLHSCFQTVDRLYFVMEYINGGDLMYHIQRMGKFKEPQAVFYAAEIAVGLFFLHRKG  459

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke ++eg tt+tfcGtPdyiaPei+++++ygks

Q: 460   IIYRDLKLDNVMLDSEGHIKIADFGMCKESMYEGMTTRTFCGTPDYIAPEIIAYQPYGKS  519

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPks+skeav+i+kgl+tk+p+

Q: 520   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSMSKEAVSICKGLMTKHPS  579

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+di+e+aff

Q: 580   KRLGCGPEGEMDIREQAFF  598

         ******************8

Domain Sequence
(FASTA)

FNFLALLGKG SFGKVMLAEM KSTDELYAIK ILKKDVVIQD DDVECTMVEK RVLAQRDKPP 60

FLTQLHSCFQ TVDRLYFVME YINGGDLMYH IQRMGKFKEP QAVFYAAEIA VGLFFLHRKG 120

IIYRDLKLDN VMLDSEGHIK IADFGMCKES MYEGMTTRTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSMSKEAVSI CKGLMTKHPS 240

KRLGCGPEGE MDIREQAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013