EKS-TAR-00046

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00046

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	319.5	4.4E-95	822	1092	271

Status

Unreviewed

Ensembl Protein

ENSTRUP00000043195

UniProt Accession

H2V1W4;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2 (2 of 2)

Gene Synonyms/Alias

JAK2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016857	ENSTRUP00000043194	ENSTRUT00000043339
ENSTRUG00000016857	ENSTRUP00000043195	ENSTRUT00000043340

Organism

Takifugu rubripes

Functional Description

Protein Length

1100

Protein Sequence
(FASTA)

MASVAAMETL ADTCPAVHQN GTAQRDSHGA GPTVGVLRLH FYPSGHGAAD SSFLSYPPGN 60

YVAEELCIDA AKACSISPLY FSLFGLFRER DCLWFSPNHT FQLDELASED VFFRIRYYFP 120

RWYSGGASRA YRYGVAKGSE SPVFDDYVMS YLFSQWRNDF VNGLVKIPSS HESQEECLGM 180

AVLDMTRTAK ESQLSPLDIY HTMSYKSFLP KEMRAQIQDC NFLTRKRIRF RFKRFIQQFS 240

QCRTTVRDLK LKYLISMESL EKAFYTETFQ VREQSKGQLI VLVAADSGIQ WCREKLKDSD 300

EELQSFCDFP DVTDISIKQA SKEGATESRV VTINKQDGKN VELEFPSLSE ALSFVSLIDG 360

YYRLTTDAHH YLCKEVAPPR LVEAITSHCH GPISLEFAIN RLQKCGNKQG LFILRCSPKD 420

FNKYFLTFPV EVYDVVEFKH CQITRTDGGK FNLSGTKRNF SSLHELLGCY QNETVRSDSV 480

VFQFSKCCPP KAKELHTLVV LTRPSPSPES QMVFHKIRKE DLEFNESLGQ GTFTKIFKGI 540

RKELGDYGLM HQTEVVMKVL DQAHRNFSES FFEAASMMTQ LSYKHLILNY GVCVCGEENI 600

MVQEFVKFGS LDTYLKKNKN SVNILWKLEV AKQLAQAMNF LEEKHLVHGN VCAKNVLLIR 660

EDDWKAGNPP FIKLSDPGIS ITVLPKEILV ERIPWVPPEC LTDPANLSLA ADKWSFGTTL 720

WEICSGGEKP LASLDNTKQK ILFYEDRYQL PAPKWIELAN LITSCMDYEP TFRPTFRAVI 780

RDLHSLFTPD SDILPNRTVG AGWSSGGFDS QEPAQFEERH LIFLQQLGKG NFGSVEMCRY 840

DPLQDNTGEV VAVKKLQHGT AEHIRDFERE IEILKSLQHE NIVKYKGVCY SAGRRNLRLI 900

MEYLPFGSLR DYLMKNRERI DHKKLVHYSS QICKGMEYLS TKRYIHRDLA TRNILVESES 960

RVKIGDFGLT KVLPQDKEYY MVKEPGESPI FWYAPESLTE SKFSVASDVW SFGVVLYELF 1020

THSDRNSSPP TVFMSMMGND KQGQLIVYHL IELLKSGSRL PPPLGCPTEM HEIMEQCWDK 1080

DPFLRPSFKE LALSIDLFRE 1100

Nucleotide Sequence
(FASTA)

