EKS-TAR-00408

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00408

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	352.7	2.9E-105	240	491	252

Status

Unreviewed

Ensembl Protein

ENSTRUP00000042998

UniProt Accession

H2V1B2;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK1 (2 of 2)

Gene Synonyms/Alias

PAK1 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016790	ENSTRUP00000042999	ENSTRUT00000043144
ENSTRUG00000016790	ENSTRUP00000042993	ENSTRUT00000043138
ENSTRUG00000016790	ENSTRUP00000042994	ENSTRUT00000043139
ENSTRUG00000016790	ENSTRUP00000042992	ENSTRUT00000043137
ENSTRUG00000016790	ENSTRUP00000042997	ENSTRUT00000043142
ENSTRUG00000016790	ENSTRUP00000042998	ENSTRUT00000043143
ENSTRUG00000016790	ENSTRUP00000042995	ENSTRUT00000043140
ENSTRUG00000016790	ENSTRUP00000042996	ENSTRUT00000043141

Organism

Takifugu rubripes

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

MSDSVDIEEK PPAPPLRMNS SSRDSSSLNH ASKPLPMAPE EKNKKVRLRS IFPGGDKTNK 60

KKEKERPEIS LPSDFEHTIH VGFDAVTGEF TGIPEQWARL LQTSNITKLE QKKNPQAVLD 120

VLKFYDSKET VNNQKYMSFT SGEHQEEDEE EEDEEEEDEE EEDEDELPPV IAPRPEHTKS 180

IYTRSVMDLP KPPTPVKNTS NTMYRHTDRQ RKKSKMTDEE ILERLRTWSI VSVGDPKKKY 240

TRFEKIGQGA SGTVYTAIDI ATGQEVAIKQ MNLQQQPKKE LIINEILVMR ENKNSNIVNY 300

LDSYLVGDEL WVVMEYLAGG SLTDVVTETC MDEGQIAAVC RECLQALDFL HSNQVIHRDI 360

KSDNILLGMD GSVKLTDFGF CAQITPEQNK RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL 420

GIMAIEMVEG EPPYLNENPL RALYLIATNG TPELQNPERL SSVFRDFLNR CLEMDVDRRG 480

SAKELLQHSF LKLAKPLSSL TPLIVAAKEA IKNSS 515

Nucleotide Sequence
(FASTA)

ATGTCTGATA GTGTCGATAT TGAAGAGAAA CCACCAGCCC CCCCCTTGAG AATGAACAGT 60

AGTTCCCGAG ACTCTTCATC ACTGAATCAC GCCTCCAAAC CGCTTCCAAT GGCTCCCGAA 120

GAGAAAAACA AGAAAGTCCG ACTGCGCTCC ATTTTCCCCG GGGGAGACAA GACAAATAAG 180

AAGAAGGAGA AGGAACGTCC CGAAATATCG CTGCCTTCAG ACTTTGAACA CACCATTCAT 240

GTCGGCTTTG ACGCTGTAAC AGGAGAATTC ACCGGCATCC CAGAACAGTG GGCCCGGCTC 300

CTGCAGACCT CCAACATCAC CAAGTTGGAA CAGAAGAAGA ACCCACAGGC CGTGCTTGAC 360

GTCCTAAAGT TCTACGACTC CAAAGAGACT GTGAACAACC AGAAGTACAT GAGCTTCACC 420

TCAGGAGAAC ATCAAGAGGA GGATGAGGAA GAAGAGGACG AAGAGGAGGA GGACGAAGAG 480

GAGGAGGACG AGGACGAGCT GCCACCGGTC ATCGCCCCTC GACCAGAACA CACCAAATCT 540

ATCTACACAC GCTCCGTCAT GGACCTGCCA AAGCCCCCCA CCCCCGTGAA GAACACGTCT 600

AACACGATGT ATCGCCACAC TGACCGCCAG CGAAAGAAGT CCAAGATGAC GGACGAGGAG 660

ATTCTGGAAA GACTCCGTAC GTGGAGTATC GTGAGTGTGG GGGATCCCAA AAAGAAGTAC 720

ACGCGCTTCG AGAAAATAGG CCAAGGGGCG TCCGGCACCG TGTACACCGC CATCGACATA 780

GCAACCGGCC AAGAGGTTGC CATCAAGCAA ATGAACCTGC AGCAGCAGCC CAAGAAAGAG 840

CTGATCATCA ACGAGATCCT GGTGATGAGG GAAAACAAAA ACTCCAACAT AGTGAACTAC 900

CTGGACAGTT ATTTGGTAGG AGATGAGCTG TGGGTGGTGA TGGAGTACTT GGCAGGCGGC 960

TCTCTCACAG ATGTAGTGAC TGAGACCTGC ATGGATGAGG GCCAGATTGC TGCAGTGTGC 1020

AGAGAGTGTC TTCAAGCCCT AGACTTCCTA CATTCCAACC AGGTGATTCA CCGAGATATA 1080

AAAAGTGACA ACATCCTCTT AGGAATGGAC GGATCCGTCA AGCTCACCGA TTTTGGCTTC 1140

TGTGCTCAGA TCACGCCAGA GCAGAACAAG CGCAGCACGA TGGTGGGAAC ACCATACTGG 1200

ATGGCCCCAG AGGTGGTGAC TCGGAAGGCT TATGGCCCGA AAGTAGATAT CTGGTCTCTG 1260

GGAATAATGG CAATAGAGAT GGTGGAGGGA GAACCACCCT ATCTGAACGA GAACCCGCTT 1320

AGGGCATTGT ACCTGATAGC TACCAATGGG ACACCAGAAC TGCAAAACCC AGAGAGGCTT 1380

TCATCTGTGT TCAGGGACTT TCTCAACCGC TGTCTGGAGA TGGATGTGGA CCGCAGAGGC 1440

TCTGCCAAGG AGCTGCTCCA GCATTCCTTC CTGAAGCTGG CGAAGCCTCT CTCCAGCCTG 1500

ACACCTCTGA TTGTAGCTGC AAAGGAAGCC ATAAAGAACA GCAGT 1545

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k++niv+

Q: 240   YTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNSNIVN  299

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ +elw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aL++lHs++vi

Q: 300   YLDSYLVGDELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVI  356

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 357   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQNKRSTMVGTPYWMAPEVVT--RKAYGPK  414

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++++s+ f++f+++cl+

Q: 415   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSSVFRDFLNRCLEM  474

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++++R sa+ell+h+Fl

Q: 475   DVDRRGSAKELLQHSFL  491

         ****************7

Domain Sequence
(FASTA)

YTRFEKIGQG ASGTVYTAID IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNSNIVN 60

YLDSYLVGDE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALDF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQN KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPER LSSVFRDFLN RCLEMDVDRR 240

GSAKELLQHS FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013