EKS-TAR-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ryk	465.2	1.4E-139	274	540	267

Status

Unreviewed

Ensembl Protein

ENSTRUP00000042392

UniProt Accession

H2UZL6;

Protein Name

Protein Synonyms/Alias

Gene Name

RYK

Gene Synonyms/Alias

RYK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016581	ENSTRUP00000042395	ENSTRUT00000042539
ENSTRUG00000016581	ENSTRUP00000042394	ENSTRUT00000042538
ENSTRUG00000016581	ENSTRUP00000042393	ENSTRUT00000042537
ENSTRUG00000016581	ENSTRUP00000042392	ENSTRUT00000042536

Organism

Takifugu rubripes

Functional Description

Protein Length

551

Protein Sequence
(FASTA)

NPSVNIYMSL EEVKKLLGLD AELYYVRNNV VNHYALSFTL PVPSETNSLH FTWHSKTKVG 60

YKLGFHTENP DAMSQPRSNI STQGEVPHIP SVFRVDLVCS GKVDGEAVLT VQLNLTTHTS 120

NYMVLNFKRR KMCYKKSDSD MNIPSPFNNN TLPRTDFEGV IAPTTSTQVF YISVSVCCIV 180

IFLVAIFLAI MHLHSMKRME MEDSMSDSGS SQGLSQPSTH TTQYLRADTP NNVAPVTSKY 240

DHPSLHIEKN DLKSVTLLEA KVKVKDIAVS RERVTLRDVL HEGTFGQIFQ GALLDEKDPS 300

KEKQVFVKTV KDHASEVQIT MMLTESCKLR GLHHRNLLPI SHVCTEDGEK PMVLLPFMAW 360

GNLKLFLRQC KLAEANNPQS ISQQDLVYMA IQIACGMSYL SRREVIHKDL AARNCVIDDN 420

MQVKITDNAL ARDLFPMDYH CLGDNENRPV RWMALESLLN NDFSSLSDVW AFGVTLWELM 480

TLGQTPYVDI DPFEMSAYLK DGYRIAQPIN CPDELFAVMA CCWALDPEER PKFQQLVQCL 540

TEFHSALGAY V 551

Nucleotide Sequence
(FASTA)