ATGGCCTCTG TGGCAGCCAT GGAAACTCTG GCTGACACGT GCCCTGCGGT GCACCAAAAC 60

GGAACTGCCC AGCGGGACTC TCACGGGGCC GGGCCGACTG TCGGCGTGCT GAGGCTTCAC 120

TTCTACCCCA GCGGCCACGG AGCGGCAGAT TCCAGCTTCC TCAGCTACCC ACCTGGGAAC 180

TACGTTGCCG AGGAGCTGTG CATAGACGCG GCCAAGGCGT GCAGTATCTC GCCACTGTAT 240

TTCAGTCTTT TCGGTCTTTT CCGAGAGCGA GACTGCTTAT GGTTTTCACC CAATCATACA 300

TTCCAGCTCG ATGAATTGGC TTCAGAAGAC GTGTTTTTCA GAATAAGGTA CTATTTCCCA 360

AGGTGGTACA GCGGGGGGGC ATCCCGAGCA TATCGATATG GGGTGGCCAA GGGGTCCGAG 420

AGCCCTGTTT TTGATGACTA CGTAATGTCA TACCTTTTCT CTCAGTGGAG GAACGACTTT 480

GTCAACGGCT TAGTGAAGAT TCCCAGTTCT CATGAATCTC AGGAAGAATG TCTCGGTATG 540

GCTGTGCTGG ACATGACCCG GACAGCCAAG GAGAGTCAGC TGTCACCTCT GGATATCTAC 600

CACACTATGA GCTATAAGTC TTTCTTGCCA AAAGAGATGA GAGCTCAGAT TCAGGACTGC 660

AACTTTTTGA CACGCAAGCG GATCCGCTTC CGTTTCAAGC GCTTCATCCA GCAGTTCAGT 720

CAGTGTCGGA CCACAGTGCG CGACCTCAAA CTCAAGTACC TCATCAGCAT GGAGTCCTTG 780

GAGAAGGCGT TCTACACCGA GACCTTCCAG GTCAGGGAAC AGTCCAAAGG CCAGCTCATC 840

GTACTGGTCG CAGCCGACAG CGGCATCCAG TGGTGTCGAG AGAAATTAAA AGATTCAGAT 900

GAGGAGCTGC AGAGCTTCTG TGATTTCCCT GATGTCACTG ACATCAGCAT CAAACAGGCC 960

AGCAAAGAGG GAGCTACAGA GAGCCGAGTG GTCACCATCA ACAAACAAGA CGGCAAGAAC 1020

GTGGAGCTGG AGTTCCCCAG CCTCTCTGAA GCGCTCTCCT TCGTGTCCCT CATTGATGGC 1080

TATTATCGGC TGACCACAGA TGCTCACCAC TATCTCTGTA AAGAAGTGGC TCCTCCGAGG 1140

CTCGTGGAGG CCATAACGTC CCATTGCCAC GGCCCCATTT CGCTGGAGTT TGCAATCAAT 1200

CGACTTCAGA AGTGCGGAAA CAAGCAGGGG TTGTTTATTT TGCGGTGTAG CCCTAAAGAC 1260

TTCAATAAGT ATTTCCTGAC GTTTCCTGTG GAGGTGTATG ACGTTGTAGA ATTCAAGCAT 1320

TGCCAGATAA CCAGGACTGA CGGCGGGAAG TTTAATCTCA GTGGAACCAA AAGAAACTTC 1380

AGCAGCCTGC ACGAGCTCCT CGGCTGTTAC CAAAATGAAA CCGTTCGCTC CGACAGTGTT 1440

GTTTTTCAGT TCAGCAAGTG CTGTCCTCCT AAAGCCAAAG AACTGCATAC CTTAGTAGTT 1500

CTTACGCGAC CCTCTCCCTC CCCAGAAAGT CAGATGGTGT TTCACAAAAT CAGGAAAGAA 1560

GATCTTGAAT TTAATGAAAG CTTGGGTCAA GGGACTTTTA CCAAAATCTT CAAAGGGATC 1620

CGGAAAGAGC TGGGAGATTA CGGCCTCATG CATCAGACCG AAGTAGTCAT GAAGGTCCTT 1680

GACCAGGCCC ACCGGAACTT CTCAGAGTCT TTCTTCGAAG CTGCCAGCAT GATGACACAG 1740

TTGTCCTATA AACACCTGAT CCTTAACTAT GGCGTCTGTG TCTGCGGAGA GGAAAATATA 1800

ATGGTGCAGG AGTTTGTAAA ATTTGGCTCC CTGGACACCT ACCTGAAGAA GAACAAGAAC 1860

TCTGTAAACA TCCTTTGGAA GCTGGAGGTG GCTAAGCAGC TCGCTCAGGC CATGAACTTC 1920

CTGGAGGAGA AGCATCTTGT CCATGGCAAC GTGTGTGCTA AAAACGTTCT CCTGATCAGA 1980

GAGGATGACT GGAAGGCCGG AAACCCTCCC TTCATCAAAC TGAGCGACCC TGGCATCAGC 2040

ATTACTGTCC TGCCCAAAGA GATCCTGGTG GAGAGGATCC CCTGGGTACC TCCTGAATGT 2100

CTCACTGATC CTGCCAACCT GAGCCTGGCA GCAGACAAAT GGAGCTTTGG CACGACACTT 2160

TGGGAGATCT GCAGTGGTGG AGAGAAGCCT TTAGCATCAC TGGACAACAC TAAGCAGAAA 2220

ATCCTCTTCT ATGAGGACCG GTACCAGCTT CCAGCTCCAA AGTGGATCGA ACTGGCAAAT 2280

TTAATAACCA GCTGCATGGA CTACGAACCG ACATTCCGGC CCACGTTTCG TGCCGTTATC 2340

CGTGACCTCC ACAGCCTCTT CACGCCAGAC AGCGACATCC TGCCAAACAG GACAGTGGGC 2400

