EKS-TAR-00192

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00192

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	544.2	1.0E-163	434	710	277

Status

Unreviewed

Ensembl Protein

ENSTRUP00000042249

UniProt Accession

H2UZ64;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1 (1 of 2)

Gene Synonyms/Alias

FGFR1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016527	ENSTRUP00000042247	ENSTRUT00000042391
ENSTRUG00000016527	ENSTRUP00000042248	ENSTRUT00000042392
ENSTRUG00000016527	ENSTRUP00000042249	ENSTRUT00000042393
ENSTRUG00000016527	ENSTRUP00000042243	ENSTRUT00000042387
ENSTRUG00000016527	ENSTRUP00000042244	ENSTRUT00000042388
ENSTRUG00000016527	ENSTRUP00000042245	ENSTRUT00000042389
ENSTRUG00000016527	ENSTRUP00000042246	ENSTRUT00000042390
ENSTRUG00000016527	ENSTRUP00000042252	ENSTRUT00000042396
ENSTRUG00000016527	ENSTRUP00000042251	ENSTRUT00000042395
ENSTRUG00000016527	ENSTRUP00000042250	ENSTRUT00000042394

Organism

Takifugu rubripes

Functional Description

Protein Length

769

Protein Sequence
(FASTA)

EMFTLYPGQP LDLSCPASDS TQAVNWTKDH VLVVDGEHTR IRNGHLEIES VELSDSGLYA 60

CTTFGNHSGL FNISGLSPVS LVDVLASSED DEEDEESSSE EAKLPMAPQW AHPEKMAKKL 120

HAVPASKTVK FRCQASGNPT PTLKWYKNGR EFKRDHRIGG FKVRDHMWTI IMEAVVPSDK 180

GNYTCVVENQ YGSINHTYQL DVVERSPHRP ILQAGLPANR TAVVGSDVEF ECKVFSDPQP 240

HIQWLKHIEV NGSRHGPDGL PYVRILKTAG FNITDKEMEV LQLRNVSFDD AGKYTCLAGN 300

SIGFSHHSAW LTVFEGKKQD LKQFPFKTNH TYLEVVIYCV GFFLIVVMIT VAIIVKIRTS 360

SKKSDFNSQV AVHKLAKSIP LRRQVSVDSG SSIHSGAMLV RPSRLSSSGS PMLSGVSEYE 420

LPQDPRWELP RDRLVLGKPL GEGCFGQVVM GEAMGLDKEK PNRVTKVAVK MLKSDATEKD 480

LSDLISEMEM MKIIGKHKNI INLLGACTQD GPLYVIVEYA SKGNLREYLR ARRPPGMEYC 540

YNPDQVPVEN MSIKDLVSCA FQVARGMEYL ASKKCIHRDL AARNVLVTED NVMKIADFGL 600

ARDIHHIDYY KKTTNGRLPV KWMAPEALFD RIYTHQSDVW SFGVLLWEIF TLGGSPYPGV 660

PVEELFKLLK EGHRMDKPST CTHELYMMMR DCWNAVPSQR PTFKQLVEDL DRCLAMTSNQ 720

EYLELSMPLD QCYPDTRSST CSSGEDSVFS HDAGAEEPCL PKFPPHSNG 769

Nucleotide Sequence
(FASTA)