AACCCCAGTG TGAACATCTA CATGAGTTTG GAGGAGGTCA AGAAGCTACT GGGTCTGGAT 60

GCAGAGCTGT ACTATGTACG CAACAACGTA GTCAATCATT ATGCTCTGTC CTTCACGTTG 120

CCTGTGCCCA GTGAGACCAA CAGCCTTCAC TTCACTTGGC ATTCCAAGAC AAAGGTTGGC 180

TACAAGCTTG GCTTTCACAC AGAGAATCCA GATGCCATGA GCCAACCTCG GAGTAACATC 240

TCCACTCAAG GGGAGGTGCC CCACATTCCT TCTGTGTTTA GGGTGGATTT GGTCTGTTCG 300

GGAAAGGTAG ATGGAGAGGC TGTTTTAACA GTGCAGCTTA ATTTGACCAC CCATACCAGC 360

AATTACATGG TGCTCAACTT TAAGAGGAGG AAAATGTGCT ATAAAAAAAG TGATTCAGAC 420

ATGAACATTC CCAGTCCATT CAACAATAAC ACTCTTCCCA GAACTGACTT TGAAGGTGTG 480

ATTGCACCTA CCACCTCCAC CCAGGTCTTC TATATAAGCG TCAGCGTGTG CTGCATCGTC 540

ATATTCCTCG TAGCAATCTT CTTGGCCATC ATGCATTTAC ACAGCATGAA GCGAATGGAA 600

ATGGAGGACA GCATGAGTGA CAGTGGCAGC TCGCAGGGTC TCTCTCAACC ATCTACACAT 660

ACCACACAGT ACCTGAGGGC TGACACTCCC AACAATGTGG CCCCTGTCAC TAGTAAGTAT 720

GACCATCCAT CTCTCCATAT CGAGAAGAAT GACCTTAAGA GTGTTACTCT ACTGGAAGCC 780

AAAGTTAAAG TGAAAGACAT CGCAGTATCT CGGGAGAGAG TCACACTACG AGATGTTTTG 840

CACGAAGGAA CATTTGGCCA AATCTTTCAA GGTGCACTAC TGGATGAAAA AGACCCCAGT 900

AAAGAAAAGC AGGTCTTTGT GAAGACAGTA AAAGATCATG CCTCTGAGGT TCAGATCACC 960

ATGATGTTGA CTGAAAGTTG CAAGCTTCGA GGACTTCATC ACAGAAATCT GTTGCCGATA 1020

AGTCATGTCT GCACAGAGGA CGGAGAGAAG CCCATGGTGC TGTTGCCTTT CATGGCTTGG 1080

GGGAATCTCA AGCTTTTCCT TCGGCAGTGC AAGTTAGCGG AGGCTAACAA CCCACAGTCC 1140

ATCTCTCAGC AAGACTTGGT TTATATGGCC ATTCAGATTG CATGTGGAAT GAGCTATTTA 1200

TCTCGCCGGG AGGTCATTCA CAAAGATCTT GCTGCCAGGA ATTGTGTCAT TGATGACAAC 1260

ATGCAAGTCA AGATTACAGA CAACGCCCTG GCACGAGACC TTTTCCCCAT GGATTACCAC 1320

TGCCTGGGCG ATAATGAGAA TCGTCCTGTT CGCTGGATGG CCCTGGAGAG CTTGCTTAAT 1380

AATGACTTCT CCAGTTTAAG CGACGTGTGG GCCTTCGGGG TGACGCTGTG GGAGCTGATG 1440

ACTCTCGGTC AGACACCCTA TGTCGACATT GACCCATTTG AGATGTCGGC CTACCTGAAG 1500

GACGGCTACA GAATAGCACA ACCGATCAAC TGTCCAGATG AATTGTTTGC AGTGATGGCT 1560

TGTTGCTGGG CGCTGGACCC AGAGGAACGG CCCAAGTTTC AGCAGCTTGT TCAGTGTCTC 1620

ACTGAGTTTC ATTCAGCGTT GGGTGCTTAT GTATAA 1656

Domain Profile

S: 1     lrlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvs  60

         ++l+++l+eGtfG+i++G l dekd++kek+v+vktvkd+ase+q++++l+e+++l+g++

Q: 274   VTLRDVLHEGTFGQIFQGALLDEKDPSKEKQVFVKTVKDHASEVQITMMLTESCKLRGLH  333

         57899*******************************************************

S: 61    hrnilsvllvsieeaekPlvvypalnkgnlkkflricklkdkekaqalstkqlvelaiqi  120

         hrn+l++ +v++e+ ekP+v++p +++gnlk flr+ckl +++++q++s+++lv +aiqi

Q: 334   HRNLLPISHVCTEDGEKPMVLLPFMAWGNLKLFLRQCKLAEANNPQSISQQDLVYMAIQI  393

         ************************************************************

S: 121   asalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkWl  180

         a++++yl +rev+hkd+aarncvidd++qvk+td+al+rdlfP+dy+clGdnenrP++W+

Q: 394   ACGMSYLSRREVIHKDLAARNCVIDDNMQVKITDNALARDLFPMDYHCLGDNENRPVRWM  453

         ************************************************************

S: 181   slealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncPd  240

         +le+l ++ +ss sdvWa+Gv+lWel+tlg++Py++idpfe++aylkdGyr+aqP+ncPd

Q: 454   ALESLLNNDFSSLSDVWAFGVTLWELMTLGQTPYVDIDPFEMSAYLKDGYRIAQPINCPD  513

         ************************************************************

S: 241   elftvmaccWallpeerPsfeqlvscl  267

         elf+vmaccWal+peerP+f+qlv+cl

Q: 514   ELFAVMACCWALDPEERPKFQQLVQCL  540

         **************************8

Domain Sequence
(FASTA)

VTLRDVLHEG TFGQIFQGAL LDEKDPSKEK QVFVKTVKDH ASEVQITMML TESCKLRGLH 60

HRNLLPISHV CTEDGEKPMV LLPFMAWGNL KLFLRQCKLA EANNPQSISQ QDLVYMAIQI 120

ACGMSYLSRR EVIHKDLAAR NCVIDDNMQV KITDNALARD LFPMDYHCLG DNENRPVRWM 180

ALESLLNNDF SSLSDVWAFG VTLWELMTLG QTPYVDIDPF EMSAYLKDGY RIAQPINCPD 240

ELFAVMACCW ALDPEERPKF QQLVQCL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR003306	; WIF.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF02019	; WIF; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50814	; WIF; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013