GCGGGCTGGT CATCGGGAGG GTTCGATAGT CAGGAGCCGG CTCAGTTCGA GGAGAGACAC 2460

CTCATATTCC TACAGCAGCT GGGCAAGGGG AACTTTGGCA GCGTGGAGAT GTGCCGATAC 2520

GATCCGCTTC AGGACAACAC CGGCGAGGTC GTGGCCGTGA AGAAACTGCA GCACGGAACG 2580

GCGGAGCACA TCCGAGACTT TGAGCGAGAA ATCGAGATCC TGAAATCTCT GCAGCACGAG 2640

AACATCGTCA AGTACAAAGG CGTCTGCTAC AGCGCAGGTC GACGGAATCT GCGTCTCATA 2700

ATGGAATATC TTCCCTTCGG AAGTCTGCGA GACTACCTCA TGAAAAACAG GGAGAGGATC 2760

GACCATAAAA AGCTCGTGCA TTACTCTTCC CAGATCTGCA AGGGAATGGA GTACCTGTCC 2820

ACCAAGCGCT ACATTCACAG AGACCTGGCA ACGCGGAATA TTCTCGTGGA GAGCGAGTCG 2880

AGGGTGAAGA TCGGAGATTT TGGCCTCACC AAAGTCCTGC CTCAAGATAA AGAGTACTAC 2940

ATGGTCAAGG AGCCGGGAGA GAGCCCCATA TTCTGGTACG CGCCCGAGTC TTTGACTGAG 3000

AGCAAGTTCT CGGTGGCTTC GGACGTCTGG AGCTTTGGGG TGGTGCTCTA TGAGCTCTTC 3060

ACCCACAGCG ACAGGAACAG CAGCCCTCCC ACAGTCTTTA TGTCCATGAT GGGAAATGAC 3120

AAGCAGGGAC AGTTGATTGT TTATCACCTC ATTGAACTCC TGAAGTCTGG CAGCCGGCTG 3180

CCTCCACCTC TGGGGTGTCC CACGGAGATG CACGAGATTA TGGAGCAGTG CTGGGACAAG 3240

GATCCCTTCC TGCGTCCTTC TTTCAAGGAG CTCGCTCTGA GCATCGACCT GTTCAGGGAA 3300

Domain Profile

S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlsheh  61

          ++++Lgkg+f++v+++r+d+ +d+t+e va+k L++++ +++rdf+re+eil++l+he+

Q: 822   IFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHGTAEHIRDFEREIEILKSLQHEN  881

         6789********************************************************

S: 62    ivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLed  119

         ivk+kgvc++ g++  rl+mey++ GsL++yL k++e++++++l+++++q++k+meYL++

Q: 882   IVKYKGVCYSAGRRnlRLIMEYLPFGSLRDYLMKNRERIDHKKLVHYSSQICKGMEYLST  941

         *********999888*********************************************

S: 120   kklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlap  178

         k+++hrd+a+rn+Lve+es+      vk++d+gl+k+++qd eYy+v+e+++s+i+w+ap

Q: 942   KRYIHRDLATRNILVESESR------VKIGDFGLTKVLPQDkEYYMVKEPGESPIFWYAP  995

         ********************......**********************************

S: 179   eclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklell  225

         e+l+e+k +s+asdvWsFgv+lyel+t  ++++sp    +++++++        +++ell

Q: 996   ESLTESK-FSVASDVWSFGVVLYELFThSDRNSSPptvfMSMMGNDkqgqlivyHLIELL  1054

         *******.*******************88889999***99999999999***********

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         +++ rlp p  cp+e++e+m++c++++p  rpsF++++

Q: 1055  KSGSRLPPPLgCPTEMHEIMEQCWDKDPFLRPSFKELA  1092

         **********************************9985

Domain Sequence
(FASTA)

IFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHGTA EHIRDFEREI EILKSLQHEN 60

IVKYKGVCYS AGRRNLRLIM EYLPFGSLRD YLMKNRERID HKKLVHYSSQ ICKGMEYLST 120

KRYIHRDLAT RNILVESESR VKIGDFGLTK VLPQDKEYYM VKEPGESPIF WYAPESLTES 180

KFSVASDVWS FGVVLYELFT HSDRNSSPPT VFMSMMGNDK QGQLIVYHLI ELLKSGSRLP 240

PPLGCPTEMH EIMEQCWDKD PFLRPSFKEL A 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013