EKS-TAR-00514

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00514

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	298.5	1.2E-88	194	459	266

Status

Unreviewed

Ensembl Protein

ENSTRUP00000042844

UniProt Accession

H2V0W2;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK4

Gene Synonyms/Alias

IRAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016737	ENSTRUP00000042845	ENSTRUT00000042990
ENSTRUG00000016737	ENSTRUP00000042842	ENSTRUT00000042987
ENSTRUG00000016737	ENSTRUP00000042844	ENSTRUT00000042989
ENSTRUG00000016737	ENSTRUP00000042843	ENSTRUT00000042988

Organism

Takifugu rubripes

Functional Description

Protein Length

466

Protein Sequence
(FASTA)

MSNSVTSATY IRNLSYSIRR QLSGILDPQE RWKEIIISIR KPNGDFRYSQ HNVRRFAGLV 60

AQGKSPTEEL LADWGTSNCT VGELVDILKS HKLLAAAAIV LPDAVPAEAQ QPDPPSAETY 120

SALPTRLLDN KGTQTVPSSA PTQIQLDSCD PEPTSEPSQR NTCFHVSQCF SSISYNDLIK 180

ITDGFNDRPV SEGGCRLGEG GFGAVYKGVL NHKLVAVKKL IPVEDMSLED LQIQFHQEIQ 240

TLTVLQHENL VDMVGFSCDG QYPCVIYPLM PNGSLLDRLA CLEGTPPLSW KQRCLIAEGT 300

ASGLEFVHRN HHVHRDVKSA NILLDEKLVA KISDFGLTRA SPKGTSTTMK TERIVGTCAY 360

MAPEALRGQV TPKSDIFSFG VVLLEILSGL PPVDENHNPQ FLMEVPSAIE DEDEELTFEG 420

FLDTKMEDVQ LGQAESVYTL ACSCLQDRKN QRPVSKQLQV LLELSG 466

Nucleotide Sequence
(FASTA)