GAAATGTTCA CGCTCTACCC CGGCCAACCT CTTGACCTGA GCTGCCCCGC CAGCGACTCC 60

ACCCAAGCTG TCAACTGGAC CAAAGACCAC GTGCTGGTGG TGGACGGGGA GCACACGCGC 120

ATCCGTAACG GCCACCTGGA GATCGAGAGC GTGGAGCTGA GCGACTCTGG CCTGTACGCC 180

TGCACCACCT TCGGGAACCA CAGCGGCTTG TTTAACATCT CAGGCCTGTC TCCTGTCTCT 240

CTAGTTGATG TTCTGGCGTC ATCGGAGGAC GACGAAGAAG ACGAGGAGTC ATCATCAGAG 300

GAAGCCAAGC TGCCGATGGC GCCGCAGTGG GCTCACCCAG AGAAAATGGC CAAAAAGCTT 360

CACGCCGTTC CAGCCAGTAA GACCGTCAAG TTTCGCTGCC AGGCCAGCGG CAACCCCACC 420

CCGACCCTGA AGTGGTACAA GAACGGCAGG GAGTTCAAGA GAGACCATCG CATCGGAGGC 480

TTCAAGGTCC GTGACCACAT GTGGACCATC ATCATGGAGG CCGTGGTCCC CTCTGACAAA 540

GGCAACTACA CCTGCGTGGT GGAGAACCAG TATGGCAGCA TCAACCACAC CTATCAGCTG 600

GATGTAGTGG AACGCTCCCC ACACAGGCCG ATCCTTCAGG CCGGCCTCCC AGCCAACCGC 660

ACCGCAGTGG TGGGCAGCGA CGTGGAGTTC GAGTGCAAAG TGTTCAGCGA CCCTCAGCCT 720

CACATCCAGT GGCTGAAGCA CATCGAGGTC AACGGCAGCC GCCACGGCCC TGACGGCCTG 780

CCGTACGTCC GCATCCTCAA GACCGCTGGC TTTAACATCA CCGACAAGGA AATGGAAGTC 840

CTCCAACTGA GAAATGTGTC TTTTGATGAC GCTGGGAAGT ATACCTGCTT GGCGGGCAAT 900

TCTATCGGGT TCTCTCATCA CTCTGCATGG TTGACCGTGT TTGAAGGAAA AAAACAAGAT 960

CTGAAGCAGT TTCCTTTTAA AACCAACCAC ACCTACCTGG AGGTCGTCAT CTACTGTGTG 1020

GGGTTCTTCC TAATCGTGGT GATGATCACC GTTGCCATCA TCGTCAAGAT CCGCACCTCG 1080

TCCAAGAAGA GTGACTTCAA CAGCCAGGTG GCCGTCCACA AGCTGGCCAA GAGCATCCCC 1140

CTGCGCAGAC AGGTGTCTGT TGACTCAGGC TCTTCCATCC ACTCTGGAGC CATGCTGGTC 1200

CGCCCGTCTC GCCTGTCCTC CAGCGGCTCT CCGATGCTTT CAGGCGTGTC GGAGTATGAG 1260

CTGCCTCAGG ACCCTCGCTG GGAGCTTCCC CGGGACAGAC TGGTTCTCGG GAAGCCTCTG 1320

GGTGAAGGCT GCTTCGGTCA GGTGGTGATG GGTGAAGCCA TGGGACTGGA CAAGGAGAAG 1380

CCAAACCGGG TCACCAAGGT GGCTGTCAAA ATGCTGAAAT CTGACGCCAC TGAGAAAGAC 1440

CTGTCGGACC TGATTTCAGA GATGGAGATG ATGAAGATCA TCGGGAAGCA CAAGAACATT 1500

ATTAATCTGC TGGGAGCCTG CACGCAAGAT GGTCCACTTT ACGTCATAGT CGAGTACGCG 1560

TCCAAGGGAA ACTTGCGGGA ATACCTCCGA GCTCGGCGCC CTCCGGGAAT GGAGTACTGC 1620

TACAACCCGG ACCAGGTCCC AGTGGAGAAC ATGTCCATCA AGGACCTGGT GTCCTGTGCC 1680

TTCCAGGTGG CTCGAGGGAT GGAGTATTTG GCCTCCAAAA AGTGCATCCA CAGAGATCTG 1740

GCTGCTCGCA ACGTTTTGGT GACAGAGGAC AACGTGATGA AGATCGCGGA CTTTGGCCTG 1800

GCGAGGGACA TCCACCATAT CGACTATTAC AAGAAGACCA CAAACGGGCG TTTGCCGGTG 1860

AAGTGGATGG CTCCTGAGGC GCTCTTTGAC CGCATCTACA CGCACCAGAG CGACGTGTGG 1920

TCGTTCGGTG TTCTGCTGTG GGAGATCTTC ACCCTGGGTG GTTCCCCGTA TCCCGGCGTG 1980

CCCGTGGAGG AGCTGTTCAA GCTGCTGAAG GAGGGTCACC GCATGGACAA ACCCTCCACG 2040

TGCACCCACG AGCTGTACAT GATGATGAGG GACTGCTGGA ATGCTGTTCC CTCTCAGAGA 2100

CCCACCTTCA AACAGCTGGT GGAGGATCTG GATCGCTGTC TGGCCATGAC GTCCAACCAG 2160

GAGTATCTGG AGCTGTCGAT GCCTCTGGAC CAGTGTTACC CCGACACCCG CAGCTCCACC 2220

TGCTCCTCCG GCGAGGACTC GGTCTTCTCC CACGACGCCG GTGCCGAGGA ACCCTGCCTG 2280

CCCAAGTTTC CTCCCCACTC CAACGGC 2307

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+ ea+gldk+k+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 434   LVLGKPLGEGCFGQVVMGEAMGLDKEKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKI  493

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+++++ +++ e+++

Q: 494   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYCYNPDQVPVENMSI  553

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+a+qvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 554   KDLVSCAFQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  613

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 614   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  673

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cw+a++s+rptfkqlvedl

Q: 674   RMDKPSTCTHELYMMMRDCWNAVPSQRPTFKQLVEDL  710

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVMGEA MGLDKEKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKI 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYCYNP DQVPVENMSI 120

KDLVSCAFQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSTCTH ELYMMMRDCW NAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013