ATGAGTAATT CGGTTACTTC CGCTACCTAC ATTCGCAACC TCAGCTACAG TATAAGGCGA 60

CAACTGTCAG GTATTTTGGA TCCTCAAGAG AGGTGGAAAG AGATTATTAT CTCCATCCGG 120

AAGCCGAATG GGGATTTTAG ATATTCTCAA CATAATGTGA GGAGATTTGC AGGTCTGGTT 180

GCGCAGGGTA AAAGCCCCAC GGAGGAGCTG CTGGCTGACT GGGGCACCAG CAACTGCACA 240

GTGGGAGAAC TGGTGGACAT TCTGAAGAGC CACAAGTTAC TGGCTGCCGC TGCCATTGTG 300

CTGCCTGATG CCGTCCCAGC AGAAGCACAG CAGCCAGACC CTCCATCAGC AGAAACATAC 360

AGCGCTCTTC CAACCAGACT GCTGGACAAC AAAGGGACGC AGACAGTTCC CAGCTCTGCT 420

CCAACCCAGA TTCAGCTGGA CAGTTGTGAT CCAGAACCCA CAAGTGAGCC CTCACAGAGA 480

AACACATGCT TTCATGTGTC CCAATGTTTC TCCAGTATCT CCTACAACGA TCTGATTAAG 540

ATCACGGACG GCTTTAATGA CCGTCCCGTA TCGGAGGGTG GCTGCAGGCT GGGGGAGGGA 600

GGCTTCGGCG CCGTCTACAA AGGCGTCCTG AACCATAAAC TGGTTGCGGT GAAAAAGCTC 660

ATTCCGGTGG AGGACATGTC CCTGGAGGAC CTACAAATCC AGTTCCACCA GGAGATCCAA 720

ACTCTGACAG TGTTACAACA TGAGAACTTG GTGGACATGG TTGGATTCTC CTGTGATGGA 780

CAGTACCCGT GTGTGATCTA CCCTCTAATG CCCAACGGGT CTCTGCTGGA CCGATTGGCC 840

TGCTTGGAAG GCACTCCTCC GTTGTCATGG AAACAGAGGT GTTTGATAGC TGAAGGGACA 900

GCGAGTGGTT TGGAGTTCGT ACACAGGAAC CACCACGTCC ACAGAGATGT AAAAAGCGCA 960

AATATCCTGT TAGATGAAAA ACTGGTGGCA AAAATCTCCG ACTTCGGGTT GACCAGAGCG 1020

TCTCCCAAGG GGACGTCCAC AACCATGAAG ACAGAGAGGA TTGTGGGTAC CTGTGCGTAC 1080

ATGGCCCCTG AGGCCCTGAG GGGACAGGTC ACGCCTAAAT CTGATATCTT CAGTTTTGGA 1140

GTGGTGCTTT TAGAAATACT GTCTGGACTT CCTCCAGTCG ATGAAAACCA CAATCCGCAG 1200

TTCTTGATGG AGGTGCCTTC TGCGATAGAG GACGAAGACG AGGAGCTGAC CTTTGAGGGC 1260

TTCTTGGACA CAAAGATGGA GGACGTCCAG CTGGGCCAGG CTGAGAGCGT CTACACGTTG 1320

GCCTGCAGCT GCCTCCAGGA CAGGAAAAAC CAGCGGCCGG TCAGCAAACA GCTGCAGGTT 1380

CTGTTGGAGC TGAGCGGC 1398

Domain Profile

S: 4     dnrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnilel  63

         + r+geGgfg vy+g l+ + vavkkl   +d+sl+ l+ +f++E+++l+ ++H+n++++

Q: 194   GCRLGEGGFGAVYKGVLNHKLVAVKKLIPVEDMSLEDLQIQFHQEIQTLTVLQHENLVDM  253

         579*********************************************************

S: 64    lgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasps  123

         +g+s +++ +c++Y++m+nGsL drL c +g++pLsW+qR+ i+ Gta ++ef+H++  +

Q: 254   VGFSCDGQYPCVIYPLMPNGSLLDRLACLEGTPPLSWKQRCLIAEGTASGLEFVHRN--H  311

         *********************************************************..*

S: 124   lihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefirv  183

         ++h+d+ksaNiLLDekl +K++Dfgl+r   +s+k +st ++t++++gt aY+++e++r

Q: 312   HVHRDVKSANILLDEKLVAKISDFGLTR---ASPKGTSTTMKTERIVGTCAYMAPEALR-  367

         ****************************...999999**********************.

S: 184   gqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekve.ilekfldkka  242

         gq+t k+D++SfG+VllE+l+Gl+ vde+++++ L ++  + ie+e+ e ++e fld k+

Q: 368   GQVTPKSDIFSFGVVLLEILSGLPPVDENHNPQFLMEV-PSAIEDEDEElTFEGFLDTKM  426

         *************************************9.777777665526899******

S: 243   gkleeellealielalaclaekakkrPtmsqvl  275

          +++   +e++++la+ cl++++++rP  +q++

Q: 427   EDVQLGQAESVYTLACSCLQDRKNQRPVSKQLQ  459

         ***************************998876

Domain Sequence
(FASTA)

GCRLGEGGFG AVYKGVLNHK LVAVKKLIPV EDMSLEDLQI QFHQEIQTLT VLQHENLVDM 60

VGFSCDGQYP CVIYPLMPNG SLLDRLACLE GTPPLSWKQR CLIAEGTASG LEFVHRNHHV 120

HRDVKSANIL LDEKLVAKIS DFGLTRASPK GTSTTMKTER IVGTCAYMAP EALRGQVTPK 180

SDIFSFGVVL LEILSGLPPV DENHNPQFLM EVPSAIEDED EELTFEGFLD TKMEDVQLGQ 240

AESVYTLACS CLQDRKNQRP VSKQLQ 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR011029	; DEATH-like.
IPR017428	; Interleukin-1_rcpt-assoc_kin4.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013